The influence of the lower patellar pole in the pathogenesis of chronic patellar tendinopathy

Resection of the lower patellar pole provides good results in the treatment of jumper’s knee. Therefore we hypothesized that the length of the lower patellar pole is increased in patients with chronic patellar tendinopathy. Cohort study, level of evidence 2. Between 2000 and 2005, 25 patients with chronic patellar tendinopathy underwent conservative and surgical treatment in our clinic. All of them had preoperative MRI were three independent examiners measured the Caton Index, the length and the ratio of the articular and non-articular patellar surface, tendon length and thickness and the thickness and length of the hypodens lesions in the patellar tendon. The measurements were compared with 50 MRI of a control group with no clinical patellofemoral disorders or patellar tendinopathy. Significant changes in tendon thickness (9.42 ± 2.87 vs. 4.88 ± 1.13; P < 0.0001), a longer non-articular surface of the patella (10.62 ± 2.86 vs. 7.098 ± 2.53; P < 0.0001) and significant higher ratio between the articular and the non-articular patellar surface (0.32 vs. 0.24; P < 0.0001) were found in the jumper’s knee group. No significant changes were seen in the length of the articular surface or the Caton Index. The development of chronic patellar tendinopathy in athletes might be associated with a longer lower patellar pole as patients with jumper’s knee showed a longer non-articular patellar surface compared with the control group.     

Marked sympathetic component in the perivascular innervation of the dorsal paratendinous tissue of the patellar tendon in arthroscopically treated tendinosis patients

During the recent years, a few studies have shed new light on the innervation patterns of the human patellar tendon, but the area of the loose paratendinous connective tissue dorsal to the proximal tendon proper has yet not been investigated. That is a drawback, since this is the area targeted in promising treatment regimens of chronic painful patellar tendinosis, namely sclerosing Polidocanol injection therapy, and a new surgical method conforming to ultrasound and color Doppler guided arthroscopic shaving, directed at neovessels found in the region. The present study thus aimed at investigating the paratendinous area dorsal to the proximal patellar tendon proper in seven patients being operated for tendinosis. Biopsies were collected through the new arthroscopic technique, approaching the tendon from the dorsal side. Samples were investigated using immunohistochemistry with antibodies delineating general (PGP 9.5), sensory (SP/CGRP), and sympathetic (TH/NPY) nerve patterns, and also antibodies against alpha1- and alpha2A-adrenoreceptors. Both small and large blood vessels had a marked perivascular innervation (PGP 9.5). Surprisingly, this perivascular innervation was found only to a very limited extent to correspond to sensory nerves, while there were marked immunoreactions for sympathetic markers. Adrenoreceptor immunoreactions frequently occurred in blood vessel walls. In conclusion, this study demonstrates, for the first time, the innervation patterns of the area dorsal to the patellar tendon in man. It shows that the area investigated is under marked influence by the sympathetic nervous system. Thus, sympathetic effects are likely to occur for blood vessels of the area, which is interesting since color Doppler has revealed that vessels of this area ("neovessels") display a pathologically high blood flow in tendinosis. The findings are discussed in relation to aspects of vascular regulation, and to pain symptoms of tendinosis.     

Is the chronic painful tendinosis tendon a strong tendon?

The chronic painful tendinosis tendon is generally considered a degenerated and weak tendon. However, this has not been scientifically verified, and is to be considered a hypothesis. We present here a case study involving a high-level Olympic weightlifter with chronic painful patellar tendinosis who started heavy-weight training very early after successful treatment with sclerosing injections. A 25-year-old super heavy-weight (+105 kg) Olympic weightlifter with 9 months duration of severe pain (prohibiting full training) in the proximal patellar tendon, where ultrasound and Doppler showed a widened tendon with structural changes and neovascularisation, was given one treatment with ultrasound and Doppler-guided injections of the sclerosing agent polidocanol. The injections targeted the neovessels posterior to the tendon. The patient was pain-free after the treatment, and already after 2-weeks he started with heavy-weight training (240 kg in deep squats) to try to qualify for the Olympics. Additional very heavy training on training camps, most often without having any discomfort or pain in the patellar tendon, resulted in Swedish records and ninth place at the European Championships 17 weeks after the treatment. Despite beating the national records, he did not qualify for the Olympics. Ultrasound and Doppler follow-ups have shown only a few remaining neovessels, and little structural tendon changes. This case questions previous theories about the weak tendinosis tendon, and stresses the importance of studies evaluating tendon strength.     

