盐酸氨溴索治疗分泌性中耳炎疗效观察

目的：观察盐酸氨溴索（沐舒坦）治疗分泌性中耳炎的疗效。方法：76例（81耳）分泌性中耳炎患者随机分二组，用药组40例，用沐舒坦针剂鼓室内注射并口服沐舒坦；对照组36例，用地塞米松和α－糜蛋白酶针剂混合液行鼓室内注射，比较治疗前后的临床症状、体征、纯音测听和鼓室图的变化情况。结果：治疗后2－3周随访，用药组中24例25耳显效，12例15耳有效，4例5耳无效，总有效率达88．9％。对照组中14例14耳显效，9例9耳有效，13例13耳无效，总有效率63．9％。结论：沐舒坦是治疗分泌性中耳炎的一种安全有效的药物。     

过氧化氢治疗分泌性中耳炎78例临床分析

目的:探讨过氧化氢治疗分泌性中耳炎的疗效。方法:78例分泌性中耳炎,行鼓膜穿刺抽液、再将0.2~0.3 ml过氧化氢液缓慢冲洗鼓室,术后用氯霉素加地塞米松溶液滴耳,口服沐舒坦。结果:83耳中72耳一个疗程治愈,总有效率为96.4%。结论:过氧化氢冲洗治疗分泌性中耳炎有显著疗效,操作简单,可广泛应用于临床。     

盐酸氨溴索治疗分泌性中耳炎疗效观察

目的观察盐酸氨溴索(沐舒坦)治疗分泌性中耳炎的疗效. 方法76例(81耳)分泌性中耳炎患者随机分二组,用药组40例,用沐舒坦针剂鼓室内注射并口服沐舒坦;对照组36例,用地塞米松和α-糜蛋白酶针剂混合液行鼓室内注射,比较治疗前后的临床症状、体征、纯音测听和鼓室图的变化情况. 结果治疗后2 ～3周随访,用药组中24例25耳显效,12例15耳有效,4例5耳无效,总有效率达88.9%.对照组中14例14耳显效,9例9耳有效,13例13耳无效,总有效率63.9%. 结论沐舒坦是治疗分泌性中耳炎的一种安全有效的药物.     

安溴索治疗分泌性中耳炎的疗效观察

目的：观察应用安溴索治疗分泌性中耳炎的治疗效果。方法：应用安溴索治疗分泌性中耳炎25例（40耳），并以20例（30耳）用糜蛋白酶＋地塞米松（糜＋地）作对照治疗。结果：安溴索治疗分泌性中耳炎有效率为97．5％．治愈率为85．0％，明显优于糜＋地组。结论：安溴索治疗分泌性中耳炎和预防粘连性中耳炎有可靠疗效，可供临床应用。     

吉诺通加二丙酸倍氯米松喷鼻治疗分泌性中耳炎疗效观察

目的观察应用吉诺通口服及二丙酸倍氯米松气雾剂喷鼻治疗分泌性中耳炎的效果。方法40例（48耳）分泌性中耳炎患者，在传统方法的基础上加用吉诺通口服及二丙酸倍氯米松气雾剂喷鼻。结果显效32耳（66．7％），有效12耳（25％），无效4耳（9．3％），总有效率91．7％。结论加用吉诺通口服及二丙酸倍氯米松气雾剂喷鼻是治疗分泌性中耳炎的有效方法。     

沐舒坦静滴佐治毛细支气管炎62例疗效观察

目的观察沐舒坦佐治毛细支气管炎的临床疗效。方法在常规治疗基础上加用沐舒坦7．5mg／次，静滴2次／d，连续5d，观察患儿临床相关症状及体征变化。结果62例毛细支气管炎经沐舒坦辅佐治疗5d后，与对照组相比，治疗组（62例），显效31例，有效22例，总有效率85．5％，对照组（50例），显效20例，有效14例，总有效率68％。2组病例经统计学处理，差异有极显著性（p〈0．001）。结论沐舒坦佐治毛细支气管炎是一种安全有效的方法。     

氧气驱动雾化吸入沐舒坦和地塞米松针剂防治早产儿呼吸窘迫综合征疗效观察

目的探讨沐舒坦、地塞米松氧气驱动雾化吸入防治早产儿呼吸窘迫综合症（NRDS）的疗效。方珐选择2007—03—2009—12本院收治的胎龄29．33周、生后2h内入院的早产儿84例,随机分成治疗组和对照组,各42例。入院后除均给予综合治疗外,治疗组加用氨溴索针剂（沐舒坦）10mg／kg．次和地塞米松针0．5mg/次氧气驱动雾化吸入,1次／8h,连用3天。站杲治疗组无1例发生NRDS,对照组发生5例,发生率12％。结论沐舒坦、地塞米松氧气驱动雾化吸入防治NRDS有较好疗效。     

中西医结合治疗分泌性中耳炎的临床效果分析

目的分析中西医结合治疗分泌性中耳炎的临床效果。方法选取2011年7月-2013年5月陕西省渭南市合阳县医院收治的分泌性中耳炎患者120例,将其随机分为实验组及对照组,各60例。对照组行单纯西医治疗,主要为口服罗红霉素150mg,2O：／d;泼尼松10mg,3次／d,中耳腔内注射20mg曲安奈德;鼓膜穿刺抽取积液等。实验组行中西医结合治疗,将山药,川穹等药物水煎,口服100ml,2次／d,连续2周,并观察两组治疗效果。结果实验组治愈37例,有效）7例,无效6例,总有效率90．0％,对照组治愈27例,有效18例,无效15例,总有效率75．0％。实验组总有效率高于对照组,且差异有统计学意义（P〈0．05）。结论中西医结合治疗分泌性中耳炎效果显著。     

沐舒坦鼓室注射治疗分泌性中耳炎临床疗效分析

目的:观察沐舒坦鼓室注射后对分泌性中耳炎伴中耳积液变化的影响,为分泌性中耳炎的治疗提供指导和依据。方法:将分泌性中耳炎患者随机分成治疗组(63例)和对照组(60例),使用回抽方法先抽出中耳积液,然后将勃林格殷格翰公司生产的沐舒坦注射液和地塞米松注射液各0.5ml注入鼓室。结果:治疗组与对照组比较有统计学意义。结论:沐舒坦鼓室注射治疗分泌性中耳炎疗效显著。     

沐舒坦联合纳洛酮治疗胎粪吸入综合征74例临床观察

目的观察沐舒坦、纳洛酮联合治疗胎粪吸入综合征的疗效。方法自2003年1月～2007年1月在我科就诊的胎粪吸入综合征74例，随机分为治疗组40例和对照组34例。两组均给予常规治疗，治疗组在常规治疗基础上加用沐舒坦、纳洛酮，其中沐舒坦每次7．5mg／kg，q6h1次；纳洛酮针首次负荷量0．1mg慨静推，1h后按0．01mg／（kg·h）的速度经微量输液泵持续静脉注射，每日总量不超过0．4mg／kg。结果在治疗结束时，治疗组显效27例（67．5％），有效11例（27．5％），总有效率为95．0％（38／40）；对照组显效15例（44．1％），有效10例（29．4％），总有效率为73．5％（25／34）。两组显效率比较差异有显著性意义（Х^2=4．09，P〈0．05），总有效率比较差异有非常显著性意义（Х^2=6．69，P〈0．01）。结论沐舒坦联合纳洛酮治疗胎粪吸入综合征疗效显著，值得临床进一步研究。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.