关节镜下爱惜邦缝线固定治疗胫骨髁间棘骨折16例

目的:探讨关节镜下爱惜邦缝线固定治疗胫骨髁间棘撕脱骨折的手术疗效。方法:收集胫骨髁间棘撕脱骨折患者16例,采用关节镜下骨折复位,爱惜邦缝线经胫骨结节内侧骨道穿入,于前交叉韧带止点围绕胫骨髁间棘撕脱骨折块交叉捆扎固定。术后进行随访观察,判定骨折愈合情况、并发症发生情况及膝关节Lysholm评分。结果:随访病例16例,随访时间6~22个月,平均12.3个月。所有患者骨折全部愈合,膝关节无不稳症状,术后参照Lysholm评分90~100分,平均95.2分。结论:关节镜下爱惜邦缝线固定治疗胫骨髁间棘撕脱骨折具有手术创伤小,固定牢固,愈合良好,避免再次取内固定物手术损伤,并可早期功能锻练。     

关节镜下单隧道改良缝线法治疗胫骨髁间嵴撕脱骨折

目的:探讨关节镜下单隧道改良缝线法治疗胫骨髁间嵴撕脱骨折的手术技术及临床效果。方法:对15例胫骨髁间嵴撕脱骨折病例,在关节镜下复位,应用单隧道改良缝线法固定。术后积极康复锻炼。结果:经过8～24个月随访,门诊摄片提示平均5个月获得骨性愈合。患膝屈伸功能恢复佳。术后6个月时Lysholm评分(95.4±4.5)分。结论:关节镜下单隧道改良缝线法治疗胫骨髁间嵴撕脱骨折拥有复位佳,固定好,可早期活动等优点,操作简便易行。     

关节镜下带线钢板治疗胫骨髁间嵴骨折

目的探讨关节镜下带线钢板治疗胫骨髁间嵴撕脱骨折的手术技术及临床效果。方法对13例胫骨髁间嵴撕脱骨折病例,在关节镜下复位,双隧道缝线法结合钢板固定。术后积极康复锻炼。结果经过8～29个月随访,门诊摄片提示平均4个月获得骨性愈合。患膝屈伸功能恢复佳。术后6个月时Lysholm评分(95.4±4.5)分。结论关节镜下双隧道缝线法结合钢板固定治疗胫骨髁间嵴撕脱骨折具有复位佳、固定好、可早期活动等优点,操作简便易行。     

关节镜下缝线“8”字缝合治疗前交叉韧带胫骨止点撕脱性骨折28例分析

目的：探讨关节镜下对前交叉韧带胫骨髁间嵴撕脱骨折应用不可吸收缝合线“8”字进行复位和内固定的疗效。方法该院2010年4月—2013年3月收治的56例前交叉韧带胫骨髁间嵴撕脱骨折患者,随机行关节镜下应用双股MB66不可吸收缝合线对胫骨髁间嵴撕脱骨折区进行“8”字缝合捆绑,通过胫骨髁前置双隧道牵引复位,固定。结果术后X线片显示胫骨嵴撕脱骨折完全复位,56例均获随访,时间10~18个月,骨折完全愈合。术前Lysholm评分（71.4±9.6）分。术后 Lysholm评分为（94.4±1.4）分。术前与术后评分比较差异有统计学意义（P＜0.05）。结论关节镜下应用MB66不可吸收缝合线“8”字固定治疗膝关节前交叉韧带胫骨髁间嵴撕脱骨折,可以对移位的撕脱骨折很好地复位,早期功能锻炼,创伤小,操作方便,固定可靠,可避免二次手术减轻患者经济负担。     

关节镜下复位固定胫骨平台髁间嵴撕脱骨折的效果观察

目的:探讨全关节镜下复位固定胫骨平台髁间嵴撕脱骨折的手术疗效。方法:选取行全关节镜下复位固定胫骨平台髁间嵴撕脱骨折病例7例,年龄14~27岁,平均18.7岁。病程3 h~12 d,平均4.7 d。均有明显外伤史,患膝肿痛,不敢负重。术前HSS膝关节评分为21.07±7.45,X光片及CT片可见胫骨平台髁间隆突骨折,MR见骨块与前交叉韧带相连。手术方法:均行常规关节镜前内、前外切口,关节镜下监视并采用前交叉韧带胫骨定位器临时复位并定位,通过胫骨髁前内侧钻克氏针并穿入5号肠线的办法固定骨折块。结果:7例患者均得到随访,随访时间1年,所有患者复查CT片示骨折骨性愈合,HSS膝关节功能评分为91.79±2.43,较术前差异有统计学意义(t=10.11,P<0.05)。结论:全关节镜下复位固定胫骨平台髁间嵴撕脱骨折效果肯定,术后功能恢复可靠。     