Evaluation of patellar tracking in symptomatic and asymptomatic individuals by magnetic resonance imaging

Objective To determine the patterns of patellar motion in subjects without knee symptoms using dynamic magnetic resonance imaging (MRI).Design Patellar tracking MR examinations were performed on 50 asymptomatic volunteers. The presence and degree of lateral subluxation and tilt of the patella was assessed independently by three radiologists, and discrepancies resolved by consensus. Using the same criteria, the tracking pattern in 50 consecutive patients, recently referred for imaging assessment of anterior knee pain, was studied.Patients Fifty volunteers (22 male, mean age 37 years) and 50 unmatched patients (15 male, mean age 25.5 years) were examined.Results and conclusions Forty-one per cent of a total of 97 knees in the volunteer group showed evidence of lateral subluxation, which was either minimal (grade 1, 32%) or minor (grade 2, 9%). No volunteer demonstrated major (grade 3) subluxation; lateral tilt without translation of the patella was also seen (2%). In the patient group, higher grades of lateral subluxation were more common. Minimal (grade 1) lateralization is a common movement pattern of the patella on knee extension, and should be regarded as normal.     

Quantification of patellar tracking using kinematic MRI

The purpose of this study was to describe a method to quantify dynamic patellar tracking using kinematic MRI (KMRI). Twelve normal females and three patients with patellofemoral pain participated. Imaging was performed with a 1.5-T/64-MHz MR system using a fast spoiled gradient-recalled acquisition in the steady state (GRASS) pulse sequence. A nonferromagnetic positioning device permitted active, bilateral knee extension against resistance (15% bwt) from 45° knee flexion to full extension. Subjects were instructed to extend their knees at a rate of 9° per second, which allowed images to be obtained at 45°, 36°, 27°, 18°, 9°, and 0°. All images were assessed for medial/lateral patellar displacement, patellar tilt, and sulcus angle using a computer-aided system. Normal patellar motion was characterized by medial movement from 45° to 18°, followed by a reversal toward lateral displacement from 18° to full extension. The results for patellar tilt revealed a tendency toward decreasing lateral tilt as the knee extended. Sulcus angle measurements indicated that the patella was moving to a more shallow portion of the trochlear groove (superiorly) during extension.     

Time dependent changes in patellar tracking with medial parapatellar and midvastus approaches

The aim of this study was to compare the alteration of patellar tracking by time, which was performed through two different approaches: midvastus and medial parapatellar. Twenty-one patients undergoing simultaneous bilateral primary total knee replacements were randomized prospectively to perform the surgery via a medial parapatellar approach on one knee and midvastus approach on the other knee. All of the patellae were resurfaced. Preoperative, early and late postoperative (mean 22 month) skyline views of the patellae were taken. We found that preoperative 2.24° lateral tilt of patella had not changed by time at the midvastus side (2.95° and 2.57°). Moreover, preoperative 0.48% lateral subluxation of the patella for midvastus approach had not changed (1.48% and 1.67%). Although 2.19° patellar lateral tilt had not significantly changed at the early postoperative period, which was performed via medial parapatellar approach, there had been a significant increase to 5.38° by time (P=0.037) compared to the preoperative radiographs. Additionally, the preoperative lateral subluxation of the patella (0.57%) at the medial parapatellar side had increased to 5.43% at the early (P=0.009) and 5.62% at the late (P=0.012) postoperative measurements. Midvastus approach is superior to medial parapatellar approach concerning the late patellar tracking.     

