Contemporary Surgical Management for Ileosigmoid Fistulas in Crohn’s Disease

Background  

Current diagnostic modalities and surgical treatments for ileosigmoid fistulas (ISF) in Crohn’s disease (CD) are not well characterized.     

Surgical Considerations in the Treatment of Small Bowel Crohn’s Disease

Journal of Gastrointestinal Surgery - Surgery remains a cornerstone of the management of Crohn’s disease (CD). Despite the rise of biologic therapy, most CD patients require surgery for...     

Pre-Colectomy Appendectomy and Risk for Crohn’s Disease in Patients with Ileal Pouch-Anal Anastomosis

Background

A subset of patients with a pre-operative diagnosis of ulcerative colitis can develop Crohn??s disease (CD) of the pouch after restorative proctocolectomy. While appendectomy has been implicated to be associated with an increased risk for CD, its impact on the development of de novo CD of the pouch in patients?? ileal pouch-anal anastomosis (IPAA) has not been studied. The aims of the study were to assess the prevalence of CD of the pouch in patients with pre-colectomy appendectomy and to investigate the impact of appendectomy on the development of de novo CD of the pouch.

Methods

All eligible patients with restorative proctocolectomy and IPAA for IBD who had available information on pre-colectomy appendectomy were studied. Demographic and clinical characteristics were evaluated. Cox regression analysis was performed.

Results

The study included 434 patients (44.9?% male) with a mean age of 45.2?±?14.4?years and follow-up of 4.6?±?2.3?years. Forty patients (9.2?%) had had appendectomy prior to colectomy. Appendectomy was not shown to be associated with CD of the pouch or its phenotypes in both univariable and multivariable analyses. In the Cox model, independent risk factors associated with CD of the pouch were active smoking (hazard ratio [HR]?=?1.58; 95?% confidence interval [CI], 1.03?C2.43) and family history of CD (HR?=?1.82; 95?% CI, 0.99?C3.32).

Conclusions

While this study has shown no association between previous appendectomy and the development of CD of pouch, active smoking was an independent risk factor for development of CD of the pouch.     

Outcome of Surgery for Coloduodenal Fistula in Crohn’s Disease

Background

This study was conducted to report the short- and long-term outcomes of surgery for coloduodenal fistula in Crohn’s disease and explore the effect of preoperative optimization on surgical outcome.

Methods

This is a retrospective review of 34 patients with coloduodenal fistula complicating Crohn’s disease between Jan 2008 and May 2015. Demographic information, preoperative management, and intraoperative and postoperative outcome data were collected.

Results

Primary duodenal repair was carried out in 33 patients (13 with duodenal defect >3 cm), and bypass surgery was performed in one patient with duodenal stenosis. Patients undergoing preoperative optimization (n?=?25) had decreased postoperative major (24.0 vs. 87.5 %, P?=?0.005) and intra-abdominal septic (20.0 vs. 75.0 %, P?=?0.008) complications compared to patients with emergent/semi-emergent surgery (n?=?8). No duodenal stenosis occurred on a median follow-up of 22.5 months. Patients with duodenum-ileocolic anastomosis fistula had longer postoperative stay (14.0 vs. 10.0 days, P?=?0.032) and increased possibility of refistulization of the duodenum on follow-up (30.0 vs. 0 %, P?=?0.031) compared with those with spontaneous duodenum-colonic fistula.

Conclusion

Primary duodenal repair can be safely performed in coloduodenal fistula in Crohn’s disease provided there was no duodenal stenosis, even for large duodenal defects. Preoperative optimization is associated with reduced postoperative complications. Patients with duodenum-ileocolic anastomosis fistula are more likely to have duodenum fistula recurrence compared to those with spontaneous duodenum-colonic fistula.

