医院触摸屏查询系统的设计与开发

目的 设计和开发医院触摸屏查询系统。方法利用计算机网络、数据库技术和触摸屏硬件设备，采用PowerBuilder6．5编程实现。结果 医院触摸屏查询系统实现了多种功能，如药品、收费标准、特色专科、医院和医保政策介绍、门诊和住院费用查询等。在我院运行的一年多时间里，该系统极大地方便了病人，体现了“以病人为核心”的政策。结论 医院触摸屏查询系统方便实用，有利于完善医院信息系统(HIS)，实现医院管理的数字化、现代化。     

Nationwide Survey of Patients with Primary Immunodeficiency Diseases in Japan

To determine the prevalence and clinical characteristics of patients with in Japan, we conducted a nationwide survey of primary immunodeficiency disease (PID) patients for the first time in 30 years. Questionnaires were sent to 1,224 pediatric departments and 1,670 internal medicine departments of Japanese hospitals. A total of 1,240 patients were registered. The estimated number of patients with PID was 2,900 with a prevalence of 2.3 per 100,000 people and homogenous regional distribution in Japan. The male-to-female ratio was 2.3:1 with a median age of 12.8 years. Adolescents or adults constituted 42.8% of the patients. A number of 25 (2.7%) and 78 (8.5%) patients developed malignant disorders and immune-related diseases, respectively, as complications of primary immunodeficiency disease. Close monitoring and appropriate management for these complications in addition to prevention of infectious diseases is important for improving the quality of life of PID patients.     

Vaccination for Patients with Inborn Errors of Immunity: a Nationwide Survey in Japan

Journal of Clinical Immunology - We conducted a nationwide survey of inborn errors of immunity (IEI) in Japan for the second time in 10 years, focusing on protective measures for IEI...     

219例成人根管治疗患者牙科畏惧症调查

目的:调查成人根管治疗牙科畏惧症状况,为其干预治疗提供基线资料.方法:采用牙科焦虑症量表(dental anxiety scales,DAS)和根管治疗牙科畏惧症量表(root canal therapy dental fear scales,RCT-DFS)调查219例成人根管治疗患者.结果:219例成人根管治疗患者中,无牙科畏惧型占79.0%,畏惧璎占16.0%,高度畏惧型占5.0%,无病态畏惧型者.女性患者DAS得分高于男性(10.0±3.1/9.0±3.1,t=2.52,P=0.012),没有做定期检查者DAS得分高于定期检查者(9.9±3.1/8.1±3.0,t=3.35,P=0.001).不同职业、是否做过牙科手术治疗患者的DAS得分差异无统计学显著性(均P>0.05).回归分析显示独立诊室、普通诊室、社区诊室根管治疗患者的RCT-DFS评分均与受传播影响因素有关(β值=0.48、0.45、0.33),但均不受治疗环境因素的影响,独立诊室患者RCT-DFS评分还受到医生技术因素、医护服务因素、患者自身因素的影响(β=-0.16、-0.20、0.38);普通诊室和社区诊室还受到患者自身的经济(费用)因素的影响(β=-0.17、-0.21).三个治疗阶段RCT-DFS评分排序位于前三位的依次是医生的责任心、怕疼痛、关心治疗效果.结论:成人根管治疗牙科畏惧症的发生率较高,且与性别、是否作定期检查等牙科经历有关;牙科畏惧症可以在成人根管治疗人群中传播;其治疗的选择与患者的自身因素和经济因素有关.     

Correction to: Vaccination for Patients with Inborn Errors of Immunity: A Nationwide Survey in Japan

Journal of Clinical Immunology -     

非典型抗精神病药合并牛黄宁宫片致白细胞减少症的药物流行病学调查

目的评估非典型抗精神病药合并牛黄宁宫片导致白细胞减少症的风险性。方法对198例使用1种非典型抗精神病药的精神分裂症患者中白细胞减少症的发生情况,进行回顾性调查,收集人口学、临床诊断、牛黄宁宫片合并治疗史等资料,应用单因素、多因素非条件性logistic回归分析。结果合并牛黄宁宫片治疗组白细胞减少症发生率为39.5%,高于单一用药组的3.8%(P=0.000)。单因素、多因素非条件性logistic回归分析均提示,合并牛黄宁宫片治疗者发生白细胞减少症的风险高于未合并治疗组(分别OR=16.74、15.98,P=0.000)。结论非典型抗精神病药合并牛黄宁宫片治疗可显著增加白细胞减少症的发生风险。     