Treatment of Jumper’s knee: promising short-term results in a pilot study using a new arthroscopic approach based on imaging findings

Sclerosing injections targeting the area with neovessels and nerves on the dorsal side of the patellar tendon has been demonstrated as giving promising clinical results in patients with chronic painful Jumper’s knee-patellar tendinosis (PT). However, a mean number of three treatments with 6–8 weeks in between were needed for a good clinical result. This study aimed to evaluate a more radical removal of the area with neovessels and nerves by using arthroscopic shaving. Fifteen patients (12 men and three women) with the diagnose Jumper’s knee-PT in altogether 15 patellar tendons were included. All patients had a long duration of pain-symptoms (mean 27 months) from the patellar tendon, and ultrasonography (US) + colour Doppler (CD) examination showed structural tendon changes with hypo-echoic areas and a neovascularisation inside and on the dorsal side of the tendon, corresponding to the painful area. All patients were treated with arthroscopic shaving of the dorsal side of the proximal tendon. At follow-up (mean 6 months) after treatment, there was a good clinical result in 13/15 tendons (6/8 elite athletes). The satisfied patients were back to previous (before injury) sport activity level, and the amount of pain recorded on a visual analogue scale (VAS)-scale had decreased significantly (VAS from 79 to 12, P < 0.05). A telephone follow-up 13 months (mean) postoperatively showed that the same 13/15 were still satisfied and active in their sports, and that the 2/15 poor cases were still not satisfied with the treatment. Our short-term results indicate that arthroscopic shaving targeting the area with neovessels and nerves on the dorsal side of the patellar tendon has a potential to reduce the tendon pain and allow for the majority of patients to go back to full tendon loading activity within 2 months after surgery. Further studies evaluating this new technique for treating Jumper’s knee-PT are in progress.     

Ultrasound guided dry needling and autologous blood injection for patellar tendinosis

Objective

To evaluate the efficacy of ultrasound guided dry needling and autologous blood injection for the treatment of patellar tendinosis.

Design

Prospective cohort study.

Setting

Hospital/clinic based.

Patients

47 knees in 44 patients (40 men, 7 women, mean age 34.5 years, age range 17 to 54 years) with refractory tendinosis underwent sonographic examination of the patellar tendon following referral with a clinical diagnosis of patellar tendinosis (mean symptom duration 12.9 months).

Interventions

Ultrasound guided dry needling and injection of autologous blood into the site of patellar tendinosis was performed on two occasions four weeks apart.

Main outcome measures

Pre‐ and post‐procedure Victorian Institute of Sport Assessment scores (VISA) were collected to assess patient response to treatment. Follow up ultrasound examination was done in 21 patients (22 knees).

Results

Therapeutic intervention led to a significant improvement in VISA score: mean pre‐procedure score = 39.8 (range 8 to 72) v mean post procedure score = 74.3 (range 29 to 100), p<0.001; mean follow up 14.8 months (range 6 to 22 months). Patients were able to return to their sporting interests. Follow up sonographic assessment showed a reduction in overall tendon thickness and in the size of the area of tendinosis (hypoechoic/anechoic areas within the proximal patellar tendon). A reduction was identified in interstitial tears within the tendon substance. Neovascularity did not reduce significantly or even increased.

Conclusions

Dry needling and autologous blood injection under ultrasound guidance shows promise as a treatment for patients with patellar tendinosis.     

