多层CT灌注成像在肺内肿瘤诊断中的应用

目的 研究16层螺旋CT灌注成像在鉴别肺内肿瘤中的价值.方法 对63例肺部单发病变进行前瞻性分析,采用Philips Brilliancel6排螺旋CT对肿块行灌注扫描.用CT灌注软件包进行分析.结果 高及中分化组的灌注值(PV),最高增强值(PE)及血容量(BV)值明显高于低分化及未分化组肺癌,差异均有统计学意义(分别为P<0.01,P<0.01,P<0.05).肺部病变PV、PE、BV值为炎性>恶性>良性,其中PV、PE值各组问差异均有统计学意义,而BV值仅炎性病变与良性病变之间差异有统计学意义(P<0.01);如果以150.05).中央型与周围型肺癌各灌注参数也无统计学意义(P>0.05).结论 螺旋CT灌注成像对鉴别肺内恶性、良性及炎性病变及判别肺癌恶性程度有较大价值.     

CT灌注成像在预判肺癌组织类型中的应用

目的 分析肺癌的灌注特点,以期了解肺癌不同组织类型血供情况和提高肺癌组织类型的预判力.方法 对临床怀疑肺癌患者37例行胸部常规加灌注扫描,数据经灌注软件处理,输出兴趣区时间密度曲线、灌注参数及对应伪彩图.对不同组织类型肺癌的灌注参数进行统计分析.结果 37例肺癌患者,经病理确诊鳞癌16例、腺癌15例、小细胞肺癌6例.强化峰值 (peak enhancement,PE):腺癌(29.61 HU±10.34 HU)>鳞癌(21.84 HU±7.57 HU)>小细胞肺癌(18.60 HU±12.19 HU)(F=3.912,P=0.030<0.05),两两比较(SNK)结果为小细胞肺癌与腺癌间有统计学差异,鳞癌与腺癌、小细胞肺癌间差异无统计学意义.3种病理类型的灌注值(perfusion value)、对比剂到达峰值时间 (time to peak,TTP)、血容量 (blood volume,BV)差异无统计学意义.以细胞分化程度进行区组比较鳞癌和腺癌,结果为鳞癌和腺癌间PE值差异有统计学意义(F=5.516,P=0.026<0.05).结论 CT灌注能反映肺癌组织类型间的差异,有助于对肺癌病理类型进行预判.     

肺癌CT灌注成像与病理分型的对照研究

目的 探讨肺肿瘤的CT灌注成像及其临床应用价值.方法 对52例肺肿瘤患者,先行常规CT扫描,确定肺肿瘤中心部位,使用高压注射器经右肘静脉注射对比剂,对选定的同一层面进行连续电影扫描,以获得该层面内组织的时间-密度曲线,根据该曲线计算出血流量(BF)、血容量(BV)及对比剂平均通过时间(MTT),以此来评价肿瘤的灌注情况.结果 各型肺癌的BV及BF值大小顺序均为小细胞未分化癌》鳞癌》腺癌》转移性癌,MTT值的大小顺序为小细胞未分化癌《鳞癌《转移癌《腺癌.结论 肺肿瘤的CT灌注本质上反映了各种类型肺癌血流特点与肿瘤内部的微血管密度情况,有利于肺恶性肿瘤的分型诊断.     

PET／CT在评价及观察大鼠肺癌放疗效果中的应用

目的观察Wistar大鼠肺癌放疗后不同时期的PET／CT表现,观察和评价大鼠肺癌放疗疗效的时间点。方法将30只近交系Wistar大鼠（鼠龄6～8周,体质量180～280g,均为雌性普通级）制作成Lewis肺癌的模型鼠,肿瘤模型建立4—6周后当肿瘤长到最大径1．5～2．0cm时,对大鼠进行^18F-脱氧葡萄糖（FDG）PET／CT显像;显像后对大鼠进行肿瘤局部单次放疗,放疗剂量为5Gy。放疗后第3天和第1、第2、第3、第4周末再对大鼠进行PET／CT显像,观察放疗的疗效,从而评价疗效观察的时间点。而后取一部分肿瘤组织制成免疫组织化学切片,观察葡萄糖转运蛋白1（Glut1）的表达。一部分肿瘤组织被制成病理切片,经HE染色,观察光学显微镜下肿瘤细胞的坏死及萎缩情况。统计学处理采用SPSS11．0软件。多组样本均数之间比较采用单因素方差分析,标准摄取值（SUV）与Glut1表达行等级相关分析。结果随着放疗后时间的延长,^18F-FDG的摄取逐渐减少,代谢活性逐渐减低,SUV放疗前为1．28±0．31,放疗后第3天为1．00±0．23,放疗后第4周下降到0．18±0．10。放疗后各不同时间点肿瘤的平均SUV与放疗前的差异具有统计学意义（F=15．126,P〈0．05）。免疫组织化学结果：Glut1表达阳性的染色主要位于胞膜和胞质,随着放疗后观察时间的延长,肿瘤组织的Glut1表达逐渐减低,Glut1表达的平均吸光度（A）值放疗前为0．2558±0．03,放疗后第3天为0．2320±0．01,放疗后第4周为0．1320±0．04。肿瘤平均SUV与Glut1表达呈正相关（等级相关系数L=0．97,P〈0．01）。病理检查结果：随着放疗后观察时间的延长,肿瘤细胞萎缩、碎裂及坏死逐渐增多。结论PET／CT能于Wistar大鼠肺癌放疗后早期（第3天）观察到治疗效果,到第4周疗效显示最佳。     

