自交联透明质酸钠凝胶预防中重度宫腔粘连分离术后再粘连

目的探讨宫腔镜下中重度宫腔粘连(intrauterine adhesion,IUA)粘连分离术后放置自交联透明质酸钠凝胶预防术后再粘连的价值。方法 2016年9月～2018年1月90例美国生育学会(American Fertility Society,AFS)IUA评分为中重度IUA在宫腔镜下行冷刀粘连分离,按照术后预防粘连方法不同分为观察组和对照组,每组45例,观察组粘连分离后宫腔内放置自交联透明质酸钠凝胶防止术后再粘连,对照组粘连分离后宫腔内放置金属宫形环防止术后再粘连。术后2个月进行第2次宫腔镜检查,再次对IUA进行分级,评价术后2个月防止IUA的有效率。结果 2组均未发生冷刀粘连分离术及材料相关的不良事件和并发症。术后2个月宫腔镜二次探查:观察组术后宫腔粘连有效率80.0%(36/45),明显高于对照组60.0%(27/45)(χ~2=4.286,P=0.038);观察组IUA累及范围得分和AFS总分明显低于对照组(t=-3.901,P=0.000;t=-3.360,P=0.001);观察组中重度IUA发生率为15.6%(7/45),明显低于对照组35.6%(16/45)(χ~2=4.731,P=0.030)。结论术后宫腔内放置自交联透明质酸钠凝胶能够有效减少中重度IUA分离手术后再粘连发生率,并降低粘连严重程度,预防IUA复发优于宫形环。     

透明质酸钠预防粘连性肠梗阻术后再粘连临床观察

Objective To investigate the prevention of intestines adhesion about sodium hyaluronic acid in postoperative intestines adhesion.Methods Eighteen cases of adhesive intestine obstruction were done intestinal release or bowel resection.2～4mL sodium hyaluronic acid was put to the wound,anastigmatic and rough surface of peritoneal.Gastrointestinal decompression,anti-infective and infusion were taken after oper-ations.Followed up 8～24 months.Results Obstructive symptoms haven't happened,the effective rate is 100%.Only 2 cases have intermittent abdominal pain without obstruction,the incidence was 11%.Conclu-sion Sodium hylauronic acid is effective to prevent the adhesion of postoperative intestines adhesion,simp-ler use,fewer side-effects and great value to appliance.     

透明质酸钠预防粘连性肠梗阻术后再粘连临床观察

Objective To investigate the prevention of intestines adhesion about sodium hyaluronic acid in postoperative intestines adhesion.Methods Eighteen cases of adhesive intestine obstruction were done intestinal release or bowel resection.2～4mL sodium hyaluronic acid was put to the wound,anastigmatic and rough surface of peritoneal.Gastrointestinal decompression,anti-infective and infusion were taken after oper-ations.Followed up 8～24 months.Results Obstructive symptoms haven't happened,the effective rate is 100%.Only 2 cases have intermittent abdominal pain without obstruction,the incidence was 11%.Conclu-sion Sodium hylauronic acid is effective to prevent the adhesion of postoperative intestines adhesion,simp-ler use,fewer side-effects and great value to appliance.     

透明质酸钠预防粘连性肠梗阻术后再粘连临床观察

Objective To investigate the prevention of intestines adhesion about sodium hyaluronic acid in postoperative intestines adhesion.Methods Eighteen cases of adhesive intestine obstruction were done intestinal release or bowel resection.2～4mL sodium hyaluronic acid was put to the wound,anastigmatic and rough surface of peritoneal.Gastrointestinal decompression,anti-infective and infusion were taken after oper-ations.Followed up 8～24 months.Results Obstructive symptoms haven't happened,the effective rate is 100%.Only 2 cases have intermittent abdominal pain without obstruction,the incidence was 11%.Conclu-sion Sodium hylauronic acid is effective to prevent the adhesion of postoperative intestines adhesion,simp-ler use,fewer side-effects and great value to appliance.     

透明质酸钠预防粘连性肠梗阻术后再粘连临床观察

Objective To investigate the prevention of intestines adhesion about sodium hyaluronic acid in postoperative intestines adhesion.Methods Eighteen cases of adhesive intestine obstruction were done intestinal release or bowel resection.2～4mL sodium hyaluronic acid was put to the wound,anastigmatic and rough surface of peritoneal.Gastrointestinal decompression,anti-infective and infusion were taken after oper-ations.Followed up 8～24 months.Results Obstructive symptoms haven't happened,the effective rate is 100%.Only 2 cases have intermittent abdominal pain without obstruction,the incidence was 11%.Conclu-sion Sodium hylauronic acid is effective to prevent the adhesion of postoperative intestines adhesion,simp-ler use,fewer side-effects and great value to appliance.     

