头颈部恶性纤维组织细胞瘤临床和预后分析

目的　探讨头颈部恶性纤维组织细胞瘤 (MFH )的临床病理特点、治疗方法 ,分析影响预后的相关因素。方法　回顾性分析 40例头颈部恶性纤维组织细胞瘤的临床资料 ,用Kaplan Meier法进行生存分析 ,对可能影响预后的 12项因素进行单因素和多因素分析 ,组间比较用Log rank检验 ,多因素分析采用Cox模型 ,不同因素间相关关系分析用 χ2 检验。结果　头颈部MFH 5年累积生存率为 42 .0 % ;局部复发率约 3 7.1% ;影响预后的因素主要为 :肿瘤发生部位、治疗方式、颈淋巴结转移、病理分级、肿瘤局部复发 (P <0 .0 1) ;病理分级与肿瘤发生部位相关 ;以手术为主的综合治疗者较单纯手术、放疗和化疗者预后佳 (P <0 .0 5 )。结论　头颈部MFH患者预后差、复发率高 ,颈淋巴结转移、病理分化差、局部复发患者预后差 ,以手术为主的综合治疗方案有助于提高患者局部控制率和生存率     

纵隔原发性恶性纤维组织细胞瘤

为了研究原发性纵隔恶性纤维组织细胞瘤的临床病理特点。采用常规石蜡包埋ＨＥ 染色及免疫组织化学方法研究３例ＭＦＨ。３ 例ＭＦＨ 均位于中纵隔,肿瘤界限清楚有包膜或假包膜,术后无局部复发及转移,最长无瘤生存者已达９ ａ。纵隔原发ＭＦＨ的病理特点与软组织ＭＦＨ 相同,但局部复发率及转移率低,提示其预后好于软组织ＭＦＨ。     

恶性纤维组织细胞瘤治疗及预后的研究现状

恶性纤维组织细胞瘤(MFH)是最常见的软组织肉瘤,常发生于四肢软组织,其治疗趋势为以手术为主的综合治疗.肿瘤分期、病理类型及治疗方式均与其预后相关.近年来涌现了大量有关MFH治疗及预后的分子生物学方面的研究,为MFH的治疗及预后评价提供了新的前景.     

胸壁恶性纤维组织细胞瘤

恶性纤维组织细胞瘤ｍａｌｉｇｎａｎｔ ｆｉｂｒｏｕｓ ｈｉｓｔｉｏｃｙｔｏｍａ，ＭＦＨ是成人最常见的软组织肉瘤，但国内外文献对原发于胸壁的ＭＦＨ仅限于小样本的个案报告。１ 材料与方法 １．１ 临床资料 自１９６４年至１９９６年中国医学科学院肿瘤医院胸外科诊治原发性胸壁ＭＦＨ共１５例。男１０例，女５例。年龄１５～６７岁，平均３９．３岁中位年龄３９岁。偶然发现皮下结节增大１０例，以胸痛为主诉５例，合并结肠癌１例有肿瘤家族史。血糖均正常。 影像检查示肿瘤边界不清１３例，侵及肋骨４例、肺１例、包饶…     

恶性纤维组织细胞瘤PCNA与AgNOR定量检测及其预后意义

目的：为探讨恶性纤维组织细胞瘤的增殖细胞核抗原（PCNA）及核仁组成区嗜银蛋白（AgNOR）定量检测与肿瘤恶性及预后的关系。方法：应用免疫组织化学染色LSAB法及AgNOR染色法46例资料完整有随结果的恶性纤维组织细胞瘤（MFH）手术切除标本进行染色以显示PCNA及AgNOR,彩色病理图像分析系统定量检测。结果：肿瘤细胞核PCNA过表达及AgNOR计数及患生存期呈负相关（rPCNA=-0.6248,rAgNOR=-0.5941,P<0.01);PCNA及AgNOR定量高值组较之定量低值组患生存期短（P＜0．01）;肿瘤组PCNA及AgNOR定量高于无转移组（P＜0．01）;肿瘤位置深在组PCNA及AgNOR定量高于肿瘤位置浅表组（P＜0．01）。结论：肿瘤细胞核PCNA及AgNOR定量与患生存期密切相关,与肿瘤转移及位置深浅等反映肿瘤恶性度的指标亦密切相关,提示肿瘤细胞核PCNA及AgNOR定量对于判断恶性纤维组织细胞瘤恶性度及预后的意义值得重视。     

