共查询到19条相似文献,搜索用时 171 毫秒
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心血管疾病是导致人类死亡的主要疾患之一, 其中以冠心病、心肌梗死最为常见。导致心功能衰竭的主要原因是心肌梗死后心肌细胞的大量丢失及内源性修复机制的缺失,受损的心肌被瘢痕组织所替代,从而进一步导致心功能的丧失。心脏移植可以治疗严重心功能衰竭,但这一有效治疗措施受供体来源和免疫排斥反应等的限制。近年来,随着人类对干细胞认识的加深,应用心肌再生治疗心血管疾病已经成为一个新的研究热点。 相似文献
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NO与心血管疾病细胞凋亡 总被引:5,自引:0,他引:5
NO是重要生物活性物质,介导着心肌、血管平滑肌、巨噬细胞、血管内皮细胞等程序性死亡与凋亡,与心血管疾病有密切的关系.并对NO与心血管疾病细胞凋亡的机制和目前研究方向及存在问题进行了文献综述. 相似文献
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心肌肌钙蛋白(cTn)检测的临床评价 总被引:3,自引:3,他引:3
在我国 ,随着人民生活水平的不断提高 ,传染病、寄生虫病的不断控制 ,人口的疾病谱已发生显著变化。解放初冠心病、心肌梗死十分少见 ,而如今我国不少地区 ,冠心病、心肌梗死病例大幅增加 ,在部分城市已成为人口死亡的主要原因。心肌肌钙蛋白I(cardiactroponinI,cTnI)是近年来发展起来的一种高特异、高灵敏反映心肌损伤的血清标志物 ,已越来越多地用于心肌梗死、心绞痛的诊断和鉴别诊断 ,并有逐渐取代心肌酶的趋势。心肌损伤标志物检测是急性心肌梗死 (acutemyocardialinfarction ,AMI)的… 相似文献
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自2001年骨髓干细胞被首次用于治疗心肌梗死以来,干细胞移植治疗心血管疾病的临床研究已历经了10余年。近年来,BMSC因其可塑性、遗传稳定性和免疫耐受性而成为用于心肌修复较为理想的细胞。本文主要对BMSC移植治疗心血管疾病的临床研究的现状和进展加以综述。 相似文献
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Thawatchai Khuanjing Siripong Palee Siriporn C. Chattipakorn Nipon Chattipakorn 《Acta physiologica (Oxford, England)》2020,228(2)
Cardiovascular diseases remain a major cause of morbidity and mortality worldwide. Cardiovascular diseases such as acute myocardial infarction, ischaemia/reperfusion injury and heart failure are associated with cardiac autonomic imbalance characterized by sympathetic overactivity and parasympathetic withdrawal from the heart. Increased parasympathetic activity by electrical vagal nerve stimulation has been shown to provide beneficial effects in the case of cardiovascular diseases in both animals and patients by improving autonomic function, cardiac remodelling and mitochondrial function. However, clinical limitations for electrical vagal nerve stimulation exist because of its invasive nature, costly equipment and limited clinical validation. Therefore, novel therapeutic approaches which moderate parasympathetic activities could be beneficial for in the case of cardiovascular disease. Acetylcholinesterase inhibitors inhibit acetylcholinesterase and hence increase cholinergic transmission. Recent studies have reported that acetylcholinesterase inhibitors improve autonomic function and cardiac function in cardiovascular disease models. Despite its potential clinical benefits for cardiovascular disease patients, the role of acetylcholinesterase inhibitors in acute myocardial infarction and heart failure remediation remains unclear. This article comprehensively reviews the effects of acetylcholinesterase inhibitors on the heart in acute myocardial infarction and heart failure scenarios from in vitro and in vivo studies to clinical reports. The mechanisms involved are also discussed in this review. 相似文献
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Mehta H Mahajan A Bansal N Vaidya S Pathak L 《The Journal of the Association of Physicians of India》1998,46(11):953-956
The above discussion on the interaction of aspirin and ACE inhibitors seems to suggest that aspirin in high doses may have adverse interaction with ACE inhibitors in patients with heart failure but the data obtained is not sufficient or conclusive to recommended omission of aspirin in patients with heart failure. This raises a query in the mind of the physician whether to use a combination or not? The role of aspirin in the early period after myocardial infarction is well established so is the role of ACE inhibitors. Hence in patients with myocardial infarction and preserved left ventricular function it would not be wrong to administer combination of ACE inhibitors and aspirin. Albeit at a lower dose. In patients with large myocardial infarction or heart failure, warfarin may be an option but still needs to be documented in large trials. As suggested long term use of aspirin after infarction is still ambiguous and may be harmful in patients with heart failure