灰阶超声结合超声弹性成像改良评分法在甲状腺实性结节中的应用

目的:探讨超声弹性成像改良评分法在诊断甲状腺结节良恶性中的价值。方法:对45例共71个实性结节进行弹性成像,按新评分法分为五级,并与病理结果进行相关分析。结果:灰阶超声诊断甲状腺疾病良恶性的敏感性、特异性、准确性分别是81%、94%、90.1%;新评分法诊断甲状腺疾病良恶性的敏感性、特异性、准确性分别是85.7%、96%、93%;二者联合使用敏感性、特异性、准确性分别是85.7%、98%、94.4%结论:改良评分法简便、准确、易于操作,与灰阶超声结合有助于提高对甲状腺疾病的诊断。     

Additional value of qualitative strain ultrasound elastography and strain ratio in predicting thyroid malignancy

Objective

To detect if strain ultrasound elastography and strain ratio have additional value to the conventional grey scale ultrasound in predicting thyroid malignancy.

Role of ultrasound,color doppler,elastography and micropure imaging in differentiation between benign and malignant thyroid nodules

Purpose

To evaluate the role of ultrasound elastography, Doppler and micropure imaging in the assessment of thyroid nodules, using the pathological analysis as the reference standard.

超声弹性成像联合常规超声鉴别诊断甲状腺良恶性结节的临床价值

目的：探讨超声弹性成像（ultrasonic elastography,UE）联合常规超声（coventional ultrasonogaphy,CUS）在甲状腺良恶性结节鉴别诊断中的临床价值。方法：应用弹性成像和常规超声分别对98例（119个结节）甲状腺结节患者进行检查,所有病例均以手术后病理诊断作为金标准。比较单独应用常规超声、单独应用弹性成像、弹性成像联合常规超声综合诊断对甲状腺良、恶性结节鉴别诊断的灵敏度（Sen）、特异度（Spe）、粗符合率（CA）、阳性预测值（PV＋）、阴性预测值（PV-）。结果：超声弹性成像联合常规超声鉴别诊断甲状腺良恶性结节的敏感性、特异性和准确性均高于常规超声和弹性成像（P〈0.05）。结论：超声弹性成像与常规超声联合应用可以明显提高对甲状腺良恶性结节的判断,具有重要的临床价值。     

The value of strain ratio in differential diagnosis of thyroid solid nodules

Objective

To assess the clinical value of strain ratio in differentiating thyroid solid nodules and explore its distribution characters based on pathological results.

Materials and methods

The study was approved by the ethic committee and the informed consents were signed. Ninety nine solid thyroid nodules (67 benign and 32 malignant) from 71 female (mean age 46.3 ± 9.8 years) and 28 male (mean age 54.9 ± 11.7 years) patients were evaluated. Five radiologists evaluated the nodules based on a four-degree elastography score system. Strain ratio was calculated on-line. Diagnostic performances of the two evaluations were compared using Receiver Operating Characteristic (ROC) curves. Values of different pathological nodules were compared by one-way ANOVA.

Results

Areas under the ROC curve (AUC) of the five readers were 0.82, 0.81, 0.79, 0.73 and 0.83, respectively. The AUC of strain ratio evaluation was higher (0.88 vs. 0.79, p < 0.001) than that of the ES score evaluation. Best cut-off points of the two evaluations were 3.5 (82% sensitivity, 72% specificity) and 4.225 (81% sensitivity, 83% specificity), respectively. Both the ES score and strain ratio were higher for malignant nodules than that for benign ones (p < 0.001).

Conclusions

Strain ratio was a useful index in differential diagnosis of thyroid solid nodules. It can provide quantitative information on thyroid nodule characterization and improve diagnostic confidence. The best cut-off point for benign and malignant nodules was 4.2.     

Efficacy of thyroid ultrasound elastography in differential diagnosis of small thyroid nodules

Objective

To explore the efficacy of thyroid ultrasound (US) elastography in differential diagnosis of small thyroid nodules.

