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1.
ObjectivesWe described the associations between demographic and injury-related factors on bone mineral density (BMD) of the spine and the hip among adult patients with chronic spinal cord injury (SCI). DesignBMD in spinal and femoral bone sites were assessed. Multivariate analysis was performed to evaluate the relationship between anthropometric and injury-related factors with BMD. Serum level and amount of dietary intake of calcium, phosphor, and 25-hydroxy vitamin D were measured. SettingA referral tertiary rehabilitation center in Iran. ParticipantsPatients with SCI who had no previous history of endocrine disorders and were not on specific medications entered the investigation. Those with non-traumatic SCI, pregnant, or with substance dependency were excluded as well. InterventionsNo interventions were applied. Main study outcome measuresDual X-ray absorptiometry was performed to estimate BMD. Body mass index was positively associated with higher femoral (P < 0.01, r = 0.56) and hip (P < 0.0001, r = 0.82) BMD only in female participants. The high prevalence of vitamin D deficiency (60%) was noticeable. ResultsOlder male patients revealed lower BMD only in spinal vertebrae (P < 0.02, r = −0.21). A significant higher BMD loss in lumbar vertebras in male patients with complete spinal cord lesion (P < 0.009) was detected. Spinal reduction of BMD was more severe when the level of injury was above T6 (P < 0.02). ConclusionAlong with the clarification of age, gender, post injury duration, and the other factors'' effect on the BMD in the SCI patients, here we have also shown the noticeable prevalence of the 25-hydoxy vitamin D deficiency in these patients which needs attention. 相似文献
2.
Background contextBone loss after spinal cord injury (SCI) occurs because of pathologic changes in osteoblastic and osteoclastic activities due to mechanical unloading. Some biochemical changes in bone metabolism after SCI are described before that were related to bone mineral loss. PurposeOur purpose was to determine bone markers' changes and related effective factors in patients with chronic traumatic SCI. Study designThis investigation was designed as an observational cross-sectional study. Patient sampleAll patients with chronic SCI who were referred to Brain and Spinal Injury Research Center and did not meet our exclusion criteria entered the study. Outcome measuresSelf-reporting measures including patient's demographic features and date of accident were obtained using a questionnaire and physiologic measures including spinal magnetic resonance imaging to determine the level of injury accompanied with physical examination along with dual-energy X-ray absorptiometry were performed. Blood samples were analyzed in the laboratory. MethodsDual-energy X-ray was used to determine bone mineral density in femoral and spinal vertebrae bone sites. Serum level of C-telopeptide cross-linked Type 1 collagen (CTX), parathyroid hormone, calcitonin, osteocalcin, and bone alkaline phosphatase (BALP) were measured. ResultsWe detected a negative association between CTX level and bone mineral density in femoral and spinal bone sites that confirms that CTX is a bone resorption marker. C-telopeptide cross-linked Type 1 collagen and BALP levels did not show any significant correlation with postduration injury. Patients with spinal injury at lumbar level had the highest calcitonin level (p<.04). C-telopeptide cross-linked Type 1 collagen was positively related with osteocalcin and BALP (p<.0001, r=0.51), and osteocalcin was positively related with BALP (p<.0001, r=0.44). Osteocalcin was related negatively only to femoral intertrochanteric zone bone mineral density. ConclusionsSome bone biomarkers undergo noticeable changes after SCI. C-telopeptide cross-linked Type 1 collagen was positively correlated with BALP and osteocalcin that shows the coincidental occurrence of osteoblastic and osteoclastic activities. Our data also support this fact that although bone reduction after 2 years is slower than acute phase after SCI, bone resorption rate is higher than bone formation. These bone markers also revealed different site of action as osteocalcin level only affected femoral intertrochanteric bone mineral density. Generally, it seems that the coincidental consideration of these factors that influence bone mineral density can lead to a better understanding of bone changes after SCI. 相似文献
3.
