灯盏花素联合鲁南欣康治疗不稳定型心绞痛的

目的 评价灯盏药花素注射液合用鲁南欣康注射液治疗冠心病不稳定型心绞痛的临床疗效.方法 将71例老年不稳定型心绞痛患者随机分成治疗组(灯盏花素联合鲁南欣康)36例和对照组(鲁南欣康)35例,两组同时常规应用拜阿司匹林、低分子肝素钙、阿托伐他汀、ACEI类或β受体阻滞剂等治疗.结果 治疗组老年不稳定型心绞痛患者临床疗效总有效率91.7%,对照组总有效率71.4%,两组比较有显著性差异(P＜0.05).结论 应用灯盏花素注射液联合鲁南欣康更适合于治疗老年不稳定型心绞痛.     

血舒通联合鲁南欣康治疗冠心病心绞痛的疗效观察

[目的 ]观察血舒通联合鲁南欣康治疗冠心病心绞痛的疗效。 [方法 ]选择冠心病心绞痛患者 6 3例 ,随机分为两组 :治疗组 (32例 )予血舒通注射液 10ml,每日 1次 ,同时联用鲁南欣康 2 0mg ,每日 1次 ,静脉滴注治疗 ,疗程 15天 ;对照组 (31例 )单纯使用鲁南欣康 2 0mg ,每日静滴治疗 ,治疗期间两组均不停用口服硝酸脂类药物。 [结果 ]治疗组总的有效率为93 7% ,对照组 71 0 % ,疗效差异有显著意义 (P <0 0 5 ) ,治疗组未见明显不良反应。 [结论 ]血舒通与鲁南欣康联合治疗冠心病疗效肯定。     

丹红联用鲁南欣康治疗45例老年不稳定心绞痛的临床分析

目的比较丹红联合鲁南欣康与单独使用鲁南欣康治疗老年不稳定型心绞痛（UAP）的疗效。方法将80例老年UAP患者随机分成治疗组（丹红＋鲁南欣康）45例和对照组（鲁南欣康）40例,两组同时常规应用阿司匹林、低分子肝素钙、他汀类等治疗。结果治疗组45例老年UAP临床疗效总有效率93.3%,对照组总有效率75.0%,两组比较差异有统计学意义（P〈0.05）。结论应用丹红注射液联合鲁南欣康治疗老年UAP疗效显著,较为安全,适宜临床应用。     

银杏达莫联合应用鲁南欣康治疗30例不稳定型心绞痛临床分析

[背景]观察银杏达莫联合应用鲁南欣康治疗不稳定型心绞痛的临床效果.[病例报告]将60例不稳定型心绞痛患者随机分为2个组,即观察组和对照组.给予观察组30例不稳定型心绞痛患者行银杏达莫联合应用鲁南欣康治疗,30例中显效及有效者分别为25,5例,显效率为83%,疗效明显优于对照组.[讨论]银杏达莫联合应用鲁南欣康是治疗不稳定型心绞痛的有效方法.     

复方丹参滴丸联合鲁南欣康治疗不稳定型心绞痛

目的　探讨联用复方丹参滴丸与鲁南欣康 (单硝酸异山梨酯片 )治疗不稳定型心绞痛 (UAP)的疗效。方法　以临床症状、体表心电图观察 ,治疗组 (联用复方丹参滴丸 10粒含服、每日 3次与鲁南欣康 2 0mg、每日 3次 ,疗程 4周 )和对照组 (单用鲁南欣康 2 0mg、每日 3次 ,疗程 4周 )治疗UAP的疗效。结果　两药合用的临床疗效 ( 87 9% )与心电图疗效 ( 75 8% )均优于单用鲁南欣康 ( 75 0 %和 5 9 4% ) ,均有显著性差异 (P均 <0 0 5 ) ;两组未见明显副反应。结论　复方丹参滴丸与鲁南欣康合用更适合治疗不稳定型心绞痛患者     

鲁南欣康联合美乐心治疗冠心病心绞痛疗效观察

目的 分析鲁南欣康联合美乐心对冠心病,心绞痛的疗效.方法 冠心病,心绞痛24 0例病人随机分两组,对照组给予鲁南欣康40mgl次/d静滴;治疗组在对照组治疗的基础上,加用美乐心60mgl次/d静滴.结果 治疗组显著缓解心绞痛的程度.(P<0.01),心肌缺血心电图改善明显(P<0.05).结论 鲁南欣康联合美乐心治疗冠心病心绞痛疗效显著.     

