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PURPOSE: To examine the spoiled steady-state (spoiled gradient-recalled echo sequence [SPGR]) signal arising from two-compartment systems and the role of experimental parameters, in particular TR for resolving signal from each compartment. MATERIALS AND METHODS: Using Bloch-McConnell simulations, we examined the SPGR signal from two-component systems in which T(1) is much greater than the mean residence time (tau(m)) of proton spins in each component. Specifically, we examined the role of TR on the ability to resolve each components signal, as well as the influence of experimental parameters on derived DESPOT1 T(1) values. RESULTS: Results revealed that when TR < or = 0.01 tau(m), the measured SPGR signal may be modeled as a summation of signal from each species using a no-exchange approximation. Additionally, under this short TR condition, the driven equilibrium single pulse observation of T(1) (DESPOT1) mapping approach provides T(1) values preferentially biased toward the short or long T(1) species, depending on the choice of flip angles. CONCLUSION: The ability to model the SPGR signal using a no-exchange approximation may permit the quantification multicomponent T(1) relaxation in vivo. Additionally, the ability to preferentially weight the DESPOT1 T(1) value toward the short or long T(1) may provide a useful window into these components. 相似文献
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This work describes observed changes in the proton T1 relaxation time of both water and lipid when they are in relatively homogeneous mixtures. Results obtained from vegetable oil–water emulsions, pork kidney and lard mixtures, and excised samples of white and brown adipose tissues are presented to demonstrate this change in T1 as a function of mixture fat fraction. As an initial proof of concept, a simpler acetone‐water experiment was performed to take advantage of complete miscibility between acetone and water and both components' single chemical shift peaks. Single‐voxel MR spectroscopy was used to measure the T1 of predominant methylene spins in fat and the T1 of water spins in each setup. In the vegetable oil–water emulsions, the T1 of fat varied by as much as 3‐fold when water was the dominant mixture component. The T1 of pure lard increased by 170 msec (+37%) when it was blended with lean kidney tissue in a 16% fatty mixture. The fat T1 of lipid‐rich white adipose tissue was 312 msec. In contrast, the fat T1 of leaner brown adipose tissue (fat fraction 53%) was 460 msec. A change in the water T1 from that of pure water was also observed in the experiments. Magn Reson Med, 2010. © 2009 Wiley‐Liss, Inc. 相似文献
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Histological validation of cardiac magnetic resonance T1 mapping for detecting diffuse myocardial fibrosis in diabetic rabbits
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Mu Zeng MD Nan Zhang MD Yi He MD Zhaoying Wen MD Zhanhong Wang MD Yike Zhao MD Andreas Greiser PhD Jing An PhD Tianjing Zhang PhD Bin Jing PhD Xin Zhang PhD Zhanming Fan MD Debiao Li PhD 《Journal of magnetic resonance imaging : JMRI》2016,44(5):spcone-spcone
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Aim of the work
To evaluate the role of magnetic resonance imaging (MRI) in preoperative assessment of ano-rectal fistula and tracing its full extent and relationship.Materials and methods
Twenty-four patients with ano-rectal fistula were enrolled in this study. They were examined with different MRI sequences for evaluation of the fistulas and their extent. Fistulas were classified according to St. James’s University Hospital MRI based classification system (which correlates the Parks surgical classification to anatomic MRI findings) into 5 grades. Then, interrelation between surgical and MRI findings was statistically analyzed with evaluation of the accuracy of each MRI sequence used.Results
Grade 1 was the most frequent (37.5%) type of ano-rectal fistula. The most common location of the internal opening of the fistula was at 6 o’clock position. Combination of oblique coronal and axial planes of contrast-enhanced fat suppressed T1-weighed fast spin-echo (CE FS T1WFSE) sequence images showed the highest accuracy (99.4%) in diagnosis of ano-rectal fistula.Conclusion
MRI is a useful imaging tool in the preoperative assessment of ano-rectal fistula. A significant accordance between surgical and MRI findings was achieved by using combination of coronal and axial planes of CE FS T1WFSE sequence images. 相似文献6.
