彩色多普勒超声对中晚期青光眼患者眼动脉血流速度的测定

目的了解中、晚期青光眼患者眼动脉血流情况及血管因素在中、晚期青光眼患者视功能损害机制中的作用。方法采用彩色多普勒超声检查仪测定１５６例中、晚期青光眼患者的眼动脉血流速度，并与正常组７５例的有关参数值进行比较。结果正常组：平均最大收缩期血流速度（ｐｅａｋｓｙｓ－ｔｏｌｉｃｖｅｌｏｃｉｔｙ，ＰＳＶ）为３５．９８±９．１３ｃｍ／ｓ，舒张期眼动脉血流速度（ｅｎｄｄｉａｓｔｏｌｉｃｖｅｌｏｃｉｔｙ，ＥＤＶ）为１１．９８±３．９０ｃｍ／ｓ。开角型青光眼（ｐｒｉｍａｒｙｏｐｅｎａｎｇｌｅｇｌａｕｃｏｍａ，ＰＯＡＧ）组：ＰＳＶ为２４．１３±４．６５ｃｍ／ｓ，ＥＤＶ为７．１０±１．８５ｃｍ／ｓ，闭角型青光眼（ｐｒｉｍａｒｙｃｌｏｓｅａｎｇｌｅｇｌａｕｃｏｍａ，ＰＣＡＧ）组：ＰＳＶ为２２．８９±５．４３ｃｍ／ｓ，ＥＤＶ为７．０６±１．９２ｃｍ／ｓ。各组间ＰＳＶ与ＥＤＶ比较：ＰＯＡＧ组与ＰＣＡＧ组间差异无显著性（Ｐ＞０．０５），青光眼组与正常组间差异有非常显著性（Ｐ＜０．０１）。结论中、晚期青光眼患者因眼动脉血流速度下降明显，导致局部血液循环障碍。青光眼患者的视功能损害与视神经的血供不足关系密切。     

颈内动脉血流动力学改变与前部缺血性视神经病变球后血流相关性研究

目的　通过彩色多普勒血流成像技术分别观察颈内动脉的血流动力学改变及前部缺血性视神经病变（ａｎｔｅｒｉｏｒｉｓｃｈｅ-ｍｉｃｏｐｔｉｃｎｅｕｒｏｐａｔｙ,ＡＩＯＮ）患者球后血流动力学改变,分析两者的相关性。方法　选取ＡＩＯＮ患者４２例,设为ＡＩＯＮ组,同时设立空白对照组４２例,分别检查两组人群的颈内动脉及球后主要血管睫状后短动脉的血流动力学指标,包括收缩期峰值血流速度（ｐｅａｋｓｙｓｔｏｌｉｃｖｅｌｏｃｉｔｙ,ＰＳＶ）、舒张末期血流速度（ｅｎｄｄｉａｓｔｏｌｉｃｖｅｌｏｃｉｔｙ,ＥＤＶ）、阻力指数（ｒｅｓｉｓｔａｎｃｅｉｎｄｅｘ,ＲＩ）,并对２组以上结果进行统计分析。结果　ＡＩＯＮ组与空白对照组球后主要血管睫状后短动脉的ＰＳＶ分别为（１０．２６±０．７３）ｃｍ?ｓ－１和（１１．６６±０.１９）ｃｍ?ｓ－１,差异有统计学意义（Ｐ＜０．０５）;ＥＤＶ分别为（３．６８±０．３８）ｃｍ?ｓ－１和（５．１２±０．５２）ｃｍ?ｓ－１,差异有统计学意义（Ｐ＜０．０５）;ＲＩ分别为０．７７±０．２７和０．６８±０．２２,差异有统计学意义（Ｐ＜０．０５）。颈内动脉血流动力学指标,ＡＩＯＮ组的ＰＳＶ为（９．１７±０．４２）ｃｍ?ｓ－１,明显低于空白对照组的（１０．６８±０．１８）ｃｍ?ｓ－１,差异有统计学意义（Ｐ＜０．０５）;ＡＩＯＮ组的ＥＤＶ为（２．１５±０．３１）ｃｍ?ｓ－１,明显低于空白对照组的（３．４７±０．５５）ｃｍ?ｓ－１,差异有统计学意义（Ｐ＜０．０５）;ＡＩＯＮ组的ＲＩ为０.６７±０.１２,明显高于空白对照组的０．５９±０．０７,差异有统计学意义（Ｐ＜０．０５）。ＡＩＯＮ组颈内动脉与球后主要血管睫状后短动脉的血流动力学指标高度相关,差异具有统计学意义（ｒ＝０．８２,Ｐ＝０．０００）。结论　ＡＩＯＮ患者的颈内动脉血流动力学已发生明显改变,并与球后血管睫状后短动脉的血流动力学改变高度相关,颈内动脉血流动力学改变可能是发生ＡＩＯＮ的因素之一。     