中西医联合治疗冠心病心绞痛患者的临床效果分析

目的观察中西医联合治疗冠心病心绞痛患者的临床效果。方法随机抽选于2017年9月～2018年9月收治的78例冠心病心绞痛患者,依照入院就诊登记顺序分为两组。观察组(n=39)应用中西医联合(益气活血汤+鲁南欣康)治疗,对照组(n=39)应用常规西医(鲁南欣康)治疗。评价及对比两组的临床疗效、心功能指标、心绞痛情况。结果两组总有效率比较差异有统计学意义(P<0.05),观察组的临床疗效高于对照组。两组心功能指标比较差异均有统计学意义(P<0.01),观察组的LVEDD、LVEF、LVPEd等心功能指标值均优于对照组。观察组的每周心绞痛发作次数少于对照组,心绞痛发作持续时间短于对照组,比较差异均有统计学意义(P<0.01)。结论临床对冠心病心绞痛患者应用益气活血汤+鲁南欣康联合治疗,可增强药物效果,改善患者心功能,是一种理想的治疗方式。     

鲁南欣康联合美乐心治疗冠心病心绞痛疗效观察

目的鲁南欣康联合美乐心对冠心病心绞痛的疗效。方法冠心病心绞痛240例病人随机分两组,对照组给予鲁南欣康40mg1次/d静滴;治疗组在对照组治疗的基础上,加用美乐心60mg1次/d静滴。结果治疗组显著缓解心绞痛的程度。(P<0.01),心肌缺血心电图改善明显(P<0.05)。结论鲁南欣康联合美乐心治疗冠心病心绞痛疗效显著。     

低分子肝素和鲁南欣康治疗不稳定性心绞痛疗效观察

目的 :为探讨联合应用低分子肝素和鲁南欣康治疗不稳定性心绞痛 (UAP)的疗效。方法 :随机将 10 5例符合WHO -UAP的诊断标准的不稳定性心绞痛住院患者分为两组 :联合应用低分子肝素和鲁南欣康组 5 5例 (治疗组 ) ,常规治疗组 5 0例 (对照组 )。治疗组在口服倍他乐克 ,肠溶阿斯匹林基础上 ,给予低分子肝素钙 5 0 0 0AXaIU ,皮下注射 ,每日两次 ,联合静脉点滴鲁南欣康 2 0mg ,每日一次 ,疗程一周。对照组给予口服倍他乐克 ,肠溶阿斯匹林 ,静脉点滴硝酸甘油10mg ,每日一次 ,疗程一周。根据用药前后心绞痛发作次数和持续时间 ,以及心电图 (EKG)变化 ,来判断临床疗效 :心绞痛发作次数和持续时间比用药前减少≥ 80 % ,EKG恢复正常或基本正常为显效 ;心绞痛发作次数和持续时间减少≥5 0 % ,EKGST -T明显改善为有效。结果 :治疗组 5 5例 ,显效率 74 5 4% ;有效 9例 ,有效率 16 3 6% ;总有效 5 0例 ,总有效率 90 91%。对照组 5 0例 ,显效 2 4例 ,显效率 48% ;有效 11例 ,有效率 2 2 % ;总有效 3 5例 ,总有效率 70 %。两组临床疗效与心电图改善总有效率对比 ,经统计学处理 (χ2 =7 43 62 ,P <0 0 1) ,有非常显著性差异。结论 :联合应用低分子肝素与鲁南欣康静脉点滴能迅速控制不稳定型心绞痛 (UAP)解除大部分患者     

复方丹参滴丸、鲁南欣康联合治疗冠心病心绞痛临床观察

目的对复方丹参滴丸联合鲁南欣康治疗冠心病心绞痛的疗效作出评价。方法选择98例冠心病心绞痛患者，采用随机的方法，分为观察组和对照组进行疗效对比。结果观察组心绞痛总有效率92．3％，明显优于对照组78．3％（P〈0．05）；治疗组心电图总有效率63．5％，明显优于对照组43．5％（P〈0．05）。结论复方丹参滴丸与鲁南欣康联合应用治疗冠心病心绞痛，两药可相互协调，提高疗效。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.