浅析痤疮古今用方之配伍规律

分析古今医家治疗痤疮的用方规律不外侧重外治之法、解毒杀虫力强、注意祛风退瘢与发展活血之法,而现代医家则治法多样,内外兼施,内治法的用方规律为初起予疏风清热、注意清热除湿、重在解毒消痈与兼以活血化瘀、补虚不忘健体,外治则多用清热解毒、活血散结之法,注意美白祛瘢,并参考现代药理研究合理用药。     

肖承悰教授治疗子宫肌瘤经验析要

子宫肌瘤是女性生殖器官中最多见的良性肿瘤,多发于30~50岁的生育期妇女,临床发病率约25%。肖承悰教授认为,子宫肌瘤主要由于患者产后或经期外感六淫,内伤七情,或多产、房劳等导致阴血亏虚,气随血耗导致气虚;而气虚则运血无力,血流缓慢,瘀血停蓄胞宫,日久则成症瘕;而瘀血又可阻碍气机、损伤正气,气机不利遂生痰湿,痰瘀互结使气虚更甚,终致气虚血瘀。子宫肌瘤患者用药分为经期和非经期治疗,非经期着重于消,寓补于消之中,消于补之上;经期着重于补,寓消于补之中,补于消之上。     

扈晓宇教授大方峻药治疗晚期原发性肝细胞癌

通过对典型病例诊治过程的分析,总结出扈晓宇教授以"大方峻药"治疗晚期原发性肝细胞癌的临床经验。认为晚期原发性肝细胞癌的病机特点以气虚血瘀为主;治疗当以"大方峻药"之法,峻补脾气,破血消癥为主,屡攻屡补,以平为期,标本兼顾。     

《外科正宗》“消补”之法探微※

目的 探析《外科正宗》的“消补”之法。方法 查阅《外科正宗》全书，总结“消补”之法的精髓，并举皮肤科验案两则以佐证其学术思想。结果 皮肤病疮疡初期易感外淫，内蓄邪毒，陈实功喜用风药发汗宣毒并结合针灸等多种方法畅通气血，调和阴阳，求病速消；而疮疡后期，津液耗伤多见，则注重养阴熄火，以绝复发。结论 “消补”之法虽言简意赅，但其道深广，皮肤科医家在临证过程中需抓住核心病机，审病详细，灵活运用。     

唐容川血证补虚法探析

“补虚”是唐容川在《血证论.卷二.吐血》中提出的血证四大治法之一。唐容川所指补虚主要指补血,并明确指出此补虚之法并非仅适用于吐血证,而是通治血证之大法,因而是统论补血之法。然“补法不一”,有先补肺胃,辨证补心,补脾为主,补肝为要,补肾宜早等不同,以五脏分治,调合五脏的阴阳气血,辨证施治,选方用药,真正体现“补虚为收功之法”。     

临证辨治小儿脾胃病

小儿脏腑娇嫩 ,脾胃薄弱 ,一旦有病 ,每虚多实少或虚实夹杂。因此 ,治疗小儿脾胃病应以健脾为主 ,不易轻用攻伐。临床常用补益之法 ,但也不可骤补 ,必须补中寓泻 ;满证宜消 ,但不可俱消 ,必须消中兼补 ;湿证宜燥 ,但不可太燥 ,必须燥中寓濡 ;阴虚宜滋 ,但不可过滋 ,必须滋中潜化。方可谓治疗小儿脾胃病之法。1　善调脾胃之偏　宜补中寓消脾胃为后天之本 ,脾胃气壮则五脏六腑皆壮。中医治疗小儿脾胃气虚证 ,主张先扶助脾胃之气 ,并逐步增加补药以调之。如早补、过补 ,往往有碍脾气的升发 ,反致虚而不耐补。故善调脾胃者 ,必须补中兼消 ,刚中…     

何新慧论治子宫肌瘤经验

介绍何新慧教授治疗子宫肌瘤的临床经验。提出分期而治的治疗原则,经期以化瘀止血为主,非经期以消瘤扶正为主;用药强调气血同调,消补兼施,寒温同用。并附验案1则。     

姜树民教授“以痈论治”胃溃疡临床经验

姜树民教授以痈论治思想治疗胃溃疡临床经验,认为其主要多因郁热内生所致,并且与脾胃素虚密不可分,将外科"消、托、补"之法融入本病治疗,针对选择一些具有保护胃黏膜,抑杀幽门螺杆菌、抑制胃酸等药物组成方药,治法以消痈生肌、平衡中焦为主。     

叶氏通补法应用特点探讨

文章通过梳理《临证指南医案》中应用通补法的相关医案,从通补阳明、通补奇经、通补营卫、通补阳气4个角度分述其证治特色,从中下二焦宜通补、经络腑道通即为补、通补法用药整体以"温"为主3方面探讨其应用特点.以期指导临床更精准地使用通补之法,提高对因虚致实类病证的诊疗效果.     

张介安辨治小儿哮喘的经验

本文从治标、治本、治未病三个方面介绍了主任医师张介安对小儿哮喘的治疗经验,重点突出三个不同时期的病变及用药特点。治标之时,提出:攻邪为主,详辨其因,勿忘调气;治本之时,强调调理脾肺为主,勿忘补之以气;治未病,则不离治本之法。以药食于夏令调养之。     

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??Chronic administration of the second-generation antipsychotic drugs (SGAs) is associated with elevated risks of weight gain, obesity and other metabolic disorders, which further leads to an increase in incidence of cardiovascular diseases and the reduced life expectancy in patients. Dyslipidemia is a critical causative factor for the metabolic syndrome. In this article, the potential molecular mechanisms in SGA-induced dyslipidemia were focused on SREBPs/AMPK??/PPAR pathways, as well as the induction of insulin resistance in peripheral tissues (liver and white fat tissue).     