Investigating the Effectiveness,Acceptability and Impact on Healthcare Usage of Providing a Cognitive-Behavioural Based Psychological Therapy Service for Patients with Primary Antibody Deficiency

Purpose

Patients with primary antibody deficiency report poorer quality of life and higher rates of anxiety and depression than the general population. Cognitive-behavioral therapy has been shown to be a valuable treatment for patients with other long-term physical health conditions, improving well-being and enabling them to manage their symptoms more effectively. The aim of this project was to establish the feasibility and effectiveness of providing cognitive-behavioral based therapy to patients with primary antibody deficiency.

Methods

Forty-four patients completed a course of psychological therapy. Participants completed a series of self-report measures examining psychological and physical health, and service usage, prior to starting treatment and following their final session. They also provided feedback on their experience of treatment.

Results

Patients showed improvements in anxiety, depression, insomnia and fatigue. There was a high level of acceptability of the service and the potential for long-term cost savings to the NHS.

Conclusion

Psychological therapy based on the cognitive-behavioral model of treatment appears to be a valuable treatment for patients with primary antibody deficiency and comorbid mental health difficulties.

     

图像配准技术在图像引导放疗中的应用

简要介绍图像配准技术及其在图像引导放射治疗中的应用现状和研究进展情况。列举说明了目前常用的三种实现方法,包括自动靶区勾画快速计划以提升靶区剂量及降低正常组织照射剂量、在线校位以找到待治疗肿瘤的等中心位置并计算得到治疗床需要调节的参数、自适应放疗以快速判断放疗过程中解剖部位的变化、退缩和位移情况来调整靶区和优化剂量。在图像引导放疗中,充分了解配准的过程以及相关算法的准确性和局限性,依据常用的实现方法,结合不同的情况实际应用图像配准技术,可大幅提高放射治疗的精确度,因此图像配准技术近年来在图像引导放疗中应用日趋广泛。由于图像配准技术在实际应用中不存在金标准,需要用户根据自己的实际情况对不同病例进行图像配准算法的验证。本文对由此存在的问题进行了具体分析并对技术改进方向和应用前景进行了展望。     

A Psychosocial Study of Schizophrenic Patients Treated at a Nigerian Psychiatric Hospital

A study of the sociodemographic and psychological characteristics of schizophrenics treated at a psychiatric hospital in Nigeria over a period of six months was conducted along with a limited five-year follow-up. Male patients exceeded female (2:1) and 65.7 percent were below 30 years of age. Whereas there were more married female subjects than single, there were more single male subjects than married ones. However, single persons predominated. The majority (61.3 percent) either were illiterate or had low education and 52 percent were either unemployed or un-skilled. Paranoid and catatonic schizophrenia were the most common diagnostic subgroups. The short-term prognosis was very good in that 96.1 percent were greatly improved at the time of discharge. There was, however, a high default rate of 57.4 percent over a period of five years. Of those still attending, 73.5 percent remained improved. The sociocultural basis of some of the findings is discussed.     

Survey of veterinary professionals for antibodies to Bartonella henselae in Japan.

The seroprevalence of Bartonella henselae among veterinary professionals in Japan was investigated by means of an immunoperoxidase (IP) test that used protein A-horseradish peroxidase conjugate. Sera were obtained from 233 veterinary professionals in the Tokyo and Chiba areas. As negative control group, sera from 155 healthy individuals (all medical students) were used. As positive control group, sera from 5 patients highly suspected of cat scratch disease (CSD) by clinical symptoms were tested. Serum antibody titers of > or = 200 to B. henselae were presumed seropositive, because the titer at which about 95.5% of all healthy individuals (148 of the 155) were negative, and 2 of the 5 suspected CSD patients' serum antibody titers were > or = 200. Of the individuals in the veterinary professionals group tested, 35 of the 233 (15.0%) were seropositive for B. henselae. Females were nearly twice as likely as males to have antibodies to B. henselae in the veterinary professionals group. Our data suggest that Japanese veterinary professionals, and in particular younger females who are veterinary assistants and animal beauticians are more often infected by B. henselae.     

