A Clinical Study of Suogudan Granule (索骨丹颗粒) in the Treatment of Rheumatoid Arthritis

Objective: To study the clinical efficacy of Suogudan Granule (SGDG, 索骨丹颗粒) in the treatment of rheumatoid arthritis (RA). Methods: Ninety patients with RA were randomly divided into the treated group and the control group. The treated group was administered orally with SGDG 6 g each time,thrice a day, while the control group with the combined therapy of Fenbid Capsules 0.3 g each time, twice a day and Tripterygium tablet 20 mg each time, thrice a day. The treatment course for both groups was 6 weeks. The changes of clinical symptoms and signs, and laboratory indices such as erythrocyte sedimentation rate (ESR), rheumatoid factor (RF), antistreptolysin O (ASO), routine examination of blood and urine,liver and kidney function, etc. before and after treatment were observed. Results: (1) The total effective rate in the treated group (88.0%) was obviously higher than that in the control group (67.5 %) with significant difference ( P＜0.05). (2) The improvement in arthralgia, joint swelling, time of morning stiffness, 15-meter walking, analgesia initiation and persistence in the treated group was better than that in the control group ( P＜0.05, P＜0.01), but there was no obvious difference in improvement of joint tenderness, range of joint motion, grip strength, and initiating detumescence time ( P＞0.05 ). (3) The improvement in ESR and RF in the treated group was better than that in the control group with significant difference ( P＜0.05). The negative-conversion rate of ASO in the treated group was also higher than that in the control group ( P＜0.01 ).(4) No evident abnormality in blood, urine, liver or kidney function was found in either group. Conclusion:SGDG is effective and safe for the treatment of RA.     

Clinical study on effect of Astragalus Injection (黄芪注射液) and its immuno-regulation action in treating chronic aplastic anemia

Objective:To observe the clinical effect of Astragalus Injection(黄芪注射液,AI) and its immuno-regulatory action in treating chronic aplastic anemia(CAA).Methods:Sixty patients with CAA were randomly assigned to two groups equally,both were treated with Stanozolol three times a day,2 mg each time through oral intake,but AI was given additionally to the patients in the treated group once a day via intravenous dripping.All were treated for 15 days as one therapeutic course and the whole medication lasted for more than 4 months totally,with follow-up adopted.The clinical effi cacy was estimated and the changes of T-lymphocyte subsets in peripheral blood as well as the serum levels of tumor necrosis factor-α(TNF-α) and interleukin-2(IL-2) were observed.Results:The total effective rate in the treated group was 83.3%(25/30),which was higher than that in the control group 66.7%(20/30),showing significant difference between them(P<0.05).Levels of hemoglobin,WBC,reticular cell and platelet were elevated in both groups after treatment,but the improvement was signif icantly better in the treated group than that in the control group with respect to the former three indexes(P<0.05).The level of CD4 increased and that of CD8 decreased signifi cantly after treatment in the treated group(P<0.05),which showed significant difference as compared with those in the control group(P<0.05).Levels of serum TNF-α and IL-2 lowered after treatment in both groups,but signifi cance only showed in the treated group(P<0.05).The degree of proliferation in bone marrow got raised signifi cantly and the percentage of non-hemopoietic cells reduced signifi cantly in the treated group after treatment,also showing significant difference to those in the control group(P<0.05).Conclusion:AI could promote the recovery of hemopoietic function,which might be through improving T-lymphocyte subsets and reducing the release of negative regulatory factors such as TNF-α and IL-2 to alleviate the inhibition on hemopoietic function.     

Clinical Observation on Cervical Spondylopathy of the Vertebroarterial Type Treated by Electro-acupuncture

Objective: To observe the clinical therapeutic effects of electro-acupuncture in the treatment of cervical spondylopathy of the vertebroarterial type. Methods: According to the consulting order, the patients were randomly divided into a treatment group (29 cases treated with electro-acupuncture), and a control group (28 cases treated with simple acupuncture). 20 treatments were given to patients in both groups. Results: The markedly effective rate of the treatment group was 75% and that of the control group was 61.54% (P<0.05). Conclusion: Electro-acupuncture has a better therapeutic effect than the simple acupuncture in the treatment of cervical spondylopathy of the vertebroarterial type.     

