Descriptive Study of Enzootic Nasal Adenocarcinoma in Goats in Southwestern China

This is the first report on enzootic nasal adenocarcinoma (ENA) in goats (Nanjiang Yellow goats and Jianyang Big‐ear Black goats) in southwestern China. The clinical, histological and ultrastructural features of ENA in goats were described. From July 2007 to May 2009, 21 cases of ENA in goats, from 6 months to 8 years old, were diagnosed solely in one big herd. Clinically, the affected goats showed nasal discharge, facial swelling, sneezing, stertorous breathing and weight loss. Tumours that originated from the ethmoid area of the nasal cavity were unilateral (18/21) or bilateral (3/21). All tumours were classified as low grade adenocarcinomas by histopathological examination and were displayed a combination of tubular and papillary growth. No metastases were detected in regional lymph nodes, brain or other organs. Ultrastructurally, virus‐like particles with an average diameter between 80 and 110 nm were observed in 5/7 examined tumours.     

Efficacy of an Immune Modulator in Enzootic Pneumonia of Dairy Calves

The objective of this cohort study was the evaluation of the efficacy of an immune modulator in the prophylaxis, metaphylaxis and treatment of enzootic bronchopneumonia (EBP). A total of 552 dairy calves on 13 farms were included. Groups of calves were included in the study if the prevalence of respiratory disease on the first visit was at least 50 %, and the number of animals aged 2–16 weeks was at least 10. Controls were treated with a placebo. Animals of both groups were treated antibiotically if body temperature exceeded 39.5°C. A clinimetric system was devised and used for classifying the animals into one of seven categories (healthy, beginning respiratory disease, acute BP, subacute BP, chronic BP, acute flare-up of chronic BP, and other disease). Animals were examined clinically on days 1, 3, 10, and 28. In animals treated prophylactically, the incidence of BP on day 10 was significantly higher (51 %) than in those that received the placebo (31 %). In animals treated metaphylactically, the average number of treatment days was significantly lower (2.86) than in the placebo group (3.81). In animals treated therapeutically, the incidence of EBP on day 10 was significantly lower than in the placebo group.     

Adenocarcinoma in Barrett's esophagus

The association of adenocarcinoma with Barrett's esophagus stimulated a review of our experience to study the clinical presentation, pathology, and results of management. Nineteen patients (15 men and four women) satisfied the criteria of primary adenocarcinoma arising in columnar epithelium in the esophagus. The majority had dysphagia (95%) and weight loss (63%). Nearly three fourths of the patients also had a history of hiatus hernia or esophagitis. Diagnosis was confirmed preoperatively in all by endoscopic biopsy and/or cytologic study. Potentially curative resection was performed in 15 patients and palliative procedures in four. Fourteen patients had advanced (Stage III) disease and only five had Stage I or II disease. Multicentric disease within the esophagus was found in seven patients. Postoperative complications included empyema, hemothorax, and pneumonia (one case each). The only postoperative death resulted from complications of previously undetected brain metastases. The median survival of the 15 patients having resection for cure is 12 months. Four are alive, one with disease at 46 months and three free of disease at 19, 87, and 93 months. All four patients undergoing palliative procedures died within 8 months. The study demonstrates that multifocal presentation of the tumor is common in this group of patients and that long-term survival is possible when early tumors are managed aggressively.     

Biphasic Low-Grade Nasopharyngeal Papillary Adenocarcinoma with a Prominent Spindle Cell Component: Report of a Case Localized to the Posterior Nasal Septum

A case (female, 39 years of) of thyroid-like nasopharyngeal low-grade papillary adenocarcinoma with a significant spindle cell component is presented. The tumor was located on the posterior nasal septum. The spindle cells displayed nuclear features very much similar to the epithelial component and the two cell types merged imperceptibly. Immunohistochemically, the neoplastic cells (including the spindle cell component) were strongly and diffusely positive for TTF-1, cytokeratins (AE1-3), cytokeratin 19 and vimentin. C-kit immunohistochemistry showed diffuse mild to moderate membranous positivity with focal areas displaying moderate to strong immunoreactivity. EMA was strongly positive in the epithelial component with membranous and cytoplasmic reactivity whereas the spindle cell component was weakly although diffusely positive. Carcinoembryonic antigen, calcitonin, chromogranin A, S100-protein, thyroglobulin, cdx2 and p63 were negative. The proliferative activity (Mib-1/Ki-67) was low; 3–4%. In the molecular genetic study we found no mutations at position 1799 (exon 15) in the BRAF-gene, (BRAFV600E) or in exons 9 and 11 of the KIT-gene.     