目的 观察脊髓损伤患骨密度的变化。方法 用SPA法和US法对45例健康人,32例卧床2月病人和48例胸腰段脊髓损伤2月患行骨密度测量。结果 脊髓损伤患跟骨密度下降最为明显,卧床组次之。桡骨骨密度卧床组变化不明显,脊髓损伤组仍明显下降。结论 骨质疏松是脊髓损伤中层得的主要并发症之一,且机理复杂,应注意预防。 相似文献
4.
Spinal cord injury (SCI) leads to severe bone loss in the paralysed limbs and to a resulting increased fracture risk thereof. Since long bone fractures can lead to comorbidities and a reduction in quality of life, it is important to improve bone strength in people with chronic SCI. In this prospective longitudinal cohort study, we investigated whether functional electrical stimulation (FES) induced high-volume cycle training can partially reverse the loss of bone substance in the legs after chronic complete SCI. Eleven participants with motor-sensory complete SCI (mean age 41.9+/-7.5 years; 11.0+/-7.1 years post injury) were recruited. After an initial phase of 14+/-7 weeks of FES muscle conditioning, participants performed on average 3.7+/-0.6 FES-cycling sessions per week, of 58+/-5 min each, over 12 months at each individual's highest power output. Bone and muscle parameters were investigated in the legs by means of peripheral quantitative computed tomography before the muscle conditioning (t1), and after six (t2) and 12 months (t3) of high-volume FES-cycle training. After 12 months of FES-cycling, trabecular and total bone mineral density (BMD) as well as total cross-sectional area in the distal femoral epiphysis increased significantly by 14.4+/-21.1%, 7.0+/-10.8% and 1.2+/-1.5%, respectively. Bone parameters in the femoral shaft showed small but significant decreases, with a reduction of 0.4+/-0.4% in cortical BMD, 1.8+/-3.0% in bone mineral content, and 1.5+/-2.1% in cortical thickness. These decreases mainly occurred between t1 and t2. No significant changes were found in any of the measured bone parameters in the tibia. Muscle CSA at the thigh increased significantly by 35.5+/-18.3%, while fat CSA at the shank decreased by 16.7+/-12.3%. Our results indicate that high-volume FES-cycle training leads to site-specific skeletal changes in the paralysed limbs, with an increase in bone parameters at the actively loaded distal femur but not the passively loaded tibia. Thus, we conclude that high-volume FES-induced cycle training has clinical relevance as it can partially reverse bone loss and thus may reduce fracture risk at this fracture prone site. 相似文献
5.
目的:建立大鼠脊髓损伤及后肢废用模型,观察建模早期两种模型大鼠股骨远端骨密度及远端破骨细胞数量的改变。方法:24只SD大鼠随机分为3组(每组8只),对照组(A组),行T10椎板切除,不损伤硬膜及脊髓;脊髓损伤(SCI)组(B组):切除T10椎板后用Allen′s法(60g.cm势能)造成脊髓损伤;制动组(C组):采用大鼠双侧腿-尾缝合,造成双下肢制动。分别于造模后第1、7天采用BBB(Basso,Beattie and Bresnahan)评分评估脊髓损伤大鼠后肢运动功能,确定模型建立成功。建模第10天后处死,取一侧尺、桡骨及股骨远端,行骨密度检测。取另一侧股骨远端行TRAP染色,观察大鼠股骨远端破骨细胞数量的变化。结果:A、B、C 3组股骨远端骨密度值分别为0.114、0.096、0.108g/cm2,B组骨密度值最低,其次为C组,A组最高(P<0.05)。尺、桡骨骨密度3组比较无差异(P>0.05)。与A组比较,B组大鼠股骨干骺端破骨细胞数量增加显著,其次为C组,A组最少(P<0.01)。结论:脊髓损伤后,股骨远端破骨细胞数量大量增多,活性增强,骨吸收加强,引起脊髓损伤平面以下肢体骨量的迅速丢失,比废用性骨量丢失的程度更重。 相似文献
7.