ReSTOR SV25T0与ReSTOR SN6AD1多焦点人工晶状体植入术后临床疗效对比

目的　对比观察ＲｅＳＴＯＲＳＶ２５Ｔ０与ＲｅＳＴＯＲＳＮ６ＡＤ１多焦点人工晶状体（ｍｏｌｔｉｆｏｃａｌｉｎｔｒａｏｃｕｌａｒｌｅｎｓ,ＭＩＯＬ）植入术后的临床视觉效果。方法　行白内障超声乳化吸出联合ＭＩＯＬ植入术的白内障患者４１例（４３眼）,根据植入的ＭＩＯＬ不同分为两组:ＳＮ６ＡＤ１组２０例（２２眼）植入ＲｅＳＴＯＲＳＮ６ＡＤ１ＭＩＯＬ,ＳＶ２５Ｔ０组２１例（２１眼）植入ＲｅＳＴＯＲＳＶ２５Ｔ０ＭＩＯＬ,观察两组患者术前及术后３个月裸眼近视力、裸眼中距离视力（５０ｃｍ、７０ｃｍ）及裸眼远视力,绘制离焦曲线,并进行对比敏感度检查、视觉质量及满意度问卷调查。结果　术后３个月两组患者５ｍ裸眼远视力对比差异无统计学意义（Ｐ＞０．０５）;ＳＶ２５Ｔ０组患者５０ｃｍ及７０ｃｍ的裸眼中距离视力分别为（０．１２±０．０７）ｌｏｇＭＡＲ和（０．１７±０．０８）ｌｏｇＭＡＲ,均明显优于ＳＮ６ＡＤ１组患者的（０．１８±０．０８）ｌｏｇＭＡＲ和（０．２４±０．０９）ｌｏｇＭＡＲ（均为Ｐ＜０．０５）,而ＳＮ６ＡＤ１组患者３３ｃｍ的裸眼近距离视力为（０．１１±０．０８）ｌｏｇＭＡＲ,高于ＳＶ２５Ｔ０组患者的（０．１６±０．０８）ｌｏｇＭＡＲ（Ｐ＜０．０５）;ＳＶ２５Ｔ０组术后暗视下３．０ｃ·ｄ－１及６．０ｃ·ｄ－１空间频率的对比敏感度优于ＳＮ６ＡＤ１组,差异均有统计学意义（均为Ｐ＜０．０５）;术后问卷调查示两组患者均未出现明显视觉干扰,ＳＶ２５Ｔ０组患者在近距离视力的视近满意度较ＳＮ６ＡＤ１组低,在中距离和远距离下满意度稍高,但是两组间差异均无统计学意义（均为Ｐ＞０．０５）。结论　ＲｅＳＴＯＲＳＶ２５Ｔ０与ＳＮ６ＡＤ１ＭＩＯＬ均能改善白内障患者术后视力及对比敏感度,ＲｅＳＴＯＲＳＶ２５Ｔ０在中距离视力的表现优于ＲｅＳＴＯＲＳＮ６ＡＤ１。     