Adenocarcinoma in Retroperitoneal Teratoma

We report a rare case of adenocarcinoma in retroperitoneal teratoma in a 38 year old female patient who attended surgical OPD with complaints of dragging pain and heaviness in left lumbar region. Straight x-ray abdomen showed few irregular calcifications in left lumbar region. USG and CT showed it to be adrenal tumor and retroperitoneal teratoma respectively. Excised specimen confirmed it as mucin secreting adenocarcinoma in a case of retroperitoneal teratoma.     

鼻唇沟皮瓣修复鼻尖及鼻翼缺损的效果

目的 探讨在鼻尖及鼻翼缺损治疗中应用鼻唇沟皮瓣修复的效果。方法 选取2018年6月-2022年 6月我院收治的82例鼻尖及鼻翼缺损患者作为研究对象,均采用鼻唇沟皮瓣修复术治疗,观察并发症发生 情况及治疗满意度,并对患者治疗前后的生活质量进行比较。结果 82例患者皮瓣成活状况均良好,未出 现静脉回流障碍、皮瓣血供障碍等并发症,治疗满意度为96.34%;治疗后躯体功能、躯体角色、活力、社 会功能、情绪角色、心理健康、总健康评分均高于治疗前,差异有统计学意义（P ＜0.05）。结论 鼻唇沟 皮瓣修复鼻尖及鼻翼缺损的效果良好,可有效改善患者的生活质量,且术后并发症发生几率较小,患者满 意度较高。但由于个体差异不同,手术治疗时还需根据患者自身情况制定科学的、合理的治疗方案。     

Adenocarcinoma of bladder

Twenty-five patients with pure primary adenocarcinoma of the bladder were treated in a fifteen-year period. Practically all patients presented with some combination of gross hematuria, irritative lower urinary tract symptoms, or obstruction. Almost half the lesions were at the dome of the bladder. Most of the lesions were high grade and invasive. Transurethral resection is, at best, only diagnostic and palliative, and radiotherapy has been of little value. Radical cystectomy seems to produce five-year survival almost twice that of segmental resection. However, solitary lesions at the dome of the bladder, which usually represent neoplasia in a urachal remnant, seem to behave somewhat differently from lesions elsewhere in the bladder. Indeed, five-year survival of patients with lesions at the dome of the bladder who underwent segmental resection approximated that of those with similar lesions who underwent total cystectomy.     

Nasal fractures in children

Summary A group of thirty children with nasal fractures was evaluated retrospectively by means of a questionnaire and hospital records. Age at the time of injury ranged from age 3 to 12 (mean = 8.6) years and mean follow-up period was 9 years. Eight patients reported some degree of nasal obstruction post reduction, but only one patient required submucous resection and two patients underwent septorhinoplasty for appearance. No patients reported class III malocclusion, or required orthodontic treatment or maxillofacial corrective surgery for maxillary hypoplasia. We concluded that a childhood nasal fracture treated by closed reduction does not have deleterious effects on facial or nasal growth.This work was supported in part by the Brigham Surgical Group Foundation, Inc., Boston, Massachusetts, USA     

Renal transplantation in Slovenia after joining Eurotransplant.