Thirty Cases of Obsession Treated by Point-Stimulation and with Small Dose of Chlorimipramine

Objective: To investigate the clinical therapeutic effects of point-stimulation for obsession. Methods: Sixty cases of obsession were divided into two groups: a control group of 30 cases treated with chlorimipramine (Ch1), and a treatment group of 30 cases treated by point-stimulation (PS) plus chlorimipramine (PS Chl). The therapeutic effects and side-effect were evaluated according to the criteria set in Yale-Brown Obsession Scale (Y-BOCS), Hamilton's depression scale (HAMD), brief psychiatric rating scale (BPRS) and treatment emergent symptom scale (TESS). Results: The cure rate and markedly effective rate were respectively 26.7% and 56.6% in the control group, and 43.3% and 50% in the treatment group, suggesting that the therapeutic effect in the treatment group was better than that in the control group. The incidence of adverse side-effects was 73.33% in the control group and 46.67% in the treatment group, with a significant difference between the two groups (P<0.05). Conclusion: Point-stimulation plus small dose of chlorimipramine was superior to the simple chlorimipramine treatment, indicating that the combined method was more effective and safe for obsession with less side effects.     

Clinical study on treatment of liver fibrosis of chronic hepatitis B patients with Ginkgo leaf

Objective: To study the anti-liver fibrosis effect of Ginkgo leaf in patients with chronic hepatitis B.Methods: Eighty-six patients with chronic hepatitis B were randomly divided into two groups with similar general condition. The 42 patients in the treated group were treated with Ginkgo leaf tablet (GLT), and the 44 patients in the control group were treated with Yiganling tablet (益肝灵片). The treatment was conducted for 3 successive months in both groups. Changes in the histo-pathology of liver, serum levels of platelet activating factor (PAF), hyaluronic acid (HA), collagen type Ⅳ (C-Ⅳ), laminin (LN) and pro-collagen peptide type Ⅲ (PCⅢ)were observed before and after treatment. Results: The markedly effective rate and the total effective rate in the treated group were 45.1% and 76.2% respectively, while in the control group the corresponding rates were 18.2% and 43.2%. Comparison between the two groups showed significant difference (P<0.01). Serum levels of PAF, HA, C-Ⅳ, LN and PCⅢ were lowered significantly in the treated group after treatment. Compared with the corresponding parameters in the control group after treatment, the differences were all significant (P<0.01 or P<0.05). The pathological examination of liver showed improvement in both groups, the inflammation grade lowered in 10 patients (55.6%) of the treated group and in 5 patients (35.7%) of the control group, insignificant difference was shown between them. But in comparing the fibrosis staging lowering patients between the two groups, 12 patients (66.7%) vs 3 patients (21.4%), the difference was significant (P<0.05). Moreover, there were 4 patients in the control group with their fibrosis aggravated, while in the treated group, none was aggravated (P<0.05).Conclusion: Ginkgo leaf tablet has some liver protective and anti-liver fibrosis benefits.     

Expressions of VEGF and Ki-67 in eutopic endometrium of patients with endometriosis and effect of Quyu Jiedu Recipe (祛瘀解毒方) on VEGF expression