Methods

This HIPAA-compliant study was approved by the Institutional Review Board and all patients provided written informed consent. Thirty-five patients with 38 small thyroid nodules as seen on transverse ultrasound image formed our study population. An US examination and a separate thyroid elastography examination with pulsation from the carotid artery used as the compression source were performed before fine-needle aspiration. Baseband US data were acquired for off-line elastography processing, where a semi-quantitative index for each nodule was calculated. The Kruskal–Wallis nonparametric rank sum test was used to assess equality of population means among the different types of thyroid nodules. Maximum likelihood estimation of the curve parameters for a binomial receiver operating characteristic (ROC) curve was performed.

Results

Elasticity contrast index calculated with elastography was effective in distinguishing between small papillary thyroid carcinomas (PTMC, n = 8) and other lesions (n = 30) in small thyroid nodules (p = 0.0036). The area under the ROC curve for diagnosing PTMCs was 0.812 with a 95% confidence interval of 0.653–0.920. The cut-off value of ECI of 3.6 led to a sensitivity of 100% and a specificity of 60% for detecting PTMCs.

Conclusion

Noninvasive evaluation of small thyroid nodules is possible using thyroid US elastography with in vivo compression to pick out the most suspicious thyroid nodules for fine-needle aspiration (FNA) and avoid FNA in benign nodules.     

弹性成像比值法与萤火虫联合应用在鉴别甲状腺良恶性结节中的价值

目的应用弹性成像（ultrasonic elastography,UE）应变比值法（Strain ratio,SR）与萤火虫成像（Micropure）联合应用鉴别甲状腺良恶性结节,及与其它方法相比较,探讨其在发现甲状腺恶性结节中的价值。方法回顾性分析甲状腺结节210例常规超声,Micropure和UE检查,并与患者手术后病理结果相对照。绘制SR值在诊断甲状腺恶性结节的受试者工作特性曲线（receiver operator characteristic curve,ROC）,确定最佳诊断界值。计算出三种检查方法中的单一指标和较有意义的几个联合指标在诊断甲状腺恶性结节中的灵敏度、特异度、阳性预测值（PPV）、阴性预测值（NPV）。比较各组间的差异,Pd0．05差异有统计学意义。结果UE比值法与Micropure联合在诊断甲状腺恶性结节中的灵敏度、特异度最高,分别为93．1％、95．6％。结论UE比值法与Micropure联合应用在甲状腺恶性结节的诊断中具有一定价值。     

Comparison analysis between conventional ultrasonography and ultrasound elastography of thyroid nodules

Objective

To compare the effectiveness of conventional ultrasonography and ultrasound elastography in differential diagnosis of thyroid nodular diseases.

Methods

244 patients with 291 thyroid nodules were examined by ultrasonography and ultrasound elastography respectively; the examination results were compared against pathological findings to determine the effectiveness of these two examination methods.

Results

The sensitivity and positive predictive value of conventional ultrasonography is higher than those of ultrasound elastography, but its specificity, accuracy, and negative predictive value is lower than those of the later.

Conclusions

Ultrasound elastography is superior to conventional ultrasonography in differential diagnosis of thyroid nodules. However, ultrasonography is the basis of examination; only on this basis, an additional ultrasound elastography examination could greatly improve the diagnostic rate of thyroid nodular diseases.     

超声造影不同增强模式对良恶性甲状腺结节的鉴别价值

目的:探讨甲状腺良恶性结节实时灰阶超声造影的增强表现及其鉴别诊断价值.方法:46例甲状腺病变患者先行常规二维超声及彩色多普勒检查后,再行超声造影检查,观察甲状腺结节的增强模式,将其分为不均匀强化、均匀强化、环形强化及不强化;同时观察甲状腺结节造影前后测值的变化.结果:46例患者共49个甲状腺结节(23个恶性结节、26个...     

