腹腔间隔室综合征动物模型的构建特点

背景：腹腔间隔室综合征导致多器官功能损害的具体机制尚不十分清楚,为深入研究其发病机制及病理生理过程,需要合适的动物模型。目的：就腹腔间隔室综合征动物模型的制备过程中可能遇到的相关问题进行讨论,包括制备模型的标准、方法、动物的选择及监测腹压的方式。方法：由第一作者检索PubMed数据及CNKI数据库1990/2011有关腹腔间隔室综合征及腹腔高压及相关动物模型方面的文献。结果与结论：一个成功的腹腔间隔室综合征动物模型最好能保持腹腔压力的稳定,并能持续一定的时间,同时尽可能少的影响实验结果。所以无论选择腹腔灌注气体还是灌注液体模型的测量腹腔内压并维持压力的稳定是关键。腹腔灌注液体模型无法动态监测腹压,且压力波动较大,与之相比腹腔灌注气体模型测压较为方便,若使用电子供气系统动态监测则更为理想。生理模型是前瞻性的实验,但现有的生理模型有待改进。     

腹腔间隔室综合征动物模型的构建特点

背景:腹腔间隔室综合征导致多器官功能损害的具体机制尚不十分清楚,为深入研究其发病机制及病理生理过程,需要合适的动物模型。目的:就腹腔间隔室综合征动物模型的制备过程中可能遇到的相关问题进行讨论,包括制备模型的标准、方法、动物的选择及监测腹压的方式。方法:由第一作者检索PubMed数据及CNKI数据库1990/2011有关腹腔间隔室综合征及腹腔高压及相关动物模型方面的文献。结果与结论:一个成功的腹腔间隔室综合征动物模型最好能保持腹腔压力的稳定,并能持续一定的时间,同时尽可能少的影响实验结果。所以无论选择腹腔灌注气体还是灌注液体模型的测量腹腔内压并维持压力的稳定是关键。腹腔灌注液体模型无法动态监测腹压,且压力波动较大,与之相比腹腔灌注气体模型测压较为方便,若使用电子供气系统动态监测则更为理想。生理模型是前瞻性的实验,但现有的生理模型有待改进。     

Psychiatric drug-induced fatal abdominal compartment syndrome

Several drugs used in psychiatry may induce constipation, paralytic ileus, or acute megacolon (Ogilvie's syndrome). We report here 2 cases of patients presenting with fatal abdominal compartment syndrome related to the absorption of antidepressants and benzodiazepines. Two patients (a 27-year-old man and a 57-year-old woman) with a previous psychiatric history and treatment with psychiatric drugs were admitted to the emergency department for coma. Both presented hypothermia; a hard, distended abdomen; and ischemia of the lower limbs. In both cases, the abdominal scan showed massive colonic dilatation without mechanical obstruction; there was even aortic compression and ischemia of the abdominal viscera. Emergency laparotomy with bowel decompression was performed in both cases, but multiple organ failure led to death in both patients. Psychiatric drugs may induce acute severe megacolon with life-threatening abdominal compartment syndrome.     

急性腹腔间室综合征及其护理

论述了急性腹腔间室综合征(ACS)的形成原因、发病率、病理生理改变、临床表现及其预防、治疗与护理要点。对于各种原因导致急性腹内压增高的病人,强调早期、动态监测腹内压,采取各种措施降低腹内压,维持循环、呼吸等系统和肾脏的功能,防止发生下肢静脉受阻、全身炎症过度性反应、多器官功能障碍综合征(MODS)和脓毒血症;当腹内压>25mmHg时,应考虑实施剖腹手术敞开腹腔,以迅速降低腹内压。     

腹腔间室综合征的护理进展

腹腔间室综合征(ACS)是由于各种原因引起的腹腔内压力(IAP)急剧升高到一定程度后,引起了包括心、肺、肾、脑、胃肠等多器官、多系统的病理生理改变所形成的一种临床综合征[1]。1984年,Kron等[2]首次提出腹腔间室综合征这一名词;1997年Meldrum等[3]将ACS定义为IAP大于20mmHg(1mmHg=0.133kPa)并伴发以下情况之一:①呼吸系统表现为气道峰压(PAP)大于40cmH2O(1cmH2O=0.098kPa)。②循环系统表现为氧输送指数(DO2I)小于600ml O2/min·m2。③泌尿系统表现为尿排出量(UO)小于0.5ml/(kg·h)。据文献报道,在ICU收治的患者中,腹内高压(I…     

Managing trauma patients with abdominal compartment syndrome

ACS is due to a rapid increase in intra-abdominal pressure. Although ACS may occur in both surgical and nonsurgical patients, patients who have abdominal or pelvic trauma and/or require massive fluid replacement are at increased risk. Critical care nurses are in a unique position to recognize early signs and symptoms of increased intra-abdominal pressure to ensure timely intervention. Aggressive hemodynamic, pulmonary, and operative management is essential for the optimal outcome of patients with ACS. Without definitive treatment, multisystem organ dysfunction and death ultimately ensue.     

