共查询到20条相似文献,搜索用时 31 毫秒
1.
Background
The chromosomal location of CUL-5 (11q 22-23) is associated with LOH in breast cancer, suggesting that CUL-5 may be a tumor suppressor. The purpose of this research was to determine if there is differential expression of CUL-5 in breast epithelial cells versus breast cancer cell lines, and normal human tissues versus human tumors. The expression of CUL-5 in breast epithelial cells (HMEC, MCF-10A), and breast cancer cells (MCF-7, MDA-MB-231) was examined using RT-PCR, Northern blot analysis, and Western blot analysis. The expression of mRNA for other CUL family members (CUL-1, -2, -3, -4A, and -4B) in these cells was evaluated by RT-PCR. A normal human tissue expression array and a cancer profiling array were used to examine CUL-5 expression in normal human tissues and matched normal tissues versus tumor tissues, respectively. 相似文献2.
3.
Menelaos Zafrakas Beate Petschke Andreas Donner Florian Fritzsche Glen Kristiansen Ruth Knüchel Edgar Dahl 《BMC cancer》2006,6(1):88
Background
Mammaglobin A (SCGB2A2) and lipophilin B (SCGB1D2), two members of the secretoglobin superfamily, are known to be co-expressed in breast cancer, where their proteins form a covalent complex. Based on the relatively high tissue-specific expression pattern, it has been proposed that the mammaglobin A protein and/or its complex with lipophilin B could be used in breast cancer diagnosis and treatment. In view of these clinical implications, the aim of the present study was to analyze the expression of both genes in a large panel of human solid tumors (n = 309), corresponding normal tissues (n = 309) and cell lines (n = 11), in order to evaluate their tissue specific expression and co-expression pattern. 相似文献4.
5.
Lisa Gallicchio Sonja I Berndt Meghan A McSorley Craig J Newschaffer Lucy W Thuita Pedram Argani Sandra C Hoffman Kathy J Helzlsouer 《BMC cancer》2006,6(1):173-11
Background
A cohort study was conducted to examine the role of genetic polymorphisms in three estrogen metabolizing enzymes (COMT, CYP1A1, CYP1B1) and the two estrogen receptors (ESR1, ESR2) in the progression of benign breast disease (BBD) to breast cancer. 相似文献6.
Ignacio García-Tuñón Mónica Ricote Antonio Ruiz A Benito Fraile Ricardo Paniagua Mar Royuela 《BMC cancer》2007,7(1):158
Background
Interferons are a group of proteins that trigger multiple responses including prevention of viral replication, inhibition of cell growth, and modulation of cell differentiation. In different mammary carcinoma cell lines IFNγ induces growth arrest at mid-G1. At the present there are no in vivo studies in human breast. The aim of this study was to investigate the expression patterns of IFNγ and its two receptors (IFNγ-Rα and IFNγ-Rβ) by Western blot and immunohistochemistry, in order to elucidate its role in the different types of human breast cancer (in situ and infiltrative). 相似文献7.
Robert C Millikan Jon Player Allan Ren de Cotret Patricia Moorman Gary Pittman Vani Vannappagari Chiu-Kit J Tse Temitope Keku 《Breast cancer research : BCR》2004,6(4):R264
Introduction
A polymorphism in the manganese superoxide dismutase (MnSOD) gene, Ala-9Val, has been examined in association with breast cancer risk in several epidemiologic studies. Results suggest that the Ala allele increases the risk of breast cancer and modifies the effects of environmental exposures that produce oxidative damage to DNA. 相似文献8.
9.
José Roberto F Caldeira érika C Prando Francisco C Quevedo Francisco A Moraes Neto Cláudia A Rainho Silvia R Rogatto 《BMC cancer》2006,6(1):48
Background
The E-cadherin gene (CDH1) maps, at chromosome 16q22.1, a region often associated with loss of heterozygosity (LOH) in human breast cancer. LOH at this site is thought to lead to loss of function of this tumor suppressor gene and was correlated with decreased disease-free survival, poor prognosis, and metastasis. Differential CpG island methylation in the promoter region of the CDH1 gene might be an alternative way for the loss of expression and function of E-cadherin, leading to loss of tissue integrity, an essential step in tumor progression. 相似文献10.