原发性青光眼眼血管血流动力学的研究

采用Ｕｌｔｒａｍａｒｋ－９型双功能彩色多普勒超声仪对４０例（８０眼）正常人及４８例（９６眼）青光眼患者的眼动脉（ＯＡ），视网膜中央动脉（ＣＲＡ）的血流动力学参数进行检测对比，结果如下：低眼压青光眼（ＮＴＧ）和慢性开角型青光眼（ＣＯＡＧ）与正常组比较，除ＣＲＡ的平均血流速度（Ｖｍ）外，ＯＡ及ＣＲＡ的血流速度均明显减慢，ＮＴＧ及ＣＯＡＧ的眼动脉舒张末期血流速度（Ｖｄ）、视网膜中央动脉峰速（Ｖｓ）较慢闭角型青光眼（ＣＣＡＧ）明显减慢     

糖尿病眼的视网膜血流超声检测

应用多普勒超声检测糖尿病６６例１３２眼视网膜血流速度。糖尿病的视网膜中央动脉血流收缩期峰速度，舒张末期速度和加速度比对照眼明显减慢（Ｐ＜０．００１）。ＰＳＶ和ＥＶＤ与血糖浓度呈正相关（ｒ＝０．２７８１，Ｐ＜０．０５；ｒ＝０．３８２２，Ｐ＜０．０１）。     

彩色多普勒血流显像对低压性青光眼的血流动力学研究

目的观察低压性青光眼血流动力学变化。方法应用彩色多普勒检测１５例正常人和１９例低压性青光眼（ｌｏｗ－ｔｅｎｓｉｏｎｇｌａｕｃｏｍａ，ＬＴＧ）的眼动脉、睫状后短动脉及视网膜中央动脉的血流参数。测定收缩期血流峰值速度（ｐｅａｋｓｙｓｔｏｌｉｃｆｌｏｗｖｅｌｏｃｉｔｙ，Ｖｍａｘ）、舒张末期血流速度（ｅｎｄｄｉａｓｔｏｌｉｃｆｌｏｗｖｅｌｏｃｉｔｙ，Ｖｍｉｎ）、平均血流速度（ｍｅａｎｅｎｖｅｌｏｐｅｄｖｅｌｏｃｉｔｙ，Ｖｍｅａｎ）、搏动指数（ｐｕｌｓｅｉｎｄｅｘ，ＰＩ）、阻力指数（ｒｅｓｉｓｔａｎｃｅｉｎｄｅｘ，ＲＩ）及收缩期血流峰值速度和舒张末期血流速度比值（Ｖｍａｘ／Ｖｍｉｎ，Ｓ／Ｄ）。结果（１）ＬＴＧ组睫状后短动脉血流速度低于正常人组（两组双眼Ｖｍａｘ、Ｖｍｉｎ及右眼Ｖｍｅａｎ比较，Ｐ＜０．０５），左眼ＲＩ及Ｓ／Ｄ低于正常人组（Ｐ＜０．０５）；（２）ＬＴＧ组左眼视网膜中央动脉血流的Ｖｍａｘ及Ｖｍｅａｎ低于正常人组（Ｐ＜０．０１）；（３）ＬＴＧ组与正常人组眼动脉血流的Ｖｍａｘ等６项参数比较，差异无显著性（Ｐ＞０．０５）。结论ＬＴＧ组的睫状后短动脉血流速度低于正常人组，支持ＬＴＧ视乳头损害的血管学说。     

慢性开角型青光眼小梁切除术后眼血流动力学改变

目的 探讨原发性开角型青光眼（ＰＯＡＧ）小梁切除术后眼血流动力学改变。方法 用彩色多普勒（ＣＤＩ）检测ＰＯＡＧ小梁切除术前,后及非手术眼的视网膜中央动脉（ＣＲＡ）,眼动脉（ＯＡ）的血流动力学改变情况。结果 术后２周及３月ＣＲＡ平均血流速度（Ｖ ｍｅａｎ）和舒张末期血流速度（Ｖｍｉｎ）比术前增加,阻力指数（ＲＩ）下降,有显著性差异;ＯＡ在术后２周及３月仅Ｖｍｅａｎ比术前增加,ＲＩ下降,差异有显著性。     

