外阴阴道念珠菌病治疗的研究进展

外阴阴道念珠菌病是育龄妇女常见的生殖道感染性疾病,现有的治疗手段包括局部和系统用药,对防止复发作用均有限,新的抗真菌药物的开发和免疫治疗为复发性外阴阴道念珠菌病的治愈带来希望。     

外阴阴道念珠菌病的诊疗

外阴阴道念珠菌病是临床常见的生殖道感染性疾病,对患者的生活质量影响较大.现有的治疗手段包括局部和系统用药,对防止复发作用都较有限.对于迁延不愈的病例,应结合患者的易感因素和药敏等实验室检查结果来确定治疗策略.纠正阴道微生态平衡和免疫治疗将为顽固难治的病例提供新的治疗途径.     

联合方法治疗外阴阴道念珠菌病83例临床观察

目的观察联合方法治疗外阴阴道念珠菌病的临床疗效。方法随机将83例患者分为两组,治疗组43例,口服伊曲康唑加“香连洗剂”局部熏洗,并联合达克宁栓阴道用药;对照组40例,口服伊曲康唑加“香连洗剂”局部熏洗。观察两组疗效。结果用药1个月后复查治疗组治愈率为100%,对照组为92%,两组间差异有显著性(P<0.05);用药后2月、3月复查,两组复发率治疗组为2.33%,对照组为10.5%,两组间差异有显著性(P<0.05)。结论联合方法治疗外阴阴道念珠菌病疗效较好。     

氟康唑治疗复发性外阴阴道念珠菌病疗效观察

笔者于2000年12月～2002年4月采用氟康唑治疗复发性外阴阴道念珠菌病(RVVC)126例,现报告如下。1病例与方法病例选择:126例患者均来自笔者所在皮防所门诊,年龄18～53岁,病程1～13年。所有患者均符合以下诊断标准:①有不同程度外阴红斑、瘙痒,阴道黏膜充血、水肿,伴伪膜样损害,阴道分泌物增多呈豆渣样;②阴道分泌物直接镜检见芽生孢子和假菌丝;③1年至少发作4次犤临床症状和(或)真菌直接镜检阳性犦。妊娠和哺乳期妇女、有肝肾等器质性疾病或其他疾病系统用药者,以及在治疗前4周内系统或阴道局部应用抗真菌药者不入选。自行中断治疗或不按时…     

外阴阴道念珠菌病

外阴阴道念珠菌病影响着大多数妇女的健康，最常见的病原菌为白念珠菌，多种因素与念珠菌病的发病及复发有关，反复发作的外阴阴道念珠菌病治疗比较困难，本文就其微生物学，发病机理，临床表现，诊断及治疗等方面进行了讨论。     

外阴阴道念珠菌病的免疫学机制研究进展

外阴阴道念珠菌病是一种常见的阴道粘膜的真菌感染性疾病 ,对妇女的身心有较大的伤害 ,近年来对此病的发病机制尤其是免疫学机制在临床和实验动物方面的研究表明 ,本病的反复发作主要与阴道局部的免疫学因素有关 ,提示免疫学治疗将成为本病治疗上一个较有前景的手段。     

糖尿病合并外阴阴道念珠菌病26例治疗体会

目的探讨糖尿病合并外阴阴道念珠菌病(VVC)的治疗方法。方法对26例糖尿病合并外阴阴道念珠菌病的治疗方法及结果进行回顾性分析。结果26例患者经过合理控制血糖,同时根据病情选用有效的抗真菌药物治疗后均获治愈,但复发性外阴阴道念珠菌病(RVVC)复发率较高。结论治疗本病应早期治疗、合理控制血糖、选用有效足量的抗真菌药物。     

外阴阴道念珠菌病

外阴阴道念珠菌病影响着大多数妇女的健康,最常见的病原菌为白念珠菌,多种因素与念珠菌病的发病及复发有关。反复发作的外阴阴道念珠菌病治疗比较困难,本文就其微生物学、发病机理、临床表现、诊断及治疗等方面进行了讨论。     

复发性外阴阴道念珠菌病的危险因素分析和治疗研究

目的：对复发性外阴阴道念珠菌病(RVVC)的致病危险因素进行统计和治疗探讨。方法：对性病门诊的60例RVVC患者，配对选择VVC患者作为对照，进行危险因素条件logistic回归统计分析；另外把RVVC患者随机分为三组，分别用伊曲康唑、氟康唑、特比奈芬间断治疗6个月，比较其治疗效果。结果：性病门诊中RWC的危险因素包括性伴感染传播、滥用抗生素、口服避孕药致内分泌改变及抗真菌药物使用不当均为RVVC的发生危险因素；用伊曲康唑和氟康唑治疗RVVC，效果要优于用特比奈芬。结论：治疗RVVC要注意消除或控制其危险因素；选择伊曲康唑或氟康唑进行每月间断抗真菌治疗有明显效果。     