Áron Altorjay Orsolya Dohán Anna Szilágyi Monika Paroder Irene L Wapnir Nancy Carrasco 《BMC cancer》2007,7(1):5
Background
The sodium/iodide symporter (NIS) is a plasma membrane glycoprotein that mediates iodide (I-) transport in the thyroid, lactating breast, salivary glands, and stomach. Whereas NIS expression and regulation have been extensively investigated in healthy and neoplastic thyroid and breast tissues, little is known about NIS expression and function along the healthy and diseased gastrointestinal tract. 相似文献11.
Larisa M Haupt Erik W Thompson Ann EO Trezise Rachel E Irving Michael G Irving Lyn R Griffiths 《BMC cancer》2006,6(1):18
Background
Members of the matrix metalloproteinase (MMP) family of proteases are required for the degradation of the basement membrane and extracellular matrix in both normal and pathological conditions. In vitro, MT1-MMP (MMP-14, membrane type-1-MMP) expression is higher in more invasive human breast cancer (HBC) cell lines, whilst in vivo its expression has been associated with the stroma surrounding breast tumours. MMP-1 (interstitial collagenase) has been associated with MDA-MB-231 invasion in vitro, while MMP-3 (stromelysin-1) has been localised around invasive cells of breast tumours in vivo. As MMPs are not stored intracellularly, the ability to localise their expression to their cells of origin is difficult. 相似文献12.
Background
Until recently, the molecular mechanisms explaining increased incidence of ovarian and breast cancers in carriers of BRCA1 gene mutations had not been clearly understood. Of significance is the finding that BRCA1 negatively regulates aromatase expression in vitro. Our objective was to characterise aromatase gene (CYP19A1) and its promoter expression in breast adipose and ovarian tissue in BRCA1 mutation carriers and unaffected controls. 相似文献13.
Background
We studied the expression of DMBT1 (deleted in malignant brain tumor 1), a putative tumor suppressor gene, in normal, proliferative, and malignant breast epithelium and its possible relation to cell cycle. 相似文献14.
Emaculate Verla-Tebit Shan Wang-Gohrke Jenny Chang-Claude 《Breast cancer research : BCR》2005,7(4):R455
Introduction
Studies on the association between the cytochrome P450c17α gene (CYP17) 5'-untranslated region MspA1 genetic polymorphism and breast cancer risk have yielded inconsistent results. Higher levels of estrogen have been reported among young nulliparous women with the A2 allele. Therefore we assessed the impact of CYP17 genotypes on the risk of premenopausal breast cancer, with emphasis on parity. 相似文献15.
16.
Damali N Martin Brenda J Boersma Tiffany M Howe Julie E Goodman Leah E Mechanic Stephen J Chanock Stefan Ambs 《BMC cancer》2006,6(1):257
Background
Two functional single nucleotide polymorphisms (SNPs) in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene, C677T and A1298C, lead to decreased enzyme activity and affect chemosensitivity of tumor cells. We investigated whether these MTHFR SNPs were associated with breast cancer survival in African-American and Caucasian women. 相似文献17.
Pamela S Larson Benjamin L Schlechter Chia-Lin King Qiong Yang Chelsea N Glass Charline Mack Robert Pistey Antonio de las Morenas Carol L Rosenberg 《BMC cancer》2008,8(1):68
Background
CDKN1C (also known as p57KIP2) is a cyclin-dependent kinase inhibitor previously implicated in several types of human cancer. Its family members (CDKN1A/p21CIP1 and B/p27KIP1) have been implicated in breast cancer, but information about CDKN1C's role is limited. We hypothesized that decreased CDKN1C may be involved in human breast carcinogenesis in vivo. 相似文献18.
Grit Kasper Matthias Reule Miriam Tschirschmann Niels Dankert Karen Stout-Weider Roland Lauster Evelin Schrock Detlev Mennerich Georg N Duda Kerstin E Lehmann 《BMC cancer》2007,7(1):12
Background
Stromelysin-3 (ST-3) is over-expressed in the majority of human carcinomas including breast carcinoma. Due to its known effect in promoting tumour formation, but its impeding effect on metastasis, a dual role of ST-3 in tumour progression, depending on the cellular grade of dedifferentiation, was hypothesized. 相似文献19.
20.
Dysregulated expression of Fau and MELK is associated with poor prognosis in breast cancer 下载免费PDF全文
Mark R Pickard Andrew R Green Ian O Ellis Carlos Caldas Vanessa L Hedge Mirna Mourtada-Maarabouni Gwyn T Williams 《Breast cancer research : BCR》2009,11(4):R60-8