关节镜下尼龙编织缝线固定胫骨髁间棘撕脱骨折

目的探讨关节镜下尼龙编织缝线固定胫骨髁间棘撕脱骨折的方法及疗效。方法24例患者均经关节镜辅助下行骨折复位,借助于前交叉韧带定位器于胫骨结节内侧做4个骨隧道,2条Ethibond 2#线于胫骨髁间棘撕脱骨折处交叉固定,经骨隧道引出固定于胫骨结节内侧。结果24例患者全部均获得随访,随访时间3-15个月,平均10.7个月。X线片示骨折全部愈合,所有病例膝关节屈伸功能正常。结论关节镜辅助下尼龙编织缝线固定胫骨髁间棘撕脱骨折具有创伤小、关节功能障碍发生率低的优点,是一种可靠的方法。     

关节镜下张力带固定治疗胫骨髁间嵴撕脱骨折

目的探讨关节镜下钢丝张力带固定胫骨髁间嵴撕脱骨折的方法和疗效。方法24例患者均经关节镜辅助下行骨折复位,借助前交叉韧带定位器于胫骨结节内侧做2—3个骨隧道,钢丝于胫骨髁间嵴撕脱骨折处交叉固定,经骨隧道引出固定于胫骨结节内侧。结果24例均获得随访,随访时间9—21个月,平均15．2个月。X线片示22例骨折全部愈合,2例未愈合,所有关节屈伸功能正常。结论关节镜下张力带技术固定术能够最大程度地恢复关节功能,是一种可靠的方法。     

关节镜下张力带固定治疗胫骨髁间嵴撕脱骨折24例临床分析

目的探讨关节镜下钢丝张力带固定胫骨髁间嵴撕脱骨折的方法和疗效。方法 24例患者均经关节镜辅助下行骨折复位,借助前交叉韧带定位器于胫骨结节内侧做2～3个骨隧道,钢丝于胫骨髁间嵴撕脱骨折处交叉固定,经骨隧道引出固定于胫骨结节内侧。结果 24例均获得随访,随访时间9～21个月,平均15.2个月。X线片示22例骨折全部愈合,2例未愈合,所有关节屈伸功能正常。结论关节镜下张力带技术固定术操作时间短、创伤小、并发症少,能够最大程度地恢复关节功能,是一种可靠的方法。     

关节镜下复位及尼龙缝线固定治疗胫骨髁间棘撕脱骨折

目的 探讨关节镜下复位及尼龙编织缝线内固定治疗胫骨髁间棘撕脱性骨折的方法及疗效分析.方法 采用关节镜下治疗胫骨髁间棘撕脱性骨折21例,其中Ⅱ型7例,Ⅲ型10例,Ⅳ型4例.在关节镜监视下行骨折复位、利用前交叉韧带胫骨导向器准确确定骨床或骨块上的钻孔位置;于胫骨结节内下部经皮向关节腔钻入两个骨隧道;采用双股5号尼龙编织缝线横穿前交叉韧带基底并经骨床或骨块上的钻孔及骨隧道引出关节外打结固定子胫骨结节内前方的骨桥上.结果 术后21例均获得随访6～30 个月,平均15个月.术后Lachman和抽屉试验均为阴性.X线片显示除2例骨块前缘有2 mm上撬外均为解剖复位,骨折全部愈合.膝关节活动正常者18例,屈膝活动受限者3例,但均超过90°,其中1例因术后3个月膝关节伸屈范围仅0°,-20°,-45°,在关节镜下行膝关节二次松解术,膝关节伸屈范围达0°,-10°,-110°.术后末次随访膝关节Lysholm评分为(92.8±2.5)分(86～100 分).结论 关节镜下复位及双股尼龙编织缝线固定治疗胫骨髁间棘撕脱骨折,复位满意、固定可靠;该手术方法简便易行,创伤小,有利于膝关节功能恢复.     

关节镜下PDS线张力固定前交叉韧带胫骨髁间嵴撕脱性骨折的疗效分析

目的 探讨关节镜下应用聚对二氧杂环已酮（PDS）线高张力固定前交叉韧带胫骨髁间嵴撕脱性骨折的临床疗效。方法 选择2008年10月-2013年1月在喀什地区第一人民医院骨科住院的胫骨髁间嵴撕脱性骨折患者42例,在关节镜下应用PDS线将撕脱的前交叉韧带止点“十”字交叉固定于髁间嵴附着点处,同时于胫骨中上段应用空心钉为PDS线提供张力,加强固定撕脱的骨折块。采用Lysholms—Tegner膝关节功能评分分析临床疗效。结果 42例随访时间3～12个月,平均6．5个月,Lysholms-Tegner评分为（96．78±1．33）分。Lachman试验均阴性,骨折愈合良好,无感染病例。结论 关节镜下应用PDS线结合胫骨中上段空心钉高张力固定前交叉韧带胫骨髁间嵴撕脱性骨折是一种创伤小、操作简单的手术,可牢固固定骨折块,愈合率高,术后膝关节功能恢复快,值得推广应用。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.