Magnetic resonance imaging pelvimetry predicts the technical difficulty of rectal surgery

BackgroundThe relationships between the pelvimetry and technical difficulties in performing rectal surgery for mid-low rectal cancer remain unclear.MethodsTwo hundred and twenty-one cases of mid-low rectal cancer patients who underwent sphincter-preserved total mesorectum excision (TME) were analyzed. The data of the pelvimetry and the relative position between trocar site and tumor were measured with magnetic resonance imaging (MRI).ResultsUnivariate analysis showed that the interspinous diameter, the sacrococcygeal distance, and the angle of sacral promontory inclination were significantly associated with the technical difficulty during laparoscopic surgery, but only the interspinous diameter remained an independent risk factor in multivariate analysis. The simulated trocar angle θ was an independent risk factor affecting the operation time during laparoscopic surgery, simulated trocar angle η was significantly related to intraoperative blood loss in both laparoscopic surgery and transanal TME (taTME) surgery groups.ConclusionInterspinous diameter can predict difficulty in laparoscopic surgery and may provide useful information for preoperative planning and consideration of approach.     

Residents entering Complex General Surgical Oncology fellowship lack confidence with pelvic MRI for rectal cancer: Results of a needs assessment survey

BackgroundMagnetic resonance imaging (MRI) is essential for the multidisciplinary treatment of rectal cancer. However, baseline experience of surgical residents with MRI is unknown. Therefore, a needs assessment survey was conducted to examine confidence with pelvic MRI for residents entering Complex General Surgical Oncology (CSGO) fellowships.MethodsA multi-institutional survey evaluated incoming CGSO fellows’ experience with pelvic MRI for rectal cancer in residency. Additionally, confidence was assessed for essential components of pelvic MRI including T- and N-stage, circumferential resection margin (CRM), extramural venous invasion (EMVI), and pelvic anatomy.ResultsOf the twenty-four incoming fellows who completed the survey (response rate = 44%), 20 reported frequent use of pelvic MRI for rectal cancer in residency, but 16 reported rarely/never interpreting images themselves for staging or operative planning. Most respondents reported low confidence for T-stage, N-stage, CRM, EMVI, as well as pelvic anatomy, particularly for lateral and posterior pelvis.ConclusionsThe development of a pelvic MRI curriculum for residents entering CGSO fellowships could enhance their clinical training in the multidisciplinary management of patients with rectal cancer.     

机器人直肠癌根治术临床应用探讨

目的 探讨达芬奇机器人手术系统在直肠癌根治术中的应用经验,总结手术操作技巧.方法 回顾性分析我院2009年6月至2011年11月行达芬奇机器人直肠癌根治术25例临床资料.结果 25例患者均顺利行机器人直肠癌根治术,无中转开腹病例.其中Dixon术式19例,Miles术式6例.手术时间平均235.5 min,术中平均出血量60.8 ml,2例因术前贫血给予输血,其余23例均未输血.淋巴结清扫10～23枚,平均13.1枚.术后排气时间33 ～ 116 h,平均73.5 h.病理切缘均为阴性.术后1例Miles患者发生会阴部切口裂开,1例Dixon患者发生肺部感染,无手术死亡病例.随访时间21～51个月,平均30.9个月,1例发生吻合口复发,2例发生肝转移.结论 达芬奇机器人直肠癌根治术操作简单、创伤小、恢复快,其独特的3D视野能清晰显露并保护输尿管、髂腹下神经和盆腔自主神经丛等重要脏器.     

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目的 探讨中下段直肠癌局部切除的途径和方法。方法 对近１０年来采用Ｍａｓｏｎ手术作局部切除的３０例中下段直肠癌病例进行分析。结果 Ｔｉｓ期癌５例,Ｔ１期癌１３例,Ｔ２期癌１０例,Ｔ３期癌２例。所有标本切缘经病理检查未发现癌残留。平均随访为５２个月。５年存活率为９３％。目前未发现癌复发病例。结论 Ｍａｓｏｎ手术应作为中下段直肠癌局部切除术的首选术式。     

