对慢性鼻窦炎药物治疗和手术治疗疗效比较

目的:探讨功能性鼻窦内镜手术(FESS)及药物治疗慢性鼻-鼻窦炎的疗效比较.方法:对2008年1月～2009年1月行功能性鼻窦内镜手术治疗慢性鼻-鼻窦炎患者78例(鼻窦炎症主要在上颌窦和前组筛窦.不伴有鼻息肉.鼻中隔明显偏曲者),患者术后6个月按时复查并有完整资料记录.及对2008年10月～2009年10月药物治疗有完整资料的慢性前组鼻窦炎患者(不伴有鼻息肉.鼻中隔明显偏曲者)82例,对疗效进行回顾性分析.(若患者有急性上呼吸道感染,就将评估时间推迟至症状完全消失2周以后进行).结果:慢性鼻-鼻窦炎患者药物治疗和手术治疗疗效相当.结论:对慢性鼻-鼻窦炎(前组鼻窦炎)应首选药物治疗.     

Gene therapy: future therapy for erectile dysfunction

Advances in molecular biological techniques, completion of the Human Genome Project, and the ensuing age of molecular medicine, in conjuction with the sum of a decades-long accumulation of knowledge of the physiology of erection and the pathophysiology of erectile dysfunction have converged to make gene therapy for erectile dysfunc-tion a distinct possibility. In short, both the intrinsic complexities of mechanisms responsible for ensuring normal erection and the multifactorial nature of erectile dysfunction ensure that there is a relatively vast number of physiologically relevant molecular targets for gene therapy. As such, perhaps it is not surprising that virtually every preclinical gene therapy strategy/target examined thus far has been largely successful in ameliorating conditions associated with compromised erectile function in vivo and/or in vitro. This report highlights the goals and strategies of gene therapy for erectile dysfunction and reviews the strategies that initially have been employed. In short, the preclinical data, while still quite preliminary in many regards, are nonetheless quite impressive and encouraging. If similar success is obtained in clinical trials, gene therapy for erectile dysfunction may provide the first concrete “proof of concept” for using gene therapy in the treatment of human smooth muscle disorders.     

Pacemaker therapy

This article reviews the indications for pacemaker implantation and the techniques and devices currently in use. The management of patients who require permanent pacemakers and the potential complications involved are discussed. The article concludes with a brief synopsis of temporary pacing.     

Biologic therapy

Biologic therapy has evolved as a fourth treatment option for patients with melanoma and other malignancies. Interrelated advances in molecular diagnostics and gene therapy techniques will further accelerate therapeutic advances in this new arena. A variety of biologic therapeutic options available to the patient with high risk melanoma are reviewed.     

Photodynamic therapy

Photodynamic therapy (PDT) is a new modality of cancer treatment. It is based on the use of photosensitizing agents and laser light which interact and produce singlet oxygen. This toxic compound destroys malignant tumours while healthy tissue remains intact. The present paper reviews the method of PDT and its possible clinical applications.     

定制你的音乐处方——记录音乐养生疗法

在生活中我们常说,喜欢唱歌的人大多心情开朗,不轻易生病。在科学上,这其实是有依据的。不同的人,不同的心情,都有相应适合的音乐,在科学家眼中,从古典音乐到现代流派,从轻音乐到嘻哈和摇滚,任何不同类型的乐曲都有着不同的“治疗功用”。这就是我们通常所说的,也是目前最新流行的“音乐养生疗法”。