Objective:To observe the clinical eff icacy of Quyu Jiedu Recipe(祛瘀解毒方,QJR) in treating endometriosis(EM),and to explore the levels of vascular endothelial growth factor(VEGF) and cell proliferative nucleoprotein antigen(Ki-67),their changes before and after treatment and the clinica signifi cance in the trial.Methods:Fifty patients of EM were randomly assigned to two groups.The 26 patients in the QJR group were treated with QJR,and the 24 patients in the gestrinone(GT) group with gestrinone.Besides,a normal control group with 20 healthy women was set up.The therapeutic effects in the two treated groups were compared.Expressions of VEGF and Ki-67 in eutopic endometrium of all subjects(with both patients and healthy women at the median secretive phase) were determined with immunohistochemical stain before treatment,and the determination in the two treated groups was repeated after 3-month treatment in the same phase.Results:Before treatment,the VEGF and Ki-67 expression positive rates and their mean optic density(MOD) were higher in patients than in healthy women(P<0.05).After treatment,the positive rate and MOD of VEGF expression lowered signif icantly than before treatment(P<0.05),but those of Ki-67 changed insignifi cantly,and comparison between the two treated groups showed no significant difference(P>0.05).Conclusion:QJR could markedly improve the symptoms of menorrhagia and menstrual disorder,and its mechanism might be related with the lowering of eutopic endometrial VEGF expression.VEGF and Ki-67 show a high expression in eutopic endometrium of patients with EM.     

Study on effect of Yishen Capsule (益肾胶囊) in preventing recurrence of chronic glomerulonephritis

Objective:To observe the effect of Yishen Capsule (益肾胶囊,YSC) on preventing the recurrence of chronic glomerulonephritis (CGN) and to explore its mechanism preliminarily.Methods: CGN patients were assigned to the treated group (61 cases) and the control group (48 cases) and all of them were orally administered with 4 mg of Perindopril twice a day,but 3 capsules of YSC,thrice a day, were given additionally to patients in the treated group.The therapeutic course for both groups was 18 months.The recurrence rate of CGN at the 6th,12th,and 18th month in the two groups was observed and compared,and the changes of 24-h urinary protein quantity and T-lymphocyte subsets before and after treatment were observed as well.Results:(1) Comparison of recurrence rate between the two groups showed insignificant difference at the 6th month,but it did show significant difference at the 12th and the 18th month,which was significantly decreased in the treated group than in the control group (P<0.05,P<0.01);(2) The 24-h urinary protein quantity at the 18th month decreased significantly in both groups (P<0.05,P<0.01),but in the treated group was more significant (P<0.01);(3) T-lymphocyte subsets showed no obvious change in the control group after treatment (P>0.05),while in the treated group,it showed significant increase in CD3,CD4 and CD4/CD8 (P<0.05 or P<0.01) and significant decrease in CD8 (P<0.05),and also the difference after treatment in T-lymphocyte subsets between the two groups was significant (P<0.05 or P<0.01).Conclusion:YSC has marked effects in reducing the recurrence of CGN and in decreasing urinary protein,and its mechanism might be related with its function in regulating the ratio of T-lymphocyte subsets to enhance the immunity of patients.     

Effects of Minimally Invasive Puncture and Drainage of Intracranial Hematoma on the Blood-brain Barrier in Patients with Cerebral Hemorrhage

The effects of minimally invasive surgery on the blood-brain barrier (BBB) of 30 patients with cerebral hemorrhage were investigated. Difference of the BBB index and serum MBP concentra-tion were assessed in 15 cases of conservative treatment group and 15 cases of minimally invasive surgery group. The BBB index in minimally invasive surgery group was significantly lower than in conservative treatment group (P<0.05), and the BBB index in the two treatment groups was signifi-cantly higher than in control group (P<0.01). Serum MBP concentration in minimally invasive sur-gery group was significantly lower than in conservative treatment group (P<0.05), and that in the two treatment groups was significantly higher than in control group (P<0.01). It was suggested the per-meability of BBB in patients with cerebral hemorrhage was increased, and BBB index and serum MBP concentration in patients with cerebral hemorrhage were increased. Minimally invasive surgery can reduce the lesion of cytotoxicity to BBB and cerebral edema.     