Context/Objective: Individuals with chronic spinal cord injury (SCI) have an increased risk of morbidity and mortality attributable to respiratory diseases. Previous studies in non-SCI populations suggest that vitamin D may be a determinant of respiratory health. Therefore, we sought to assess if lower vitamin D levels were associated with decreased pulmonary function in persons with chronic SCI. Design: Cross-sectional study. Setting: Veterans Affairs Medical Center. Participants: 312 participants (260 men and 52 women) with chronic SCI recruited from VA Boston and the community participating in an epidemiologic study to assess factors influencing respiratory health. Methods: Participants provided a blood sample, completed a respiratory health questionnaire, and underwent spirometry. Linear regression methods were used to assess cross-sectional associations between plasma 25-hydroxyviatmin D and spirometric measures of pulmonary function. Outcome Measures: Forced expiratory volume in one second (FEV1), forced vital capacity (FVC), and FEV1/FVC. Results: Adjusted and unadjusted for a number of confounders, there was no significant association between plasma vitamin D levels and FEV1, FVC, or FEV1/FVC. For example, in fully adjusted models, each 10?ng/ml increase in vitamin D was associated with a 4.4?ml (95%CI ?64.4, 73.2, P?=?0.90) ml change in FEV1. Conclusion: There was no significant cross-sectional association between plasma vitamin D and FEV1, FVC, or FEV1/FVC in this cohort of individuals with chronic SCI. 相似文献
8.
Summary Osteoporosis is a well acknowledged complication of spinal cord injury. We report that motor complete spinal cord injury and
post-injury alcohol consumption are risk factors for hospitalization for fracture treatment. The clinical assessment did not
include osteoporosis diagnosis and treatment considerations, indicating a need for improved clinical protocols.
Introduction Treatment of osteoporotic long bone fractures often results in lengthy hospitalizations for individuals with spinal cord injury.
Clinical features and factors that contribute to hospitalization risk have not previously been described.
Methods Three hundred and fifteen veterans ≥ 1 year after spinal cord injury completed a health questionnaire and underwent clinical
exam at study entry. Multivariate Cox regression accounting for repeated events was used to assess longitudinal predictors
of fracture-related hospitalizations in Veterans Affairs Medical Centers 1996–2003.
Results One thousand four hundred and eighty-seven hospital admissions occurred among 315 participants, and 39 hospitalizations (2.6%)
were for fracture treatment. Median length of stay was 35 days. Fracture-related complications occurred in 53%. Independent
risk factors for admission were motor complete versus motor incomplete spinal cord injury (hazard ratio = 3.73, 95% CI = 1.46–10.50).
There was a significant linear trend in risk with greater alcohol consumption after injury. Record review indicated that evaluation
for osteoporosis was not obtained during these admissions.
Conclusions Assessed prospectively, hospitalization in Veterans Affairs Medical Centers for low-impact fractures is more common in motor
complete spinal cord injury and is associated with greater alcohol use after injury. Osteoporosis diagnosis and treatment
considerations were not part of a clinical assessment, indicating the need for improved protocols that might prevent low-impact
fractures and related admissions. 相似文献
9.