新生血管性青光眼患者房水中信号素3A表达水平的研究

目的　检测新生血管性青光眼（ｎｏｎｖａｓｃｕｌａｒｇｌａｕｃｏｍａ,ＮＶＧ）患者房水中信号素３Ａ（Ｓｅｍａｐｈｏｒｉｎ３Ａ,Ｓｅｍａ３Ａ）的水平,探讨Ｓｅｍａ３Ａ在ＮＶＧ发生发展中的作用。方法　选取在我院眼科２０１４年１月至２０１５年２月诊断为ＮＶＧ行抗青光眼手术患者４２例（４３眼）作为ＮＶＧ组,并根据病因分为糖尿病组１１眼、静脉阻塞组１１眼、青光眼组８眼及原因不明组１３眼;选取同期收治行单纯白内障手术患者１６例（１６眼）作为对照组。分别于术前抽取房水样本,利用双抗体夹心酶联免疫吸附试验测定房水中Ｓｅｍａ３Ａ含量,对比分析ＮＶＧ组和对照组在Ｓｅｍａ３Ａ浓度上的统计学差异。分析检测ＮＶＧ组房水中Ｓｅｍａ３Ａ水平与眼压水平的相关性。结果　ＮＶＧ组患者的眼压为（３２．６３±１１．１６）ｍｍＨｇ（１ｋＰａ＝７．５ｍｍＨｇ）,较对照组（１５．５６±１．９３）ｍｍＨｇ明显升高（ｔ＝２３．９６,Ｐ＜０．０００１）。ＮＶＧ组患者房水中Ｓｅｍａ３Ａ浓度为（２．１３±１．９４）ｎｇ?ｍＬ－１,明显高于对照组（０．６６±０．５８）ｎｇ?ｍＬ－１,差异有显著统计学意义（ｔ＝２．９８５,Ｐ＜０．０００１）。但ＮＶＧ组房水中Ｓｅｍａ３Ａ与眼压水平无明显相关性（ｒ＝－０．２１６４,Ｐ＝０．１１８５）。根据引起ＮＶＧ的原发病进行分组比较,糖尿病组Ｓｅｍａ３Ａ浓度为（２．１４±１．４４）ｎｇ? ｍＬ－１、静脉阻塞组Ｓｅｍａ３Ａ浓度为（１．６７±０．９８）ｎｇ?ｍＬ－１及青光眼组Ｓｅｍａ３Ａ浓度为（１．８７±１．８０）ｎｇ?ｍＬ－１,与对照组房水中Ｓｅｍａ３Ａ浓度相比均明显升高,差异均有统计学意义（Ｐ＝０．００１、０．００２、０．０２１）。结论　Ｓｅｍａ３Ａ在ＮＶＧ患者房水中明显升高,推测其表达增加可能参与了ＮＶＧ患者虹膜新生血管形成及眼部损伤性改变。     

阻塞性睡眠呼吸暂停综合征基础脑血流评价

目的 探讨无创伤性方法评价阻塞性睡眠呼吸暂停综合征（ＯＳＡＳ）患者的基础脑血流速度及其意义。方法 采用彩色三维经颅多普勒（３Ｄ－ＴＣＤ）检测１３例ＯＳＡＳ病例组觉酷暑状态脑动脉血流速度并与正常对照组比较。结果 病例组大脑中动脉（ＭＣＡｓ）、基底动脉（ＢＡＳ）和椎动脉（ＶＡＳ）血流速度较正常对照组明显减慢（Ｐ〈０．０５）。结论 ＯＳＡＳ患者基础脑血流速度较正常减慢,用ＴＣＤ评价其变化具有很好的实用价     

兔眼晶体机械伤后谷胱甘肽过氧化物酶活性和丙二醛含量动态变化

兔眼晶体机械性损伤后不同时间测定谷胱甘肽过氧化物酶（ＧＳＨ－ＰＸ）活性和丙二醛（ＭＤＡ）含量，其结果表明：伤后８小时至２１天内，ＧＳＨ－ＰＸ活性较对照组明显降低（Ｐ＜０．０１），而ＭＤＡ含量则显著升高（Ｐ＜０．０１）。提示晶体外伤后抗自由基及脂质过氧化作用降低，是导致ＧＳＨ－ＰＸ活性下降、ＭＤＡ含量升高和白内障形成的重要原因。     