High magnetic field water and metabolite proton T1 and T2 relaxation in rat brain in vivo. 总被引:1,自引:0,他引:1
Robin A de Graaf Peter B Brown Scott McIntyre Terence W Nixon Kevin L Behar Douglas L Rothman 《Magnetic resonance in medicine》2006,56(2):386-394
Comprehensive and quantitative measurements of T1 and T2 relaxation times of water, metabolites, and macromolecules in rat brain under similar experimental conditions at three high magnetic field strengths (4.0 T, 9.4 T, and 11.7 T) are presented. Water relaxation showed a highly significant increase (T1) and decrease (T2) with increasing field strength for all nine analyzed brain structures. Similar but less pronounced effects were observed for all metabolites. Macromolecules displayed field-independent T2 relaxation and a strong increase of T1 with field strength. Among other features, these data show that while spectral resolution continues to increase with field strength, the absolute signal-to-noise ratio (SNR) in T1/T2-based anatomical MRI quickly levels off beyond approximately 7 T and may actually decrease at higher magnetic fields. 相似文献
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Ashley Williams Brandon Mikulis Nitya Krishnan Martha Gray Charlie McKenzie Deborah Burstein 《Magnetic resonance in medicine》2007,58(4):830-834
Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) is based on the theory that Gd-DTPA(2-) will distribute in inverse relation to cartilage glycosaminoglycan (GAG). T(1Gd) (T(1) after penetration of a 0.2 mmol/kg dose of Gd-DTPA(2-)) has been used as the dGEMRIC index, although (1/T(1Gd)-1/T(1o)) should be more representative of Gd-DTPA(2-) concentration (where T(1o) = T(1) before contrast). T(1o) and T(1Gd) were measured in 20 volunteers at both 1.5T and 3T and the correlation between the metrics of T(1Gd) and (1/T(1Gd)-1/T(1o)) was calculated. There was a high correlation coefficient between the two metrics at both field strengths, with R = 0.94, 0.93, and 0.90 for central medial femur, posterior medial femur, and medial tibia, respectively, at 1.5T and 0.87, 0.94, 0.96 at 3T. In all cases P < 0.0001. Therefore, these data suggest that, for native cartilage, the current practice of measuring T(1Gd) (but not also T(1o)) is adequate at both 1.5T and 3T. 相似文献
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目的:探讨地震伤MRI检查的扫描时间、序列和成像平面在快速显示病变中的作用,提出地震伤MRI检查的合理扫描方案。方法:用1.5TMR根据临床要求和伤情,对20例汶川地震伤员分别行横轴位和冠状位的T1WI、T2WI及T2WI+FS扫描,评价显示病变的效果和成像时间。结果:T2WI+Fs序列对病变的显示范围优于T2WI,但显示解剖结构比T2WI差。轴位显示病变与周围组织清晰,但成像时间成倍增加;冠状位能在很短时间内完成较大范围扫描。结论:T1WI、T2WI及T2WI+FS为必须扫描序列,轴位和冠状位为必须基本扫描平面;增加重BWI水成像和GRE快速序列,以显示继发脏器损伤。 相似文献
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P. M. Walker P. Y. Marie C. Mezeray M. Bessieres J. M. Escany G. Karcher N. Danchin S. Mattei J. P. Villemot A. Bertrand 《Magnetic resonance in medicine》1993,29(5):637-641
An ECG-triggered, two-sequence MRI technique is proposed for the precise measurement of proton T1 relaxation times of the human myocardium at a field strength of 0.5 T. The combination of an inversion recovery (IR) sequence and a spin echo (SE) sequence is not new. It is, however, rarely used in quantitative in vivo cardiac studies. Our approach employs a synchronization of the 90° read pulse to the systolic period. In a study of 22 healthy volunteers, the globally measured T1 value was estimated to be 714 ± 23 ms. Four of the volunteers also