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缫丝女工月经失调病因分析陈岳生(安岳县卫生防疫站)报道:1988年6月对安岳县缫丝厂710名缫丝女工月经失调情况作(?)调分析,结果月经失调306人(43.1%),其中以痛经和周期紊乱为多。劳累、情绪变化,纺织噪声、睡眠不足、工作时间过长等对女工月经失调有明显影响。     

噪声影响女工月经周期的Meta-分析

目的 通过对国内1979～2000年发表的生产性噪声对女工月经影响的研究结果进行Meta-分析,探讨噪声对女工月经影响的作用规律.方法 应用Meta-analysis方法的Stouffer法和Winner法,对<中国生物医学文献数据库>及<中文生物医学期刊文献数据库>的相关文献进行分析.结果 Meta-分析观察到在较高噪声接触水平下噪声对女工月经周期有影响,月经周期紊乱的危险性随着暴露噪声强度的增高而增加,观察到剂量一反应关系.结论 噪声对女工月经周期有不良影响,存在剂量一反应关系.     

纺织作业噪声对女工月经的影响及防治

<正> 为进一步了解噪声对女工月经的影响,1985年我们对某市棉纺织厂786名纺织女工的近半年的月经情况进行了调查。调查对象及方法一、对象以噪声声强级高的103分贝的布机车间229名女工为调查组,噪声90分贝以下符合国家卫生标准的557名女工为对照组。两组女工的婚姻、年龄、工龄等情况基本相同。二、判定标准(一)月经病是指月经异常、痛经、经前紧张症有一项以上者。(二)月经异常是指经量、经期、周期异常具有一项以上者。(三)痛经是指经期必须使用止痛药或休假者。(四)经前紧张症是指经前具有较重的     

噪声对纺织女工月经功能影响的调查

目的 为研究探讨噪声对纺织女工月经功能的影响。方法 对接触不同噪声强度的织布和细纱车间192名女工的月经功能进行问卷调查,并同对照组进行比较。结果 织布车间女工月经异常率显著高于细纱车间(P<0.05)和对照组相比差异有非常显著性(P<0.01),且有随着工龄增长有增高的趋势(P<0.05),提示接触高强度噪声织布车间对女工月经功能有一定的影响并与工龄有关。结论 应加强该车间噪声治理和女工卫生保健。     

1200例女档车工月经状态分析

本文调查１２００名女档车工月经状态,包括月经周期延长、缩短、紊乱,经期延长,减少,痛经等情况。结果显示女工长期暴露强噪声会对月经功能状态产生不良影响,尤其是痛经及经量增多在接触噪声时间短（～３年）的女工发生率高,随着工龄的增长发生率下降。     

采油高压注水泵噪声及其对作业女工健康影响的调查

[目的]了解采油高压注水泵噪声强度及其对作业女工健康的影响,为采取防制措施提供科学依据。[方法]2002年对胜利油田胜利采油厂15个采油高压注水泵房进行噪声测定,对 112 名作业女工进行听力、心电图检查与内科体检。[结果]噪声强度为86 9~96 1 dB(A);112名接噪工人中听力损伤、痛经、月经周期不稳定、窦性心率不齐检出率较高,均高于对照组(P<0 05)。[结论]噪声对作业女工听力、心血管系统及月经均有不同程度的影响。     

视屏作业对女工月经影响的调查

对２２８名视屏作业女工进行了月经史调查。结果表明，视屏作业女工月经异常发生率均高于对照组，尤其以月经周期紊乱、经期延长和痛经为明显。女工月经异常发生率与工龄有一定规律变化。     

长期站立作业对女工月经功能的影响

[目的]了解长期站立作业对机械加工女工月经功能的影响.[方法]对1285名机加工女工进行了问卷调查,并选取对照组进行比较.[结果]月经异常率观察组(52.53%)明显高于对照组(35.69%),P＜0.001,其中痛经发生率观察组为24.82%,对照组为20.14%,两者差异有非常显著性.月经异常率随工龄增长有增高趋势.[结论]长期站立作业对机加工女工的月经功能有一定的影响,其中以痛经为著,且与工龄有一定关系.局部冲洗可以有效地减少月经异常的发生.     