BACKGROUND: This report presents data on renal transplantation in Slovenia before and after joining Eurotransplant (ET). METHODS: Slovenia (population: 2 million) has one renal transplant centre. The establishment of an appropriate national transplantation organization resulted in an increase in transplantations and the acceptance of Slovenia into ET at the beginning of 2000. Current immunosuppression is composed of cyclosporin (Neoral), mycophenolate mofetil, methylprednisolone and anti-interleukin-2 receptor monoclonal antibodies. RESULTS: By the end of 2004, 607 renal transplantations had been performed. From 1970 to 1998, 124 patients were given living related donor kidneys. From 1986 to 1999, 239 patients received renal grafts from deceased donors. From 2000 to 2004, 244 patients were transplanted from deceased donors. In 2004, 55 renal transplantations were carried out. One hundred and forty one (57.8%) renal grafts were shipped from other ET countries. The HLA-antigen mismatch of 2.8+/-1.1 was not significantly different from what it was before 2000. Up to 31 December 2004, the 1- and 3-year patient survival rates were 98.3% and 96.0%, respectively. The concomitant graft survival rates were 95.8% and 93.5%, respectively. CONCLUSIONS: In the ET era, the number of deceased donor renal transplants per year was 2.8 times higher than in the 14 years before. In 2004, we reached the average number of deceased donor renal transplants per million population of ET. Although tissue compatibility in these recipients was not significantly better than it was before the ET era, it would have been much worse had we not joined ET. Short- and medium-term results in the ET era have been entirely comparable to those in large reports.     

改良鼻外侧截骨术治疗歪鼻畸形的临床疗效

目的 分析对歪鼻畸形患者采用改良鼻外侧截骨术治疗的效果。方法 选取2022年11月-2023年12月 南京市玄武艺星医疗美容门诊部收治的90例歪鼻畸形患者,按治疗方法不同将患者分成参比组（45例）和 研究组（45例）。参比组行不对称驼峰锉削术治疗,研究组行改良鼻外侧截骨术治疗,比较两组鼻外形偏 斜值、鼻塞情况、鼻整形美观度以及不良反应发生情况。结果 两组治疗后鼻外形偏斜值低于治疗前,且 研究组低于参比组（P＜0.05）;两组治疗后VAS评分低于治疗前,且研究组低于参比组（P ＜0.05）;两组 治疗后ROE评分高于治疗前,且研究组高于参比组（P ＜0.05）;两组不良反应发生率比较,差异无统计 学意义（P＞0.05）。结论 针对歪鼻畸形患者,改良鼻外侧截骨术可改善其鼻外形偏斜、鼻塞情况,且鼻 整形美观度较高,具有较高安全性。     

Adenocarcinoma of the colon in adolescents

A retrospective study was carried out in nine children between the ages of 10 and 20 years with adenocarcinoma of the colon. No family history, significant medical history, or predisposing factors were identified, except for Turcot's syndrome in one child. Common presenting signs and symptoms were vague abdominal pain, nausea and vomiting, weight loss, change in bowel habits, and guaiac-positive stools. Five of the patients' diagnoses were delayed for an average of 11.6 months, the majority of whom had Dukes' D disease. Their median survival was 4 months compared with 24 months in the four patients diagnosed early. As with adults, the mainstay of therapy is operation. Our data indicate that an increased awareness and consideration of colon cancer in children will result in earlier diagnosis, a more favorable disease stage, and prolonged survival.     

Predictors of Survival in Sinonasal Adenocarcinoma

Objectives To identify factors associated with disease-specific survival (DSS) in intestinal and nonintestinal sinonasal adenocarcinoma. Design Retrospective review. Setting Surveillance Epidemiology and End Results database. Participants Adult patients with sinonasal adenocarcinoma. Main Outcome Measures DSS. Results We identified 325 patients; of these, 300 had the nonintestinal type and 25 had intestinal type histologies. The 5-year DSS rates for patients who had no treatment, radiation (RT), surgery, and surgery and postoperative RT were 42.5, 46.1, 85.6, and 72.6%, respectively (log-rank test; p < 0.001). Black race, age ≥ 75 years, paranasal sinus involvement, and high grade were independently associated with decreased DSS. Compared with RT, surgery (hazard ratio [HR]: 0.34; 95% confidence interval [CI]: 0.15–0.77), and adjuvant RT (HR: 0.47; 95% CI, 0.26–0.86) were associated with improved DSS. Conclusions There is no difference in prognosis between intestinal and nonintestinal subtypes of sinonasal adenocarcinoma. Treatment with surgery alone or adjuvant RT is associated with a more favorable prognosis.     

Adenocarcinoma of the kidney in childhood

Renal adenocarcinoma in children is a rare tumor. A case report is presented and review of the available literature. There is no difference in symptomatology, therapy and prognosis between children and adults.