Experimental vitreous tamponade using polyalkylimide hydrogel

Purpose  

To evaluate polyalkylimide as a possible vitreous tamponading agent.     

Level of education associated with ophthalmic diseases. The Beijing Eye Study

Objective  

To determine associations between educational level and ophthalmic diseases in Chinese.     

Refractive error, ocular and general parameters and ophthalmic diseases. The Beijing Eye Study

Objective  

To assess relationships between refractive error and ocular and general parameters.     

Glaucoma screening in Western Cameroon

Purpose  

To quantify glaucoma-related parameters in a rural African region.     

Verminderung der Lipidperoxidation und der Apoptoserate in kornealen Endothelzellen durch Vitamin?A

Hintergrund  

In dieser Arbeit wird der Einfluss von Vitamin A auf die Lipidperoxidation und Apoptoserate in kornealen Endothelzellen untersucht.     

Bilateral uveal melanoma in an arc welder

Purpose  

To report sequential bilateral uveal melanoma in an arc welder.     

Different types of optic disc shape in patients with advanced open-angle glaucoma

Purpose  

To study the characteristics of patients with advanced open-angle glaucoma.     

Body height and ocular diseases. The Beijing Eye Study

Background  

To determine whether body height is associated with ocular diseases.     

Occurrence of capsular delamination in the dislocated in-the-bag intraocular lens

Purpose  

To examine the lens capsules of dislocated in-the-bag IOLs.     

Conjunctivocystorhinostomy with Jones tube—is it the surgery for children?

Background  

To present experience with conjunctivocystorhinostomies (CDCR) at pediatric age.     

Clinical characteristics of patients with congenital high myopia

Background  

Four cases of congenital high myopia showing similar myopic fundus changes.     

Cryopreservation and long-term culture of transformed murine corneal endothelial cells

Purpose  

To characterize the morphology and gene expression of transformed murine corneal endothelial cells.     

Bilateral macular hole formation secondary to sclopetaria caused by shockwaves transmitted by a posterior vector: case report

Background  

Sclopetaria is a rare ophthalmic finding in trauma     

Choroidal metastasis from hepatocellular carcinoma,diagnosed by fine needle aspiration biopsy and treated by iodine-125 brachytherapy

Purpose  

To report a rare case of choroidal metastasis from hepatocellular carcinoma.     

Congenital rotated macula with good vision and binocular function

Background  

Two patients presented with congenital rotated macula with good vision and binocular function.     

The RELATION study: efficacy and safety of ranibizumab combined with laser photocoagulation treatment versus laser monotherapy in NPDR and PDR patients with diabetic macular oedema

Purpose

To assess efficacy and safety of intravitreal ranibizumab 0.5 mg plus laser (COMBI) versus laser monotherapy (LASER) in patients with visual impairment due to diabetic macular oedema (DME) in either nonproliferative diabetic retinopathy (NPDR) or proliferative diabetic retinopathy (PDR) and to analyse the relevance of inner versus outer retinal thickness.

Methods

In this double‐masked, multicentre phase IIIb study, patients (N = 128) were randomized (2:1) to receive COMBI (n = 85) versus LASER (n = 43). Patients received four initial monthly injections of ranibizumab 0.5 mg (COMBI) or sham (LASER) followed by pro re nata (PRN) injections. In both groups, patients received laser at baseline and additional laser at 3 monthly intervals, as needed. The study was started in 2010 and was prematurely terminated due to approval of ranibizumab for DME.

Results

The least squares (LS) mean change in mean best‐corrected visual acuity (BCVA) from baseline to month 12 was higher in the COMBI (6.5) versus LASER (2.3) group (LS mean difference: 4.2 [95% CI 0.9; 7.4] letters, p = 0.01, primary end‐point). There was also a tendency in the same direction for the subgroup of 26 patients with PDR (LS mean difference 14.7, p = 0.11). Mean central retinal thickness decreased by 107.3 μm in the COMBI group and by 80.3 μm in the LASER group from baseline to month 12 (p = 0.28). Ranibizumab was well tolerated.

Conclusion

This study showed that ranibizumab plus laser is a valuable treatment option for the management of DME. Patients with DME in PDR might also benefit from combined therapy compared to laser alone.     

Effect of trabeculectomy on ocular and corneal higher order aberrations

Purpose  

To examine the effect of trabeculectomy on ocular and corneal higher order wavefront aberrations.     

Optic disc analysis with Heidelberg Retina Tomography III in glaucoma with unilateral visual field defects

Purpose  

To find the optic disc features of asymmetric primary open-angle glaucoma.     

Continuous changes in macular morphology after macular hole closure visualized with spectral optical coherence tomography

Background  

To report on changes in retinal morphology during the 12 months after macular hole surgery.