羊水过少与妊娠并发症的关系及对围生儿的影响

目的 :探讨羊水过少与妊娠并发症的关系及对围生儿的影响。方法 :收集我院 2 0 0 2年 1月至 2 0 0 3年 4月住院治疗的羊水过少孕妇 10 6例 ,随机抽取同期我院分娩的羊水量正常孕妇 12 0例作为对照组 ,两组病例就妊娠并发症、围生儿情况进行比较。结果 :羊水过少组中胎儿生长受限 (FGR)、妊娠高血压综合征 (简称妊高征 ,PIH)、过期妊娠及胎儿畸形的发生率均较对照组高 ,差异具有非常显著性 (P <0 .0 1) ,羊水过少组中同时合并两种、三种妊娠并发症的发生率均较对照组高 ,差异具有显著性或非常显著性 (P <0 .0 5 ,P <0 .0 1) ,胎儿宫内窘迫、新生儿窒息及羊水粪染的发生率也明显升高 (P <0 .0 5 ,P <0 .0 1)。伴有妊娠并发症的羊水过少孕妇 ,其胎儿宫内窘迫及羊水Ⅱ、Ⅲ度粪染率远较无妊娠并发症孕妇高 (P <0 .0 1)。结论 :羊水过少与妊娠并发症密切相关 ,它严重威胁围生儿生命 ,如果同时合并妊娠并发症则风险更大 ,羊水过少可作为许多妊娠并发症的危险信号。     

羊水过少对母婴的影响

羊水在胎儿的生长发育过程中起很重要的作用 ,为胎儿提供一个恒温、恒压的生长环境 ,提供一个活动空间 ,使胎儿能在其中运动 ,促进肌肉、骨骼及其它器官的发育。它又起到保护胎儿避免外环境的机械性损伤作用 ,当子宫收缩时又可避免宫腔内压力直接作用于胎儿。　　羊水又能反映胎儿在宫内的情况 ,因为胎儿吞咽、呼吸、排泄时均与羊水发生直接相关。所以 ,通过羊水量及羊水成分的变化可以了解胎儿生长发育、胎儿某些器官的成熟度 ,以及宫内安危情况。　　羊水过少常与妊娠并发症有关 ,而其后果又对母婴产生影响 ,造成不良围产结局。由于羊水过…     

羊水过少对围生儿的影响分析

目的探讨羊水过少对围生儿的影响，寻求改善围生儿预后的措施。方法对150例羊水过少的产妇与同期200例羊水量正常者进行对比分析。结果羊水过少对胎儿的影响有胎儿窘迫、新生儿窒息、足月低体重儿及胎儿畸形和围生儿死亡；阴道分娩的新生儿窒息发生率显著高于剖宫产（P〈0．01）。结论羊水过少严重影响围生儿的预后，对羊水过少的产妇，应加强监护，适时选择剖宫产结束分娩。     

羊水过少对围生期结局的影响

目的探讨晚期妊娠羊水过少对围生期结局的影响。方法2003年7月至2004年12月郑州市妇幼保健院应用超声测定羊水指数(AFI),对估测羊水量及分娩时羊水总量<300mL的230例妊娠妇女临床情况及围生期结局进行分析。结果羊水过少高发于孕40~42 6周,占7·58%(101/1332);有妊娠合并症、并发症的高危妊娠羊水过少多发生于孕37~39 6周,占71·43%(75/105)。围生儿死亡率为43·5/万。用超声测定羊水指数作为监测羊水量的指标,符合率为95·92%(188/196)。剖宫产率为71·74%(165/230)。结论诊断羊水过少孕妇,应根据综合检查结果及妊娠是否存在高危因素选择最佳分娩方式及时终止妊娠,可以明显改善围生儿预后。     

妊娠晚期羊水过少290例母儿围生结局分析

本文回顾性分析290例妊娠晚期羊水过少孕妇的母儿围生结局。 1资料与方法2001年9月至2006年12月，辽宁省盘锦市大洼县第一人民医院和中国医科大学附属盛京医院经超声诊断并于产时或剖宫产时收集羊水〈300mL的290例患者为羊水过少组。     

208例羊水指数异常患者的围生儿结局分析

随着围产医学的发展,对妊娠期羊水过少的认识逐渐深入,羊水过少是引起围生儿死亡的主要原因之一。回顾性分析本院2004年6月至2007年6月208例羊水指数异常病例的临床资料,以探讨其围生儿结局的相关影响因素。     