腹腔间室综合征临床研究进展

从腹腔间室综合征的概念、发病机制、特点、诊断、防治、开腹减压术指证、术后护理等方面介绍了腹腔间室综合征的临床研究进展。     

腹腔间室综合征临床研究进展

从腹腔间室综合征的概念、发病机制、特点、诊断、防治、开腹减压术指证、术后护理等方面介绍了腹腔间室综合征的临床研究进展.     

A critical care nurse's guide to intra abdominal hypertension and abdominal compartment syndrome.

Abdominal compartment syndrome (ACS) is a life-threatening syndrome that is increasing in incidence amongst critically ill patients. A 2005 survey of critical care nurses revealed that there were recognised knowledge deficits of ACS amongst surveyed nurses. The purpose of this review is to inform critical care nurses about ACS and its antecedent, intra abdominal hypertension (IAH). Detection techniques, causes, clinical manifestations and pathophysiology of IAH and ACS will be outlined and medical and nursing management will be reviewed. The incidence of ACS is reported to be up to 35% in the intensive care population with reduced survival when compared to other intensive care patients. Physiological changes that occur with ACS include compromise to the cardiovascular, respiratory, renal and neurological systems and development of metabolic acidosis. Management may incorporate percutaneous drainage of ascitic fluid, use of muscle relaxants, prone positioning and surgical intervention to open, decompress and gradually close the abdomen. Throughout this care the critical care nurse should ensure accurate monitoring of organ function, assessment for recurrence of ACS as well as the amount and type of drainage, appropriate wound management and provision of physical and psychosocial support of the patient. These aspects of care have the potential to impact significantly on patient outcome.     

腹腔室隔综合征病人的护理

介绍了腹腔室隔综合征(ACS)发生的高危因素,ACS的监护应重点加强腹内压及胃肠黏膜pH值测定,严密监测循环系统、肺功能以及肾功能,预防肺栓塞、伤口感染等并发症发生。     

腹腔室隔综合征病人的护理

介绍了腹腔室隔综合征（ACS）发生的高危因素，ACS的监护应重点加强腹内压及胃肠黏膜pH值测定，严密监测循环系统、肺功能以及肾功能，预防肺栓塞、伤口感染等并发症发生。     

Pathophysiology and management of abdominal compartment syndrome.

Abdominal compartment syndrome is a potentially lethal condition caused by any event that produces intra-abdominal hypertension; the most common cause is blunt abdominal trauma. Increasing intra-abdominal pressure causes progressive hypoperfusion and ischemia of the intestines and other peritoneal and retroperitoneal structures. Pathophysiological effects include release of cytokines, formation of oxygen free radicals, and decreased cellular production of adenosine triphosphate. These processes may lead to translocation of bacteria from the gut and intestinal edema, predisposing patients to multiorgan dysfunction syndrome. The consequences of abdominal compartment syndrome are profound and affect many vital body systems. Hemodynamic, respiratory, renal, and neurological abnormalities are hallmarks of abdominal compartment syndrome. Medical management consists of urgent decompressive laparotomy. Nursing care involves vigilant monitoring for early detection, including serial measurements of intra-abdominal pressure.     

腹腔室隔综合征的早期急诊处理

目的 总结腹腔室隔综合征(ACS)的诊断和早期急救治疗经验。方法 11例均以间接腹腔测压和临床特征得出诊断,行早期剖腹腹腔和胃肠腔内减压引流术和非手术治疗 结果 1例死于术后呼吸功能衰竭,1例死于伤口全层裂开腹腔内感染性休克,2例死于MODS,死亡率为36.3％,7例治愈出院 结论 动态监测腹腔内压和全身变化是发现ACS的关键,并有助于手术指征和时机的确定,一旦确诊,尤其是中、重度ACS应早期开腹充分减压引流,才可望改善预后     

5例腹腔间室综合征病人的护理

腹腔间室综合征(abdominal compartment syndrome,ACS)是因各种原因引起腹内高压导致心血管、肺、肾、胃肠道及颅脑等功能障碍或衰竭的综合征[1],常发生于肠梗阻、腹腔出血、腹部闭合性损伤、出血性胰腺炎、腹腔感染等情况时.临床上以严重腹胀合并少尿、呼吸窘迫为主要特征,若得不到及时有效的处理,往往导致心血管、肺、肾、内脏和颅脑等脏器的功能障碍或衰竭导致病人死亡.我科自2007年以来收治了5例重度ACS的病人,现将护理介绍如下.     

腹腔筋膜室隔综合征的监测与护理

腹腔筋膜室隔综合征(ACS)又称腹腔室隔综合征、腹腔高压综合征,是由各种原因,进而导致的腹内压(IAP)进行性、急剧升高而影响腹腔内组织器官的血液循环,进而导致的一种临床综合征。其病死率较高,国外文献报道为62.5%～75.0%[1]。如果不予以严密监测、积极治疗、细致的护理,将引起致命性的器官功能衰竭。因此,护理人员及早发现ACS的早期症状和体征,以便及时诊断和治疗,是预防多器官功能衰竭和死亡的关键。2002年,我科共收治15例ACS患者,经对症治疗、严密的病情监测和精心护理后,除1例因原发病死亡外,其余均治愈出院,现报道如下。临床资料…