Effect of Xuesaitong Soft Capsule(血塞通软胶囊)on Hemorrheology and in Auxiliarily Treating Patients with Acute Cerebral Infarction

Objective: To observe the therapeutic effect of Xuesaitong soft capsule(血塞通软胶囊,XST)and its effect on platelet counts, coagulation factor 1 (CF1) as well as hemorrheologic indexes in treating patients with acute cerebral infarction (ACI). Methods: Two hundred and four patients with ACI were assigned into two groups, the control group ( n = 96) and the treated group ( n = 108). They were all treated with conventional Western medicines, including mannitol, troxerutin, citicoline, piracetam and aspirin, while to the treated group, XST was given additionally through oral intake, twice a day, 2 capsules each time for 8successive weeks. The clinical efficacy was evaluated according to the nerve function deficits scoring and the changes of platelet count. CF1 and hemorrhe.ological indexes were measured before and after treatment. Results: The total effective rate was 87.0% in the treated group, and 87.5% in the control group, respectively, showing insignificant difference between them. But the markedly effective rate in the treated group (66.7%) was significantly higher than that in the control group (27.1%, P＜0.01). The count of platelet was not changed significantly in both groups after treatment, while CF1 inthem evidently lowered at the end of the 4th and 8th weeks of treatment, but showed insignificant difference between the two groups. The hematocrit, whole blood viscosity and plasma viscosity in both groups were all improved significantly after treatment, but also showed insignificant difference in comparison of the two groups. Conclusion: XST has good efficacy in auxiliary treatment of patients with ACI, though its mechanism remains to be further explored.     

AN OBSERVATION ON COMBINED USE OF CHEMOTHERAPY AND TRADITIONAL CHINESE MEDICINE TO RELIEVE CANCER PAIN

We have treated 50 patients with stage Ⅲ, Ⅵmalignant tumors confirmed by pathology. The patients were divided into two groups. One group was treated by combination of chemotherapy and traditional Chinese medicine (treatment group); the other only by chemotherapy (control group). The effect of cancer treatment was evaluated according to the criteria of WHO. The results showed that the effective rate was 80% in treatment group and 52% in control group. The pain relieving rate was 68% in treatment group and 40% in control group (P< 0.01). This fact demonstrates that the application of traditional Chinese medicine can invigorate blood circulation, eliminate blood stasis, soften hardness and dissolve the mass, nourish blood and increase vigor. This kind of application can not only enhance the effect of cancer treatment but also increase the cancer pain relieving rate.     

Effect of Xin’ anning Nasal Drop (心安宁滴鼻剂) in treating coronary heart disease with unstable angina pectoris

Objective： To observe the clinical efficacy of Xin＇anning Nasal Drop （XAND,心安宁滴鼻剂） in treating coronary heart disease with unstable angina pectoris （CHD-UAP）. Methods： Sixty patients with CHD-UAP were assigned, according to the randomizing number table, to two groups, the control group treated with conventional Western medicine, and the treated group treated with conventional Western medicine plus XAND. The clinical efficacy and the changes of S-T segment in resting EKG and total ischemia burden （TIB） in 24-h dynamic EKG were observed. Results： The clinical efficacy, including the effect of angina alleviation, its initiation, and the effect of TOM syndrome score reduction, were significantly superior in the treated group to those in the control group （ P〈0.05 or P〈0.01 ）. The degree and extent of myocardial ischemia were significantly improved in both groups （ P〈0.01 ）, but the improvement in the treated group was better than that in the control group （ P〈0.05）. Moreover, it was worth mentioning that the immediate effect in the treated group was better than that in the control group, and the reduction of TIB, the improvement in heart rate and myocardial oxygen consumption （ immediately after the first administration or by the end of the therapeutic course）, and systolic blood pressure after treatment in the former were all superior to those in the latter, showing significant difference （ P〈0.05 or P〈0.01 ）. Conclusion： XAND has a quick effect in alleviating angina in patients with CHD-UAP, and it is worthy of further studies and spreading in clinical practice.     