BackgroundSpinal cord injury with no radiographic bone lesion described as spinal cord injury without radiographic abnormality (SCIWORA) in childhood is less often reported in adults than in children. This study was undertaken to report our experience in the management of nine cases over 25 years. Patients and methodsThis was a retrospective study from 1985 to 2009 concerning nine adult patients who sustained spinal cord injury with no radiographic abnormality. The ratio among all cervical spine traumas for the same period was 2.21%. Magnetic resonance imaging (MRI) was performed in all the patients. The patients’ clinical status at the time of admission and discharge was evaluated using the Frankel's grading system. We report the results based on the clinical, epidemiologic and radiological findings and outcomes. ResultsThe mean age of our population was 37.43 years, ranging from 18 to 60 years. All the patients were men. The main etiology was falls (5/9) followed by road traffic accidents (4/9). According to the Frankel's grading system, four patients (44.45%) were grade A, four were grade B (44.45%), and one was grade C (11.11%). On MRI, medullar lesions were: contusion, non-compressive cervical disc herniation, cervical spine stenosis, and two cases of normal cervical spine. Four patients were operated on via the posterior cervical spine approach (laminectomy, C3-C7 in three cases and C1-C3 in one case). The other five patients were treated orthopaedically for 6 to 8 weeks. Three patients (3/9), who were Frankel's grade B and C with no demonstrable injury on MRI, improved to Frankel a useful neurological grade (Frankel's grades D or E) at the time of discharge. One patient evaluated as Frankel's grade A died from cardiovascular disturbance. ConclusionSpinal cord injury with no radiographic abnormality accounted for 2.21% of cases of spinal cord injury in our series. MRI is the investigation of choice, having diagnostic and prognostic value because it demonstrates neural and extraneural injuries and helps to identify surgically correctable abnormalities. 相似文献
10.
AbstractBackgroundOrthopedic literature states that fractures of long bones, when associated with traumatic brain injuries, frequently heal with excessive callus and faster than normal. Few studies, however, have reported these phenomena being induced by spinal cord injury (SCI). Our objective is to compare the extent of callus and the rate of healing of long-bone fractures in patients with or without SCI. Subgroup comparisons were performed among the patients with SCI in terms of different levels of SCI.MethodsThe final mean volume of callus formation and the rate of union of nailed fractures of the femur were determined radiologically in 22 femoral fracture patients with SCI (seven cervical, six thoracic, and nine lumbar spine injury) and compared with those in a group of 22 patients with similar types of fractures but without SCI.ResultsThe final mean callus volume in the fracture/SCI group was significantly higher than the fracture-only group (P < 0.001). The fractures in the fracture/SCI group united in an average time of 22.86 weeks compared with 25.04 weeks in the fracture-only group (P < 0.05). We observed 84.6% (11 of 13) of patients with cervical and thoracic SCI patients with accelerated fracture healing (cervical 6 of 7, thoracic 5 of 6), but only 44.4% (4 of 9) of patients with lumbar SCI appeared to show this phenomenon (P < 0.05).ConclusionsThese results confirm that SCI may be associated with accelerated fracture healing and enhanced callus formation. Furthermore, our study revealed a trend toward enhanced osteogenesis in cervical or thoracic SCI compared with lumbar SCI. 相似文献
11.
In a cross-sectional study, 46 male patients with paralysis after spinal cord injury (average age 32 years; injuries sustained
from 1 to 26 years ago; 33 Frankel A, 13 Frankel B, C, D) were examined clinically and by dual-energy X-ray absorptiometry
(DEXA). Their bone mineral density (BMD) values were compared with age-related controls and correlated to clinical parameters.
BMD was reduced in the proximal femur ( p < 0.05) and the distal forearm ( p < 0.05), but not in the lumbar spine. Demineralisation was influenced in the proximal femur (Z-score –2.95) by immobilisation
after surgical treatment. Patients suffering from complete lesions had significantly lower BMD in the lumbar spine (–1.47)
compared with patients with incomplete lesions (+0.02). BMD was not significantly influenced by the level of the lesion and
the ambulatory status. Long-term monitoring showed significant demineralisation in the proximal femur ( r = –0.36) and the distal forearm ( r = –0.4), but not in the lumbar spine ( r = –0.21). By correlating BMD with clinical parameters, it can be deduced that, firstly, immobilisation after surgical treatment
should be reduced to a minimum; secondly, that every effort must be expended to prevent turning an incomplete into a complete
lesion; and finally, that rehabilitation treatment should be lifelong.
Received: 15 August 1999 相似文献
12.
