集训新兵睡眠特点及其相关因素分析

目的了解不同训练阶段新兵的睡眠特点及其影响因素.方法采用匹兹堡睡眠质量指数(PSQI)、成人EPQ、症状自评量表(SCL-90)、简易应付方式问卷和社会支持量表对1432名集训新兵分别在集训前、集训1个月末、集训2个月末作追踪调查.结果集训第1个月客观睡眠障碍明显,第2个月主观睡眠质量差;以PSQI为因变量,SCL-90症状指数、文化程度、社会支持利用度、EPQ神经质、EPQ精神质、EPQ掩饰、主观社会支持进入回归方程,方程R2＝0.42,adjusted R2＝0.408.结论新兵集训前1个月的客观睡眠障碍明显,睡眠状况与心理症状、社会支持、个性特征等因素有关.     

新兵集训期睡眠质量与自评训练量的关系

目的评价陆军新兵集训期间的睡眠质量及其与自评训练量的关系。方法采用整群抽样方法随机抽取某军区2011年度陆军参训的1389名新兵作为研究对象。用匹兹堡睡眠质量指数（Pittsburgh sleep quality index,PSQI）量表评价新兵集训第1、2、3个月的睡眠质量,通过新兵自评方式评价训练量。采用Kruskal-Wallis H检验、单因素及无序多分类logistic回归分析数据。结果新兵集训第1、2、3个月PSQI平均得分分别为（3.79±2.66）、（4.10±2.65）和（4.28±2.85）;3个月睡眠问题发生率依次为9.1%、10.7%、13.2%,呈现上升趋势（P〈0.05）。城市籍新兵在集训期间有2个月和3个月出现睡眠问题的风险低于农村籍新兵（OR=0.49、0.36）;自评训练量过大为新兵出现睡眠问题的危险因素,其中有1个月、2个月和3个月出现睡眠问题对应的OR值分别为2.24、2.57和2.08。结论部分陆军新兵集训期间存在一定程度的睡眠问题,农村籍新兵和自感训练量过大新兵应作为睡眠干预的重点。     

消化性溃疡患者主观睡眠质量及其与心理因素相关分析

目的: 探讨消化性溃疡患者的主观睡眠质量与心理因素以及二者之间的相关性.方法:采用匹茨堡睡眠质量指数量表(PSQI)、焦虑自评量表(SAS)、抑郁自评量表(SDS)和症状自评量表(SCL-90),对本院消化内科60例消化性溃疡患者及60例正常对照组进行调查,并通过相关分析探讨消化性溃疡患者主观睡眠质量和心理因素之间的关系.结果:患者组与对照组PSQI、 SAS、SDS及SCL-90各量表分的差异均有统计学意义( P< 0.05).消化性溃疡患者的PSQI总分与SAS、SDS、SCL-90总分之间呈正相关关系 (r分 别为0.356、0.440、0.341; P<0.05).结论:消化性溃疡患者主观睡眠质量较差,并存在与精神症状相关的睡眠障碍.     

消化性溃疡患者主观睡眠质量及其与心理因素相关分析

目的：探讨消化性溃疡患者的主观睡眠质量与心理因素以及二者之间的相关性。方法：采用匹茨堡睡眠质量指数量表（PSQI）、焦虑自评量表（SAS）、抑郁自评量表（SDS）和症状自评量表（SCL-90）,对本院消化内科60例消化性溃疡患者及60例正常对照组进行调查,并通过相关分析探讨消化性溃疡患者主观睡眠质量和心理因素之间的关系。结果：患者组与对照组PSQI、SAS、SDS及SCL-90各量表分的差异均有统计学意义（P〈0.05）。消化性溃疡患者的PSQI总分与SAS、SDS、SCL-90总分之间呈正相关关系（r分别为0.356、0.440、0.341;P〈0.05）。结论：消化性溃疡患者主观睡眠质量较差,并存在与精神症状相关的睡眠障碍。     

某市交通警察心理卫生状况与睡眠质量的相关性研究

目的 了解某市交通警察心理健康状况与睡眠质量的相关性.方法 采用症状自评量表(SCL-90)和匹兹堡睡眠质量指数量表(PSQI)评定交通警察的心理健康状况,并调查睡眠质量.结果 1 737名交通警察,SCL-90总分呈阳性(＞160分)者高达50.5％,阳性比例最高为躯体化因子(48.8％);睡眠质量好的警察占64.7％,差的占35.3％.睡眠质量差的交通警察SCL-90总均分和各因子得分均高于睡眠质量好的交通警察,差异有统计学意义(P＜0.001);其中,45％的交通警察主观睡眠质量较差,49.2％入睡时间长,47.2％存在睡眠障碍,25.8％存在日间功能障碍;PSQI各成份与SCL-90各因子间大部分呈正相关(r＞0.3,P＜0.05).结论 交通警察的总体心理健康状况偏差,主要睡眠问题表现为主观睡眠质量较差、入睡时间长和睡眠障碍;睡眠质量与心理状况密切相关,睡眠问题可影响心理健康水平.     