羊水过少孕妇血液流变学指标变化及其围生儿预后

目的:探讨羊水过少孕妇血液流变学指标变化及其围生儿预后。方法:测定羊水过少合并贫血组、合并胎儿窘迫组、合并妊娠期高血压疾病或(和)妊娠期肝内胆汁淤积症(ICP)组、其余羊水过少组和对照组孕妇的血液流变学指标。结果:①羊水过少合并贫血组全血粘度、血细胞比容(HCT)均低于对照组(P <0 .0 5 ,P <0 .0 1) ;羊水过少合并胎儿窘迫组全血粘度、HCT和聚集指数均高于对照组(P <0 .0 5 ,P <0 .0 1) ,血沉低于对照组(P <0 .0 1) ;羊水过少合并妊娠高血压疾病或(和)ICP组全血粘度、血浆粘度、HCT和聚集指数均高于对照组(P <0 .0 1,P <0 .0 5 )。②伴发并发症的羊水过少孕妇新生儿窒息、低体重及其羊水粪染的发生率均高于对照组(P <0 .0 5 )。结论:血粘度增加和贫血可能是引起羊水过少孕妇胎盘及胎儿缺氧的因素;血液流变学指标可作为羊水过少孕妇治疗监测指标之一。     

妊娠晚期羊水过少分娩方式的临床分析

目的:探讨妊娠晚期羊水过少分娩方式对围生儿的影响。方法:对2006年12月至2010年12月我院89例羊水过少病例进行回顾性分析,对妊娠晚期羊水过少患者采用不同分娩方式的围生儿进行观察比较。结果:选择性剖宫产与急诊剖宫产、阴道分娩差异显著(P<0.05)。结论:选择性剖宫产为羊水过少的最佳分娩方式,可明显改善围生儿预后。     

羊水过少妊娠及分娩经过

为研究羊水过少对妊娠、分娩经过及围产结局的影响，250例羊水过少妊娠妇女(妊娠30～40周)纳入研究(Ⅰ组)，其中中度羊水过少者92例(Ⅰa组)，重度158例(Ⅰb组)，Ⅱ组为150例羊水量正常孕妇。超声测量胎儿、羊水量，计算出羊水指数，评价胎儿宫内发育迟缓(IUGR)的程度。多普勒测量母体-胎盘-胎儿系统血流，计算脐动脉、胎儿大脑中动脉及孕     

羊水过少69例临床分析

目的探讨羊水过少的相关因素及对围生儿的影响。寻找正确的处理方法，降低围生儿病死率。方法采用回顾分析方法，将我院69例剖宫产中证实羊水过少的产妇作为观察组，另取其每例后的下一个产妇作为对照组，进行分析比较。结果羊水过少组：妊娠高血压综合征、胎儿宫内发育迟缓（IUGR）、过期、延期妊娠、胎儿窘迫、新生儿窒息率明显高于对照组。结论羊水过少是胎儿宫内慢性缺氧的最敏感特异性指征，一旦确诊，宜及早终止妊娠，以剖宫产终止妊娠为宜。     

Isolated oligohydramnios in term pregnancy as an indication for induction of labor

Objective. To evaluate the outcome of active induction of labor for isolated oligohydramnios in low-risk term gestation.

Methods. This retrospective study analyzed the obstetric and perinatal outcome of 412 singleton term pregnancies with cephalic presentation and no maternal risk factors or fetal abnormalities. Two groups were compared: 206 deliveries after induced labor for isolated oligohydramnios, and 206 deliveries matched for gestational age following spontaneous labor with normal amniotic fluid index.

Results. The overall rate of cesarean deliveries and cesarean deliveries for nonreassuring fetal status, and operative vaginal delivery rates and those for nonreassuring fetal status were higher in the oligohydramnios group than in the control group. There were no differences between groups in neonatal outcome or perinatal morbidity or mortality.

Conclusion. Active induction of labor in term low risk gestations with isolated oligohydramnios translated into higher labor induction, operative vaginal delivery and cesarean section rates. This led to increased maternal risk and an increase in costs with no differences in neonatal outcome.     

The role of antepartum transabdominal amnioinfusion in the management of oligohydramnios in pregnancy

Objective.?The purpose of this study was to evaluate the role of transabdominal amnioinfusion in the management of oligohydramnios with the view to improving pregnancy outcome.

Methods.?The study consisted of a retrospective analysis of 17 pregnant women presenting with oligohydramnios who were treated with amnioinfusion during pregnancy in a period from 2003 to 2006.

Results.?The mean gestational age at first treatment was 24 weeks. The mean pre-procedure deepest pool of amniotic fluid was 1.8?cm and post-procedure was 3.8?cm. The mean number of infusions was 1.05. The mean first infusion to delivery interval was 31 days. Perinatal mortality was 88% and neonatal mortality was 35%, with only one baby surviving the neonatal period. There were three cases of chorioamnionitis, with one of these cases presenting with premature rupture of the membranes at the time of amnioinfusion.

Conclusions.?Transabdominal amnioinfusion is a useful procedure to reduce complications that result from oligohydramnios. Although the results show a high perinatal mortality, it must be borne in mind that most of these pregnancies had multiple fetal abnormalities with an already predicted poor outcome. Importantly, as this procedure increases the latency period, it may be useful in preterm pregnancies where prolonging the duration of the pregnancy may result in better perinatal outcome by improving important factors that influence survival including increased birthweight.     