AbstractBackground/Objective: To compare the t-scores of proximal femur and lumbar spine of patients with spinal cord injury (SCI) with different levels of weight bearing. Methods: Cross-sectional study comparing 3 groups of patients with SCI: patients with daily standing times of more than 1 hour, patients with daily standing times of less than 1 hour, and nonstanding patients. Seventy-one patients with chronic SCI were recruited. They were assigned to 1 of 3 groups according to their reported daily standing time. The bone density of lumbar and proximal femoral regions was measured with dual-energy x-ray absorptiometry. Results: The 3 groups were similar in terms of demographics and clinical variables. No significant difference was found among the mean t-scores of lumbar and proximal femoral regions of the groups. However, the patients in the group that stood more than 1 hour daily had a slight tendency to have higher t-scores than those in the control group. Conclusions: There was no significant difference among the 3 groups. However, standing might be partially helpful in protecting the bone density in SCI by opposing the effects of immobilization. 相似文献
13.
Summary Both spinal cord injury and ovariectomy can result in ostepenia in rats. SCI induces more deterioration of cortical geometric
structure and trabecular microstructure in the proximal tibial metaphysis than OVX. The proximal tibial metaphysis microstructure
significantly correlates with its biomechanical properties.
Introduction The purpose of the present study was to compare the effects of spinal cord injury (SCI) and ovariectomy (OVX) on bone gain
in young female rats.
Methods Thirty young female Sprague-Dawley rats were randomized into three groups: age-matched intact control (CON), OVX and SCI.
The tibiae were assessed for DXA and micro-CT analysis, biomechanical testing, the upper tibial epiphyseal plate height, and
blood samples for biochemical analysis.
Results SCI rats showed lower aBMD in the proximal tibiae as compared with OVX rats. Cortical geometric structural parameters of the
tibial midshaft in SCI rats were significantly lower than OVX rats. SCI or OVX induced significant changes in all trabecular
microstructural parameters in the proximal tibial metaphysis. The trabecular separation (Tb.Sp) and structure mode index (SMI)
in SCI rats were significantly higher than in OVX rats. BV/TV explained 84% of the variation of ultimate load of the proximal
tibial metaphysis. There was no difference of the upper tibial epiphyseal plate height between SCI and OVX rats. Serum NTX
level in SCI rats was significantly higher than in OVX rats.
Conclusions SCI induces more deterioration of cortical bone geometric structure and trabecular microstructure in the proximal tibial metaphysis
than OVX. 相似文献
14.
Objective: To identify T-score values at the total hip (TH) and femoral neck (FN) that correspond to the cutoff value of <0.60?g/cm 2 for heightened risk of fracture at the distal femur (DF) and proximal tibia (PT ). Design: Retrospective analysis of data in a research center’s database. Setting: Community-based individuals with spinal cord injury (SCI). Participants: 105 unique individuals with SCI. Outcome Measurements: DXA derived areal BMD (aBMD) and T-score of the DF, PT, TH, and FN. Results: The aBMD at the DF and PT regions were predictors of T-scores at the TH ( R 2?=?0.63, P?<?0.001 and R 2?=?0.65, P?<?0.001) and FN ( R 2?=?0.55, P?<?0.001 and R 2?=?0.58, P?<?0.001). Using the DF and PT aBMD of 0.60?g/cm 2 as a value below which fractures were more likely to occur, the predicted T-score was ?3.1 and ?3.5 at the TH and ?2.6 and ?2.9 at the FN, respectively. However, when the predicted and observed T-score values disagree outside the 95% limit of agreement, the predicted T-score values are lower than the measured T-score values, overestimating the measured values between ?2.0 and ?4.0 SD. Conclusion: The DF and PT cutoff value for aBMD of 0.60?g/cm 2 was a moderate predictor of T-score values at the TH and FN, with considerable inaccuracies outside the clinically acceptable limits of agreement. As such, the direct measurement of knee aBMD in persons with SCI should be performed, whenever possible, prior to prescribing weight bearing upright activities, such as robotic exoskeletal-assisted walking. 相似文献
15.