直肠癌与腹膜反折位置相关的MRI表现分析

目的:评价MRI检查判断直肠癌肿块与腹膜反折位置关系的准确性。方法:2010年1月至2012年12月我院64例直肠癌手术病人,术前行薄层MRI检查,由两位高年资医师行影像评估,并与术中发现对照。结果:本研究64例病人均经手术证实,常规序列术前MRI检查直肠癌位置的准确率为90.6%。MRI判断直肠癌位于腹膜反折之上的诊断符合率为94.4%,直肠癌位于腹膜反折处的诊断符合率为84.6%,直肠癌位于腹膜反折之下的诊断符合率为86.7%。结论:MRI检查可用于判断直肠癌与腹膜反折的位置关系,指导制定正确的治疗方案。     

Effect of rectal washout on local recurrence of rectal cancer in the era of total mesorectal excision: Meta-analysis

IntroductionPresence of intraluminal viable cancer cells implanting into the anastomosis has been proposed as a potential cause for developing local recurrence in patients undergoing anterior resection for rectal cancer. Rectal washout has been proposed as a method to prevent this from happening. There have been conflicting reports in literature regarding the effect of rectal washout on local recurrence. We aim to look at the role of rectal washout in preventing local recurrence of rectal cancer in patients undergoing total or tumor-specific mesorectal excision (TME).Materials and methodsA literature review of studies evaluating the role of rectal washout on rectal cancer local recurrence was performed using PubMed, Scopus, EMBASE and non-English language literature search using CiNii (Japanese) and CNKI (Chinese). Inclusion criteria were use of TME, comparison of rectal washout with no washout, and evaluation of local recurrence as outcome.ResultsFour studies were identified according to inclusion criteria. The meta-analysis showed a protective effect of rectal washout on local recurrence (OR 0.45 95% CI 0.45–0.75). However, one of the studies included had more than 90% weightage. Excluding this study from analysis showed no difference on local recurrence with rectal washout (OR 0.94, 95% CI 0.37–2.36).ConclusionThe effect of rectal washout on rectal cancer local recurrence in patients who undergo TME is questionable and needs to be evaluated further by prospective studies.     

直肠癌全直肠系膜切除术107例临床分析

目的探讨直肠癌全直肠系膜切除法在直肠癌中的应用。方法回顾性分析107例直肠癌患者行全直肠系膜切除的临床资料。本组病例行Miles术式18例;Dixon术式89例,其中76例使用吻合器吻合。结果全组术中出血100-150ml,术中术后均无输血。术后发生吻合口瘘3例,占2.8%。性功能障碍1例,占0.93%。排尿功能障碍1例,占0.93%。术口感染12例,占11.21%。随访6-42个月,局部复发率4.67%（5/107）。结论直肠癌全直肠系膜切除术,对提高直肠癌术后患者生存质量和生活质量确有裨益。     

MRI在直肠癌术前分期中的作用

目的:评估盆腔MRI检查在直肠癌术前分期和治疗决策中的作用。方法:对2009年4月至2010年6月手术治疗的60例直肠癌病例的术前盆腔MRI检查结果与术后组织病理学诊断结果进行比较,分析MRI对直肠癌术前分期的准确率。结果:MRI对直肠癌浸润深度(T分期)的诊断准确率为75%,对T2期肿瘤的诊断准确率为73.1%,对T3期肿瘤的诊断准确率为86.7%;对淋巴结转移的诊断准确率为32.4%。在病理确诊淋巴结转移的16例病人中,MRI检出淋巴结平均数为5.8枚;在淋巴结转移阴性的44例病人中,MRI检出淋巴结平均数为2.4枚;两组淋巴结数有显著差异(P0.05)。结论:术前MRI检查可较准确地判断肿瘤在直肠壁的浸润深度,但对淋巴转移的诊断准确率较低,故MRI可作为直肠癌术前分期的方法,为新辅助治疗提供依据,为术后辅助化疗提供信息。     

Robotic total mesorectal excision for the treatment of rectal cancer

Robotic techniques have been developed to facilitate endoscopic surgery and to overcome its disadvantages. Thus, we performed robotic total mesorectal excison (TME) in a patient with rectal cancer, using the da Vinci^® Surgical System. To our knowledge, this is the first robotic low anterior resection, based on standard TME principles, with pelvic autonomic nerve preservation. In conclusion, this robotic system is an excellent instrument for performing the standard TME procedure in rectal cancer patients.     