复发性外阴阴道念珠菌病的病因与控制对策

复发性外阴阴道念珠菌病(recurrent vulvovaginal candidiasis RVVC)指一年中发生4次或以上的外阴阴道念珠菌病(vulvovaginal candidiasis VVC)^[1].以往的资料显示,约75%的已婚妇女一生中要罹患一次VVC,其中约一半要发作2次,而在这些患者中,约5%发展成RVVC^[2].由于病原菌和机体双方面的多种因素,使该病顽固难治,对患者身心影响较大,近年来成为研究热点.本文从RVVC的易患因素、发病机制和控制对策等几方面作简要阐述.     

Vulvovaginal candidiasis complicating recurrent bacterial vaginosis

In this study the authors reveal a high incidence of asymptomatic and symptomatic vulvovaginal yeast infection in patients with recurrent bacterial vaginosis. Symptomatic yeast vaginitis in these patients presents frequently as a mixed infection with symptoms and signs of both clinical entities being present simultaneously. The authors diagnosed vulvovaginal candidiasis in 10 (29%) out of 35 patients with a history of recurrent bacterial vaginosis; vulvovaginal candidiasis and bacterial vaginosis together were detected in 12 (34%) out of 35 women. Optimal therapeutic results usually require concomitant treatment of both candidal vaginitis and bacterial vaginosis. The lack of specificity of signs and symptoms of vaginitis mandates that women with recurrent bacterial vaginosis, for each symptomatic recurrence, be examined and evaluated by the use of simple laboratory tests to determine a specific diagnosis. Failure to appreciate the frequency of candida superinfection leads to empirical and inappropriate therapy for bacterial vaginosis.     

Vulvovaginal candidiasis in women who have sex with women

OBJECTIVES: To determine whether vulvovaginal candidiasis (VVC) is associated with sexual activity between women. STUDY DESIGN: Cross-sectional survey of 708 new patients attending 2 sexual health clinics for lesbians and bisexual women in London, UK. Questionnaire for demographic variables, sexual history, symptoms, and sexual practice data linked with the results of Gram stain and/or culture of vaginal preparations for identification of Candida species. RESULTS: VVC (either symptomatic or asymptomatic) was common in this sample of women who have sex with women (18.4%). Logistic regression showed that VVC was significantly associated with larger numbers of female sexual partners in the previous year [OR 2.18 (CI 1.35-3.53) for 2 female partners compared with 0 or 1] but not with specific sexual practices, numbers of male partners, use of lubricants or vaginal douching. CONCLUSIONS: The increasing odds of candidiasis with greater numbers of female sexual partners raises the possibility that Candida species could be sexually transmitted between women.     

Congenital cutaneous candidiasis: a case with review of the literature

The clinical features of CCC are stereotyped. Twenty-two cases have been found in the literature. Skin lesions are present at birth (12/22) or within the first twelve hours of life (7/22) and sometimes later, up to the sixth day of life. Maculopapular lesions are the first to appear, followed by the more typical vesiculopustular rash and secondary desquamation. Involvement of the upper half of the body is frequent. Interestingly, palm and sole pustules are almost constant. Oral, periungueal and conjunctival lesions are rare. In most cases, healing occurs within ten days of topical treatment using either nystatin or imidazole derivatives. Rarely (2/22), systemic candidiasis may be associated and may progress to death because of lung or meningeal involvement. Differential diagnosis includes post-natal acquired candidiasis, infectious pustulosis-impetigo, herpes, varicella-, and syphilis. In the authors' experience, pustular erythema toxicum is the most difficult diagnosis to rule out and the value of the direct smear must be emphasized. The clinical picture of CCC correspond to intrauterine infection due to a specific chorioamnionitis, for the following reasons: the rash may occur at birth; experimental cutaneous candidiasis required from 2 to 7 days of incubation; C. albicans has already been demonstrated in the adnexae, even in cases with late onset; culture of C. albicans in multiple sites favours intrauterine infection. Ascending infection of the fetal skin by C. albicans via the birth canal occurs probably through intact membranes, but fissures or late amniocentesis may create a portal of entry. CCC is rare as compared with the frequent maternal carriage of C. albicans.(ABSTRACT TRUNCATED AT 250 WORDS)