Dual-photon absorptiometry characterized bone loss in males aged less than 40 years after complete traumatic paraplegic and quadriplegic spinal cord injury. Total bone mass of various regions and bone mineral density (BMD) of the knee were measured in 55 subjects. Three different populations were partitioned into four groups: 10 controls (healthy, age matched); 25 acutely injured (114 days after injury), with 12 reexamined 16 months after injury; and 20 chronic (greater than 5 years after injury). Significant differences (p less than 0.0001) in bone mass mineral between groups at the arms, pelvis, legs, distal femur, and proximal tibia were found, with no differences for the head or trunk. Post hoc analyses indicated no differences between the acutely injured at 16 months and the chronically injured. Paraplegic and quadriplegic subjects were significantly different only at the arms and trunk, but were highly similar at the pelvis and below. In the acutely injured, a slight but statistically insignificant rebound was noted above the pelvis. Regression techniques demonstrated early, rapid, linear (p less than 0.0001) decline of bone below the pelvis. Bone mineral loss occurs throughout the entire skeleton, except the skull. Most bone loss occurs rapidly and below the pelvis. Homeostasis is reached by 16 months at two thirds of original bone mass, near fracture threshold. 相似文献
16.
Objective: To investigate the neurological and functional recovery patterns of ischemic spinal cord injury (ISCI) compared with traumatic spinal cord injury (TSCI) in the acute to chronic phase.Design: Retrospective cohort study.Settings: Department of Neurology, Neurosurgery, Rehabilitation Medicine at a tertiary hospital.Participants: Fifty-four patients with ISCI and 86 patients with TSCI.Interventions: Not applicable.Outcome measures: MRI findings, American Spinal Injury Association Impairment Scale (AIS), modified Rankin Scale (mRS), Korean Spinal Cord Independence Measure (KSCIM), ambulatory status, and bladder status were reviewed. The functional outcomes were measured at admission, discharge, and >6 months after discharge.Results: AIS classification did not significantly change after 6 months in both ISCI and TSCI groups. Between admission and discharge, the proportion of patients needing a wheelchair or assistive device to ambulate decreased more in the ISCI group compared with the TSCI group [odds ratio (OR) 0.40, P = 0.04]. In addition, the proportion of catheterized voiding in the ISCI group was significantly higher than in the TSCI group at all time points (OR 5.12, P < 0.001). Lastly, both groups showed that functional improvement was the greatest between admission and discharge. In addition, the proportion of catheterized voiding decreased (Diff = −0.12, P = 0.019) and mRS score decreased (Diff=−0.48, P < 0.001) significantly in the ISCI group at >6 months post discharge.Conclusion: The ISCI group showed better recovery of mobility during inpatient rehabilitation period and worse recovery of bladder function as demonstrated by higher number of patients requiring bladder catheterization at all time points when compared with the TSCI group. 相似文献
17.
PurposeThe long-term situation of children with spinal cord injury (SCI) was investigated, and suggestions for helping them better return to the society were provided. MethodsSCI patients less than 18 years old hospitalized in Beijing Boai Hospital from January 2011 to December 2020 were retrospectively analyzed. Information including motor function, complications, characteristic changes, self-care abilities, school attendance and social participation were collected by telephone interview and electronic questionnaire. All the answers were statistically analyzed. ResultsA total of 86 cases were enrolled, 77 girls and 9 boys, with a median injury age of 6 years and 2 months. The follow-up time was 3–130 months. The main cause of trauma in these children was sport injury (66.3%), the thoracic spinal cord was involved the most (91.9%), and complete SCIs accounted for the majority (76.7%). In terms of complications, children with complete SCIs were more likely to have urinary incontinence, constipation and characteristic changes ( p < 0.05); whereas the incomplete SCIs often have spasticity ( p < 0.05). As to the daily living abilities, children with incomplete lumbar SCIs were more capable to accomplish personal hygiene, transfer, and bathing independently than those with complete injuries, or cervical/thoracic SCIs, respectively ( p < 0.05). Moreover, children older than 9 years care more able to dress and transfer independently than the youngers ( p < 0.05). Wheelchair users accounted for 84.9% and more than half of them were able to propel wheelchair independently, and those who move passively in wheelchairs were mostly introverted kids ( p < 0.05). Almost all (93.8%) children with incomplete injuries were able to walk independently. Most (79.1%) children continued to attending school, and 41.9% participated in interest classes. Unfortunately, 67.4% of the children spent less time playing with their peers than before the injury. ConclusionSCIs impair physical structures and function of children, affect their independence in daily living, and restrict school attendance and social interaction. Comprehensive rehabilitation after injury is a systematic work. Medical staff and caregivers should not only pay attention to neurological function, but also help them improve self-care abilities. It is also important to balance rehabilitation training and school work and social participation. 相似文献
19.
