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1.
目的 探讨白细胞流变性一支气管哮喘发病的关系。方法 检测了68例支气管哮喘病人哮喘发作时和缓解后白细胞变形能力(LD)和白细胞粘附功能(LAF)的变化,并与42例健康人作比较。结果 支气管哮喘病人发作期白细胞滤过指数(LFI)和白细胞粘附率(LAR)均明显高于对照组和哮喘缓解期,差异均有极显著性。支气管哮喘病人发作期和缓解期LFI与LAR呈正相关。结论LD降低和LAF增高可能参与了支气管哮喘的发病 相似文献
2.
①目的探讨白细胞粘附功能(LAF)和细胞粘附分子(CAMs)表达与肺心病的关系。②方法采用酶联免疫吸附法(ELISA),分别检测了68例肺心病病人急性加重期和缓解期及46例健康人外周血白细胞CD18表达,血清可溶性细胞间粘附分子-1(sICAM-1)和白细胞粘附率(LAR)的变化。③结果肺心病病人白细胞LAF,CD18表达及sICAM-1浓度明显增高,与对照组比较差异有极显著性(t=6.902,21.482,31.923,P均<0.001),且急性加重期较缓解期增高更明显(t=4.578,8.264,17.806,P均<0.001)。肺心病病人白细胞LAF与CD18表达及sICAM-1浓度呈正相关(r=0.672,0.803,P均<0.001)。④结论LAF增高和CAMs表达增加参与了肺心病的发生与发展,以及与病情严重程度均有密切关系。 相似文献
3.
急性脑梗死病人白细胞流变特性及细胞黏附分子表达的变化及意义 总被引:2,自引:1,他引:1
①目的 探讨急性脑梗死(ACI)病人白细胞流变特性及细胞黏附分子表达的变化及意义。②方法采用红细胞变形能力测定仪、体外血栓血小板黏附两用仪及酶联免疫吸附法(ELISA),检测了72 例ACI病人、42例脑出血病人及48 例健康人白细胞变形能力(LD)、白细胞黏附功能(LAF)、白细胞CD18 表达及血清可溶性细胞间黏附分子-1(sICAM-1)和可溶性血管细胞间黏附分子(sVCAM-1)浓度的变化。③结果 ACI病人白细胞滤过指数(LFI)、白细胞黏附率(LAR)、白细胞CD18表达及sICAM-1 及sVCAM-1 浓度均明显升高,与脑出血病人及对照组比较差异有极显著性(t= 7.663~14.872,P< 0.001),且这些指标变化随着ACI病变程度加重而明显。ACI病人LFI和LAR与白细胞CD18 表达、sICAM-1 和sVCAM-1 浓度呈正相关(r= 0.680~0.724,P均< 0.001),LFI与LAR呈正相关(r= 0.685,P< 0.001)。④结论 白细胞流变特性和细胞黏附分子表达异常与ACI发病和病变程度有密切关系 相似文献
4.
采用WJY-Ⅲ型体外血栓血小板粘附两用仪和DXC-300型核孔膜红细胞变形能力测定仪,检测了83例缺血性脑血管病(ICVD)病人白细胞粘附功能(LAF)和白细胞变形能力(LD)的变化,以探讨其在ICVD发生和发展中的作用。结果显示,ICVD病人白细胞粘附率(LAR)和白细胞滤过指数(F)均明显增高,与对照组相比,差异有极显著性(P<0.001)。且随着病情加重、梗塞面积的扩大及预后不良,LAR和IF的增高逐渐明显。提示LAF增高和LD降低与ICVD发生有一定关系。 相似文献
5.
支气管哮喘患者血清可溶性白细胞介素2受体的研究 总被引:1,自引:0,他引:1
应用酶标单克隆与多克隆双抗体夹心法测定14例支气管哮喘发作期病人血清可溶性白细胞介素2受体水平,并同健康人、慢性支气管炎并发肺气肿病人和哮喘缓解期病人相比较;同时观察哮喘病人入院第四天sIl-2R变化同FEV1.0%变化的关系。结果表明,哮喘发作期sIL-2R显著高于健康组(P<0.01)和哮喘缓解组及慢支肺气肿组(P<0.05),sIL-2R变化同FEV1.0%变化有显著相关性(r=-0.766 相似文献
6.
《吉林大学学报(医学版)》1994,(2)
应用酶标单克隆与多克隆双抗体夹心法测定14例支气管哮喘发作期病人血清可溶性白细胞介素2受体(SolubleInterleukin2,sIL-2R)水平,并同健康人、慢性支气管炎并发肺气肿病人和哮喘缓解期病人相比较;同时观察哮喘病人入院第四天sIL-2R变化同FEV1.0%变化的关系。结果表明,哮喘发作期sIL-2R显著高于健康组(P<0.01)和哮喘缓解组及慢支肺气肿组(P<0.05),sIL-2R变化同FEV1.0%变化有显著相关性(r=-0.766,P<0.05)。提示活化的淋巴细胞同哮喘病发作密切相关。 相似文献
7.
①目的探讨高血压(EH)病人红细胞变形能力(ED)与红细胞膜脂质成分和血小板激活因子乙酰水解酶(PAF-AH)的关系。②方法观察了66例EH病人和38例健康人红细胞滤过指数(IF)、红细胞膜胆固醇(Ch)、磷脂(PL)、脂质过氧化物(LPO)及PAF-AH的变化。③结果EH病人红细胞IF较对照组明显增高(t=4.726,P<0.001)。EH病人红细胞膜Ch,LPO及Ch/PL明显增高,而PL和PAF-AH活性明显降低,与对照组比较差异均有极显著性(t=3.882~4.715,P<0.001)。这些指标变化随着EH病程进展而逐渐明显。EH病人红细胞IF与膜Ch,LPO及Ch/PL呈正相关(r=0.532,0.538,0.655,P<0.001),与PL和PAF-AH呈负相关(r=-0.527,-0.609,P<0.001)。④结论EH病人ED降低与红细胞膜脂质异常和PAF-AH活性降低有密切关系。 相似文献
8.