腹腔镜直肠全系膜切除术治疗中、低位直肠癌的临床安全性对比研究

目的：探讨腹腔镜直肠全系膜切除治疗中、低位直肠癌手术的安全性。方法：回顾性对比分析我院2002年12月～2005年12月开腹直肠癌全系膜切除的病例（开腹组52例），以及2003年1月～2006年6月腹腔镜直肠癌全系膜切除的病例（腹腔镜组49例）。结果：腹腔镜组与开腹组一般资料差异无显著性。与开腹组比较，腹腔镜组术中出血量少[直肠癌前切除术（160±106）ml（n=37）vs（298±186）ml（n=36），t=-3．908，P=0．000；腹会阴联合直肠癌根治术（180±153）ml（n=10）vs（356±170）ml（n=14），t=-2．604，P=0．016]。腹腔镜组肠道功能恢复时间早于开腹手术组[（2．4±1．8）dVS（3．6±1．5）d，t=-3．648，P=0．000]。腹腔镜组总并发症的发生率低于开腹组[14．3％（7／49）g844．2％（23／52），x^2=10．834，P=0．001]。两组清扫淋巴结的数目无差异（12．7±6．5VS13．6±7．0，t=-0．668，P=0．505），下切缘均为阴性。腹腔镜组45例（91．8％）随访2～42个月，开腹组47例（90．4％）随访6～42个月，局部复发率分别4．4％（2／45）、4．3％（2／47）。结论：腹腔镜直肠全系膜切除治疗中、低位直肠癌安全、可行。     

Laparoscopic rectal resection with anal sphincter preservation for rectal cancer

Background Total mesorectal excision (TME) is the surgical gold standard treatment for middle and low third rectal carcinoma. Laparoscopy has gradually become accepted for the treatment of colorectal malignancy after a long period of questions regarding its safety. The purposes of this study were to examine prospectively our experience with laparoscopic TME and high rectal resections, to evaluate the surgical outcomes and oncologic adequacy, and to discuss the role of this procedure in the treatment of rectal cancer. Methods Between December 1992 and December 2004, all patients who underwent elective laparoscopic sphincter preserving rectal resection for rectal cancer were enrolled prospectively in this study. Data collection included preoperative, operative, postoperative and oncologic results with long-term follow-up. Results A total of 218 patients were operated on during the study period: 142 patients underwent laparoscopic TME and 76 patients underwent anterior resection. Of the TME patients, 122 patients were operated using the double-stapling technique, and 20 patients underwent colo-anal anastomosis with hand-sewn sutures. Mean operative time was 138 min (range, 107–205), and mean blood loss was 120 ml (range, 30–350). Conversion to open surgery occurred in 26 cases (12%). Mortality rate during the first 30 days was 1%. Anastomotic leaks were observed in 10.5% of the patients. Of these, 61.9% needed reoperation and diverting stoma, and the rest were treated conservatively. Three patients had postoperative bleeding requiring relaparoscopy. Other minor complications (infection and urinary retention) occurred in 9.1% of patients. Mean ambulation time and mean hospital stay were 1.6 days (range, 1–5) and 6.4 days (range, 3–28) , respectively. Patients were followed for a mean period of 57 months. No port site metastases were observed during follow-up. The recurrence rate was 6.8 %. Overall survival rate was 67% after 5 years and 53.5% after 10 years. Conclusion Laparoscopic anterior resection and TME with anal sphincter preservation for rectal cancer is feasible and safe. The short- and long-term outcomes reported in this series are comparable with those of conventional surgery.     