Ultrasound characteristics of the patellar and quadriceps tendons among young elite athletes

Tendons adapt in response to sports‐specific loading, but sometimes develop tendinopathy. If the presence of ultrasound changes like hypoechoic areas and neovascularization in asymptomatic tendons precede (and predict) future tendon problems is unknown. The aim of this prospective cohort study was to investigate the relationship between the development of ultrasound changes in the patellar and quadriceps tendons and symptoms of jumper's knee, as well to examine the medium‐term effects of intensive training on tendon thickness among adolescent athletes. Elite junior volleyball athletes were followed with semi‐annual ultrasound and clinical examinations (average follow‐up: 1.7 years). Of the 141 asymptomatic athletes included, 22 athletes (35 patellar tendons) developed jumper's knee. In a multivariate logistic regression analysis, a baseline finding of a hypoechoic tendon area (odds ratio 3.3, 95% confidence interval 1.1 to 9.2) increased the risk of developing symptoms of jumper's knee. Patellar tendon thickness among healthy athletes did not change (Wilk's lambda, P = 0.07) while quadriceps tendon thickness increased (P = 0.001). In conclusion, ultrasound changes at baseline were risk factors for developing symptoms of jumper's knee. Also, among healthy athletes, we observed a 7–11% increase in quadriceps tendon thickness, while there was no increase in patellar tendon thickness.     

髌股疼痛综合征患者髌骨运动轨迹的动态CT研究

目的 应用320排动态容积CT描述髌股疼痛综合征患者在膝关节屈曲运动中的动态髌骨轨迹,为髌股疼痛综合征的临床诊断及治疗方案的选择提供理论依据.方法 随机选择济南军区总医院2010年3月～2011年2月间资料完整确诊髌股疼痛综合征的女性患者24例（32膝）为实验组,年龄18～46岁,平均年龄31.1岁;随机选择健康女性13例（26膝）为对照组,年龄19～45岁,平均年龄32.1岁.应用320排动态容积CT检查：股四头肌等长收缩状态下自主屈曲膝关节,在膝关节屈曲0°～120°范围内间隔15°依次垂直髌骨进行动态CT扫描.应用Vitrea 2.1软件进行图像后处理,获得膝关节三维重建图像,测量髌骨运动轨迹参数：髌骨倾斜、髌骨移位和髌骨旋转.所有计数资料以均数和标准差描述,应用SPSS 16.0软件进行两样本均数t检验,P≤0.05有显著性意义.结果 15°～45°范围内两组的髌骨倾斜有显著性差异,P＜0.001;膝关节屈曲15°～45 °范围内两组的髌骨中心外移有显著性差异,P＜0.001;15°～120°范围内两组的髌骨旋转有显著性差异,P＜0.001.结论 膝关节屈曲15°～45°范围内髌股疼痛综合征患者的髌骨轨迹最具临床诊断、治疗意义.     

The role of patellar alignment and tracking in vivo: The potential mechanism of patellofemoral pain syndrome

Purpose and method

Lateral patellar malalignment and maltracking are commonly believed to be associated with patellofemoral pain. In the current review, a computerized and manual search of English-language articles was performed using multiple combinations of the following keywords: ‘patellofemoral pain syndrome’ or ‘patellofemoral pain’, and ‘patellar alignment’ or ‘patellar tracking’. The role of patellar alignment and tracking in vivo is discussed via a review of papers regarding the differences in asymptomatic and symptomatic patella. An attempt is made to identify the potential mechanism of patellofemoral pain syndrome (PFPS).

Conclusion

Evidence suggests that symptomatic patella do not consistently demonstrate lateral malalignment or tracking in patellar tilt and translation. Abnormal patellar alignment and tracking may be potential risk factors that are associated with patellofemoral pain. Other contributing factors should be considered in dealing with patellofemoral pain syndrome. Further studies are required to determine what normal patella alignment and tracking is before going on to define how these are altered in subjects with patellofemoral pain. Furthermore, prospective studies are needed to identify the alteration of patellofemoral kinematics, if any, and whether these are the causative factor or the consequence of the patellofemoral pain syndrome, as well as to determine the risk of development of patellofemoral pain syndrome in individuals with and without abnormal patellar tracking.     