     

Comparing Outcomes Between Side-to-Side Anastomosis and Other Anastomotic Configurations After Intestinal Resection for Patients with Crohn’s Disease: A Meta-Analysis

Background

Anastomotic configurations may be a predictor of postoperative recurrence for Crohn’s disease. One previous meta-analysis showed side-to-side anastomosis was associated with fewer anastomotic leaks but did not reduce postoperative recurrence rates. After 2007, more articles that found distinct results were published. We aimed to update the meta-analysis comparing outcomes between side-to-side anastomosis and other anastomotic configurations after intestinal resection for patients with Crohn’s disease.

Methods

A literature search that included PubMed, EMBASE, the Science Citation Index, and the Cochrane Library was conducted to identify studies up to May 2012. Trials comparing side-to-side anastomosis with other anastomotic configurations for Crohn’s disease were analyzed. Sensitivity analysis and heterogeneity assessment were also performed.

Results

Eleven trials compared side-to-side with other anastomotic configurations were included. Overall, results showed a significant reduction in the overall postoperative complications [n = 777; odds ratio (OR) = 0.60; P = 0.01], but side-to-side anastomosis did not reduce the anastomotic leak rate (n = 879; OR = 0.48; P = 0.07), complications other than anastomotic leak (n = 777; OR = 0.72; P = 0.13), endoscopic recurrence rates [hazard ratio (HR) = 0.73; P = 0.07], symptomatic recurrence rates (HR = 0.74; P = 0.20), and reoperation rates for recurrence (HR = 0.37; P = 0.06). Sensitivity analysis including two randomized controlled trials found no significant differences in short-term complications between the two groups. Sensitivity analysis including nine trials comparing only stapled side-to-side anastomosis with other anastomotic configurations showed stapled side-to-side anastomosis could reduce reoperation rates (HR = 0.38; P = 0.01).

Conclusions

Side-to-side anastomosis did not reduce short-term complications and postoperative recurrence for Crohn’s disease. Stapled side-to-side anastomosis may lead to fewer reoperations needed for recurrence. Further randomized, controlled trials should be conducted for confirmation of recurrent events.     

Crohn’s Disease but not Diverticulitis Is an Independent Risk Factor for Surgical Site Infections in Colectomy

Introduction

Surgical site infections (SSIs) after colectomy for colon cancer (CC), Crohn’s disease (CD), and diverticulitis (DD) significantly impact both the immediate postoperative course and long-term disease-specific outcomes. We aim to profile the effect of diagnosis on SSI after segmental colectomy using the National Surgical Quality Improvement Program (NSQIP) data set.

Method

NSQIP data from 2006 to 2011 were investigated, and segmental colectomy procedures performed for the diagnoses of Crohn’s disease, DD, and colon malignancy were included. SSI complications were compared by diagnosis using univariate and multivariate analysis.

Result

We included 35,557 colectomy cases in the analysis. CD had the highest rate of postoperative SSI (17 vs. 13 % DD vs. 10 % CC; p?p?≤?0.001), deep incisional SSI (OR?=?1.85, p?=?0.03), and organ space SSI (OR?=?1.51, p?=?0.02).

Conclusion

For patients undergoing segmental colectomy in the NSQIP data set, statistically significant increases in SSI are seen in CD, but not DD, when compared to CC, thus confirming CD as an independent risk factor for SSI.     

Factors Associated with Operative Recurrence Early After Resection for Crohn’s Disease

Introduction  

Some Crohn’s disease (CD) patients develop rapid disease recurrence requiring reoperation. Identification of factors associated with early operative recurrence of CD may help risk-stratify patients and prevent recurrence.     

Surgical management of Crohn’s disease

Introduction

Crohn’s disease is an inflammatory bowel disease that can affect the entire gastrointestinal tract. It is chronic and incurable, and the mainstay of therapy is medical management with surgical intervention as complications arise. Surgery is required in approximately 70% of patients with Crohn’s disease. Because repeat interventions are often needed, these patients may benefit from bowel-sparing techniques and minimally invasive approaches. Various bowel-sparing techniques, including strictureplasty, can be applied to reduce the risk of short-bowel syndrome.