彩色多普勒超声诊断良恶性甲状腺结节的参考价值

目的分析良、恶性甲状腺结节的彩色多普勒超声表现,以提高超声诊断和鉴别诊断良、恶性甲状腺结节的价值。方法回顾性分析经手术、病理明确诊断的157个良、恶性甲状腺结节的彩色多普勒超声表现,良、恶性结节的形态、回声、钙化特点、彩色多普勒血流图血流信号分布等。结果157个甲状腺结节经病理诊断,其中 90个为良性结节,67个为恶性结节;本组病例彩色多普勒超声检查的特异性为92.2%,敏感性为80.6%,诊断符合率为87.2%;彩色多普勒超声图像显示甲状腺良、恶性结节的形态、边界、包膜、回声、血流信号分布、内部钙化情况、血流阻力指数值比较,差异比较均具有统计学意义（P<0.05）。结论彩色多普勒超声可诊断甲状腺病变,依据重要的参考指标,可评价甲状腺结节的良、恶性。     

甲状腺良恶性结节的超声鉴别诊断

目的探讨甲状腺良恶性结节声像图表现及鉴别诊断。方法对经手术病理证实的60例甲状腺良性结节和21例恶性结节的超声二维及彩色多普勒血流声像图（CDFI）表现进行对比分析。结果良恶性结甲在形态,边界,内部回声,彩色血流分布,阻力指数,颈部淋巴结肿大等指标有统计学显著性差异。结论形态不规整,边界不清,内部不均匀低回声,微钙化,内部血流丰富而周边少或无血流,RI〉0．7等可以作为恶性结节的主要指标;不清晰、不完整、宽窄不一的晕环及颈部淋巴结肿大高度提示恶性;囊性结节可作为排除恶性指标。微小乳头状癌结节及良恶性并发的多源性结节常常会被误诊。     

二维超声与弹性成像技术在甲状腺癌诊断中的价值

目的:探讨二维超声与弹性成像技术在甲状腺癌诊断中的价值。方法:回顾性分析经手术病理证实的66例81个恶性病灶的二维声像图及超声弹性图表现;二维超声诊断甲状腺癌的指标包括病灶大小、边界、形态、纵横比、内部回声、钙化类型、周边声晕、有无后方衰减等;同时分析81个甲状腺恶性病灶的超声弹性图表现,将图像分为0~Ⅳ级,并与病理结果作对比。结果:根据二维超声诊断指标,将可疑恶性病灶归入恶性组内,二维声像图与病理符合率74.07%;将二维声像图与弹性图联合诊断,则联合诊断指标与病理符合率86.42%,二者比较差异有统计学意义(P0.05)。结论:二维超声和弹性成像技术综合判断肿瘤良恶性,明显提高了超声对甲状腺癌诊断的准确性。     

ACR TI-RADS分类联合剪切波弹性成像对甲状腺结节的诊断价值

目的探讨美国放射学会(ACR)甲状腺影像报告与数据系统(TI-RADS)联合剪切波弹性成像(SWE)对甲状腺结节的诊断价值。方法回顾性分析167例患者的甲状腺结节(共243个)的ACRTI-RADS分类和SWE图像特征,以手术病理结果为金标准,绘制受试者工作特征(ROC)曲线,得出SWE诊断甲状腺结节良恶性的最佳阈值。分析ACRTI-RADS分类、SWE以及两者联合应用对甲状腺结节良恶性诊断的结果,绘制ROC曲线,将三种方法的诊断结果与病理结果进行一致性分析。结果243个甲状腺结节中,病理诊断恶性结节183个,良性结节60个。当选择最佳阈值SWE_max=38.6kPa,SWE_mean=27.5kPa时,两种方法联合诊断甲状腺结节良恶性的敏感性、特异性为96.72%、88.33%,曲线下面积(0.925)明显大于ACRTI-RADS分类(0.793)或SWE(0.843)单独诊断,差异有统计学意义(P<0.01)。结论ACRTI-RADS分类联合SWE应用可进一步提高甲状腺结节的诊断水平。     

探讨超声弹性成像对甲状腺良恶性结节鉴别诊断的应用价值

目的:研究超声弹性成像在鉴别甲状腺良、恶性结节临床诊断中的应用价值。方法:对术前52例(93个)甲状腺结节进行常规二维、彩色多普勒超声及弹性成像检查,对弹性成像进行分析,并与病理结果进行对照。结果:93个甲状腺结节中,良性结节64个,恶性结节29个。其良性结节中,47个结节评为1～2分,恶性结节中,27个结节评为4～5分,两组弹性成像评分比较有统计学差异(P<0.01)。其诊断恶性结节的敏感性87.10%、特异性96.77%、准确性93.55%。结论:超声弹性成像对鉴别甲状腺良恶性病变提供很大的帮助。     

