共查询到20条相似文献,搜索用时 31 毫秒
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D. Nathanson B. Zethelius C. Berne J. J. Holst Å. Sjöholm T. Nyström 《Diabetologia》2010,53(2):277-280
Aims/hypothesis
Besides the insulinotropic effects of glucagon-like peptide-1 (GLP-1) mimetics, their effects on endothelial dysfunction and myocardial ischaemia are of interest. No previous study has investigated associations between plasma levels of GLP-1 and CHD. 相似文献3.
S Vollert N Kaessner A Heuser G Hanauer A Dieckmann D Knaack HP Kley R Beume C Weiss-Haljiti 《Diabetologia》2012,55(10):2779-2788
Aims/hypothesis
The cAMP-degrading phosphodiesterase 4 (PDE4) enzyme has recently been implicated in the regulation of glucagon-like peptide-1 (GLP-1), an incretin hormone with glucose-lowering properties. We investigated whether the PDE4 inhibitor roflumilast elevates GLP-1 levels in diabetic db/db mice and whether this elevation is accompanied by glucose-lowering effects. 相似文献4.
Nagashima M Watanabe T Terasaki M Tomoyasu M Nohtomi K Kim-Kaneyama J Miyazaki A Hirano T 《Diabetologia》2011,54(10):2649-2659
Aims/hypothesis
Several lines of evidence suggest that incretin-based therapies suppress the development of cardiovascular disease in type 2 diabetes. We investigated the possibility that glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) can prevent the development of atherosclerosis in Apoe −/− mice. 相似文献5.
Association of a glucagon-like peptide-1 receptor gene variant with glucose response to a mixed meal
Mona Mashayekhi MD Jessica R. Wilson MD Scott Jafarian-Kerman MD Hui Nian PhD Chang Yu PhD Megan M. Shuey PhD James M. Luther MD Nancy J. Brown MD 《Diabetes, obesity & metabolism》2021,23(1):281-286
Dipeptidyl peptidase-4 (DPP-4) inhibitors increase endogenous glucagon-like peptide-1 (GLP-1). We hypothesized that genetic variation in the gene encoding the GLP-1 receptor (GLP1R) could affect the metabolic response to DPP-4 inhibition. To evaluate the relationship between the GLP1R rs6923761 variant (G-to-A nucleic acid substitution) and metabolic responses, we performed mixed meal studies in individuals with type 2 diabetes mellitus and hypertension after 7-day treatment with placebo and the DPP-4 inhibitor sitagliptin. This analysis is a substudy of NCT02130687. The genotype frequency was 13:12:7 GG:GA:AA among individuals of European ancestry. Postprandial glucose excursion was significantly decreased in individuals carrying the rs6923761 variant (GA or AA) as compared with GG individuals during both placebo (P = 0.001) and sitagliptin treatment (P = 0.045), while intact GLP-1 levels were similar among the genotype groups. In contrast, sitagliptin lowered postprandial glucose to a greater degree in GG as compared with GA/AA individuals (P = 0.035). The relationship between GLP1R rs6923761 genotype and therapies that modulate GLP-1 signalling merits study in large populations. 相似文献
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Vittone F Liberman A Vasic D Ostertag R Esser M Walcher D Ludwig A Marx N Burgmaier M 《Diabetologia》2012,55(8):2267-2275
Aims/hypothesis
Inhibitors of dipeptidyl peptidase-IV (DPP-IV), such as sitagliptin, increase glucagon-like peptide-1 (GLP-1) concentrations and are current treatment options for patients with type 2 diabetes mellitus. As patients with diabetes exhibit a high risk of developing severe atherosclerosis, we investigated the effect of sitagliptin on atherogenesis in Apoe −/− mice. 相似文献7.
K. Pilgaard C. B. Jensen J. H. Schou V. Lyssenko L. Wegner C. Brøns T. Vilsbøll T. Hansen S. Madsbad J. J. Holst A. Vølund P. Poulsen L. Groop O. Pedersen A. A. Vaag 《Diabetologia》2009,52(7):1298-1307
Aims/hypothesis We studied the physiological, metabolic and hormonal mechanisms underlying the elevated risk of type 2 diabetes in carriers
of TCF7L2 gene.