15例肺恶性纤维组织细胞瘤临床分析

背景与目的肺恶性纤维组织细胞瘤(MFH)十分罕见。本研究旨在探讨肺MFH的临床特点、治疗方法及预后。方法回顾性分析经手术病理证实的15例肺原发性MFH。结果本组男性10例,女性5例;年龄56.2岁±14.0岁(20~72岁)。主要症状:咳嗽、咯血、发热、胸痛、气急。肿瘤直径8.3cm±8.0cm,最大35cm,最小0.3cm。以手术治疗为主,全肺切除术5例、肺叶切除术8例、剖胸探查术2例。1年、3年、5年生存率分别为56.2%、24.1%、16.7%。姑息性手术患者预后差。结论肺原发性MFH恶性度高,预后差,外科手术是主要治疗手段。     

上颌窦恶性纤维组织细胞瘤

恶性纤维组织细胞瘤(malignantfi-broushistiocytoma,简称MFH),1964年由O'Brian等[1]首先报道,是一种来源于间叶组织的恶性肿瘤,常见于中老年人,好发于肢体,偶见于头颈部,而发生于上颌窦者罕见。现将我院由病理证实原发于上颌窦的16例MFH报道如下。1　资料与方法1.1　一般...     

肾脏恶性纤维组织细胞瘤

恶性纤维组织细胞瘤(MFH)是来源于间叶组织的高度恶性的肿瘤,是最常见的软组织肉瘤之一,多见于四肢,发生于肾脏的MFH相当罕见。本文报道4例如下。     

4例少见部位原发恶性纤维组织细胞瘤

恶性纤维组织细胞瘤是软组织恶性肿瘤之一，多见于四肢和腹膜后，其它部位少有发生。我科自1996年5月～2002年6月诊治4例原发于内脏和骨骼的恶性纤维组织细胞瘤，现报道如下。     

Postirradiation malignant fibrous histiocytoma

Three patients who were treated successfully with postoperative external radiation therapy for ovarian carcinoma, endometrial adenocarcinoma and bilateral retinoblastoma respectively developed years later malignant fibrous histiocytoma (MFH) within the irradiated field. MFH is a recently described soft tissue sarcoma known for its dual fibroblastic and histiocytic differentiation resulting in a pleomorphic histologic appearance.     

Primary intrathoracic malignant fibrous histiocytoma and angiosarcoma

Primary intrathoracic malignant fibrous histiocytoma and angiosarcoma are rare sarcomas constituting less than 0.2% of lung cancers. The typical imaging appearance is a large, well-circumscribed, non-cavitating, non-calcified, peripheral lung mass without hilar or mediastinal lymphadenopathy. Bronchoscopy and percutaneous needle aspiration are of limited value in differential diagnosis, and thoracotomy is warranted for definitive diagnosis.     

Malignant fibrous histiocytoma

A malignant fibrous histiocytoma of the shoulder in an elderly woman is reported. This heterogenous tumor is thought to be the most common soft tissue sarcoma of late adult life. Typically, the tumor appears as an enlarging soft tissue mass in the proximal portion of an extremity. On histological examination, the tumor contains a bimodal cell population of fibroblast and histiocytelike cells. The location, size, and depth of the tumor have a significant effect upon survival. The biological behavior of malignant fibrous histiocytoma is usually one of local recurrence followed by metastasis. At the present time complete surgical removal offers the best hope for cure.     

Radiation-induced malignant fibrous histiocytoma of the brachial plexus

Summary Brachial plexopathy is a common and disabling complication in cancer patients most often attributed to metastasis or radiation-induced fibrosis. Occasionally, other rare but potentially treatable causes are found. A 73 year old woman had a left radical mastectomy followed by radiation to the chest wall and axilla 24 years ago. She recently presented with left arm pain, chronic, nonprogressive lymphedema, profound distal arm sensory loss and progressive severe hand weakness. There was moderate atrophy of all intrinsic hand muscles, anesthesia of the hypothenar eminence and 4th and 5th digits, and no adenopathy or palpable mass in the axilla. EMG confirmed a brachial plexopathy. MRI showed loss of tissue planes consistent with radiation fibrosis, but CT showed a discrete mass in the brachial plexus. Open biopsy showed pleomorphic spindle shaped cells with immunoperoxidase stains consistent with malignant fibrous histiocytoma.Radiation-induced malignant fibrous histiocytoma may present with a brachial plexopathy in the absence of a palpable mass and should be considered in the differential diagnosis of brachial plexus lesions in cancer patients. CT scanning through the plexus may be useful when MRI is normal or equivocal.     