Clinical observation on treatment of Tourette syndrome by integrative medicine

Objective:To explore the clinical efficacy of integrative Chinese and Western medicine in treating Tourette syndrome(TS).Methods:Ninety children with TS were randomized into two groups by randomizing digital table method:the 60 patients in the treated group were treated by Ningdong Granule(宁动颗粒,NDG) plus haloperidol,and the 30 in the control group treated by haloperidol alone.The course for both groups was 6 months.Conditions of the patients were estimated before and after treatment with Yale Global Tic ...     

Clinical observation on chemical damage of nephron and the preventive and therapeutic effects of Baoshen Mixture (保肾合剂) on it

Objective:To observe the change of nephron damaged by chemotherapy and to evaluate the effect of Baoshen Mixture(保肾合剂,BSM) in protecting and treating damaged nephrons.Methods:Four hundred tumor patients with normal renal function and ready to receive chemotherapy were randomly assigned to two groups.Both groups received one cycle of chemotherapy program of 28-30 days with conventional hydratization,alkalization and chloridization.To the 200 cases in the treated group BSM was given orally thrice a day,150 mL every time for 15 successive days and the other 200 cases in the control group were treated by chemotherapy alone.The clinical efficacy was compared after treatment,and the changed condition of damaged nephrons were monitored dynamically and compared at different time points(the 3rd,7th,14th and 21st day after chemotherapy) by measuring the micro-globulin β2(β2-MG),albumin(Alb) and immunoglobulin G(IgG) levels in urine with radioimmunoassay(RIA).Results:(1) The effective rates in the treated group at the 4 time points of observation were all higher than those in the control group respectively(P<0.05 or P<0.01);(2) Less occurrence of abnormal β2-M,Alb and IgG levels on the 14th and 21st day in the treated group took place compared to that in the control group(P<0.01);(3) Urinary levels of β2-MG,Alb and IgG reached the peak on the 7th day in both groups,and then,they came down gradually and returned to the normal level on the 21st day.However,comparison between the two groups showed that all the three parameters in the treated group on day 3,14 and 21 were lower than the respective one at the corresponding time points in the control group(P<0.05 or P<0.01).Conclusion:The chemotherapy damage on nephron is regular in time,and reversible when treated suitably.TCM shows a marked effect in protecting and treating the damage on nephron caused by chemotherapy.     

Effect of treatment of rosacea in females by Chibixiao Recipe (赤鼻消方) in combination with minocycline and spironolactone

To observe the clinical efficacy of Chibixiao Recipe （赤鼻消方, CBX） in combination with minocycline and spironolactone in treating rosacea in females. Methods： Sixty-eight women with rosacea were randomly assigned to the treated group （48 cases） and the control group （20 cases）, both of which were treated with minocycline and spironolactone taken orally, but to the treated group, the Chinese herbal recipe, CBX was given additionally. Besides, cryotherapy with liquid nitrogen was applied to those with apparent capillary dilatation. The therapeutic course for both groups was 8 weeks. The levels of serum testosterone before and after treatment were determined by radioimmunoassay （RIA）, and a 4-month followup was conducted. Results： In the treated group the cure-markedly effective rate was 87.5% and the recurrent rate was 6.5 %, while in the control group, they were 45.0 % and 41.2 % respectively. Comparisons in the indexes between the two groups all showed significant difference （both P〈0. 01 ）, with the cure-markedly effective rate higher, and the recurrent rate lower in the treated group. The serum level of testosterone got lowered in both groups （ P〈0. 05 and P〈0. 01 ）, but the lowering in the treated group was more significant, showing significance when compared with that in the control group （ P〈0. 01 ）. Conclusion： CBX in combination with Western medicine has effect in treating rosacea superior to that of Western medicine alone, and could effectively reduce recurrent rate and the serum level of testosterone.     