彩色多普勒超声对青光眼眼血流动力学变化的研究

目的：研究青光眼患者眼部血流动力学改变及手术前手的对比。方法：采用多普勒超声检查仪测定48例（78眼）原发性闭角型青光眼（primary close-angle alaucoma,PCAG),6例（12眼）原发性开角型青光眼（primary open-angle glaucoma,POAG),9例（18眼）单侧发病青光眼和26例（52眼）正常对照组的眼动脉（Ophthalmic artery,OA)、视网膜中央动脉（central retinal artery,CRA)的血流动力学参数,同时对11例（19眼）原发性青光眼进行手术前后血流参数的检测对比。结果：PCAG、POAG组、单侧发病青光眼的双眼均较正常对照组OA、CRA显示了明显的舒张末期血流速度（end diastolic velocity,EDV) 降低（P＜0．05）,阻力指数（resistive index,RI)增高（P＜0．05）,手术后OA、CRA的EDV较术前明显增加,RI下降（P＜0．01）。结论：局部血液循环障碍,导致视神经血供不足,对青光眼视神经损害有着重要的影响;手术可降低血管阻力,增加眼局部血液供应,改善并保护青光眼患者的视功能。     

原发性青光眼患者血流变学和血流动力学的变化(英文)

目的:探讨原发性青光眼患者血粘度水平改变及眼血流动力学变化对视神经的损害的意义及二者间的关系。方法:测定原发性开角型青光眼、急性闭角型青光眼、慢性闭角型青光眼和正常对照组(老年性白内障患者)各20例的全血比粘度、血浆比粘度、纤维蛋白原进行分析比较,并使用彩色多普勒成像技术检测其眼动脉(OA)和视网膜中央动脉(CRA)的收缩期血流速度(PSV)、舒张末期血流速度(EDV)、阻力指数(RI)、频谱形态和监听频声。各组间的均数差异比较用t检验,并将原发性青光眼患者的血流变指标分别与CDI血流动力学各项指标进行线性相关分析。结果:3组青光眼与对照组比较除纤维蛋白原差异无统计学意义外,其余各项血流变指标均显著升高;OA、CRA的PSV和EDV有明显下降,而RI明显增高;3组青光眼的血粘度各项指标与OA和CRA的PSV、EDV呈负相关,与RI呈正相关;正常对照组内血粘度水平与血流动力学各项指标无相关性。结论:原发性青光眼患者眼部存在不同程度的血液循环障碍,其血粘度水平升高可能是原发性青光眼视神经损害的潜在性危险因素;CDI对球后血管血流改变有较高的敏感性,在青光眼早期诊断及预后判断等方面均有重要的参考价值。     

急性闭角型青光眼彩色多谱勒眼血流动力学研究

目的　了解急性闭角型青光眼 (AACG)急性发作期和临床前期眼血流动力学变化及其在视功能损害中的作用。方法　应用彩色超声多谱勒检测急性闭角型青光眼急性发作期 33眼 ,临床前期 19眼 ,正常对照 6 6眼。结果　与正常组比较 ,急性发作期组视网膜中央动脉 (CRA)、睫状后动脉 (PCA)、眼动脉 (OA)的舒张末期峰值速度 (EDV)明显降低 ,PCA、OA的阻力指数 (RI)明显增高 (P <0 0 1) ;临床前期组PCA、OA的EDV明显下降 ,RI显著增高 (P <0 0 1)。结论　AACG急性发作期眼局部血液循环障碍是造成视功能损害的原因之一 ,临床前期眼存在PCA和OA循环障碍。     

The response of retrobulbar vasculature to hypercapnia in primary open-angle glaucoma and ocular hypertension

PURPOSE: To evaluate the physiological effects of hypercapnia on the retrobulbar vasculature in ocular hypertension (OH) and open-angle glaucoma (OAG). METHODS: Peak systolic velocity (PSV), end-diastolic velocity (EDV) and resistive index (RI) of the ophthalmic (OA) and central retinal arteries (CRA) were evaluated in 12 eyes with OH and 8 eyes with OAG using color Doppler imaging. Measurements were taken before and during hypercapnia. RESULTS: Patients with OAG were found to have increased EDV (p < 0.035) of the CRA, and decreased PSV (p < 0.097) and EDV (p < 0.098) of the OA, during hypercapnia. Patients with OH had increased PSV (p < 0.062) and EDV (p < 0.072) of the CRA during hypercapnia. Patients with OH also demonstrated a greater percent change in the calculated RI (p < 0.065) of the CRA in response to hypercapnia when compared to OAG. The mean RI of the CRA decreased during hypercapnia. DISCUSSION: Patients with OH were found to have a normal vasodilatory response within the retrobulbar vasculature during hypercapnia resulting in increased volumetric blood flow to the retina while patients with OAG did not, suggesting there is vasospasm at or downstream from the CRA resulting in decreased volumetric blood flow to the retina.     