Primary Renal Malignant Fibrous Histiocytoma Four-Case Report and Review of the Literature

OBJECTIVE To evaluate the diagnosis and treatment for primary renal malignant fibrous histiocytoma, a rare tumor arising from the kidney.METHODS The clinical and pathological data from 4 cases of malignant fibrous histiocytoma of the kidney detected in our hospital are described.One case of special interest involved a giant cell subtype, the first to be reported in the oncology literature. The clinicopathologic features and prognostic factors of this tumor were analysed and summarized after reviewing 55 documented cases in the English and Chinese literature.RESULTS A palpable mass (71.2%), emaciation (54.2%) and pain (54,2%) were common manifestations in renal MFH, Of all the cases, 51 were identified as a storiform-pleomorphic subtype by pathologists. Inconsideration of all the prognosis related factors, the residual tumor and high TNM stage predicted a shortened survival duration, but the symptom of a fever served as a better prognostic factor.CONCLUSION Malignant fibrous histiocytoma which arises from the kidney is a rare pathologic type, and possesses a high tendency towards local recurrence and distant metastasis. Despite the poor prognosis, early detection and radical surgery can prolong survival in selected cases.     

Prolonged remission of metastatic malignant fibrous histiocytoma induced by combination chemotherapy

A patient with metastatic malignant fibrous histiocytoma (MFH) achieved a complete remission with polychemotherapy lasting 42+ months. In view of this long-term survival and two similar prior reports of long-term survival after aggressive treatment, the goal of therapy for metastatic MFH must be reconsidered.     

脑部恶性纤维组织细胞瘤1例报道

Malignant fibrous histiocytoma (MFH) firstly described as "malignant fibrous xanthoma" by O'Brien and Stout in 1964, is the most common soft tissue sarcoma of late adult life. Uncertain histogenesis and numerous subtypes make MFH a rather controversial entity. MFH only rare arises from structures of the head and neck. When it does, it most often originates in facial structures, particularly the maxilla. This report details a case of a patient with malignant fibrous histiocytoma presenting clinically as a right-sided large indurated frontoparietal mass, three months after head trauma and eight years after radiation therapy for brain lymphoma located in the right frontal and parietal lobes. Radical excision was a surgical challenge because of the extensiveness of the lesion.     

原发性软组织恶性纤维组织细胞瘤的MRI影像诊断（附15例报告）

目的：探讨原发性软组织恶性纤维组织细胞瘤（MFH）的MRI影像诊断。方法：回顾性分析15例经手术病理证实的原发于软组织的恶性纤维组织细胞瘤患者的影像学资料,15例患者均行MRI检查,有7例行CT检查,8例行增强扫描。结果：原发于软组织恶性纤维组织细胞瘤15例,肿瘤形态多样,以卵圆形、分叶状多见。病变于T1WI呈低信号或等信号,T2WI呈高信号或等信号为主混杂信号影,7例病变内可见低信号之分隔影。13例病变内见坏死或黏液样改变,2例伴出血。明确有包膜3例。增强扫描均呈显著不均匀强化。结论：MRI对原发性软组织恶性纤维组织细胞瘤的诊断具有重要价值,是首选的影像学检查方法。     

39例恶性纤维组织细胞瘤临床分析

目的：探讨恶性纤维组织细胞瘤(MFH)的临床特点及合理治疗。方法：回顾性分析39例病例，其中6例为首程治疗病例，33例为院外局部手术后复发病例。按治疗方式分为两组：一组为单纯手术，共18例，另一组为手术加术后放疗，共2l例。结果：单纯手术组5年生存率为33％(6／18)，手术加术后放疗组为57％(12／21)。结论：MFH属于中高度恶性肿瘤，易出现局部复发和全身转移，术后放疗能降低局部复发率。     

软组织恶性纤维组织细胞瘤17例临床分析

目的　探讨软组织恶性纤维组织细胞瘤的合理治疗方法。方法　分析 17例病人的临床、病理特点 ,并总结其治疗结果。结果　男 13例 ,女 4例 ,平均年龄 5 5 .8岁 ,平均病程 8.7个月。发生于肢体 7例 ,占 41.2 %。 2年、3年和 5年生存率分别为 47.1%、2 9.4%和 17.6 %。发生远处转移 8例 ( 47.1% ) ,区域淋巴结转移 7例 ( 41.2 % )。首次术后复发率 10 0 %。结论　临床诊断困难 ,术后复发率高 ;根治性切除为其关键治疗手段。