透明质酸钠预防粘连性肠梗阻术后再粘连临床观察

Objective To investigate the prevention of intestines adhesion about sodium hyaluronic acid in postoperative intestines adhesion.Methods Eighteen cases of adhesive intestine obstruction were done intestinal release or bowel resection.2～4mL sodium hyaluronic acid was put to the wound,anastigmatic and rough surface of peritoneal.Gastrointestinal decompression,anti-infective and infusion were taken after oper-ations.Followed up 8～24 months.Results Obstructive symptoms haven't happened,the effective rate is 100%.Only 2 cases have intermittent abdominal pain without obstruction,the incidence was 11%.Conclu-sion Sodium hylauronic acid is effective to prevent the adhesion of postoperative intestines adhesion,simp-ler use,fewer side-effects and great value to appliance.     

透明质酸钠预防粘连性肠梗阻术后再粘连临床观察

Objective To investigate the prevention of intestines adhesion about sodium hyaluronic acid in postoperative intestines adhesion.Methods Eighteen cases of adhesive intestine obstruction were done intestinal release or bowel resection.2～4mL sodium hyaluronic acid was put to the wound,anastigmatic and rough surface of peritoneal.Gastrointestinal decompression,anti-infective and infusion were taken after oper-ations.Followed up 8～24 months.Results Obstructive symptoms haven't happened,the effective rate is 100%.Only 2 cases have intermittent abdominal pain without obstruction,the incidence was 11%.Conclu-sion Sodium hylauronic acid is effective to prevent the adhesion of postoperative intestines adhesion,simp-ler use,fewer side-effects and great value to appliance.     

透明质酸钠预防粘连性肠梗阻术后再粘连临床观察

Objective To investigate the prevention of intestines adhesion about sodium hyaluronic acid in postoperative intestines adhesion.Methods Eighteen cases of adhesive intestine obstruction were done intestinal release or bowel resection.2～4mL sodium hyaluronic acid was put to the wound,anastigmatic and rough surface of peritoneal.Gastrointestinal decompression,anti-infective and infusion were taken after oper-ations.Followed up 8～24 months.Results Obstructive symptoms haven't happened,the effective rate is 100%.Only 2 cases have intermittent abdominal pain without obstruction,the incidence was 11%.Conclu-sion Sodium hylauronic acid is effective to prevent the adhesion of postoperative intestines adhesion,simp-ler use,fewer side-effects and great value to appliance.     

透明质酸钠预防粘连性肠梗阻术后再粘连临床观察

目的 探讨透明质酸钠对粘连性肠梗阻松解术后再粘连的预防作用.方法 对18例粘连性肠梗阻粘连松解或肠切除后,于创面、吻合口及腹膜粗糙而处涂透明质酸钠2～4 mL后关腹,术后胃肠减压、抗感染、输液等治疗,随访8月～2年.结果 18例均未出现肠梗阻,有效率100%,2例出现间歇性腹部隐痛,发生率为11%,但无梗阻症状.结论 透明质酸钠对预防粘连性肠梗阻术后再粘连效果好,且使用简单,不良反应少,推广应用价值大.     

透明质酸钠预防粘连性肠梗阻术后再粘连临床观察

Objective To investigate the prevention of intestines adhesion about sodium hyaluronic acid in postoperative intestines adhesion.Methods Eighteen cases of adhesive intestine obstruction were done intestinal release or bowel resection.2～4mL sodium hyaluronic acid was put to the wound,anastigmatic and rough surface of peritoneal.Gastrointestinal decompression,anti-infective and infusion were taken after oper-ations.Followed up 8～24 months.Results Obstructive symptoms haven't happened,the effective rate is 100%.Only 2 cases have intermittent abdominal pain without obstruction,the incidence was 11%.Conclu-sion Sodium hylauronic acid is effective to prevent the adhesion of postoperative intestines adhesion,simp-ler use,fewer side-effects and great value to appliance.     

透明质酸钠预防粘连性肠梗阻术后再粘连临床观察

Objective To investigate the prevention of intestines adhesion about sodium hyaluronic acid in postoperative intestines adhesion.Methods Eighteen cases of adhesive intestine obstruction were done intestinal release or bowel resection.2～4mL sodium hyaluronic acid was put to the wound,anastigmatic and rough surface of peritoneal.Gastrointestinal decompression,anti-infective and infusion were taken after oper-ations.Followed up 8～24 months.Results Obstructive symptoms haven't happened,the effective rate is 100%.Only 2 cases have intermittent abdominal pain without obstruction,the incidence was 11%.Conclu-sion Sodium hylauronic acid is effective to prevent the adhesion of postoperative intestines adhesion,simp-ler use,fewer side-effects and great value to appliance.     