A clinical study of Suogudan Granule in the treatment of rheumatoid arthritis

Objective: To study the clinical efficacy of Suogudan Granule (SGDG) in the treatment of rheumatoid arthritis (RA).Methods: Ninety patients with RA were randomly divided into the treated group and the control group. The treated group was administered orally with SGDG 6 g each time, thrice a day, while the control group with the combined therapy of Fenbid Capsules 0.3 g each time, twice a day and Tripterygium tablet 20 mg each time, thrice a day. The treatment course for both groups was 6 weeks. The changes of clinical symptoms and signs, and laboratory indices such as erythrocyte sedimentation rate (ESR), rheumatoid factor (RF), antistreptolysin O (ASO), routine examination of blood and urine, liver and kidney function, etc. before and after treatment were observed.Results: (1) The total effective rate in the treated group (88. 0%) was obviously higher than that in the control group (67. 5%) with significant difference (P<0.05). (2) The improvement in arthralgia, joint swelling, time of morning stiffness, 15-meter walking, analgesia initiation and persistence in the treated group was better than that in the control group (P<0.05,P<0.01), but there was no obvious difference in improvement of joint tenderness, range of joint motion, grip strength, and initiating detumescence time (P>0.05). (3) The improvement in ESR and RF in the treated group was better than that in the control group with significant difference (P<0.05). The negative conversion rate of ASO in the treated group was also higher than that in the control group (P<0. 01). (4) No evident abnormality in blood, urine, liver or kidney function was found in either group.Conclusion: SGDG is effective and safe for the treatment of RA. Supported by grants from the Bureau of Education of Shaanxi Province(No. 05JK171)     

A Randomized Trial of Chinese Medicine Lirukang Granule (利乳康颗粒) Combined with Psychological Intervention for Cyclomastopathy and Menoxenia

Objective:To observe the influence of therapy with Chinese medicine Lirukang Granule（利乳康颗粒）,LRKG) combined with psychological intervention on anxiety states and sex hormones in patients with cyclomastopathy and menoxenia.Methods:A total of 470 subjects were randomly assigned to three groups by the net-central randomization system,the treatment group（161 patients,treated with LRKG and psychological intervention）,the Chinese medicine group（157 patients,treated with LRKG）,and the psychological intervention group（152 patients,treated with psychological intervention）.The dose of LRKG was 12 g three times per day; psychological intervention included establishing relations,cognitive intervention and psychological persuasion, 30-40 min per session,once a week.The therapy duration for all groups was three months.The efficacy was compared and anxiety state/State-Trait Anxiety Invertory（STAI） scoring was measured before and after treatment.The serum estradiol（E₂）,progesterone（P）,prolactin（PRL） and follicle stimulating hormone（FSH） levels of 60 patients selected randomly from each group during the luteal phase were measured before and after treatment,and a group of 20 healthy women were evaluated for comparison.A follow-up was arranged for one year after treatment.Results:Thirty subjects were lost to follow-up.（1） Comparison of efficacy:the markedly effective rate and the total effective rate of the treatment group were 86.67%（131/150） and 98.00%（147/150）, respectively;of the Chinese medicine group,64.58%（93/144） and 90.27%（130/144）,respectively;and of the psychological intervention group,0%（0/146） and 3.42%（5/146）,respectively.The markedly effective rate and the total effective rate in the treatment group were significantly higher than those in the Chinese medicine and psychological intervention groups（P<0.05）.（2） Comparison of STAI scoring:STAI scoring was decreased dramatically in the treatment group after treatment compared with that of the Chinese medicine group（P<0.01）, but there was no significant difference compared with the psychological intervention group.（3） Comparison of levels of sex hormones:E₂,P,PRL and FSH of the three patient groups were disordered before treatment,and significantly different from healthy women（P<0.01）.After treatment,the levels of P and FSH of the treatment group were significantly increased（P<0.01）,E₂ and PRL were significantly reduced,which were also significantly decreased compared with the psychological intervention groups（P<0.01）.（4） Follow-up:the markedly effective rate and the total effective rate of the treatment group remained higher than those of the other two groups after one year of treatment（P<0.05）.（5） Adverse reactions:no obvious adverse reactions were found among the three groups.Conclusions:Therapy with Chinese medicine combined with psychological intervention was effective for short-term and long-term treatment of cyclomastopathy and menoxenia.The mechanism might be related to the regulation of sex hormones.     