青光眼小梁切除术前后眼部血流动力学变化的研究

目的:比较青光眼32眼小梁切除术前后的血流动力学变化。方法:利用彩色多普勒成像技术(CDI)分别检测正常对照组与青光眼组术前、术后2,12wk的眼部血流情况,包括眼动脉(OA)、睫状后短动脉(SPCA)和视网膜中央动脉(CRA)的收缩期峰值血流速度(PSV)、舒张末期血流速度(EDV)和阻力指数(RI)。结果:(1)青光眼组手术前后比较:青光眼组在小梁切除术后血流灌注明显好转,表现为PSV,EDV增高,RI下降;(2)青光眼术后组之间比较:PSV,EDV,RI有改变,但差异无统计学意义;(3)青光眼组术后与正常对照组比较:青光眼组在小梁切除术后眼压降至正常范围时OA,SPCA,CRA的PSV,EDV和RI仍不及正常人(P<0.05);(4)青光眼组术前与正常对照组比较:OA,SPCA,CRA均表现为PSV,EDV下降,RI增高(P<0.01)。结论:(1)青光眼患者与正常人相比较存在明显的血流灌注不足,小梁切除术可以有效的改善眼部血流灌注情况;(2)CDI可长期用于监测和评价青光眼小梁切除术的治疗效果。     

Glaucoma patients demonstrate faulty autoregulation of ocular blood flow during posture change

BACKGROUND/AIMS: Autoregulation of blood flow during posture change is important to ensure consistent organ circulation. The purpose of this study was to compare the change in retrobulbar ocular blood flow in glaucoma patients with normal subjects during supine and upright posture. METHODS: 20 open angle glaucoma patients and 20 normal subjects, similar in age and sex distribution, were evaluated. Blood pressure, intraocular pressure, and retrobulbar blood velocity were tested after 30 minutes of sitting and again after 30 minutes of lying. Retrobulbar haemodynamic measures of peak systolic velocity (PSV), end diastolic velocity (EDV), and resistance index (RI) were obtained in the ophthalmic and central retinal arteries using colour Doppler imaging (CDI). RESULTS: When changing from the upright to supine posture, normal subjects demonstrated a significant increase in OA EDV (p = 0.016) and significant decrease in OA RI (p = 0.0006) and CRA RI (p = 0.016). Glaucoma patients demonstrated similar changes in OA measures of EDV (p = 0.02) and RI (p = 0.04), but no change in CRA measures. CONCLUSION: Glaucoma patients exhibit faulty autoregulation of central retinal artery blood flow during posture change.     

Color Doppler Imaging in the Study of Retrobulbar Hemodynamic Changes of Primary Angle—closure Glaucoma

Purpose: To investigate the hemodynamic changes of ophthalmic and central retinal artery (OA,CRA) in Primary Angle-closure Glaucoma (PACG) and the effects of intraocular pressure (TOP) on the retrobulbar hemodynamics.Methods: The hemodynamic changes of OA, CRA in PACG were explored with color Doppler imaging (CDI) technique. Peak systolic blood flow velocity (PSV), end-diastolic blood flow velocity (EDV),pulsatile and resistive indices (PI,RI) were recorded and compared with those of the normal subjects. There were 20 patients (40 eyes) with PACG who were divided into two groups according to their IOP levels; ocular hypertension (15 eyes) and normal tension (25 eyes) .Results : Compared with the normal subjects, the hypertension group of PACG showed significant reduction in the EDV and increases in PI, RI of CRA; normal tension group of PACG also showed remarkable increase in RI of CRA. The ocular hypertension was significantly correlated with the RI and not with the EDV by the analysis of multiple line     

