A variant serum cholinesterase and a confirmed point mutation at Gly-365 to Arg found in a patient with liver cirrhosis.

A 64-year-old man was admitted to our hospital because of possible liver cirrhosis. His serum cholinesterase was anomalously low with a delta pH of 0.1 (normal range; 0.8-1.1). His enzyme was more heat-labile than the normal controls. Km value of his enzyme for benzoylcholine was 1.1 x 10(-5) mol/l, while that for normal controls was 2.3 x 10(-6) mol/l. In addition, isozymic alteration of his enzyme was observed. Sequencing of the white blood cell DNA of the patient showed a point mutation at nucleotide 1093 (GGA to CGA), which changes codon 365 from glycine to arginine.     

Allopurinol metabolism in a patient with xanthine oxidase deficiency.

A patient with complete deficiency of xanthine oxidase would not be expected to oxidase allopurinol to oxipurinol if allopurinol did not have any alternative metabolic pathway. 400 mg of allopurinol was administered to a patient with xanthine oxidase deficiency, and plasma allopurinol, oxipurinol, hypoxanthine, and xanthine levels were determined serially by the use of high-performance liquid chromatography (HPLC). Plasma oxipurinol as well as allopurinol was increased after the administration of allopurinol, and oxipurinol reached a maximum level of 13.1 micrograms/ml at 6 hours after the administration. This was the same pattern as that of normal controls. This result demonstrated the existence of some other oxidising enzyme of allopurinol than xanthine oxidase.     

肺结核患者血清胆碱酯酶的变化

我们观察了 50例浸润型肺结核患者的血清胆碱酯酶的活性 ,发现肺结核患者血清胆碱酶活力在进展期明显降低 ,而在好转期复升。对象与方法1 .对象 :本组 50例肺结核患者均随机选自我科住院及门诊病人 ,其中男性 33例 ,女性 1 7例 ,平均年龄 39.9岁。均以临床症状、体征、Ｘ线检查及痰抗酸杆菌检查为诊断依据。按照1 998年全国肺结核的分类标准 ,50例患者均属于浸润型肺结核 ,其中进展期 32例 ,好转期 1 0例 ,稳定期 8例。所有患者均排除肝脏疾病以及其它可能引起血清胆碱酯酶活力变化的疾病。以 2 7例健康体检者作为对照组 ,均经过较系统全面…     

Priapism in a patient with protein C deficiency

Summary We present the case of a patient with classical protein C deficiency presenting with acute priapism during warfarinization for thrombophlebitis. Priapism is a well-recognized complication of a number of conditions including sickle cell disease and haematological malignancies, but to our knowledge it has not previously been reported in association with protein C deficiency. This case highlights the potential dangers of initiating oral anticoagulant therapy using conventional loading dose regimens in patients with protein C deficiency.     

Alterations of serum cholinesterase in patients with gastric cancer

AIM:To understand the correlation of serum cholinesterase (CHE) activity with gastric cancer and to assess their clinical significance. METHODS:The velocity method was adopted to detect the activity of serum CHE in patients with gastric cancer and in patients with non-malignant tumor as controls. RESULTS:The serum CHE activity in the treatment group was significantly lower than that in the control group with a very significant difference between the two groups (83.3:113.1,P=0.0003). Age was significantly associated with the incidence of gastric caner. CONCLUSION:Serum CHE activity has a close relation with the incidence of gastric cancer.     

Replacement therapy in a patient with congenital prekallikrein deficiency undergoing surgery.

A patient with congenital prekallikrein (PK) deficiency underwent left endonasal radical ethmoidectomy and nasal polypectomy after receiving a transfusion of 6 ml/kg body weight of fresh frozen plasma (FFP). His plasma PK activity was under 1% before transfusion, and 46% after transfusion. The patient had no bleeding tendency during operation, but bled extensively from the wound 7 days after operation. At that time, his plasma PK activity was 3%. Since the bleeding could not be stopped simply by plugging his nasal cavities with tampons, he was given 3 ml/kg body weight of FFP. As a result, his nasal bleeding rapidly decreased. No clinical sign of thrombotic complication was observed throughout the clinical course.     

单纯性胆碱酯酶极度降低1例报告

1病历资料女性患者42岁,因查胆碱酯酶极度降低于2012年2月17日来天津市传染病医院就诊.患者2011年10月常规检查发现胆碱酯酶( ChE)260 U/L(正常值:4000 -10 000 U/L),2011年11月查ChE 200 U/L,2011年12月查ChE 160 U/L,今来我院查ChE62.0U/L,患者始终无任何不适.     

Pseudotumor of hemophilia in a patient with PTC deficiency

1. A case of pseudotumor of the ilium in a PTC deficient patient is reported.

2. The natural history and treatment of this serious complication ofhemophilia are reviewed.

Submitted on July 7, 1958 Accepted on July 25, 1958     

Inherited protein C deficiency, protein S deficiency and hyperhomocysteinaemia in a patient with hereditary spherocytosis.

We report a family with hereditary spherocytosis in whom there is, in addition, a cluster of genetic predispositions to thrombosis. Although inherited prothrombotic abnormalities are prevalent in the general population, the likelihood of this combination of abnormalities being found in a single family is extremely low. The management of such high risk individuals is discussed.     

Growth hormone modulates serum cholinesterase

Adult male rats have lower serum cholinesterase activity levels than adult female rats and hypophysectomized male rats have higher activity levels than sham-operated males (similar to control females). GH administered to hypophysectomized male rats abolishes the effect of hypophysectomy on serum cholinesterase. Adult male rats treated neonatally with monosodium L-glutamate to induce arcuate nucleus lesions of the hypothalamus have higher serum cholinesterase activities and decreased serum GH concentrations. GH administered to these male rats results in decreased serum cholinesterase activities. These experiments demonstrate that GH is a negative modulator of serum cholinesterase in the male rat.