Methods

A review of the available literature using the PubMed search engine was undertaken to compile data on the surgical treatment of Crohn’s disease.

Results and conclusion

Data support the use of laparoscopy in treating Crohn’s disease, although the potential technical challenges in these settings mandate appropriate prerequisite surgical expertise.     

Surgical Management of Peyronie’s Disease

The development of a lymphocele after pelvic surgery is a well-documented complication, especially where pelvic lymph node dissection (PLND) is part of the operation. However, not all lymphoceles are symptomatic and require treatment. Most lymphoceles spontaneously resolve, and even lymphoceles that become symptomatic may resolve without any intervention. Robotic assisted radical prostatectomy (RARP) is a common operation in urology where PLND is likely to be performed in intermediate and high-risk prostate cancer patients. The rationale for performing a PLND in prostate cancer is for accurate staging and potential therapeutic benefits. However, due to potential intraoperative and postoperative complications there is still a debate regarding the value of PLND in prostate cancer. In this review, we will discuss the potential risk factors to be aware of in pelvic surgery in order to minimize the formation of a lymphocele, along with the management for clinically significant lymphoceles.     

Mesenteric Lymphatic Vessel Density Is Associated with Disease Behavior and Postoperative Recurrence in Crohn’s Disease

Purpose

The aims of the present study were to examine the density of lymphatic vessels in the mesentery and to assess the predictive value of the mesenteric lymphatic vessel density for postoperative clinical recurrence.

Methods

Ileocolonic resection specimens were obtained from 53 patients with Crohn’s disease and 10 non-inflammatory bowel disease control subjects. Mesentery adipose tissues adjacent to the bowel wall were used for the histological quantification of lymphatic vessels using immunohistochemistry with the D2-40 antibody. The relationships between lymphatic vessel density and disease behavior, the presence of granulomas, the presence of creeping fat, and postoperative clinical recurrence were assessed.

Results

Median lymphatic vessel density in the mesentery adjacent to inflamed or non-inflamed intestine was lower in control subjects than in Crohn’s disease patients (2.13‰; interquartile range [IQR], 1.83–2.61; 8.34‰; IQR, 6.39–10.22; 4.43‰; IQR, 3.32–5.78; P ? 0.001). Increased mesenteric lymphatic vessel density was significantly associated with stricturing behavior, the presence of intestinal granulomas, the presence of creeping fat, and bowel thickness. Interestingly, patients with disease recurrence had an increased mesenteric lymphatic vessel density of the proximal mesenteric margin at the time of resection compared with those who did not have disease recurrence (6.23‰; IQR, 5.43–6.75 vs. 3.28‰; IQR, 2.93–4.29; P ? 0.001).

Conclusions

In addition to its correlation with disease behavior, bowel thickness, and the presence of intestinal granulomas and creeping fat, increased mesenteric lymphatic vessel density in the proximal margin is predictive of early clinical recurrence after surgery in patients with Crohn’s disease.

     

Enteroliths in Crohn’s Disease: a Case Report

Subtraction angiography is an invasive diagnostic method, which for a long time was a gold standard in carotid artery and intra-cranial vessel imaging. The aim of this research is to evaluate angiographic imaging in predicting atherosclerotic plaque type VI by AHA morphology and to assess its significance in establishing patients’ suitability for a particular operative method. Secondarily, we assessed atherosclerotic lesions in common carotid artery bifurcation. In the paper we analyzed 158 bilateral angiograms of common and internal carotid arteries in extra-and intra-cranial locations.

The material consisted of patients hospitalized in the Vascular Surgery Ward of Memorial Copernicus Hospital in Lodz during 2002–2004 who underwent angiography. We concluded that: 1. In symptomatic patients irregular plaque images in subtraction angiography is correlated with plaque type VI by AHA morphology. 2. Angiography is not a sufficient method for selection of the appropriate operative treatment due to its low sensitivity and specificity in plaque morphology imaging. 3. Plaque type VI by AHA is characteristic even for the second group of carotid bifurcation stenosis (by NASCET) and it definitely dominates in group III (by NASCET).     