目的采用定量CT(QCT)骨密度仪测量激素治疗康复SARS患者腰椎的骨密度(BMD),以监测短时间大剂量静脉用激素治疗对腰椎BMD的影响。方法采用GE CT/e型CT扫描机和QCT-5000型QCT骨密度测量体模和软件,测量了128例使用激素治疗的康复SARS患者和116例对照组人群L2-4腰椎椎体BMD。进行统计学处理,检验使用激素治疗SARS患者的腰椎BMD与对照组或文献报道值之间差别的显著性。结果128例使用激素治疗的康复SARS患者,其中82例平均使用激素剂量3773mg,其余46例使用了激素但不知确切剂量。其中男性23例,平均腰椎BMD为148.2mg/cm^3,与对照组(37例)年龄相当,平均腰椎BMD为142.9mg/cm^3,两组之间差异无显著性。女性两组年龄不匹配,选择20—49岁范围,每10岁为一组分别与对照组和文献报道的相对应年龄段进行比较,两组之间差异均无显著性。结论治疗SARS所采用的短时间大剂量静脉用激素在用药后半年时间没有引起腰椎BMD减低。 相似文献
20.
The bone mineral density (BMD), the cross- links (PYD, DPD and NTx) and the bone specific alcaline phosphatase (BAP) was investigated
in a cross-sectional study in 62 male patients with spinal cord injury (SCI), n = 28 short-term (0–1 year after SCI) and n = 34 long-term SCI patients (> 5 years after SCI). Knowledge about this parameters are necessary to find an adequate therapy
for this special kind of osteoporosis. Immobilisation osteoporosis in SCI patients is a well-known problem that may lead to
pathological fractures. Little is known regarding the extend of the osteoporosis as well as the causative factors. Measurements
of the BMD in the proximal femur and the lumbar spine were performed with dual-energy-X-ray-absorptiometry (DEXA), of the
osteoblast marker BAP (bone specific alkaline phosphatase) from serum and the osteoclast markers PYD (pyridinoline), DPD (desoxy-pyridinoline)
and NTx (N-telopeptide of collagen type I) from urine. We found a significant decrease of BMD in the proximal femur and no
relevant change in the lumbar spine compared to an age- and sex correlated control group ( Z-score) in short-term and long-term SCI patients. There was a significant bone loss at the proximal femur between short and
long-term SCI patients, whereas at the lumbar spine the BMD even slightly increases. Bone resorption (cross-links) was increased
in both groups, though in long-term SCI patients it is significantly decreased compared to short-term SCI patients (DPD from
211.7 u/g creatinine to 118.1 u/g creatinine; NTx from 215.1 nmol/mmol creatinine to 83,6 nmol/mmol creatinine). The bone
formation marker BAP is slightly below normal range in both groups (12.3 U/l in short-term, 9.7 U/l in long- term SCI patients).
Only the proximal femur is affected by the immobilisation osteoporosis of SCI patients, therefore the BMD measurements in
these patients should be performed at the lower limb. The problem of the immobilisation osteoporosis in SCI patients is the
striking increase of bone resorption and the missing reaction of the bone formation. 相似文献
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