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Jeffrey P. Phelan Cortney Kirkendall Lisa M. Korst Gilbert I. Martin 《The journal of maternal-fetal & neonatal medicine》2013,26(5):377-380
Objective.?Recent research has suggested that a nucleated red blood cell (NRBC) count ≥26 per 100 white blood cells (%) or the development of a platelet count ≤100 000 per mm3 within five days of birth is characteristic of neonates who have experienced acute birth asphyxia.Study design.?Study cases were from the population defined in a prior publication (Prenat Neonat Med 1997;2:286). The impaired neonates were separated into three groups: group 1, persistent non-reactive fetal heart rate (FHR) pattern from admission until delivery; group 2, reactive FHR pattern on admission followed by a tachycardia, non-reactivity, repetitive variable or late decelerations, and usually a loss of variability; group 3, cases with a reactive FHR pattern on admission followed by a sudden, rapid and sustained deterioration of the FHR usually in response to a hypoxic sentinel event that lasted until delivery or a bradycardia on admission. The FHR pattern in group 3 is considered most consistent with acute birth asphyxia. We then examined these FHR groups with respect to the presence of hematologic injury. Chi-square testing was used to describe differences among the study populations.Results.?Of the original 52 cases, sufficient hematologic data were available for 47. Of these, the proportion of cases with NRBC ≥26% was: group 1, 10/21 (47.6%); group 2, 0/14 (0%); group 3, 0/12 (0%). Those with a platelet count ≤100 000 per mm3: group 1, 11/21 (52.4%); group 2, 2/14 (14.3%); group 3, 0/12 (0%). Group 1 was significantly more likely to have an NRBC count ≥26% than group 3 (p = 0.0135). A platelet count ≤100 000 per mm3 within five days of birth was also significantly more likely to be encountered in group 1 as compared with group 3 (p = 0.0072).Conclusion.?In cases of acute birth asphyxia, hematologic injury was infrequently encountered. Our findings suggest that a neonatal NRBC count ≥26% and/or a platelet count ≤100 000 per mm3 within five days of birth is inconsistent with acute birth asphyxia. 相似文献