A型肉毒素在面部除皱中的应用

目的探讨A型肉毒素注射祛除面部皱纹的临床疗效。方法本组56例面部除皱患者,通过设计不同注射点,采用A型肉毒素进行多部位、微剂量局部注射,每次总剂量小于100U。结果经注射后,54例效果显著(96.43%),2例有效(3.57%),总有效率100%。结论 A型肉毒素用于面部除皱,疗效确切,见效快,痛苦小,是一种安全有效的方法。     

肉毒杆菌毒素注射在面部美容中的应用效果

探究临床面部美容中注射肉毒杆菌毒素的应用价值。方法 选择2022年5月-2023年2月滕州市中心人民医院收治的90例面部美容患者为研究对象,经随机抽签法分为对照组和观察组,每组45例。对照组采用微针导入富血小板血浆治疗,观察组在对照组基础上注射肉毒杆菌毒素,比较两组临床疗效、皮肤状态、不良反应发生情况以及美容满意度。结果 观察组总有效率为95.56%,高于对照组的80.00%,差异有统计学意义（P＜0.05）;观察组治疗后滋润度与弹性度评分高于对照组,油脂和斑纹评分低于对照组,差异有统计学意义（P ＜0.05）;两组不良反应发生率比较,差异无统计学意义（P ＞0.05）;观察组美容满意度为93.33%,高于对照组的77.78%（P ＜0.05）。结论 临床面部美容患者给予注射肉毒杆菌毒素,能够有效提高美容效果,改善其皮肤滋润、弹性、油脂以及斑纹等皮肤状态,不良反应少,具有较高的患者满意度。     

Botulinum Toxin A for Lower Facial Contouring: A Prospective Study

Background A prominent mandibular angle is a common reason for aesthetic treatment among Asian women. Such women usually present with hypertrophic masseteric muscles, and one treatment for this uses botulinum toxin A (BoNTA). Detailed effectiveness and physiologic influences of this therapy are still under investigation. Methods The authors report a prospective study of 10 female volunteers with hypertrophic masseteric muscles who received a single treatment comprising intramuscular injection of BoNTA. The facial change and the discomfort of the injection were self-rated using a visual analog scale, and the patients were regularly inspected up to 1 year. Bite forces also were measured for chronological documentation. Volume changes of masticating muscles were evaluated by three-dimensional computed tomography (CT) scans before and 3 months after injection of BoNTA. Results The serial photographs and patient subjective evaluation showed an obvious facial change 3 to 6 months after injection. Bite forces decreased from the first day after injection, but started to recover during week 3 and were normal 3 months after injection. Three-dimensional CT evaluation showed a statistically significant mean masseter reduction of about 30%, but no change in the volume of other masticating muscles. There were no serious complications during this study. Conclusions Injection of BoNTA is an effective alternative for contouring of the lower facial profile by reducing the bulkiness of masseteric muscles. Its effectiveness was noticed as early as 2 weeks after injection and reached a peak effect in month 3. The facial contour gradually returned 6 months after injection. The reduction in bite force was temporary and caused no daily life interference.     

CO2点阵激光联合A型肉毒毒素注射技术治疗面部外伤后手术缝合 瘢痕的临床观察

目的 观察CO2点阵激光联合A型肉毒毒素注射技术治疗面部外伤后手术缝合瘢痕的治疗效果及 安全性。方法 选取2019年7月-2021年1月苏北人民医院医学美容科就诊的60例面部外伤后手术缝合瘢痕患 者,采用随机数字表法分为试验组和对照组,各30例。对照组予以CO2点阵激光治疗,试验组在CO2点阵激 光治疗后予以A型肉毒毒素局部注射,比较两组温哥华瘢痕量表（VSS）评分、临床疗效、不良反应发生情 况及患者满意度。结果 两组治疗后1、6个月VSS权重评分低于治疗前,且试验组低于对照组,差异有统计 学意义（P＜0.05）;试验组治疗后1个月治疗总有效率高于对照组,差异有统计学意义（P＜0.05）;两组 治疗后6个月治疗总有效率比较,差异无统计学意义（P＞0.05）;试验组满意度高于对照组,差异有统计 学意义（P＜0.05）;两组色素沉着发生率比较,差异无统计学意义（P＞0.05）。结论 CO2点阵激光联合A 型肉毒毒素注射技术治疗面部外伤后手术缝合瘢痕的疗效确切,可改善瘢痕外观,且不增加不良反应发生 几率,应用安全性较高。     