Variations in ocular hemodynamics in patients with early and late glaucoma

PURPOSE: To determine the retrobulbar hemodynamics in glaucoma patients with different degrees of optic nerve damage. METHODS: Color Doppler imaging was performed in 52 patients with controlled primary open angle glaucoma (POAG) and in 25 control subjects. Glaucomatous eyes were divided into early and late groups based on the perimetry findings. Peak systolic velocity (PSV), end diastolic velocity (EDV), and resistive index of the central retinal artery (CRA) and posterior ciliary arteries (PCA) were evaluated. RESULTS: Early glaucoma showed significantly decreased PSV in nasal PCA when compared with the normal. Late glaucoma showed significantly decreased PSV and EDV in the CRA and nasal PCA, and significantly decreased PSV in temporal PCA as compared with the control and early glaucoma. The resistive index of the CRA also increased significantly in late glaucoma. CONCLUSION: Eyes with advanced glaucomatous optic neuropathy were associated with more marked alterations in retrobulbar circulation than eyes with less nerve damage.     

Retrobulbar hemodynamic parameters in pseudoexfoliation syndrome and pseudoexfoliative glaucoma

OBJECTIVE: To compare the hemodynamic parameters in the retrobulbar vessels in pseudoexfoliative syndrome (PXS), pseudoexfoliative glaucoma (PXG), and age-matched healthy subjects by using color Doppler imaging (CDI). SUBJECTS AND METHODS: 72 eyes from 72 patients with PXS, 70 eyes from 70 patients with PXG, and 66 eyes from 66 age-matched healthy subjects who met the inclusion/exclusion criteria were included in this prospective cross-sectional study. Peak systolic velocity (PSV), end-diastolic velocity (EDV), and Pourcelot resistance index (RI) were assessed in the ophthalmic artery (OA), central retinal artery (CRA), and temporal short-posterior ciliary arteries (SPCA). Visual function was assessed using the 24-2 Swedish Interactive Threshold Algorithm (SITA). The main outcomes of the study were PSV, EDV and RI in the OA, SPCA, and CRA. RESULTS: The EDV in the OA, SPCA and the CRA was decreased significantly (p < 0.001, <0.001, and 0.003 respectively) in the eyes of PXG patients compared with controls and PSX respectively. The RI in the OA, SPCA, and the CRA was significantly higher (p = 0.022, 0.005, and 0.007 respectively) in the eyes of PXG patients compared with healthy controls and PSX patients respectively. The mean difference in mean EDV in the OA between the control group and the PXS was 0.18 cm/s, 95% confidence interval (CI) -0.60 to 0.95, p = 0.661. The mean difference in mean EDV in the SPCA between the control healthy subjects and the pseudoexfoliative subjects was -0.18 cm/s, 95% CI -0.45 to 0.08, p = 0.176. Multivariate regression analysis showed that in the PXG patients the PSV and EDV in the CRA were significantly positively correlated with the mean defect (p = 0.006 and 0.002 respectively). The RI in the CRA was significantly negatively correlated with the mean defect in PXG patients, p = 0.009. CONCLUSION: The results of this study showed that the retrobulbar hemodynamics might be disturbed in patients with PXG, especially in the central retinal artery. Our results have found no significant differences in the retrobulbar hemodynamic parameters between pseudoexfoliative syndrome patients and age-matched healthy subjects.     

眼挫伤的眼血流动力学变化研究

目的：观察眼挫伤患者的眼血流动力学变化。方法：应用彩色多普勒检测５０例（１００只眼）正常人和３０例（３４只眼）眼挫伤患者的视网膜中央动脉（ＣＲＡ）及睫状后动脉（ＰＣＡ）的血流参数。测定收缩期峰值速度（Ｖｍａｘ）、舒张末期血流速度（Ｖｍｉｎ）及阻力指数（ＲＩ）。结果：①眼挫伤组ＣＲＡ和ＰＣＡ的Ｖｍａｘ均大于正常人组（Ｐ〈０．０５），其ＲＩ值均高于正常人组（Ｐ〈０．０１）。②眼挫伤急性期和恢复期的ＣＲ