underwent additional imaging scans for the purposes of reproducibility assessment. The T1 precision was found to be 3.9 ± 1.1% for the IR/SE combination and 16.9 ± 5.3% for a combination of SE sequences. Total imaging time for the IR and SE sequences was 19.2 ± 3.0 mins. The relative rapidity of this classic technique and the T1 precision obtained give this technique an obvious application in the discrimination of normal and diseased myocardium. In the same study, valuable supplementary tissue characterization is provided by T2, calculated from the SE sequence. T2 was evaluated to be 50 ± 3 ms. 相似文献
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目的探讨低场强MRI对于基底节区脑出血T1、T2加权像(T1WI、T2WI)信号的影像特征,减少误诊。方法对13例以低场强磁共振为首诊的脑出血患者作常规横断位SE T1WI、FSE T2WI和T1FLAIR、T2 FLAIR序列扫描。结果与结论低场MRI对急性基底节区脑出血的诊断有特异性,充分认识,可以避免误诊。 相似文献
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Pierre-Jean Lattanzio K Wayne Marshall Andrei Z Damyanovich Hartwig Peemoeller 《Magnetic resonance in medicine》2005,54(6):1397-1402
In vitro proteoglycan (PG) depletion in the 20-40% range (enzymatic PG depletion of normal cartilage in the early osteoarthritis (OA) PG depletion range) was investigated in articular cartilage using 2D time domain NMR relaxation techniques. Spin-lattice relaxation times were measured at low fields (T(1rho)) and at high fields (T(1)) using nonselective and selective excitation pulse sequences. The short relaxation time magnetization components in T(1rho) ( approximately 8% signal) and nonselective T(1) ( approximately 5% signal) experiments were significantly altered with PG degradation. In addition, a magnetization component ( approximately 5% signal) with a "fast " T(1) approximately 7 ms was observed in the T(1) experiment involving selective excitation. This fast T(1) was at least 10 times shorter than the short T(1) in the nonselective experiment and was associated with a strong magnetization exchange mechanism between collagen and PG. The results suggest that T(1rho) and T(1) (nonselective and selective) relaxation based MRI techniques, which focus on the short relaxation time magnetization components, have the potential of detecting molecular abnormalities associated with early OA earlier than single, long relaxation time component approaches. 相似文献
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S. Newman V. M. Haughton Z. Yetkin R. Breger L. F. Czervionke A. L. Williams K. C. Ho R. A. Papke A. A. Rimm M. E. Fischer G. A. Meyer R. Asleson 《European radiology》1993,3(1):49-52
The possibility that cerebral tumours may be graded by measuring T1 or T2 with magnetic resonance (MR) imaging was studied. A consecutive series of patients with subsequently verified gliomas was enrolled, and studied with MR. Patients who had prior surgical, chemotherapeutic or steroid treatment were excluded. Single slice multiple saturation recovery and multiple spin echo techniques were used to measure T1, T2 and proton density in the tumour. In 33 patients with cerebral gliomas there were 5 grade I, 12 grade II, 7 grade III and 9 grade IV. T1 and T2 values tended to be smaller in grade I gliomas than in grades II, III and IV gliomas. Relaxation parameters overlapped considerably in tumours with different grades. Proton density values did not show much change between different grades of gliomas. Relaxation parameters cannot be used to determine tumour grade reliably.