肉毒素联合脂肪填充在面部年轻化中的应用

目的 探讨肉毒素联合脂肪填充在面部年轻化手术中的美容治疗效果。方法 选取沧州美医美医 疗美容诊所2021年6月-2022年6月收治的52例拟接受面部塑形的患者为研究对象,随机分为对照组与观 察组,每组26例。对照组予以肉毒素治疗,观察组予以肉毒素联合脂肪填充治疗,比较两组临床疗 效、面部轮廓参数、皮肤状况及并发症发生情况。结果 观察组治疗总有效率为92.31%,高于对照组的 65.38%,差异有统计学意义（P ＜0.05）;观察组治疗后面下部长度、宽度参数优于对照组,差异有统 计学意义（P＜0.05）;观察组治疗后暗斑、水润、弹性评分优于对照组,差异有统计学意义（P＜0.05）; 观察组并发症发生率为19.23%,低于对照组的26.92%,差异有统计学意义（P ＜0.05）。结论 肉毒素与脂 肪填充联合应用可提升面部年轻化效果,改善皮肤轮廓及肤质,减少并发症发生几率,值得临床应用。     

Microneedling Delivery of Botulinum Toxin Versus Intradermal Injection in the Treatment of Facial Hyperhidrosis

BackgroundThe current treatments of Facial hyperhidrosis (FH) are often limited and are associated with many adverse effects.ObjectiveThe objective was to study the efficacy and safety of botulinum toxin-A delivery by microneedling versus its intradermal injection in the treatment of FH. Forty-two patients with FH were subjected to microneedling (Mn) followed by topical application of BTX-A on one side of the face and intra-dermal injection of BTX-A on the other side. Two sessions were performed at two week intervals. The assessment tools were Hyperhidrosis Disease Severity Scale (HDSS), the Dermatology Life Quality Index (DLQI), and patient satisfaction.ResultsA score of one of HDSS was achieved in 85.7 percent of patients on the intradermally injected side versus 83.3 percent on the microneedling side (P=0.76%). Most of the patients on the injection side responded with the first session while the microneedling side responded with the second one (P<0.001). The DLQI was highly significant on both sides post-treatment (P<0.001). The side effects were mild in the form of pain on the intradermally injected sides, and mild transient erythema on the microneedling side. The microneedling side showed higher patient satisfaction compared to the intradermally injected side. ConclusionBoth techniques were safe and effective in controlling the FH. Microneedling delivery of BTX-A was less painful and had higher patient satisfaction.     

Complications with the Use of Botulinum Toxin Type A in Facial Rejuvenation: Report of 8 Cases

The botulinum toxin A is produced by Clostridium botulinum and causes a reversible, selective muscle relaxation that leads to a temporary flattening of the mechanical component of wrinkling without the stigmata of invasive surgery. Since the end of the 1980s, this neurotoxin has been used to treat mimic facial lines with good results. Although this is considered a safe therapy, with adverse effects typically self-limited, more severe complications have been observed when it is used by nonskilled physicians or in improper dosages. This article reports eight patients treated with botulinum toxin A for aesthetic purposes who developed different complications. Treatment of the complication included the use of electrical stimulation, lymphatic drainage, antiinflammatory therapy, dipivefrine cloridrate drops, and other approaches. With specific treatment for each patient, the lengths of these complications seemed to be reduced.     