测定外源性哮喘、内源性哮喘及正常人循环中性粒细胞(PMN)的化学发光(chemiluminescence,CL)强度,结果表明:外源性哮喘PMN-CL及内源性哮喘PMN-CL均显著高于正常对照组(P<0.01),内源性哮喘与外源性哮喘PMN-CL无显著性差异(P>0.05);哮喘发作期PMN-CL明显高于缓解期(P<0.01),缓解期高于正常对照(P<0.05)。上述结果提示:循环PMN释放氧自由基(OFR)能力增强参与哮喘的发病,内源性哮喘和外源性哮喘循环PMN释放OFR能力无差异表明两者发病机制有共同之处。 相似文献
9.
目的探讨冠心病病人外周血淋巴细胞补体Ⅰ型受体(CR1)表达及血清可溶性白细胞介素-2受体(sIL-2R)浓度的变化。②方法采用淋巴细胞花环试验和酶联免疫吸附法(ELISA),检测了72例冠心病病人和63例健康人淋巴细胞CR1花环率(L-CR1R)及血清sIL-2R浓度变化。③结果冠心病病人L-CR1R明显降低,sIL-2R浓度明显增高,与对照组比较差异有极显著性(t=6.414,7.806,P<0.001)。冠心病病人L-CR1R与sIL-2R呈负相关(r=-0.815,P<0.001)。不稳定心绞痛(UA)、急性心肌梗死(AMI)和陈旧性心肌梗死(OMI)病人L-CR1R和sIL-2R比较,差异亦具有极显著性(F=7.860,11.579,q=6.627~10.550,P<0.001),且以AMI病人的变化最明显。④结论外周血淋巴细胞CR1表达和血清sIL-2R浓度异常与冠心病病情变化有密切关系。 相似文献
10.
不稳定型心绞痛病人红细胞变形能力变化与红细胞膜脂质成分的关系 总被引:1,自引:0,他引:1
①目的探讨不稳定型心绞痛(UA)病人红细胞变形能力(ED)与红细胞膜脂质组成的关系。②方法采用DXC-300A型红细胞变形能力测定仪,邻苯二甲醛-醋酸-硫酸法、TBA比色法和化学定量法,分别检测了47例UA病人和40例健康人红细胞滤过指数(EFI),红细胞膜胆固醇(CH),磷脂(PL)和脂质过氧化物(LPO)含量的变化。③结果UA病人EFI,CH,LPO和CH/PL均明显增高,PL明显降低,与对照组比较差异均有极显著性(t=4.822~9.650,P均<0.001)。UA病人EFI与CH,CH/PL,LPO呈正相关(r=0.764~0.881,P<0.001),与PL呈负相关(r=-0.627,P<0.001)。④结论UA病人ED降低与红细胞膜脂质成分异常有密切关系。 相似文献
11.
Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P < 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (>0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P <0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P < 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD. 相似文献
12.
Jiageng Zhu Jun Li Ruipeng Ji Jianghao Su Mingshun Shen Zhigang Cao 《南京医科大学学报(自然科学版)》2007,21(2):125-128
Objective: To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods: SD rats served as both donors and recipients. 4℃ sodium lactate Ringer's was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava (IVC) inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results: Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion: This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment. 相似文献
13.
Tao Ye * Zhi-quan Liu Jian-jun Mu Xi-han Fu Jun Yang Bao-lin Gao and Xiao-hong Zhang Department of Cardiology First Hospital of Xi'an Jiaotong University Xi'an Hanzhong Cardiovascular Institute Hanzhong 《中国医学科学杂志(英文版)》2004,19(4):248-251
Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P< 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P< 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure. 相似文献
14.
目的:评价使用安心颗粒对急诊经皮冠状动脉介入术(PPCI)术后生活质量的影响.方法:将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组(术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次)和对照组(仅接受基础药物治疗).所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表(MIDAS)、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果:入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异(P>0.05);出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低(P<0.05);组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低(P<0.05).两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血(P>0.05).两组发生轻度血小板减少症的患者数比较无差异(P>0.05).结论:PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险. 相似文献
15.
Jingming Zhu Ningning Hui Xiuhong Jiang Huaxing Zhang Chengzhang Fu 《南京医科大学学报(自然科学版)》2007,21(6):386-389
Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P<0.01);the MAP decreased(P<0.01)and the HR increased drastically(P<0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients. 相似文献
16.
Objective:To investigate the gene expression of osteoprotegerin(OPG) and osteoclast differentiation factor(ODF) in the bone tissue of patients with hip fracture due to osteoporosis. Methods:OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers(over 50 years old) with hip fracture(Observer Group) and 30 cases of hip facture sufferers with no osteoporosis(Control group) were analyzed with the Semi-Quantitative RT-PCR method. Results:The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion:Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption. 相似文献
17.
Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P. 相似文献
18.
Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine. 相似文献
19.
Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center. 相似文献
20.
Scientific principles and rigorous processes should be followed in developing clinical guidelines for therapeutic interventions of integrative medicine
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A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care(~'4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes. 相似文献