结合珠蛋白的临床意义

结合珠蛋白(haptoglobin,Hp),又称触珠蛋白,亲血色蛋白。它广泛存在于人、哺乳动物及脊椎动物血液及体液中含糖的α_2球蛋白内,约占血浆α_2球蛋白的1/4。它可与血红蛋白(hemoglobin,Hb)特异结合,形成稳定的复合物。     

结合珠蛋白及其临床意义

1938年Polonovski和Jayle在血清中发现一种具有结合血红蛋白(Hb)能力的蛋白质,并被称之为Haptoglobin,Hp,译成结合珠蛋白或触珠蛋白。1955年Smithies使用淀粉凝胶电泳将血清Hp区别为Hp1-1,Hp2-1和Hp2-2三种遗传表现型,开辟了新的血清型领域。近年来,国内外对Hp的理化性质、型别分布、遗传方式和临床意义等进行了研究。本文对此综述如下。一、结构和功能Hp属血清α_2-球蛋白区中     

冠心病患者的血清结合珠蛋白

血清结合珠蛋白(Haptoglobin简称Hp)水平已作为各种疾病活动程度的指标,特别对有组织破坏的疾患,恶性肿瘤,肾脏疾患和心肌梗塞等病尤为适用.已有其它作者报告冠心病患者(IHD)Hp水平增高且升高水平与心脏损害程度密切相关.本文研究了76例IHD患者及151例正常人Hp,探讨Hp对IHD患者的诊断和预后价值.应用Qwen等的分光光度法测定血清Hp,按Davis法用聚丙烯酰胺凝胶(Polyacylamide gel)测定Hp表型.结果表明,IHD组的Hp水平升高有统计学意义(P<0.05).Hp水平与年龄、血型无关,但与性别有关.IHD组中男性Hp水平明显高于同组女性.Hp水平与患者心电图改变密切相关,     

血清结合珠蛋白比色测定方法探讨

结合珠蛋白(Haptoglobin 简写HP)是由肝脏合成的α_2区的一种糖蛋白,它能与Hb结合成HP-Hb复合物,在清除体内的游离Hb中发挥作用。同时,它也是一种急性相反应蛋白,在机体遭受某些病理因子攻击时有显著     

结合珠蛋白与肝脏疾病的关系

结合珠蛋白(haptoglobin,Hp)是血清α2球蛋白组分中的一种酸性糖蛋白,广泛存在于人类和许多哺乳动物的血清及其他体液中,其主要功能是结合血红蛋白(heamoglobin,Hb)并将其运至肝中代谢,从而避免Hb和铁从肾脏丢失以及对肾脏的损伤.     

肝病患者血清结合珠蛋白含量的测定

血清结合珠蛋白(简称HP)是由肝细胞合成的一种糖蛋白,属于急性期反应性蛋白质,在多种急病时其含量可发生较显著改变。因此测定HP含量,有助于某些疾病的辅助诊断和肝病病情变化的分析。     

缺铁性贫血病人血结合珠蛋白观察

结合珠蛋白(HP)是一种含糖的α_2球蛋白,它能与游离的血红蛋白结合成稳定的复合物,防止铁丢失。在溶血性贫血时血清HP水平明显降低。而缺铁性贫血HP观察国内尚未见报道,我们最近对35例缺铁性贫血患者进行了血清HP测定,现报告如下。材料与方法①正常人:共220名。为健康大学生与职工。其中男性122名,女性98名,年龄16～68     

结合珠蛋白清除血红蛋白作用及机制

结合珠蛋白(Hp)又称触珠蛋白,是1种极丰富的急性时相血浆糖蛋白,结构上是α2球蛋白的一部分,1938年由Polonovski和Jayle[1]报道。在血管内溶血期间,游离血红蛋白(Hb)可释放入血循环,Hp与这部分Hb结合,Hp-Hb复合体通过与巨噬细胞表面的清道夫受体CD163结合,经内吞作用     

Haptoglobin: function and polymorphism

Haptoglobin is an acute phase protein capable of binding haemoglobin, thus preventing iron loss and renal damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. There are 3 major haptoglobin phenotypes--Hp(1-1), Hp(2-1) and Hp(2-2). Possession of a particular phenotype has been associated with a variety of common disorders (e.g. cardiovascular disease, autoimmune disorders, malignancy), a fact which can only be explained by the idea that possession of a particular phenotype offers some protection against the development of these disorders. Knowledge of phenotype could therefore aid in the prognosis of disease and allow treatment to be better tailored to suit an individuals' needs.     

Haptoglobin phenotype and gestational diabetes

OBJECTIVE: Haptoglobin (Hp), an Hb-binding plasma protein, exists in two major allelic variants. Hp1 has higher Hb binding and antioxidant capacity compared with Hp2. Individuals with Hp1 exhibit a lower incidence of angiopathies. Gestational diabetes mellitus (GDM) is an early manifestation of type 2 diabetes in pregnant women. It is usually confined to the time of gestation, but carries an increased risk to develop type 2 diabetes later in life. RESEARCH DESIGN AND METHODS: From consecutive Caucasian pregnant women (n = 250) referred for oral glucose tolerance testing, the Hp phenotype was determined. Significance of distribution and odds ratios (ORs) associated with Hp phenotype were calculated for women with GDM (n = 110) and women with normal glucose tolerance (n = 140). RESULTS: -Frequency of GDM in Hp phenotype classes increased with the number of Hp2 alleles (P < 0.001). ORs for GDM in women heterozygous and homozygous for Hp2 were 2.7 (95% CI 1.06-6.84) and 4.2 (1.67-10.55), respectively. CONCLUSIONS: Hp phenotype is an apparent risk factor for the development of GDM in our study population. This might be due to the low antioxidative potential of Hp2 compared with Hp1.     

Haptoglobin polymorphism and iron homeostasis

BACKGROUND: There is a marked difference in the degree of expression of the homozygous C282Y HFE genotype that is associated with hereditary hemochromatosis. It has been reported that individuals with the haptoglobin 2-2 type manifest increased iron concentrations, including serum iron, transferrin saturation, and ferritin. METHODS: We studied 232 patients, 115 homozygous for the c.845G-->A (C282Y) mutation and 117 matched controls with the wild-type HFE genotype, for haptoglobin phenotypes. Haptoglobin types were determined by electrophoresis of the denatured protein. The HFE genotype was determined by allele-specific oligonucleotide hybridization. Ferritin and transferrin saturation were measured by standard methods. RESULTS:There was no relationship between haptoglobin type and ferritin concentration or transferrin saturation. CONCLUSIONS: The effect of haptoglobin type on iron homeostasis cannot account for the marked phenotypic variation that is seen in patients homozygous for the HFE C282Y mutation.