A型肉毒素注射联合透明质酸填充在面部美容中的应用

目的 探讨A型肉毒素注射联合透明质酸填充在面部美容中的应用效果。方法 选取2021年 3月-2022年12月解放军联勤保障部队第九六九医院收治的74例行面部皮肤填充患者为研究对象,按照随 机数字表法分为对照组与观察组,每组37例。对照组采取A型肉毒素治疗,观察组采取A型肉毒素联合透 明质酸治疗,比较两组临床疗效、并发症发生情况、尊严感及自信心评分、治疗满意度。结果 观察组治 疗总有效率高于对照组（P＜0.05）;观察组并发症总发生率低于对照组（P＜0.05）;观察组治疗后尊严 感、自信心评分优于对照组（P＜0.05）;观察组治疗满意度高于对照组（P＜0.05）。结论 A型肉毒素注 射联合透明质酸填充在面部美容中应用价值较高,除皱效果确切,可提高患者尊严感及自信心,促进治疗 满意度提升,值得临床应用。     

自体脂肪移植联合A型肉毒毒素注射在面部年轻化中的应用效果

探讨自体脂肪移植联合A型肉毒毒素注射在面部年轻化中的应用效果。方法 选择2020年 5月-2023年5月西安顺美医疗美容门诊部收治的80例面部年轻化患者为研究对象，以治疗方案不同分为对 照组和研究组，各40例。对照组给予自体脂肪移植，研究组则联合A型肉毒毒素注射，比较两组临床疗 效、面部轮廓参数、皮肤状况及自信程度、治疗满意度。结果 研究组治疗总有效率为92.50%，高于对照 组的72.50%（P ＜0.05）；研究组治疗后面部轮廓参数改善情况优于对照组（P ＜0.05）；研究组治疗后皮 肤状况、BES分数均优于对照组（P ＜0.05）；研究组满意度为95.00%，高于对照组的75.00%（P ＜0.05）。 结论 在面部年轻化中联合应用自体脂肪移植与A型肉毒毒素注射，可有效改善面部轮廓及皮肤状况，治 疗效果及患者满意度高，具有较高的临床应用价值。     

肉毒毒素注射治疗单侧口角歪斜

目的：探讨单侧口角歪斜的一种新的治疗方法-A型肉毒毒素注射。方法：自2003年起笔者应用A型肉毒毒素注射健侧降下唇肌群,治疗面神经下颌缘支瘫痪造成的单侧口角歪斜20例。结果：20例患者注射治疗后均出现明显的口角歪斜改善,至治疗完毕,未出现任何并发症。结论：对单侧口角偏斜的患者行肉毒毒素注射治疗安全、有效。     

A型肉毒毒素联合透明质酸钠微整形注射在颜面部轮廓重塑中的应用效果

分析微整形注射A型肉毒毒素联合透明质酸钠在颜面部轮廓重塑中的效果和安全性。方法选取2020年1月-2023年3月于西安国际医学中心医院接受颜面部轮廓重塑的128例患者为研究对象,根据治疗方式不同分为观察组（n =64）和对照组（n =64）。两组均行重塑颜面轮廓,对照组采用A型肉毒毒素注射联合自体脂肪填充,观察组采用A型肉毒毒素注射联合透明质酸钠,比较两组面下部轮廓变化、除皱效果、治疗情况及不良反应。结果 两组治疗后面下宽度、面下长度、面中长度、面下颏夹角及面部比值变化均优于治疗前,且观察组面下部轮廓各变化幅度均优于对照组（P ＜0.05）;对照组治疗3个月后除皱总有效率优于观察组（P ＜0.05）;观察组住院时间短于对照组,治疗费用少于对照组（P ＜0.05）;观察组与对照组面部僵硬、面部不对称、透明质酸钠栓塞、面部凹凸不平等不良反应发生率比较,差异无统计学意义（P＞0.05）。结论 自体脂肪填充可改善患者静态皱纹,A型肉毒毒素可改善患者动态皱纹,在面部轮廓改善方面效果更佳,可有效缩短治疗时间,减少治疗费用,且不增加不良反应,应用价值更高。     