Recent advances and future directions in anti‐tumor activity of cryptotanshinone: A mechanistic review

In respect to the enhanced incidence rate of cancer worldwide, studies have focused on cancer therapy using novel strategies. Chemotherapy is a common strategy in cancer therapy, but its adverse effects and chemoresistance have limited its efficacy. So, attempts have been directed towards minimally invasive cancer therapy using plant derived‐natural compounds. Cryptotanshinone (CT) is a component of salvia miltiorrihiza Bunge, well‐known as Danshen and has a variety of therapeutic and biological activities such as antioxidant, anti‐inflammatory, anti‐diabetic and neuroprotective. Recently, studies have focused on anti‐tumor activity of CT against different cancers. Notably, this herbal compound is efficient in cancer therapy by targeting various molecular signaling pathways. In the present review, we mechanistically describe the anti‐tumor activity of CT with an emphasis on molecular signaling pathways. Then, we evaluate the potential of CT in cancer immunotherapy and enhancing the efficacy of chemotherapy by sensitizing cancer cells into anti‐tumor activity of chemotherapeutic agents, and elevating accumulation of anti‐tumor drugs in cancer cells. Finally, we mention strategies to enhance the anti‐tumor activity of CT, for instance, using nanoparticles to provide targeted drug delivery.     

中药扶正在化疗过程中时间 强度 密度的应用探讨

中药扶正在化疗过程中早期干预,长期应用,集中用药,剂量偏大,对增效减毒,如期完成化疗计划及化疗后免疫力的提升,生活质量的提高,明显优于较晚应用或偶尔应用、剂量偏小者。在时间、强度、密度及克服耐药方面论述中药抗肿瘤的优势。     

抗糖尿病中药之研究进展

糖尿病在传统中医药系统中,属于阴、阳和气失调,被称为消渴症。该综述回顾近年来用于治疗糖尿病及其并发症之中药的研究进展,并重点阐述国际专业期刊中,抗糖尿病中药的化学、药理和临床研究等范畴。此外还包括中药在该领域的优势分析及未来发展前景等方面的讨论。     

加强中药饮片炮制用辅料标准工作的建议

为促进炮制辅料标准工作,确保炮制辅料质量,对炮制辅料标准工作提出建议。对目前炮制辅料标准及监管情况进行总结,对存在的问题进行分析。应通过加强基础研究,完善标准体系,改进监管模式,推动炮制辅料标准工作。     

影响中药毒性的主要因素

从中药的配伍、用量、炮制、剂型、煎服方法和给药途径等方面,论述了影响中药毒性的主要因素,并进一步阐明了这些因素对中药毒性有不同的影响,主要表现为增毒、减毒、生毒、蓄毒等。为临床合理用药提供了理论依据。     

中药制剂的安全性评价

目的:分析中药制剂不良反应(ADR)的特点、一般规律及影响因素,以促进临床合理用药。方法:采用回顾性分析方法,对我院2007至2009年收集到的70例中药制剂ADR报告分别从患者年龄、药品种类、给药途径、涉及器官或系统以及临床表现等方面进行统计、分析。结果:中药注射剂是引起ADR的主要剂型(91.63%);其中心脑血管用中药制剂引起的ADR所占比例最高(占中药制剂的60%)。结论:应及时报告中药制剂ADR,加强对其监测的意识,保障临床用药安全、有效。     

中药内服并中药保留灌肠治疗子宫内膜异位症疗效观察

目的:观察加用中药保留灌肠治疗轻、中度子宫内膜异位症的治疗效果。方法:符合诊断的200例病例,随机分为2组,治疗组100例给予内异1号方内服并5号方灌肠治疗,对照组100例给予内异1号方内服治疗,2组疗程均为3个月。结果:治疗组痊愈38例,显效36例,有效21例,无效5例;对照组痊愈23例,显效30例,有效34例,无效13例。治疗组疗效较优(P<0·01),且在控制症状、缩小盆腔包块方面疗效明显。结论:采用中药内服并保留灌肠的方法治疗轻、中度子宫内膜异位症,较单予中药内服能提高治疗效果。     

Mechanism-based inactivation of COX-1 by red wine m-hydroquinones: a structure-activity relationship study

Resveratrol (1) is a m-hydroquinone found in red wine, which has antiinflammatory, cardiovascular protective (antiplatelet), and cancer chemopreventive properties. It is a potent peroxidase-dependent mechanism-based inactivator of COX-1, a desired target for antiplatelet agents, and has no similar effect on COX-2. Much attention has focused on resveratrol (1) as being the sole agent responsible for the cardioprotective effects associated with red wine consumption (commonly known as the "French paradox"). In this study we show that other red wine constituents, namely, the catechins (2, 3) and epicatechins (4, 5), act as peroxidase mediated mechanism-based inactivators of COX-1 but not of COX-2. Structure-activity relationships identify these agents as being as effective as resveratrol with respect to their ability to specifically inactivate COX-1. We show that resorcinol (6) is the minimum structure necessary for mechanism-based inactivation of COX-1. These findings imply that resveratrol is not the sole agent responsible for the antiplatelet activity of red wine and suggest that all dietary m-hydroquinones should be examined for cardioprotective effects.     

喻昌治疗中风经验

喻昌将中风病因分为内风和外风。辨证分为中经络、中脏腑两型。治法以祛风为主,兼填人体空窍,主要分为补虚熄风和清热除湿祛风。用药时注意金石之药的使用以堵塞风邪的入侵。主张节制房事以预防中风。