孕妇的主观睡眠质量及心身状况的对照研究

目的了解孕妇在妊娠期的主观睡眠质量及心身状况.方法采用匹兹堡睡眠质量指数量表(PSQI)、焦虑自评量表(SAS)、状态-特质焦虑量表(STAI)、抑郁自评量表(SDS)及症状自评量表(SCL-90)评定孕妇组与对照组的睡眠及心身状况.结果与对照组相比,孕妇组PSQI主观睡眠质量、睡眠紊乱因子分高,睡眠时间、白天功能紊乱因子分低(P＜0.05)SAS总分、STAI总分、状态焦虑因子分高,非状态焦虑因子分低(P＜0.05);SDS躯体化障碍因子分高,精神情感症状因子分低(P＜0.05);SCL-90躯体化因子分高,人际关系因子分低(P＜0.05).结论孕妇在妊娠期有明显的睡眠紊乱、焦虑及躯体化症状.     

南战区官兵睡眠现状及常模研究

目的调查南战区官兵的睡眠状况,建立南战区官兵匹兹堡睡眠质量指数（Pittsburgh Sleep Quality In-dex,PSQI）量表常模,为科学干预提供参考。方法采用症状自评量表（Symptoms Checklist 90,SCL-90）和PSQI量表对南战区6580名官兵进行调研。结果①南战区官兵睡眠质量、入睡时间、睡眠时间、睡眠效率和日间功能障碍分值高于国内常模（P〈0.001）,催眠药物分值明显低于国内常模（P〈0.001）;②南战区官兵睡眠量表各项因子分均高于平原士兵（P〈0.001）;③南战区官兵睡眠质量、睡眠时间、睡眠效率、睡眠障碍、催眠药物分值高于飞行员（P〈0.001）,入睡时间分值低于飞行员（P〈0.001）;④南战区官兵睡眠指数、睡眠质量、入睡时间、睡眠时间、睡眠障碍和日间功能障碍分值与SCL-90各项分值呈正相关（P〈0.001）。结论睡眠质量和心理健康具有一定程度的相关性,建立南战区官兵的睡眠常模,关注战区官兵睡眠状况,改善官兵的睡眠质量,利于提升官兵心理健康水平。     

安徽省社区居民睡眠质量状况及影响因素分析

目的：了解安徽省社区居民睡眠状况及其影响因素。方法：2021年1月至4月，采用分层整群抽样的方法抽取大学生1 000人，再通过滚雪球抽样的方式选取安徽居民2 072人，合计3 072例调查对象。采用匹兹堡睡眠质量指数（PSQI）量表评定睡眠质量，采用多因素Logistic回归模型分析居民睡眠质量的影响因素，采用Pearson相关分析PSQI量表各维度得分与社会支持的相关性。结果：3 072位居民睡眠质量平均分为（3.19±2.69）分，有221 (7.19%)人存在睡眠障碍问题。Logistic回归结果显示，婚姻状况（参照：已婚，离异OR=3.053,95%CI:1.411～6.604）、性格（参照：外向，内向OR=1.683,95%CI:1.098～2.581）、体育锻炼频率（参照：从不，每周1～4次OR=0.499,95%CI:0.346～0.721；每周5次及以上OR=0.324,95%CI:0.163～0.642）是居民睡眠质量的主要影响因素（P<0.05）。相关分析结果显示，主观支持与睡眠效率呈正相关；客观支持与主观睡眠质量、睡眠时间、睡眠干扰因素、日间功能障碍和PSQ...     

精神科医护人员睡眠质量与心理健康状况的关系

目的了解精神科医护人员睡眠质量与心理状况的关系.方法运用匹茨堡睡眠质量指数量表(PSQI)和症状自评量表(SCL-90),对浦东新区精神卫生中心的86名临床医护人员的睡眠质量及其心理状况进行调查.结果精神科医护人员PSQI总分为5.63±4.12,有54.65%的精神科医护人员存在睡眠质量问题,22.09%的医护人员睡眠质量较差.精神科组PSQI睡眠效率因子分、睡眠障碍因子分显著高于内科组.除入睡时间外,PSQI各成分与SCL-90各因子及总分呈正相关关系.结论精神科医护人员睡眠质量较差,且睡眠质量与心理健康状况是互为影响的因素.     

消化性溃疡伴出血患者睡眠质量与社会支持分析

目的探讨消化性溃疡伴活动性出血患者的睡眠质量和社会支持度。方法采用匹茨堡睡眠质量指数量表(PSQI)和社会支持评定量表(SSRS)调查25例消化性溃疡伴活动性出血患者及与25例匹配的正常对照组的睡眠质量指数及社会支持情况。结果与对照组相比,消化性溃疡伴出血患者的PSQI总分降低,存在入睡时间长,睡眠障碍(P<0.05)。消化性溃疡伴出血患者的社会支持总分、客观支持分、主观支持分及对支持的利用度均低于正常对照组(P<0.05)。结论消化性溃疡伴出血患者存在睡眠障碍及社会支持缺陷。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.