Methods We undertook genotyping of 81 healthy young Danish men for rs7903146 of TCF7L2 and carried out various beta cell tests including: 24 h glucose, insulin and glucagon profiles; OGTT; mixed meal test; IVGTT;
hyperglycaemic clamp with co-infusion of glucagon-like peptide (GLP)-1 or glucose-dependent insulinotropic polypeptide (GIP);
and a euglycaemic–hyperinsulinaemic clamp combined with glucose tracer infusion to study hepatic and peripheral insulin action.
Results Carriers of the T allele were characterised by reduced 24 h insulin concentrations (p < 0.05) and reduced insulin secretion relative to glucose during a mixed meal test (beta index: p < 0.003), but not during an IVGTT. This was further supported by reduced late-phase insulinotropic action of GLP-1 (p = 0.03) and GIP (p = 0.07) during a 7 mmol/l hyperglycaemic clamp. Secretion of GLP-1 and GIP during the mixed meal test was normal. Despite
elevated hepatic glucose production, carriers of the T allele had significantly reduced 24 h glucagon concentrations (p < 0.02) suggesting altered alpha cell function.
Conclusions/interpretation Elevated hepatic glucose production and reduced insulinotropic effect of incretin hormones contribute to an increased risk
of type 2 diabetes in carriers of the rs7903146 risk T allele of TCF7L2.
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorised users. 相似文献
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Enteral supplementation with glutamine,fiber, and oligosaccharide modulates incretin and glucagon‐like peptide‐2 secretion
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Akihiro Hamasaki Norio Harada Shunsuke Yamane Yaeko Kondo Kazuyo Suzuki Daniela Nasteska Kimitaka Shibue Takanari Harada Kanako Iwasaki Hidemi Tsuji Kenichiro Shide Nobuya Inagaki 《Journal of diabetes investigation.》2015,6(3):302-308
Aims/Introduction
A dietary supplementation product enriched with glutamine, dietary fiber and oligosaccharide (GFO) is widely applied for enteral nutrition support in Japan. The aim of the present study was to evaluate the effects of GFO ingestion on secretion of incretins, gastric inhibitory polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), and glucagon-like peptide-2 (GLP-2).Materials and Methods
We carried out a cross-over study involving 20 healthy Japanese volunteers. The participants received GFO or 17 g of glucose, the equivalent carbohydrate in GFO as the control. Plasma glucose, serum insulin, and plasma total GIP, total GLP-1 and total GLP-2 levels during GFO or glucose loading were determined.Results
GFO loading produced significantly higher plasma GLP-1 levels at 30 min and 60 min, area under the curve-GLP-1 value, and area under the curve-GLP-2 value after administration compared with those by glucose loading. In contrast, plasma GIP levels at both 30 and 60 min, and area under the curve-GIP value after glucose loading were significantly higher than those after GFO loading.Conclusions
These results show that GFO ingestion stimulates GLP-1 and GLP-2 secretion, and reduces GIP secretion compared with glucose ingestion. Therefore, GFO could have an intestinotrophic effect as well as an ameliorating effect on metabolic disorders through modification of release of gut hormones. 相似文献11.
Aims/hypothesis
The endogenous production of stromal cell-derived factor-1 (SDF-1) in beta cells in transgenic mice attenuates the development of diabetes in response to streptozotocin. Here we propose that beta cell injury induces SDF-1 production, and the SDF-1/chemokine (C-X-C motif) receptor 4 (CXCR4) interaction auto-activates Sdf1 expression, resulting in the autocrine production of SDF-1 by beta cells and the paracrine activation of glucagon-like peptide-1 (GLP-1) production by alpha cells. 相似文献12.
Favaro E Granata R Miceli I Baragli A Settanni F Cavallo Perin P Ghigo E Camussi G Zanone MM 《Diabetologia》2012,55(4):1058-1070
Aims/hypothesis
Pancreatic islet microendothelium exhibits unique features in interdependent relationship with beta cells. Gastrointestinal products of the ghrelin gene, acylated ghrelin (AG), unacylated ghrelin (UAG) and obestatin (Ob), and the incretin, glucagon-like peptide-1 (GLP-1), prevent apoptosis of pancreatic beta cells. We investigated whether the ghrelin gene products and the GLP-1 receptor agonist exendin-4 (Ex-4) display survival effects in human pancreatic islet microendothelial cells (MECs) exposed to chronic hyperglycaemia. 相似文献13.
da Silva Xavier G Mondragon A Sun G Chen L McGinty JA French PM Rutter GA 《Diabetologia》2012,55(10):2667-2676
Aims/hypothesis
Individuals carrying type 2 diabetes risk alleles in TCF7L2 display decreased beta cell levels of T cell factor 7 like-2 (TCF7L2) immunoreactivity, and impaired insulin secretion and beta cell sensitivity to glucagon-like peptide 1 (GLP-1). Here, we sought to determine whether selective deletion of Tcf7l2 in mouse pancreas impairs insulin release and glucose homeostasis. 相似文献14.