Correspondence to: S. Newman 相似文献
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Busch S Hatridge M M??le M Myers W Wong T Mück M Chew K Kuchinsky K Simko J Clarke J 《Magnetic resonance in medicine》2012,67(4):1138-1145
The proton T(1) was measured at 132 μT in ex vivo prostate tissue specimens from radical prostatectomies of 35 patients with prostate cancer. Each patient provided two specimens. The NMR and MRI measurements involved proton repolarization, a field of typically 150 mT and detection of the 5.6-kHz signal with a superconducting quantum interference device. Values of T(1) varied from 41 to 86 ms. Subsequently, the percentages of tissue types were determined histologically. The theoretical image contrast is quantified for each case by δ = [1 - T(1) (more cancer)/T(1) (less cancer)]. A linear fit of δ versus difference in percentage cancer yields T(1) (100% cancer)/T(1) (0% cancer) = 0.70 ± 0.05 with correlation coefficient R(2) = 0.30. Two-dimensional T(1) maps for four specimens demonstrate variation within a single specimen. These results suggest that MR images with T(1) contrast established at ultra-low fields may discriminate prostate cancer from normal prostate tissue in vivo without a contrast agent. 相似文献
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Kathryn Richdale OD MS Peter Wassenaar MS Katharine Teal Bluestein BS Amir Abduljalil PhD John A. Christoforidis MD Titus Lanz PhD Michael V. Knopp MD PhD Petra Schmalbrock PhD 《Journal of magnetic resonance imaging : JMRI》2009,30(5):924-932
Purpose:
To develop a protocol which optimizes contrast, resolution and scan time for three‐dimensional (3D) imaging of the human eye in vivo using a 7 Tesla (T) scanner and custom radio frequency (RF) coil.Materials and Methods:
Initial testing was conducted to reduce motion and susceptibility artifacts. Three‐dimensional FFE and IR‐TFE images were obtained with variable flip angles and TI times. T1 measurements were made and numerical simulations were performed to determine the ideal contrast of certain ocular structures. Studies were performed to optimize resolution and signal‐to‐noise ratio (SNR) with scan times from 20 s to 5 min.Results:
Motion and susceptibility artifacts were reduced through careful subject preparation. T1 values of the ocular structures are in line with previous work at 1.5T. A voxel size of 0.15 × 0.25 × 1.0 mm3 was obtained with a scan time of approximately 35 s for both 3D FFE and IR‐TFE sequences. Multiple images were registered in 3D to produce final SNRs over 40.Conclusion:
Optimization of pulse sequences and avoidance of susceptibility and motion artifacts led to high quality images with spatial resolution and SNR exceeding prior work. Ocular imaging at 7T with a dedicated coil improves the ability to make measurements of the fine structures of the eye. J. Magn. Reson. Imaging 2009;30:924–932. © 2009 Wiley‐Liss, Inc. 相似文献17.
T1 mapping in the rat myocardium at 7 tesla using a modified CINE inversion recovery sequence
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Henk Smit MSc Ruben Pellicer Guridi MSc Jamal Guenoun MD Dirk H. J. Poot PhD Gabriela N. Doeswijk BSc Matteo Milanesi PhD Monique R. Bernsen PhD Gabriel P. Krestin PhD Stefan Klein PhD Gyula Kotek PhD 《Journal of magnetic resonance imaging : JMRI》2014,39(4):901-910
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Walter R T Witschey Arijitt Borthakur Mark A Elliott Eric Mellon Sampreet Niyogi Chenyang Wang Ravinder Reddy 《Magnetic resonance in medicine》2007,57(1):2-7
The origin of image artifacts in an off-resonance spin-locking experiment is shown to be imperfections in the excitation flip angle. A pulse sequence for off-resonance spin locking is implemented that compensates for imperfections in the excitation flip angle through an off-resonance rotary echo. The off-resonance rotary echo alternates the frequency offset and phase of the RF transmitter during two spin-locking pulses of equal duration. The underlying theory is detailed, and MR images demonstrate the effectiveness of the technique in agarose gel phantoms and in in vivo human brain at 3T. 相似文献
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Myocardial T1rho mapping of patients with end‐stage renal disease and its comparison with T1 mapping and T2 mapping: A feasibility and reproducibility study
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Lin Wang MD Jing Yuan PhD Shi‐Jun Zhang MD Min Gao MD Yuan‐Cheng Wang MD Yi‐Xiang Wang PhD Shenghong Ju MD PhD 《Journal of magnetic resonance imaging : JMRI》2016,44(3):723-731