工业噪声对女工月经及生殖机能的影响

目的研究工业噪声对女工月经及生殖机能的影响。方法对1536名接触工业噪声的育龄女工进行生殖流行病学调查,并选取对照组进行比较。结果工业噪声可使女工各月经异常指标、妊高症、早产、自然流产的发生率明显增高,脉冲噪声还可使女工先兆流产、低体重儿的发生率增高。结论必须重视工业噪声对女工月经及生殖机能的影响,加强女工的劳动保护。     

纺织噪声对女性生殖功能及子代发育影响的调查

为了解纺织噪声对女性生殖功能及子代发育的影响 ,选择纺织噪声作业工龄 >1a的女工 81 3人为观察对象 ,另选商场女营业员 1 6 0人为对照组。对两组女工的生殖功能 (月经、妊娠经过和妊娠结局 )及子代发育状况进行了对比分析。结果表明 ,在布机车间平均噪声强度超标的作业条件下 ,接噪组女工的月经异常率、痛经患病率及妊娠贫血、自然流产、妊娠高血压综合征的发病率均高于对照组 ,差异具有显著性 (P <0 0 1 ,P <0 0 5 )。接噪组的足月低体重儿、智力低下儿的发生率与对照组相比 ,差异有显著性。提示 ,纺织噪声对女性生殖功能及子代发育有一定的影响     

经腹超声检测原发性痛经子宫动脉血流动力学研究

目的:经腹超声(TBUS)检测未婚少女原发性痛经(Primary Dysmenorrhea,PD)子宫动脉血流动力学改变,探讨痛经程度与子宫血流灌注的相关性。方法:54名PD未婚少女和41名正常对照者在月经周期第一天经腹超声检查,记录子宫动脉、弓状动脉、放射动脉、螺旋动脉的搏动指数(PI)与阻力指数(RI),按《中药新药治疗痛经的临床研究指导原则》进行痛经积分和痛经程度判定。结果:中度组、重度组与对照组比较在月经期第一天子宫动脉较细分支血流阻力较高;螺旋动脉的搏动指数、阻力指数与痛经积分具有一定相关性。结论:经腹超声能够检测到未婚少女子宫动脉血流参数;PD月经周期第一天子宫动脉灌注阻力高;PD严重程度与螺旋动脉的搏动指数、阻力指数相关。     

The relationship between smoking and dysmenorrhea: A meta-analysis

Many studies have investigated the potential association between smoking and dysmenorrhea. However, results from such studies have been inconsistent. In this study, we assessed the association between smoking and dysmenorrhea by meta-analysis. We performed a systematic search of the international databases, including PubMed, Scopus, Web of Science, EBSCO and Google Scholar by the MeSH heading and/or additional terms to obtain relevant studies published from 1990 until 2017. I² statistics were used to assess heterogeneity. Pooled effects size was obtained using a random effects model. Subgroup analyses were also conducted. Data were analyzed through Stata software version 12 (Stata Corp, College Station, TX, USA). A total of fourteen studies were included in meta-analysis. A significant positive association was observed between current smoking and dysmenorrhea in both the unadjusted (odds ratio [OR] = 1.60; 95 percent confidence interval [CI]: 1.35, 1.85) and adjusted models (AOR = 1.44; 95 percent CI: 1.18, 1.69). Also, the association between current smoking and primary dysmenorrhea was significant only in the unadjusted model (OR = 1.53; 95 percent CI: 1.21, 1.85). The pooled effects size showed a significant association between smoking and dysmenorrhea in the fourteen eligible studies. This provides a new approach for prevention from dysmenorrhea in females for policymakers.     