A型肉毒毒素在治疗咬肌肥大中的作用

目的 评价A型肉毒毒素在治疗咬肌肥大中的作用。方法 2005年8月至2014年1月,对15例咬肌肥大患者行A型肉毒毒素治疗,并应用B型超声于术前和术后4、12、24周测量咬肌厚度。结果 本组患者术后随访6个月,咬肌注射A型肉毒毒素后4、12、24周,咬肌厚度萎缩(15.60±4.96)%、(27.72±9.13)%和(24.32±8.86)%。结论 A型肉毒毒素能有效减少咬肌厚度;B型超声测量能有效地反映咬肌萎缩的程度。     

A 型肉毒毒素联合透明质酸钠微整形注射在重塑颜面部轮廓中的应用效果

目的 探究A型肉毒毒素联合透明质酸钠微整形注射在重塑颜面部轮廓中的应用效果。方法 选 取2021年10月-2022年11月于我院行颜面部轮廓重塑的患者60例为研究对象,采用随机数字表法分为A组、B 组、C组,每组20例。A组单纯注射肉毒毒素,B组单纯注射透明质酸钠,C组注射肉毒毒素联合透明质酸, 比较三组面下部轮廓变化、形态改善效果、治疗满意度及不良反应发生情况。结果 C组面下部宽度、面下部 长度、面下部宽度/面下部长度、面中长度、下颏夹角均优于A组、B组（ P ＜0.05）;C组形态改善总有效率 均高于A组、B组（ P ＜0.05）;C组治疗满意度高于A组、B组（ P ＜0.05）;三组不良反应发生率比较,差异 无统计学意义（ P ＞0.05）。结论 A型肉毒毒素联合透明质酸钠微整形注射在重塑颜面部轮廓中的应用效果 确切,改善患者面部轮廓形态的效果良好,且不会增加不良反应发生风险,患者满意度较高。     

Treatment of Hypertrophic Scars With Intralesional Botulinum Toxin Type A Injections: A Preliminary Report

Background  Hypertrophic scar is the abnormal appearance of wound healing that usually causes major physical, psychological, and cosmetic problems. Treatment of the hypertrophic scar still is a dilemma due to the lack of effective and excellent methods and agents. Recent reports show that botulinum toxin type A (BTX-A) improves wound healing. Therefore, the authors hypothesized that BTX-A may be favorable for the improvement of hypertrophic scars. Methods  A total of 19 patients were randomly assigned to a prospective clinical study. At 1-month intervals, BTX-A (2.5 U per cubic centimeter of lesion) was injected in these patients for a total of 3 months. All the patients were followed up for at least half a year. Therapeutic satisfaction was recorded, and the lesions were assessed for erythema, itching sensation, and pliability. Results  The study was completed by 19 patients. At the half-year follow-up visits, all the patients showed acceptable improvement, and the rate of therapeutic satisfaction was very high. The erythema score, itching sensation score, and pliability score after the BTX-A injection all were significantly lower than before the BTX-A injection. The differences all were statistically significant (P < 0.01). Conclusion  For the treatment of hypertrophic scars, doctors and patients both found BTX-A acceptable because of its better therapeutic results. Its effect of eliminating or decreasing hypertrophic scars was promising. Zhibo Xiao and Fengmin Zhang are the primary authors of this article.     

