美国医学会杂志

2002—2004年间与接种天花疫苗相关的神经系统不良事件；动脉粥样硬化血栓形成门诊患者心血管危险因素的国际患病率、认识和治疗。     

欧洲儿科学杂志

1例极低出生体重儿的香豆素胚胎病伴新生儿肝炎与眼畸形；新生儿意外肌肉注射阿曲库铵后出现的临床表现和神经发育后果；Chilaiditi综合征所致的呼吸窘迫；DiGeorge综合征伴SAPHO性骨髓炎和类肉瘤样皮炎1例；不同表型先天性肾上腺增生症患儿的出生身长和体重     

斯堪的纳维亚胃肠病学杂志

胶原性结肠炎结肠黏膜的撕裂;通过清除细胞抑制异常隐窝细胞灶的唯一缓泻剂：聚乙二醇;对散发性结肠直肠腺瘤患进行的3项随机长期监测试验;S型支架治疗慢性胰腺炎患主胰管狭窄的效果;假性胰腺囊肿的治疗和结果     

新英格兰医学杂志

β-阻断剂对肝硬化患胃食管静脉曲张的预防作用；具有高并发症率和死亡率的难辨梭状芽胞菌相关性腹泻：多个卫生机构的暴发性流行；英夫利昔单抗对溃疡性结肠炎的诱导与维持治疗作用。     

眼科学

AIDS相关性巨细胞病毒性视网膜炎患者更昔洛韦埋植剂治疗的相关预后研究,兰尼单抗治疗新生血管性老年性黄斑变性的Ⅰ／Ⅱ期多中心临床对照多剂量研究,[编者按]     

Chenotherapy for gallstone dissolution. I. Efficacy and safety.

Clinical experience with chenodeoxycholic acid therapy for dissolving gallstones is reported, with particular attention to determinants of response. Of 12 patients receiving 15 mg/kg/day or more, ten responded (83%); only 15 of 40 patients (38%) receiving less than 15 mg/kg/day responded. Large solitary stones and stones in gallbladders that visualized poorly after oral cholecystography had a lower response rate. Radiopaque stones did not respond in 18 patients. Five of ten patients with stones in the common bile duct responded. Small, dose-related elevations in SGOT were the only biochemical abnormality observed. Liver biopsy specimens showed no notable abnormality. Diarrhea was an infrequent problem. Stones recurred in three of 15 patients during six to 48 months of observation without treatment. Chenodeoxycholic acid, when given in adequate dosage, continues to appear promising as medical therapy for asymptomatic radiolucent gallstones in radiologically visualizing gallbladders.     

国际妇产科学杂志

钙加亚油酸治疗妊娠期高血压疾病;舌下含服硝酸甘油处理胎盘滞留;脐-大脑中动脉搏动指数在生长受限胎儿中的预测价值;经阴道子宫切除术中双极导管电凝;比较治疗压力性尿失禁的膀胱颈悬吊术、耻骨阴道吊带术和无张力尿道中段悬吊术的效果;在乌干达首都坎帕拉对严重先兆子痫处理基于标准的审查;孟加拉国首都达卡的分娩相关并发症和产后早期发病率.     

The Lehigh--Medical College of Pennsylvania six-year B.A.-M.D. program.

Lehigh University and the Medical College of Pennsylvania have developed a program in which selected high school students are admitted directly to medical school. The students spend two years at the university completing the premedical basic sciences and the required humanities and social sciences for the bachelor's degree. Students may choose to extend the two-year university phase to three or four years. Science credit is given by the university for medical school courses, and the student graduates with a B.A. degree after four years and an M.D. degree after six years.     

美国医学会杂志

新加坡暴发的与佩戴接触镜相关的镰刀菌角膜炎;补体因子H多态性、补体激活物与罹患老年性黄斑变性的风险;[编者按]     

新英格兰医学杂志

羹达非尼对轮班工作睡眠障碍相关性过度嗜睡的作用;全身低温治疗新生儿缺氯缺血性脑病;血浆置换治疗原发性自身免疫性自主神经衰竭;与Williams-Beuren基因座重复相关的严重表达性语言延迟;[编者按]     

临床胃肠病学杂志

慢性丙型肝炎中ISG分析确定蛇毒素为一种潜在的抗病毒效应物质；爱沙托立宾（一种TLR7受体激动剂）可减少慢性丙型肝炎感染血浆中病毒浓度；PillCam ESO食管胶囊内镜和传统上消化道内镜在诊断慢性胃食管反流病患准确性的前瞻性研究。     

TREATMENT OF PNEUMONIAS IN CHILDREN WITH SULFAPYRIDINE, ORALLY AND INTRAMUSCULARLY' L.K. TSANC, M.D. AND MARY E. McCRACKEN, M.D. Department of Pediatrics, American Hospitat for Refugee8 St. Luke's Hospital, No. g, Shanghai.

The therapeutic value of sulfapyridine in the treatment of children with lobar pneumonia, pertussis pneumonia, and with bronchopneu- monia secondary to measles has been well established. Table l gives a summary of the literature with 378 cases of pneumonia in children with a mortality rate of l.06 per cent as compared with the text-book mortality rates of 3-5 per cent in lobar pneumonia, 10-20 per cent in primary bronchopneumonia, and 50-80 per cent in secondary broncho- pneumonia in institutions (9), (10). The authors agree that the lowering of the mortality rate is not the only indication of the therapeutic vaIue of suIfapyridine. It is remarkable to see how often an acutely ill child becomes well within forty-eight hours, often within twenty-four hours. The toxic symptoms encountered are nausea and vomiting, sometimes cyanosis, rarely morbilliform eruptions,neutro penia, hematuria, and irritability-they do not usualIy necessitate the cessation of the drug.     