TGF-β_1与子宫腺肌病痛经的相关性研究

目的:从蛋白水平检测TGF-β1在腺肌病病灶及内膜组织的表达,了解其与痛经强度的相关性。方法:采用免疫组化法检测TGF-β1在子宫腺肌病病灶、腺肌病在位内膜和肌瘤组内膜组织中的表达。结果:免疫组化显示腺肌病异位内膜、在位内膜及对照组内膜组织TGF-β1表达无月经周期性变化,且腺肌病组异位内膜TGF-β1表达强于腺肌病组在位内膜及对照组内膜组织,同时与痛经强度评分呈正相关。结论:腺肌病病灶TGF-β1呈高表达,与患者痛经程度呈正相关,但不随月经周期变化,提示腺肌病病灶局部TGF-β1合成增多与痛经关系密切。     

噪声与高血压关系的Meta-分析

目的应用Meta-分析方法,对1980年以来所发表的关于生产性噪声与高血压关系的流行病学研究进行分析,由此提供噪声与高血压因果关系的线索,进一步确定噪声与高血压的关联。方法应用Meta-分析方法对《中国生物医学文献数据库》及英文MEDLINE光盘数据库相关文献进行分析。结果分析结果显示,噪声与高血压有关联,合并指标d值和r值均为正值,合并OR值为1.831。结论噪声与高血压患病率有正向关联,特别是以听力损伤为生物标志物推断累积噪声接触,较易得出噪声接触与血压之间有关联的阳性结果。     

青少年痛经与子宫内膜异位症的关系

子宫内膜异位症(endometriosis,EMs)是女性常见的妇科疾病,痛经、慢性盆腔痛及不孕是其主要临床表现.EMs的发病机制尚不清楚,但EMs相关暴露因素和发生、发展可贯穿女性一生,对女性生命健康造成严重的负面影响.痛经是青少年女性最常见的月经症状,EMs是青少年继发性痛经最常见的原因.青少年痛经与EMs的诊断密...     

Relationship between noise annoyance from road traffic noise and cardiovascular diseases: a meta-analysis

Road traffic noise is an important source of noise annoyance in the community. We performed a meta-analysis to assess whether there is an association between noise annoyance from road traffic noise and cardiovascular diseases (arterial hypertension and ischemic heart disease) in adult population. The meta-analysis included studies that: a. had noise annoyance as exposure, quantified either as "annoyed versus non-annoyed" or with various scales collected by standardized questionnaires; b. arterial hypertension or ischemic heart disease as outcome; c. had included only adult population (age >18 years); d. the studies had to have as effect size odds ratios or relative risk. From the individual studies those odds ratios were selected for meta-analysis which compared most distant categories. Eight studies that fulfilled criteria published between 1992 and 2006 were included in the meta-analysis: 6 studies had a cross-sectional design, 1 study had a case-control-design and 1 study had a cohort design. Increased annoyance was significantly associated with arterial hypertension (pooled risk estimate = 1.16, 95% confidence interval 1.02-1.29) while the association with ischemic heart disease did not reach statistical significance (pooled risk estimate = 1.07, 95% confidence interval 0.99-1.14). No publication bias was evidenced. The results of this meta-analysis demonstrated the existence of a positive and significant association between noise annoyance from road traffic and the risk of arterial hypertension and a positive yet insignificant association between noise annoyance and the risk of ischemic heart disease.     

OTR、ER在子宫腺肌病中的表达及与痛经的关系

目的:探讨OTR、ER在子宫腺肌病患者在位及病灶组织中的表达及其与痛经的关系。方法:采用免疫组化法检测30例子宫腺肌病在位和异位内膜中OTR、ER的表达,以子宫正常肌层组织和在位内膜为对照。结果:在子宫腺肌病灶组织中OTR、ER的表达高于在位内膜组及对照组(P<0.05);在子宫腺肌病组的在位内膜和病灶组织中,痛经组OTR、ER的表达高于无痛经组及对照组(P<0.05);在不同痛经程度分组中OTR、ER的表达依次降低。在子宫腺肌病的在位内膜和病灶组织中,OTR、ER两者之间存在正相关关系。结论:子宫腺肌病组织中OTR、ER的表达随痛经程度增强而增加,在子宫腺肌病痛经的发生与发展间可能存在协同作用。     