with its anticedent side effects. But long term benefits of ACE inhibitors in heart failure are well documented. Hence if a choice has to be made whether to discontinue either of the two drugs it would be preferable to stop the aspirin. To answer the issue of use of aspirin in patients with heart failure it would be essential to conduct a double blind randomized trial comparing known anti-thrombotic treatment, aspirin and anti-coagulants on mortality in patients with heart failure, especially caused by coronary artery disease. Such a trial is underway at the present and till the results are available it should be left to clinical judgement of the physician whether to administer aspirin in patients with heart failure after weighing the benefits versus risk. 相似文献
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心力衰竭作为多种心血管疾病的共同归宿和主要死因,早期诊断和有效干预是提高患者预后结果和转归的重要手段。半乳糖凝聚素-3(Gal-3)是近年来出现的一种新的生物标志物,与心肌纤维化及心力衰竭相关,在心力衰竭的诊断及治疗中具有参考价值,可有望作为心力衰竭治疗的一个新靶点。 相似文献
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Wnt-frizzled信号通路与心血管疾病关系的研究进展 总被引:1,自引:0,他引:1
Many researches have focused on the wnt- frizzled cascade in the recent years, while much work has been done in neoplastic diseases and embryology, the role of the wnt- frizzled signal transduction pathway in cardiovascular diseases has only recently begun to be explored. It plays a very important role in many physiological and pathophysiological processes, such as its transduction pathway, the healing after myocardial infarction, the proliferation, differentiation and orientation of cardiomyocytes, angiogenesis/neovascularization, cardiac hypertrophy and heart failure, the deposition of the extracellular matrix and so on. This article is aimed at its relation with myocardial infarction and the role of this pathway in cardiovascular diseases. 相似文献
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Avinash Agrawal Anand Kumar Shuchi Consul Ambuj Yadav 《Indian Journal of Critical Care Medicine》2015,19(4):233-236
Scorpion bites are common in India. Usually, these bites are harmless but sometimes have serious clinical sequelae, including death. We report herein a case of scorpion bite with electrocardiographic abnormalities simulating early myocardial infarction. Pulmonary edema and congestive heart failure accompanied these electrocardiographic changes as well as serum cardiac markers. The etiology of cardiovascular manifestations in severe scorpion sting is related to venom effect on sympathetic nervous system and the adrenal secretion of catecholamines as well as to the toxic effect of the venom on the myocardium itself. It is a rare case of scorpion sting presented as myocardial infarction and heart failure, successfully treated with Intensive Care Unit care, noninvasive ventilation, vasopressors, and antiischemic treatment. 相似文献
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Mechanisms of Apoptosis in the Heart 总被引:14,自引:0,他引:14
Apoptosis is a complex and highly regulated form of cell death, and believed to contribute to the continuous decline of ventricular function in heart failure. Apoptotic cell death is observed in a variety of cardiovascular diseases, including myocardial infarction, ischemia-reperfusion injury, end-stage heart failure, arrhythmias, and adriamycin cardiomyopathy. There are several pathways leading to programmed cell death. Apoptosis can be initiated by extracellular or intracellular stimuli, leading to the activation of caspases and subsequent cell death. A better understanding of the process of apoptosis in the heart is clearly important as it may lead to the identification of novel therapies for cardiovascular disease. This review is focused on the basic cellular mechanisms of apoptosis, as well as our current understanding of this process in the heart. 相似文献
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脂肪来源细胞(褐色脂肪来源细胞、脂肪干细胞和去分化脂肪细胞)可分化成心肌样细胞,移植后可改善心梗后心功能,降低心室重塑,有可能成为最有潜力的治疗缺血性心脏病的干细胞来源。 相似文献