Effect of Lirukang oral liquid on neurotransmitters and estrogen in rats with hyperplasia of mammary gland

Objective: To investigate the effects of Lirukang oral liquid (LRK) on release of neurotransmitter in rats with hyperplasia of mammary glands (HMG) and to explore its mechanism.Methods: Sixty rats were divided into six groups, the normal control group, the model control group, the large dosage (3.6g/kg) and the small dosage (1.8g/kg) LRK groups, the Ruzengning (RZN, 2.5g/kg) group and the tamoxifen (TAM, 5mg/kg) group, 10 in each group. Except those in the normal control group, all the animals were made into rat model of HMG by intraperitoneal injection of estradiol benzoate. Levels of dopamine (DA) and 5-hydroxytryptamine (5-HT) in hypothalamus and mammary gland in rats were detected by fluorescence luminosity assay, and level of prolactin (PRL) in serum was detected by radioimmunoassay.Results: In the model group, the level of DA reduced significantly (P<0.01), and 5-HT and PRL increased obviously (P<0.01). Compared with the model group, the LRK groups of both dosages and the TAM group had their level of DA significantly increased (P<0.01), and level of 5-HT significantly decreased (P<0.01). The serum PRL in both LRK groups was significantly decreased (P<0.01). No obvious changes in DA, 5-HT and PRL were found in the RZN group.Conclusion: LRK and TAM have similar effects in regulating the release of neurotransmitter in hypothalamus and mammary gland and serum content of estrogen in the animal models of HMG. This study was supported by Jiangsu Provincial Administration Bureau of Traditional Chinese Medicine [No. SZ 95-B18]     

Clinical experience in treatment of Amanita mushroom poisoning with Glossy Ganoderma Decoction (灵芝煎剂) and routine Western medicines

Objective:To assess the effects of treatment of Amanita mushroom poisoning with Glossy anoderma Decoction(灵芝煎剂,GGD).Methods:Twelve patients with acute Amanita mushroom poisoning received conventional treatment(penicillin and reduced glutathione) combined with oral administration of GGD(treated group),which was prepared out of 200 g Glossy ganoderma decocted in water to 600 mL,and 200 ml was given once,three times a day for 7 successive days;while conventional treatment alone was given to the other 11 patients assigned to the control group.The therapeutic eff icacy and changes in serum levels of total bilirubin(TBil),bile acids(BA),alanine transaminase(ALT),and aspartate transaminase(AST) activities in the two groups were compared.Results:The cured-markedly effective rate in the treated group was more signif icant than that in the control group(P<0.01).Elevation in TBil,BA,ALT,and AST activities were observed in both groups 3 days after poisoning,which progressively increased thereafter in the control group.In the treated group,they reached their peak on the 3rd day and then declined gradually.The differences between pre-treatment and post-treatment in both groups were obviously signif icant(P<0.01),so were the differences between the two groups at corresponding time points(P<0.01).Conclusion:GGD shows excellent clinical eff icacy in the treatment of acute Amanita mushroom poisoning and can reduce mortality signif icantly.     

Clinical observation on Breviscapine in treating hypertension patients complicated with micro-albuminuria of renal impairment

Incidence of renal impairment of essen tial hypertension (EH) has been displayingan ascending trend from year to year, great ly threatened the EH patients ' health andlife. According to the statistics of AmericanAssociation of Nephropathy, in the 5 yearsbetween 1983-1987, owing to renal impair ment by EH in the end stage renal disease(ESRD), the number of patients who werein need of dialysis and renal transplantationincreased by 1. 5 times, just next to thenumber …