Local methods of treatment of rectal cancer

Over 11 000 new cases of rectal cancer are reported in the UK each year. Recent technical advances have increased interest in local management of the disease. The introduction of screening for colorectal cancer will potentially lead to an increased number of early rectal cancers suitable for local curative treatment. In addition, as the proportion of elderly patients in the population rises, local methods of treatment of rectal cancer will become increasingly important in this group of patients with comorbid disease. A literature search was performed on Medline database for English language publications on local treatments of rectal carcinoma. Preoperative assessment, selection of patients, local therapeutic and palliative methods of treatment were evaluated. Local methods of treatment can be used for potentially curative operations for rectal cancer. Preoperative endoanal ultrasound appears to be the most useful investigation for determining depth of local invasion. Transanal endoscopic microsurgery has extended the boundaries of local surgery and permits access to the mid and upper rectum with results similar to those of conventional local techniques. Laser therapy and transanal resection provide the best form of palliation for more advanced rectal carcinomas.     

Local excision of stratified T1 rectal cancer

BACKGROUND: Local excision has been accepted therapy for T1 rectal cancers. A recent study demonstrated that primary tumors with deeper submucosal invasion were associated with a higher rate of lymph node metastases than those with shallow invasion. Our aim was to determine the effect of the depth of submucosal penetration on recurrence and mortality rates following transrectal excision of T1 tumors. METHODS: This was a 34-year retrospective review of patients who had transrectal excision with clear margins for T1 rectal cancer. Tumors were stratified into submucosal (SM) levels, and recurrence and mortality rates were determined. RESULTS: Of 101 patients with T1 rectal cancer undergoing local excision, 31 had a full-thickness transrectal excision. Eight (26%) of the 31 patients developed a local recurrence, 2 of whom had both a local and distant recurrence. Four patients (13%) died from metastatic rectal cancer. CONCLUSIONS: The recurrence rate for transrectal excision of T1 rectal cancer is high. It may be beneficial for patients with early rectal cancer to have postoperative chemoradiation therapy or a more radical surgical procedure.     

A pictorial description of extralevator abdominoperineal excision for low rectal cancer

Aim Extralevator abdominoperineal excision in the prone position has been reported as a method to improve the poor outcome sometimes observed after abdominoperineal excision (APE) for low rectal cancer. In this paper a pictorial guide is presented describing the key anatomical steps and landmarks of the operation. Method Intraoperative footage of five APE operations filmed in high definition was reviewed and key stages of the operation were identified. Still frames were captured from these sequences to illustrate this guide. An edited video sequence was produced from one of these operations to accompany this paper. Conclusion The prone APE allows improved visualization of the perineal portion of the operation by the surgeon, assistants and observers. It permits clear demonstration for teaching. Prospective evaluation is still required to identify patients who would benefit from extralevator APE.     

Transanal excision of early rectal carcinoma—review of a personal series

Transanal excision of small rectal tumours is a relatively minor procedure that is potentially curable and can be employed in selected cases of rectal cancer. The outcome of 22 cases treated by local excision was reviewed. This represented 9% of patients treated for rectal cancer over the study period. All patients had a transanal excision with curative intent and included three patients who were medically unfit for a major procedure. Follow up was for a minimum of 5 years or until death if this was earlier. The mean age was 65.7 years with 10 males and 12 females. The 5‐year recurrence rate was 27% (five of 22). The crude 5‐year survival for curative resection was 77%. Of the 22 local excisions, 10 were T1 and 12 were T2. The size of tumour varied from 0.5 cm to 3.5 cm. Eight were well differentiated, 10 moderate and two poorly differentiated. Two of the earlier cases in the series were unclassified. There were six recurrences, all of which were extraluminal. Three recurrences were in less than 3 years (early recurrence) and three beyond this time. Of the recurrences, one presented with liver metastases within 2 months of surgery, one was unfit for a major procedure and subsequently died of a myocardial infarction. The remaining patients with recurrences had salvage surgery. Three are still alive and one died over 5 years after a local excision, with the presence of recurrence. All recurrences were of T2 stage, with moderate (n=5) or poor differentiation (n=1). Three of the six tumours measuring > 3 cm recurred compared with three of the 16 tumours between 0.5 cm and 3 cm. Analysis of these cases demonstrates that local resection of small rectal tumours can give good results and salvage operation is possible in the event of recurrence. Long term follow up is recommended because of risks of late recurrence. The best prognosis group appears to be with the well‐differentiated T1 tumours with no involved margins.