A 型肉毒素治疗面部皱纹的美容效果

为探究A型肉毒素治疗面部皱纹的美容效果,本研究选取2021年1月-2023年1月于我院行面部 皱纹修复的50例患者为研究对象,所有患者均采用A型肉毒素进行治疗,观察临床治疗效果和不良反应发 生情况。结果显示,治疗总有效率高达98.00%,不良反应发生率较低,仅为4.00%。可见,在面部皱纹治疗 中,应用A型肉毒素治疗效果肯定,治疗过程安全,值得临床应用。     

自体脂肪移植联合A型肉毒毒素在面部吸脂后凹陷患者中的应用效果

目的 探究自体脂肪移植与A型肉毒毒素治疗面部吸脂后凹陷的效果。方法 选取2020年4月-2022年 4月本院整形科收治的64例面部吸脂后凹陷患者为研究对象,随机分为对照组和观察组,各32例。对照组 给予自体脂肪移植治疗,观察组给予自体脂肪移植联合A型肉毒毒素治疗,比较两组临床疗效、并发症发 生情况及脂肪组织坏死情况。结果 观察组治疗总有效率为96.88%,高于对照组的81.25%（P＜0.05）;观察 组并发症总发生率为0,低于对照组的18.75%（P＜0.05）;观察组自体脂肪组织坏死率为3.13%,低于对照 组的18.75%,但差异无统计学意义（P＞0.05）。结论 自体脂肪移植联合A型肉毒毒素在面部吸脂后凹陷患 者中的应用效果确切,可有效改善患者面部凹陷问题,提高其面部流畅度及美观度,同时能够促进移植脂 肪成活,降低不良反应发生几率,应用安全性较高。     

Botulinum Toxin,Physical and Occupational Therapy,and Neuromuscular Electrical Stimulation to Treat Spastic Upper Limb of Children With Cerebral Palsy: A Pilot Study

Spasticity has been successfully managed with different treatment modalities or combinations. No information is available on the effectiveness or individual contribution of botulinum toxin type A (BTA) combined with physical and occupational therapy and neuromuscular electrical stimulation to treat spastic upper limb. The purpose of this study was to assess the effects of such treatment and to inform sample‐size calculations for a randomized controlled trial. BTA was injected into spastic upper limb muscles of 10 children. They received 10 sessions of physical and occupational therapy followed by 10 sessions of neuromuscular electrical stimulation on the wrist extensors (antagonist muscles). Degree of spasticity using the Modified Ashworth scale, active range of motion, and manual function with the Jebsen hand test, were assessed. Meaningful improvement was observed in hand function posttreatment (P = 0.03). Median spasticity showed a reduction trend and median amplitude of wrist range of motion registered an increase; however, neither of these were significant (P > 0.05). There is evidence of a beneficial effect of the combined treatment. Adequate information has been obtained on main outcome‐measurement variability for calculating sample size for a subsequent study to quantify the treatment effect precisely.     

注射用A型肉毒毒素与眼袋整形术治疗眼周皮肤松弛的临床价值研究

目的 观察注射用A型肉毒毒素与眼袋整形术在眼周皮肤松弛治疗中的临床应用效果。方法 选择我院2019年5月-2020年5月接诊的50例眼周皮肤松弛患者,按随机数字表法分为参照组和观察组,每组25例。参照组采取眼袋整形术治疗,观察组采取注射用A型肉毒毒素与眼袋整形术联合治疗。比较两组患者术后皮肤状况改善情况、不良反应发生情况及治疗满意度。结果 两组治疗半年后眼袋、鱼尾纹、皮肤色泽评分均高于治疗前,且观察组高于参照组,差异有统计学意义（P＜0.05）;观察组不良反应发生率（12.00%）与参照组（20.00%）比较,差异无统计学意义（P＞0.05）;观察组治疗满意度（92.00%）高于参照组（68.00%）,差异有统计学意义（P＜0.05）。结论 对眼周皮肤松弛患者予以注射用A型肉毒毒素与眼袋整形术联合治疗,效果确切,能改善患者眼周皮肤状态,提升患者治疗的满意度,且不良反应少,值得在临床应用。