透明质酸钠预防术后粘连的研究进展

外科术后粘连一直是临床上较为常见的并发症,可导致肠梗阻、不育症和疼痛等;超声引导下甲状腺结节热消融术后,也会由于局部组织粘连引起颈部异物感、声音嘶哑、吞咽困难等。透明质酸钠因具有良好的粘弹性、生物相容性、稳定的理化性质等优势,已被广泛应用于预防外科术后粘连。本文针对透明质酸钠的物理结构、理化性质、预防术后粘连的机制以及应用进展进行综述。     

医用透明质酸钠HA在子宫肌瘤术后预防粘连效果观察

目的观察医用透明质酸钠（HA）在子宫肌瘤术后预防粘连的效果。方法对本院86例子宫肌瘤手术患者进行临床随机分组观察,对照组采用常规手术方案,观察组在对照组基础上使用医用透明质酸钠HA,观察两组患者术后宫腹腔粘连情况及相关并发症。结果观察组术后粘连率为4．65％,明显低于对照组的23．26％（P〈0.05）。此外,观察组各类并发症比例为4．65％,亦较对照组的13．95％为低（P〈0．05）。结论HA能够有效预防子宫肌瘤患者术后出现粘连,且能够降低术后并发症。     

医用透明质酸钠预防甲状腺术后粘连的探讨

目的观察医用透明质酸钠对于预防甲状腺术后粘连的作用。方法214例(实验组)甲状腺手术患者,于切除甲状腺病灶后,取医用透明质酸钠3～6ml均匀涂抹于甲状腺等创面上,并与同期未用医用透明质酸钠的182例(对照组)甲状腺手术患者作对比,评估术后粘连情况,进行数据分析。结果实验组:甲状腺术后粘连26例,对照组:甲状腺术后粘连41例。两组患者甲状腺手术后出现术后粘连情况比较,差异有显著意义(P<0.01)。结论医用透明质酸钠对预防甲状腺术后粘连有满意的功效。     

透明质酸钠预防术后腹腔粘连的实验研究

目的 探讨透明质酸钠对术后腹腔粘连的预防作用。方法 将３８只大鼠随机分为Ａ、Ｂ、Ｃ３组,于腹腔内损伤部位分别注入生理盐水,６％右旋糖酐－４０和透明质酸钠（术康林－１）,术后第１４天处死动物,观察各组腹腔粘连情况。结果 ３组粘连分级差异有显著性意义。光镜下见Ｃ组炎症反应轻微,纤维增生不显著;电镜下见Ｃ组纤维细胞分泌胶原能力弱,间质细胞增生活跃。结论 透明质酸钠可减少术后腹腔 的程度,其作用优于右旋糖     

医用透明质酸钠预防小儿包茎环套术后粘连的评价

目的：了解小儿包茎术后包皮粘连的发生及透明质酸预防粘连的效果。方法：2008年12月～2009年1月门诊小儿包茎包皮环套术90例，随机分A、B、C三组，术中分别局部用1％透明质酸、局部用红霉素、空白对照。随访2个月，观察冠状沟处粘连情况。结果：A、B、C三组术中无粘连率分别为10％、6％、10％。粘连面积50％以上三组分别为43％、53％、40％。术后评估，三组术中无粘连者术后粘连率均为0。三组术中有粘连者术后粘连率分别为74．7％（20／27）、78．6％（22／28）、100％（27/27）。总无粘连率分别为33．3％、26．7％、10．0％，透明质酸与红霉素组粘连发生率与空白对照比较，差异有统计学意义（P〈0．05）。结论：透明质酸可减少小儿包茎、包皮环套术后包皮粘连的发生。     

透明质酸钠预防跟腱断裂术后粘连的疗效观察

跟腱断裂是一种常见创伤,但术后常发生跟腱粘连,导致踝关节活动受限。我科自2000～2003年对跟腱损伤修复常规应用透明质酸钠预防粘连,与1993～1999年同种病例治疗比较,效果良好。报告如下。     

透明质酸钠预防屈指肌腱断裂术后粘连的疗效分析

<正>手术是治疗手屈指肌腱断裂外伤的常用方法之一。行屈指肌腱断裂修复或肌腱移位术后不但制动时间较长,而且在指肌腱损伤修复过程中由于周围组织的增生和侵入肌腱,可导致不同程度的屈指肌腱粘连使关节功能活动受限。透明质酸钠广     

羧甲基纤维素透明质酸钠预防术后腹膜粘连的实验研究

目的 探讨羧甲基纤维素透明质酸钠复合物（CMC-HA）在腹膜粘连预防中的价值.方法 将90只Wistar大鼠分为A、B、C 3组,每组30只,制成腹膜粘连模型后分别于创面置入羧甲基纤维素（CMC）、透明质酸钠（HA）和CMC-HA各3 ml,分别于术后3 d、7 d和14 d观察腹腔粘连情况.结果 术后3 d于光镜下可见,与A组和B组相比,C组大鼠肠壁纤维细胞增生较轻,胶原纤维排列较疏松.术后14 d,C组大鼠腹膜粘连程度明显轻于A组和B组（均P＜0.01）.结论 CMC-HA预防术后腹膜粘连安全有效.     

腹腔内应用透明质酸钠预防术后粘连的实验研究

为证明透明质酸钠对术后暖腔粘连的预防作用,将38只大鼠随机分为A、B、C三组,于腹腔内损伤部位分别应用0.9％生理盐水,6％右旋糖酐-40和透明质酸钠(术康林-1)。术后14天处死动物。结果显示,三组粘连分级差异有显著统计学意义(P<0.01)。显微镜下见透明质酸钠治疗组炎症反应轻微。纤维增生不显著。实验证明,透明质酸钠可减少术后腹腔粘连的程度,其作用优于右旋糖酐。