Frequency and Risk Factors of Postoperative Recurrence of Crohn’s Disease After Intestinal Resection in the Chinese Population

Background

Data on risk factors of postoperative recurrence in patients with Crohn??s disease (CD) have shown conflicting results. The aim of this retrospective study is to identify predictors of early symptomatic recurrence of CD after surgical intestinal resection in the Chinese population.

Materials and Methods

Patients diagnosed as CD who underwent intestinal resection in Jinling Hospital between May 2004 and December 2010 were included in our study. Clinical data of these patients were reviewed. Multivariable survival analysis was performed to elucidate risk factors of early postoperative symptomatic recurrence.

Results

There were a total of 141 CD patients who had at least one previous curative resection for CD under regular follow-up in our unit. Our data indicated disease behavior (95?% CI 1.01?C1.70, P?=?0.044), smoking habits (95?% CI 1.32?C2.84, P?=?0.001), indication of perforation (95?% CI 1.09?C4.02, P?=?0.026), and location of anastomosis (95?% CI 1.09?C3.39, P?=?0.023) which are, as a result, strong independent predictors of symptomatic recurrence, while the anastomosis type as side-to-side anastomosis (SSA) was significantly associated with a decreased risk of symptomatic recurrence when compared with other anastomosis type (95?% CI 0.26?C0.94, P?=?0.038). Medical prophylaxes also played a role in the prevention of postoperative symptomatic recurrence.

Conclusions

A smoking habits and perforation indication for surgery at the time of resection are associated with an increased risk of symptomatic recurrence. Anastomosis type with SSA is associated with a reduced risk of symptomatic recurrence. This population-based study supports the concept that environmental factors, disease character, and surgical technique influence the risk of postoperative symptomatic recurrence of CD.     

Surgical Management of Recto-Sigmoid Hirschsprung’s Disease

Introduction : Over the years, the surgical management of recto-sigmoid Hirschsprung’s disease (HD) has evolved radically and at present a single stage transanal pull-through can be done in suitable cases, which obviates the need for multiple surgeries.

Aim : The aim of this paper was to evaluate the role of transanal pull-through in the management of recto-sigmoid HD in our institution.

Material and Methods : A retrospective analysis (between January 2003 and December 2009) was carried out on all cases of Hirschsprung’s reporting to unity of pediatric surgery of Tunis Children’s Hospital that were managed by transanal pull-through as a definitive treatment. All selected patients including neonates had an aganglionic segment confined to the rectosigmoid area, confirmed by preoperative barium enema and postoperative histology. Twenty-six children (86%) had their operation done without construction of prior colostomy.

Results : Transanal pull-through was performed in 31 children. Mean operating time was 150 minutes (range 64 to 300 minutes). No patients required laparotomy because all patients including neonates had an aganglionic segment confined to the rectosigmoid area. Blood loss ranged between 20 to 56 ml without blood replacement. Since all children were given an epidural caudal block, the requirement of analgesia in these cases was minimal. Postoperative complications included perianal excoriation in 7 out of 31 patients lasting from 3 weeks to 6 months. Complete anorectal continence was noted in 21 of 31 (67%) children in follow up of 3–5 years.

Conclusions : Transanal endorectal pull-through procedure for the management of rectosigmoid HD is now a well-established and preferred approach. Parental satisfaction is immense due to the lack of scars on the abdomen. As regards the continence, a long-term follow-up is necessary to appreciate better the functional results of this surgery.     