Prospective study of exposure to environmental tobacco smoke and dysmenorrhea

Dysmenorrhea is a common gynecologic disorder in women of reproductive age. Previous studies have found an association between current cigarette smoking and prevalence of dysmenorrhea. This study investigated the association between exposure to environmental tobacco smoke (ETS) and the occurrence of dysmenorrhea among women without a history of this disorder. The study population consisted of 165 newly wed, nonsmoking Chinese women (in Shenyang, China), who intended to get pregnant and who had no past history of dysmenorrhea at the time of enrollment. These women completed a baseline questionnaire interview upon enrollment and were prospectively followed by daily diary. Dysmenorrhea was defined as a diary recording of abdominal pain or low back pain for at least 2 days during a menstrual period. A subject's ETS exposure was defined as the mean number of cigarettes smoked per day at home by household members over an entire menstrual cycle before the menstrual period. A logistic regression model was used to assess the effect of ETS on the risk of dysmenorrhea, with adjustment for age, body mass index, education, season, area of residence, occupation, shift work, perceived stress, passive smoking at work, and occupational exposure to chemical hazards, dust, and noise. Generalized estimating equations were used to account for autocorrelations as a result of multiple cycles per subject. This report is based on 625 prospectively followed menstrual cycles with complete baseline and diary data. ETS exposure was reported in 77% of cycles, within which average daily exposures throughout the cycle ranged from 0.02 to 10. 3 cigarettes. The incidence of dysmenorrhea was 9.7% and 13.3% among nonexposed and exposed cycles, respectively. Among ETS-exposed cycles, there was a positive dose-response relationship between the numbers of cigarettes smoked and the relative risk of dysmenorrhea. The adjusted odds ratios of dysmenorrhea associated with "low," "middle," and "high" tertiles of ETS exposure versus no exposure were 1.1 [95% confidence interval (CI), 0.5-2.6], 2.5 (CI, 0.9-6.7), and 3.1 (CI, 1.2-8.3), respectively. The findings were consistent with those of analyses limited to the first follow-up menstrual cycle from each woman. These data suggest a significant dose-response relationship between exposure to ETS and an increased incidence of dysmenorrhea in this cohort of young women.     

Passive smoking, cytochrome P450 gene polymorphisms and dysmenorrhea

PURPOSE: This study investigated whether the association between passive smoking exposure and dysmenorrhea is modified by two susceptibility genes, CYP1A1MspI and CYP1A1HincII. METHODS: This report includes 1,645 (1,124 no dysmenorrhea, 521 dysmenorrhea) non-smoking and non-drinking newly wedding female workers at Anqing, China between June 1997 and June 2000. Multiple logistic regression models were used to estimate the associations of passive smoking exposure and genetic susceptibility with dysmenorrhea, adjusting for maternal age, BMI, age of menarche, education, vibration exposure, shift work, noise exposure, pregnancy history, perceived stress and physical laboring stress. RESULTS: In the passive smoking group, women who have C/C6235 genotype (OR = 1.8, 95% CI = 1.0-3.3) in CYP1A1MspI and Ile/Ile462 genotype (OR = 2.9, 95% CI = 1.1-7.7) in CYP1A1HincII was associated with an increased risk of dysmenorrhea. When stratified by women genotype, the adjusted OR of dysmenorrheal was 1.6 (95% CI = 1.2-2.1) for passive smoking group with Ile/Ile462 genotype, and 1.5 (95% CI = 1.0-2.1) with C/C6235 genotype, compared to non-passive smoking group, respectively. The data further showed that there was a significant combined effect between passive smoking and the CYP1A1 Msp1C/C6235 (OR = 1.5, 95% CI = 1.0-2.1), and HincII Ile/Ile462 (OR = 1.6, 95% CI = 1.2-2.1), respectively. CONCLUSION: CYP1A1 MspI and HincII genotypes modified the association between passive smoking and dysmenorrhea.