Aims/hypothesis
Exendin-4, a glucagon-like peptide-1 (GLP-1) analogue, is reported to have modest anti-inflammatory effects in addition to that of improving beta cell survival. We therefore sought to determine whether exendin-4 decreases expression of the gene encoding chemokine (C-X-C motif) ligand (CXCL)10, which plays a role in initiating insulitis in type 1 diabetes. 相似文献15.
Xueyuan Guo PhD Caihua Sang PhD Ribo Tang PhD Chenxi Jiang PhD Songnan Li PhD Nian Liu PhD Deyong Long PhD Xin Du PhD Jianzeng Dong PhD Changsheng Ma PhD 《Diabetes, obesity & metabolism》2023,25(Z1):53-63
Aims
To perform a meta-analysis to assess the effects of glucagon-like peptide-1 receptor agonists (GLP-1RAs) on major coronary events, including myocardial infarction (MI), unstable angina and coronary revascularization, in patients with type 2 diabetes mellitus (T2DM).Materials and methods
We systematically searched the PubMed, CENTRAL, EMBASE and clinicaltrial.gov databases to seek eligible studies with a cardiovascular endpoint comparing GLP-1RAs with a placebo in T2DM patients. Odds ratio (ORs) and 95% confidence intervals (CIs) were calculated for the outcomes.Results
Nine studies, with a total of 64 236 patients, were included. GLP-1RA treatment reduced fatal and nonfatal MI by 8% (OR 0.92, 95% CI 0.86–0.99; P = 0.02, I2 = 39%). The reduction reached 15% in human-based GLP-1RA-treated patients. Similarly, once-weekly GLP-1RA treatment reduced the risk of MI by 13%. In contrast, GLP-1RA treatment did not reduce the risk of hospitalization for unstable angina (OR 1.11, 95% CI 0.97–1.28; P = 0.13, I2 = 21%). GLP-1RAs exhibited a tendency to lower the risk of coronary revascularization (OR 0.95, 95% CI 0.89–1.02; P = 0.15, I2 = 22%), but without statistical significance. Human-based GLP-1RAs decreased the risk by 11%.Conclusions
In high-risk patients with T2DM, GLP-1RAs were associated with a decrease in MI, especially the human-based and once-weekly GLP-1RAs. No benefit was seen for hospitalization for unstable angina or coronary revascularization. Further research is urgently needed to ascertain improvements in coronary events. 相似文献16.
González-Sánchez JL Martínez-Larrad MT Zabena C Pérez-Barba M Serrano-Ríos M 《Diabetologia》2008,51(11):1993-1997
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Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms 总被引:8,自引:5,他引:3
Schäfer SA Tschritter O Machicao F Thamer C Stefan N Gallwitz B Holst JJ Dekker JM 't Hart LM t'Hart LM Nijpels G van Haeften TW Häring HU Fritsche A 《Diabetologia》2007,50(12):2443-2450
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Aims/hypothesis We hypothesised that TCF7L2 single nucleotide polymorphisms (SNPs) are associated with cardiovascular disease (CVD) and that the associations differ
in diabetic and non-diabetic persons.
Methods Our analysis included black and white participants from the Atherosclerosis Risk in Communities study who were free of prevalent
CVD at baseline and had been genotyped for rs7903146, rs12255372, rs7901695, rs11196205 and rs7895340 (n = 13,369). Cox proportional hazard regression was used to estimate the associations between polymorphisms and incident events;
logistic and linear regression were used for associations with baseline risk factor levels.
Results
TCF7L2 SNPs were not significantly associated with incident coronary heart disease, ischaemic stroke, CVD, prevalent peripheral
artery disease (PAD) or all-cause mortality in the full cohort or when stratified by race.
Conclusions/interpretation In the whole cohort, TCF7L2 SNPs were not associated with incident CVD, all-cause mortality or prevalent PAD. This result suggests that the increased
health risk associated with rs7903146 genotype is specific to diabetes. 相似文献
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Aston-Mourney K Hull RL Zraika S Udayasankar J Subramanian SL Kahn SE 《Diabetologia》2011,54(7):1756-1765