Intervention-free Interval following Strictureplasty for Crohn’s Disease

Introduction Strictureplasty is now well established as a bowel-sparing alternative for surgical treatment of complicated Crohn’s disease. Limited resection is still preferred in patients with uncomplicated disease, as subsequent reoperation rates are low. Methods A retrospective review of 26 patients who underwent surgery for small bowel Crohn’s disease between 1996 and 2004 was undertaken. A total of 96 small bowel strictureplasties had been performed; 19 patients had strictureplasties performed in isolation, and the remaining 7 patients underwent strictureplasty with concomitant limited resection. Results There was no operative mortality. The median follow-up was 41 months. Four patients developed complications that required further surgery. At 41 months, 73.3% of patients undergoing strictureplasty alone and 79.7% undergoing strictureplasty with concomitant resection were intervention-free. If followed up to 70 months or more, the same proportion of patients would remain intervention-free. Four patients developed further recrudescent disease and required surgery: strictureplasty, limited resection, or both. Of these patients, 25% were intervention-free at 41 months. Conclusions Our results show that strictureplasty alone or with concomitant resection can confer intervention-free periods of 41 months or more in 73.3% of patients, suggesting that strictureplasty can be utilized as an alternative to limited resection in uncomplicated Crohn’s disease.     

Readmission After Abdominal Surgery for Crohn’s Disease: Identification of High-Risk Patients

Background

Although many predictive factors for postoperative morbidity are known, few data are available about readmission after abdominal surgery for Crohn’s disease (CD). The objective of this study is to identify predictive factors and high-risk patients for readmission after abdominal CD surgery.

Methods

All patients who underwent abdominal surgery for CD in one tertiary referral center between January 2004 and December 2016 were included. Patients who required readmission and those without were compared. Perineal procedures, elective readmissions, and abdominal procedures for non-Crohn’s indications were not included.

Results

Nine hundred eight abdominal procedures were performed in 712 patients. Readmission rates were 8, 8.5, 8.6, 8.8, and 8.9% at 30, 60, and 90 days and 12 and 60 months, respectively. The main reasons were wound infection (14%), deep abscess (13%), small-bowel obstruction (13%), and dehydration (11%). Eight (11%) patients required percutaneous drainage and 19 (27%) underwent an unplanned surgery. After multivariate analysis, three independent predictive factors for readmission were identified: older age (OR 1.02, 95%CI 1.005–1.04; p?<?0.006), a history of previous proctectomy (OR 3, 95%CI 1.2–9, p?<?0.02), and higher blood loss volume during surgery (OR 1.0001, 95%CI 1–1.002, p?<?0.05).

Conclusion

Readmission occurred in 8–9% of abdominal procedures for CD within 1–3 months after surgery and it required unplanned reoperation in a quarter of them. Identification of high-risk groups and knowledge of the more common postoperative complications requiring readmission help in increasing postoperative vigilance to select patients who may benefit from early interventions.

     

Strictureplasty in Crohn’s Disease: Short and Long-Term Follow-Up

Strictureplasty for obstructive Crohn’s disease is still controversial because lesions are left in place and the suture is performed on a diseased bowel. Many surgeons prefer to perform bowel resection, hoping for fewer complications and a lower recurrence rate. In this paper, the authors report their strictureplasty experience. They performed a systematic retrospective review of the patients suffering from Crohn’s disease who underwent strictureplasties during a 10-year period in the abdominal surgery department of the University Hospital of Liège Sart Tilman, and studied the short-and long-term clinical results of 68 strictureplasties performed in 18 patients. Median follow-up was 63 months (range 12 to 144). Mortality was 0% and septic morbidity was 11% (one wound abscess and one leakage). Among the 16 patients available for the latest follow-up, symptomatic stenotic recurrence had to be medically treated in hospital for 4 patients (25%) with a recurrence delay range of 19 to 49 months. Stenosis recurrence needed re-intervention in one patient 48 months after surgery: stenosis occurred at a distance from the corrected site. These results confirmed that strictureplasty is a safe and efficient procedure in selected patients undergoing surgery for obstructive Crohn’s disease.