MRI appearance of primary non-Hodgkin’s lymphoma of bone

 Objective. To evaluate the signal characteristics of primary non-Hodgkin’s lymphoma of bone on MRI. Designs and patients. Ten patients with primary non-Hodgkin’s lymphoma of bone were included in the study. T1- and T2-weighted imaging was performed. The signal intensity of the lesions was compared with that of the surrounding muscle. Results. The results of the MRI were compared with the histological findings. In the majority of cases (5/10) the lesion involved the femur. In one case each the tibia, humerus, ileum, sacrum, and skull, respectively, were affected. A soft tissue mass was present in four cases. In nine of ten cases on T1-weighted imaging the lesion was hypointense. On T2-weighted imaging seven of ten lesions were hypointense compared with muscle, one isointense and, in two cases, part of the lesion showed slightly hyperintense signal. In all ten cases the signal pattern appeared inhomogeneous. Pathological examination showed extensive fibrosis in the majority of cases. Conclusion. According to our results there is decreased signal intensity of bone marrow on both T1- and T2-weighted imaging, unlike other primary round cell tumors of bone. Because the diagnoses were established with small tissue biopsies, the reason for these findings is speculative.     

MRI appearances of dysplasia epiphysealis hemimelica of the knee

 Objective. The study was undertaken to describe the magnetic resonance imaging (MRI) appearances of dysplasia epiphysealis hemimelica (DEH) of the knee and to determine whether MRI provides additional information concerning the anomaly compared with more traditional methods of diagnosis. Design and patients. The subjects of the study were three children (one girl and two boys, aged 13 months, 3 years and 11 years) with DEH of the knee. All the patients had plain films of the knee and MRI scans. Results and conclusion. Plain radiographs showed bone overgrowth and asymmetrical ossification centres with adjacent scattered calcifications which coalesced to form a lobulated irregular mass. MRI showed a definite cartilaginous or osteocartilaginous lesion. Its origin from the epiphysis was much more clearly defined. MRI showed the extent of the lesion non-invasively, as well as any potential cleavage plane between the epiphysis and the mass lesion. Abnormal surface nodularity and joint involvement could be determined. It is concluded that plain films supplemented with MRI provide the greatest amount of diagnostic information in cases of DEH. MRI is useful to show the exact location and extent of the lesion, any joint involvement and any potential cleavage between the epiphysis and the mass lesion.     

Increased versican content is associated with tendinosis pathology in the patellar tendon of athletes with jumper's knee

Expansion of the extracellular matrix is a prominent but poorly characterized feature of tendinosis. The present study aimed to characterize the extent and distribution of the large aggregating proteoglycan versican in patients with patellar tendinosis. We obtained tendon from tendinopathy patients undergoing debridement of the patellar tendon and from controls undergoing intramedullary tibial nailing. Versican content was investigated by Western blotting and immunohistochemistry. Microvessel thickness and density were determined using computer-assisted image analysis. Markers for smooth muscle actin, endothelial cells (CD31) and proliferating cells (Ki67) were examined immunohistochemically. Western blot analysis and immunohistochemical staining revealed elevated versican content in the proximal patellar tendon of tendinosis patients ( P =0.042). Versican content was enriched in regions of fibrocartilage metaplasia and fibroblast proliferation, as well as in the perivascular matrix of proliferating microvessels and within the media and intima of arterioles. Microvessel density was higher in tendinosis tissue compared with control tissue. Versican deposition is a prominent feature of patellar tendinosis. Because this molecule is not only a component of normal fibrocartilagenous matrices but also implicated in a variety of soft tissue pathologies, future studies should further detail both pathological and adaptive roles of versican in tendons.     

The influence of open and closed high tibial osteotomy on dynamic patellar tracking: a biomechanical study

High tibial osteotomy (HTO) can cause alterations in patellar height, depending on the surgical technique, the amount of correction and the postoperative management. Alterations in patella location after HTO may lead to postoperative complications. However, information on changes in dynamic patellar kinematics following HTO is very limited. We conducted a biomechanical study, to analyze the effect of open (OWO) and closed wedge osteotomy (CWO) on patellar tracking. Using an inventive experimental set-up, we studied the 3D dynamic patellar tracking in ten cadaver knees before and after valgus HTO. In each specimen, corrections of 7° and 15° of valgus according to, both, the OWO and CWO technique, were performed. Patellar height significantly increased with CWO and decreased with OWO. Both, OWO and CWO led to significant changes in the patellar tracking parameters tilt and rotation. We also found significant differences between OWO and CWO. Valgus high tibial osteotomy increased the medial patellar tilt and reduced the medial patellar rotation. These effects were more profound after OWO. No significant differences were found for the effect on medial–lateral patellar translation. These observations can be taken into consideration in the decision whether to perform an OWO or a CWO in a patient with medial compartment osteoarthritis of the knee.     