美国皮肤病学会杂志

日常家庭刺激物致刺激性接触性皮炎：采用非侵袭性方法评估皮肤对刺激物反应的种族差异性,掌跖蕈样肉芽肿的临床病理特征和T细胞受体基因重排检测结果,采用ISA247治疗慢性斑块型银屑病的多中心、随机、双盲、安慰剂对照Ⅱ期临床试验,UV硬化治疗：针对光敏性皮肤红斑狼疮患者的一种新型干预疗法.     

胃肠病学杂志

食管黑变病：一种与日本噜酒人群上段气遒消化道鳞状细胞肿瘤及非活性醛脱氢酶-2相关的内镜下所见；胃溃疡愈合期间胃酸抑制剂对新生血管的影响；幽门部早期胃癌患环氧化酶-2的表达升高；对结肠直肠癌中SMAD4／DPC4多倍体基因改变的分析；CT评估胆管癌患的主动脉旁淋巴结转移。[编按]     

A Provincial Hospital C.C.U. After ISIS 2

A prospective study of admissions to an Irish provincial coronary care unit in the light of reported benefits of streptokinase and oral aspirin as reported in the Isis study was carried out. of 115 patients admitted with suspected myocardial infarction (M.I.), the diagnosis was confirmed in 41. The average delay from onset of chest pain to admission to C.C.U. was 6.65 hours (0.3 – 18 hours, median 6 hours). Twenty-six of the 41 patients were given streptokinase after a median time lapse of six hours from the onset of pain. 88% of the M.I. patients were on oral aspirin at discharge but only 12% were on oral beta blockers. These findings are compared with the findings of the Isis 2 study worldwide and in Ireland. The presence of risk factors in the patients with M.I. is analysed, 16 of the 41 had serum cholesterol levels greater than 6 mmols/1. As an index of community risk factor screening, an enquiry was made of the patients and of their family doctor as to whether serum cholesterol had previously been checked, this had been done in only 12 of 41 and in only 2 had it been carried out by the family doctor. Pre-hospital analgesic use was also examined and 36 of the 41 patients had chest pain and were seen by their G.P.s but only 18 were given analgesics of whom 13 received morphine. We conclude that greater public education is necessary to reduce the delay in summoning help after an M.I., greater efforts are needed by hospitals to streamline admissions to the C.C.U. and to provide mobile C.C.U. in rural areas and greater efforts are required by family doctors to provide risk factor screening and to provide adequate analgesia in patients with M.I. prior to hospital admission.     

国际心脏病学杂志

表现为围生期心肌病的孤立性左室心肌致密化不全;心力衰竭患者静息状态呼气末二氧化碳分压的预后价值;中度运动锻炼对慢性心力衰竭患者骨骼肌肌球蛋白重链分布的影响;肺炎衣原体或幽门螺杆菌血清学阳性与冠状动脉疾病的关系;检测卵圆孔未闭右向左分流时，大的Eustachian瓣是经食管造影超声心动图的混淆因素，但不影响彩色多普勒经食管超声心动图     

The iron-enrichment-now brouhaha. Response to Dr. Lasagna.

High-dose bolus urography was evaluated in 38 patients with severe renal failure. Iothalamate meglumine (Conray 60) (2 ml/kg of body weight) was injected within one minute and nephrotomograms were taken for 30 minutes, with delayed films until 24 hours. Immediate nephrograms were obtained in all cases. The collecting systems, seen in 29 cases, were dilated in three. In the rest, obstruction could be ruled out by a combination of roentgenographic criteria. No untoward reactions occurred, and all the required information was obtained within 30 minutes. The results were superior to plain nephrotomography or infusion pyelography. We conclude that bolus nephrotomography is the procedure of choice in the investigation of severe renal failure.     

Strongyle infections in ponies. II. Reinfection of treated animals.

Five of seven ponies whose strongyle worm burdens had previously been removed or markedly reduced by repeated thiabendazole treatments were reinfected with doses ranging from 100,000 to 500,000 small strongyle infective larvae. Reinfection of ponies resulted in the development of clinical signs characterized by abnormal feces, marked loss of weight and delayed shedding of winter hair coats. An abrupt increase in circulating eosinophils occurred during the first three weeks following reinfection. Patent infections developed in all ponies with worm eggs appearing in the feces from 12 to 15 weeks after receiving infective larvae. Worm egg outputs followed a cyclic pattern with approximately four to five peaks in egg output per year. There was an abrupt drop in the high worm egg counts in two untreated ponies approximately two and a half years after reinfection. No worms were recovered in the feces of these animals when they were subsequently treated, suggesting that a depletion in the number of inhibited larvae present in these ponies might have occurred.     

美国眼科学杂志

光动力疗法对迟发型眼底黄色斑点症患者脉络膜新生血管的治疗；视觉诱发电位在评价眶周血管瘤中的价值；新生血管性老年性黄斑变性患者伴黄斑裂孔的自发性视网膜色素上皮撕裂；动态轮廓眼压测量法测量眼内压。     

Successful pregnancy in I.D.D.M. with intravenous programmable insulin pump

Management of subcutaneous insulin resistance remains a difficult problem which can be treated by administering insulin intravenously by means of infusion pumps1,2. We wish to report the case of a 31 year old primigravida with subcutaneous insulin resistance who developed a hitherto undescribed clinical complication of clot formation at the catheter tip, successfully treated with anti-coagulant therapy. Previous publications on the use of pumps in pregnancy have reported on the intraperitoneal route for insulin administration.