Monitoring of CRT-D Devices during Radiation Therapy in vitro

<正>Using of active cardiac medical devices increases steadily.In Europe,there were 183 implants of ICD and 944 implants of PM,119 of biventricular ICD and 41 of biventricular PM,all per million inhabitants in 2014.Healthcare environments,including radiotherapy treatment rooms,are considered     

Study of the Validity of a Questionnaire to Assess the Adherence to Therapy in Patients Infected by HIV

Abstract

Purpose: The purpose of our study was to examine the validity of a questionnaire to detect nonadherence in HIV-infected patients under antiretroviral treatment. Method: This was a cross-sectional study to validate a diagnostic test. Participants consisting of 242 HIV-infected patients were elected by consecutive sampling in a hospital in Madrid. The validation standard was the pharmacy dispensing records with the cut point being 80% and 90% of delivered drugs. Sensitivity (S), specificity (SP), positive predictive value (PPV), and positive likelihood ratio (PLR) of the questionnaire were estimated. Results: The mean age of the participants was 36.2 years old (SE 0.42), 55% were men, and 68.2% had used parenteral drugs. Eighty-three patients (34.3%) did not reach 80% of the prescribed dose and 129 patients (53.3%) did not reach 90%. In the 80% group, S was 25.3% (95% CI, 16.7%-36.2%),SP was 86.2% (95% CI, 79.6%-90.9%), PPV was 48.9% (95% CI, 33.5%-64.3%), and the PLR was 1.83 (95% CI, 1.07-3.13). In the 90% group, the S was 19.4% (95% CI, 13.4%-27.4%), SP was 84.0% (95% CI, 75.7%-90.0%), PPV was 58.1% (95% CI, 42.4%-72.6%), and PLR was 1.22 (95% CI, 0.70-2.12). Conclusion: The proposed questionnaire is not a reliable diagnostic method to detect nonadherence. It should only be incorporated into the daily clinical practice along with other methods of nonadherence measurement.     

Reaction to Intradermally Applied Phytohaemagglutinin in Asthma Patients in Relation to Corticosteroid Therapy

Phytohaemagglutinin (PHA) skin test (diameter of induration 24 h following intradermal injection of 1.0 (μg purified PHA) was carried out on 23 patients with exacerbated atopic asthma and 28 patients with exacerbated non-atopic asthma. Preselected adult patients had either not previously been treated with systemic corticosteroids or steroid therapy had been suspended for at least 3 months. Nearly all non-atopic asthma patients and patients with atopic asthma previously treated with corticosteroids showed increased reactions to PHA. Patients with atopic asthma not earlier treated with corticosteroids demonstrated normal responses. None of the asthmatics showed a negative PHA reaction. Administration of single depot doses of corticosteroids produced decreased reactivity to PHA in nearly all patients. These results suggest that neither atopic nor non-atopic asthma is in itself associated with impaired PHA skin reactivity but that changes in this reactivity are largely due to the corticosteroid therapy administered to these patients. In relation to PHA reactivity certain effects of this therapy may persist for as long as 3 months after its cessation.     

Cumulative Dose Response Study Comparing Clinical Effects of Two Doses of Terbutaline Sulphate Administered via a 750 ml Spacer to Asthmatic Patients

Thirteen out-patients suffering from chronic reversible bronchial obstruction were treated on two separate days with two doses of terbutaline aerosol, administered with a 750 ml spacer interposed between the actuator and the mouth, in order to evaluate whether clinical responses showed a dose dependency during a 4-h period. On each day the two different doses (65 μg versus 250 μg) were inhaled three times at 15-min intervals. Fifteen minutes after the first dose there was a significant difference in FEV₁ increase between the small dose and the normal dose, FEV1 being higher after 250 μg, but no significant differences in increase after the 2nd and 3rd inhalations. This study indicates that the bronchodilating effect of terbutaline administered via the spacer is dose-dependent at the first inhalation, and that succeeding inhalations show no dose-response effects.     

光动力治疗中激光辐射有效吸收剂量

光动力治疗中激光辐射有效吸收剂量郑蔚谢树森（福建师范大学激光研究所，福州３５０００７）ＡｂｓｔｒａｃｔＲｅｓｅａｒｃｈｅｒｓｔｙｐｉｃａｌｙｕｓｅｒａｄｉａｎｔｅｘｐｏｓｕｒｅｏｎｔｈｅｓｕｒｆａｃｅｏｆｔｉｓｕｅｔｏｅｖａｌｕａｔｅｔｈｅｌｉｇｈｔ...