Benign tumefactive soft tissue extension from Paget’s disease of bone simulating malignancy

Osteosarcoma is a frequently fatal complication of Paget’s disease of bone typically manifesting radiographically as a lytic lesion with soft tissue extension. A clinically worrisome, but benign manifestation of Paget’s disease simulating malignancy because of an extraosseous mass is reported. Received: 19 January 2000 Revision requested: 18 August 2000 Revision received: 31 October 2000 Accepted: 3 November 2000     

Simultaneous occurrence of a supra- and an infratentorial glioma in a patient with Ollier’s disease: more evidence for non-mesodermal tumor predisposition in multiple enchondromatosis

A case is presented in which two neuro-ectodermal tumors, an infra- and a supratentorial glioma, developed in a young man with multiple enchondromatosis of Ollier’s disease. This is the third such case of multifocal low-grade glioma in Ollier’s disease, suggesting a predisposition for non-mesodermal tumors in Ollier’s disease. The related condition of multiple enchondromatosis and hemangiomas (Maffucci’s syndrome) is well known for its malignant potential, developing both mesodermal and non-mesodermal tumors. Along with other authors, we support the concept of two variants of the same disease with a predisposition to development of tumors from various germ layers.     

MRI of anterior cruciate ligament repair with patellar and hamstring tendon autografts

Objective. Several MRI sequences were used to evaluate the 2-year postoperative appearance of asymptomatic knee with a torn anterior cruciate ligament (ACL) reconstructed with bone–patellar tendon–bone (BTB) and semitendinosus and gracilis (STG) tendon autografts. Design and patients. Two groups with successful repair of ACL tear with BTB (n=10) or STG (n=10) autografts were imaged at 1.5 T with sagittal and oblique coronal proton density-, T2-weighted and sagittal STIR sequences and plain and contrast-enhanced oblique coronal T1-weighted sequences. The appearance of the graft and periligamentous tissues was evaluated. Results. In all 20 cases, the ACL graft showed homogeneous, low signal intensity with periligamentous streaks of intermediate signal intensity on T2-weighted images. In 10 cases, localised areas of intermediate signal intensity were seen in the intra-articular segment of the graft on proton density- and T1-weighted images. The graft itself did not show enhancement in either of the two groups, but mild to moderate periligamentous enhancement was detected in 10 cases. Conclusion. The MRI appearance of ACL autograft is variable on proton density- and T1-weighted images. Periligamentous tissue showing contrast enhancement is a typical MRI finding after clinically successful ACL reconstruction. Received: 22 February 2000 Revision requested: 27 June 2000 Revision received: 21 August 2000 Accepted: 23 August 2000     

Chondrosarcoma as a complicating factor in Paget’s disease of bone

 A 65-year-old male patient with an 8-year history of poliostotic Paget’s disease complained of shoulder pain that started 6 months prior to admission. An extensive lytic area was identified in the right proximal humerus along with Paget’s disease. There was cortical destruction and a soft tissue mass. Following an incisional biopsy, a diagnosis of grade 2 chondrosarcoma associated with Paget’s disease was made. The histologic identification of chondrosarcoma associated with Paget’s disease is rare. However, the presence of a calcified matrix in a destructive lesion associated with Paget’s disease should alert the radiologist and the pathologist to the possibility of a chondromatous differentiation taking place in the sarcoma associated with Paget’s disease. The histologic evaluation of the lesion will form the basis for the diagnosis.