Perinatal outcomes in pregnancies with oligohydramnios after preterm premature rupture of membranes

Objective: Our purpose was to determine whether singleton pregnancies complicated by preterm premature rupture of membranes (PPROM) and oligohydramnios are at an increased risk of having maternal and neonatal morbidity.

Methods: We performed a retrospective analysis of 389 women with PPROM between 24 and 34 weeks of gestation in a single tertiary center during 2008–2014. Patients were divided into two groups on the basis of amniotic fluid index (AFI)?n?=?188) or AFI?≥?5?cm (n?=?201). Perinatal outcomes were compared according to amniotic fluid volume. The Student's t-test and Mann–Whitney U test were used to compare variables with normal and abnormal distribution, respectively. Categorical variables were examined by the chi-square test.

Results: Patients with an AFI?p?p?=?0.029) and emergency cesarean delivery (p?=?0.043) and a lower neonatal Apgar score at first minute (p?=?0.004).

Conclusion: Initial oligohydramnios after PPROM is associated with shorter latency to delivery, higher rate of clinical chorioamnionitis, higher rate of emergency cesarean delivery, and lower 1-min Apgar score.     

妊娠期单纯疱疹病毒感染与不良妊娠结局

单纯疱疹病毒(HSV)能引起生殖器官感染,妊娠合并HSV感染可造成胎儿宫内感染,引发流产、死胎、畸形、胎儿生长受限和新生儿感染等不良妊娠结局。此外,HSV感染还与输卵管妊娠及不孕等密切相关。文章阐述了妊娠合并HSV感染的流行病学、发病机制、临床特征、不良妊娠结局、诊断、预防和治疗的研究概况。     

孕早期双胎妊娠甲状腺功能减退对妊娠结局的影响

Objective?To investigate the impact of hypothyroidism of twin pregnancy in first trimester on pregnancy outcomes. Methods?A total of 1 203 cases of twin pregnant women were enrolled in this retrospective study and divided into three groups based on maternal TSH concentration in first trimester. Normal TSH group contained twin pregnant women with TSH levels between 0.01 to 3.35 mIU/L in first trimester, TSH>3.35 group contained twin pregnant women whose TSH concentrations between 3.35 to 4 mIU/L, TSH>4 group included those with TSH levels beyond 4 mIU/L. The pregnancy outcomes were analyzed between three groups. Results?Logistics analysis between maternal TSH levels and pregnancy outcomes of twin pregnancy showed TSH beyond 4 mIU/L in first trimester was corelated with the incidence of gestational diabetes mellitus (GDM), and its OR was 3.48, 95% CI was 1.27~9.55. Conclusion?The risk of GDM in twin pregnant women with hypothyroidism in first trimester may increase and TSH>4 mIU/L was one of independent risk factors of GDM.     

辅助生殖技术单胎妊娠结局分析

目的:研究辅助生殖技术(ART)与自然受孕两种不同受孕方式单胎妊娠的妊娠结局。方法:回顾分析2009年1月1日至2017年12月31日在广州医科大学附属第三医院住院分娩的妊娠≥20周的单胎妊娠病例资料。按受孕方法分为ART组及自然妊娠组,分析两组母儿结局,再按是否为高龄妊娠,比较ART组及自然妊娠组的母儿结局。结果:ART组孕妇的平均年龄、初产妇、定期产检、非足月胎膜早破(PPROM)、羊水量异常、子痫前期、妊娠期高血压、妊娠合并血小板减少症、妊娠期糖尿病、糖尿病合并妊娠、前置胎盘、胎盘植入/粘连、产后出血、剖宫产分娩、产钳/吸引产助产、人工剥离胎盘、药物/机械性引产、流产、胎儿窘迫及胎儿为男性发生率均高于自然妊娠组,ART组的住院天数更长,分娩孕周更低,转诊重症监护病房(ICU)、急性器官衰竭发生风险较低,ART组围产儿平均体重高于自然受孕组。高龄妊娠孕妇中,ART组的妊娠期糖尿病、剖宫产分娩发生风险增加。非高龄妊娠孕妇中,ART组子痫前期、妊娠期高血压、妊娠期糖尿病、糖尿病合并妊娠、流产、PROM、羊水量异常、前置胎盘、胎盘植入/粘连、产后出血、胎儿窘迫、人工剥离胎盘、药物/机械性引产发生风险增加。ART组较自然妊娠组钳产/吸引产风险均增加,产妇转诊ICU及非规律产检发生风险均降低,差异均有统计学意义(均P<0.05)。结论:ART受孕单胎妊娠并发症及新生儿不良结局发生率高于自然妊娠组孕妇,但其更注重孕期产检;在非高龄妊娠孕妇中,ART组母儿不良结局风险增加,而高龄妊娠孕妇中,ART组母儿不良结局风险增加不明显。