弹性应变率比值法对甲状腺癌的诊断价值

目的:探讨弹性应变率比值法对甲状腺癌的诊断价值。方法:对190例患者的211个甲状腺结节分别行常规超声和弹性超声检查,测量结节周围正常甲状腺组织与结节间的弹性应变率比值(E2/E1),并将结果与术后病理结果进行比较。结果:弹性应变率比值法诊断甲状腺癌的ROC曲线下面积(AUC)为0.902(95%CI,0.862~0.942);良性结节的E2/E1均值为0.59±0.17,甲状腺癌的E2/E1均值为0.31±0.10,两者间比较差异有统计学意义(P0.05)。超声弹性应变率比值法与常规超声对甲状腺癌的检出率比较差异无统计学意义(P0.05),但联合应用两法较单独应用弹性应变率法敏感性显著提高(P0.05)。结论:超声弹性应变率比值法作为一项相对客观的诊断甲状腺良恶性结节的半定量指标,具有较高的诊断准确性,与常规超声联合应用可提高甲状腺癌的检出率。     

Logistic回归模型评估超声弹性成像对乳腺良恶性结节的诊断价值

目的:采用logistic回归分析建立乳腺结节超声特征参数为变量的诊断模型,评价超声弹性成像对乳腺良恶性结节的鉴别诊断价值.方法:以术后病理结果为金标准,回顾性分析132例患者共185枚乳腺结节的超声声像图特点,甄别出有价值的超声参数,建立logistic回归模型,评价其诊断效能及预测能力.结果:二分类logistic...     

超声弹性成像分级法及评分法在甲状腺结节鉴别诊断中的应用

目的 探讨超声弹性成像分级法及评分法在甲状腺结节鉴别诊断中的应用价值.方法 选取106例甲状腺结节患者,分别进行二维超声TI-RADS分类评分、超声弹性成像分级评分、以及联合评分诊断,构建受试者工作特征(ROC)曲线,分析各自诊断效能.结果 二维超声评分、超声弹性成像评级评分、及联合诊断的ROC曲线下面积分别为0.83...     

剪切波弹性成像对甲状腺良恶性结节的诊断价值

目的:探讨超声剪切波弹性成像(SWE)对甲状腺良恶性结节的诊断价值.方法:收集104例(126个结节)甲状腺结节为研究对象,采用常规超声检查结节的回声、边缘、内部钙化程度、组成及形状;采用CDFI评估结节血流;采用SWE定性和定量评估结节弹性,获取剪切波速度(SWV),并通过ROC曲线计算SWV的最佳临界值.以最大SW...     

甲状腺良恶性结节超声诊断的研究进展

甲状腺结节是临床的常见病,甲状腺结节良恶性的诊断对治疗方案的选择及预后的判断有重要意义。目前超声仍然是诊断甲状腺结节良恶性的首选影像学检查方式。随着超声探头的改进及计算机图像处理技术的发展,超声对甲状腺组织的图像分辨率及诊断准确性都有了很大提高。     

二维及彩色多普勒超声对甲状腺微小乳头状癌的诊断价值

目的 探讨二维与彩色多普勒超声对直径＜10mm甲状腺微小乳头状癌(papillary thyroid microcarcinoma,PTC)的诊断价值.方法 回顾性总结分析经手术病理证实的376例单、多发结节性病灶中的单发86例PTC超声与相关临床资料,并将其二维及彩色多普勒声像特征与病理结果对照.结果 86例PTC中除5例超声诊断不符合外,81例诊断正确,占94.1％.PTC的主要声像特征为:低或极低回声结节、A/T比值≥1、微钙化、不规则毛刺状边缘及少数结节血流相对丰富、颈部淋巴结肿大.结论 甲状腺PTC的二维及彩色多普勒声像图具有特异性,本检查方法具有重要临床价值.