CT灌注成像在腮腺肿瘤诊断中的应用进展

腮腺肿瘤是头颈部常见的肿瘤之一,CTPI作为一种功能成像技术在显示形态学变化的同时亦能反映组织、器官生理和病理情况下的血流动力学变化,对腮腺肿瘤的早期检出、治疗效果及预后的评估有一定的价值。通过阅读国内外文献,现将CTPI在腮腺肿瘤诊断中的应用做一简要综述。     

多层螺旋CT灌注成像在胃癌术前评估中的应用

目的探讨多层螺旋 CT(MSCT)进行胃癌灌注成像的可行性,评价其在胃癌术前评估中的应用价值.资料与方法67例经胃镜证实的胃癌患者行MSCT 灌注成像扫描,计算肿瘤感兴趣区的灌注参数,包括血流量(BF)、血容量(BV)、平均通过时间(MTT)和表面通透性(PS).分析胃癌细胞分化程度、临床分期、病理分期、淋巴结转移、远处转移及转移部位与各灌注参数的关系.结果 PS 值在胃癌不同细胞分化程度、TNM 分期、病理分期、有无淋巴结转移、有无远处转移各组间差异有统计学意义(P <0.05),MTT 值在胃癌各组间差异均无统计学意义(P >0.05),BF、BV 在不同 TNM 分期组间差异有统计学意义(P <0.05),BF 在病理分期组间差异有统计学意义(P <0.05).结论 MSCT 灌注成像能反映胃癌的血流动力学变化,对胃癌的术前评估有重要意义.     

PET/CT在评价及观察大鼠肺癌放疗效果中的应用

Objective The aim of this study was to understand the role of PET/CT in monitoring the therapeutic effect of radiotherapy (RT) on lung cancer with Wistar rats. Methods Thirty Wistar in-bred strain rats (6-8 weeks, weighed 180-280 g, female, ordinary) were made into Lewis pulmonary tumor model rats. 18F-fluorodeoxyglucose (FDG) PET/CT was performed when tumor reached 1.5-2.0 cm in greatest diameter (4-6 weeks) as a baseline. In order to get the optimal time point of PET/CT for moni-toring RT effect in rat cancer model, PET/CT was performed at the 3rd day, 1st, 2nd, 3rd, and 4th week after giving single dose of 5 Gy to each rat. Standardized uptake values (SUV) from FDG PET were measured and rats were sacrificed at different time point for validation. Besides, the expressions of glucose transport1 (Glut1) in tumor tissue were studied using immunohistochemistry. The level of tumor cell apoptosis, degra-dation, and necrosis were observed. SPSS 11.0 software was used for data analyses. Results A negative correlation of SUV uptake and time after RT and negative correlation of Glut1 expression and time after RT were observed in rat tumors, respectively. Positive correlation of SUV uptake and Glut1 expression in rat tumors was observed (Spearman rank correlation test, rs = 0.97, P < 0.01). Before RT, the SUV in rat tumor was 1.28 ± 0.31 and was decrease to 1. 00 ± 0.23 at the 3rd day and 0.18 ± 0. 10 at the 4th week after RT (F=15. 126, P<0.05). Before RT, the Glut1 in rat tumor was 0.2558 ±0.03 and was decrease to 0. 2320 ± 0. 01 at the 3rd day and 0. 1320±0.04 at the 4th week after RT. The amounts of tumor cell apopto-sis, degradation, and necrosis increased with time after RT. Conclusion Though FDG PET could monitor the therapeutic effect at the 3rd day after giving single dose of RT to rat lung tumor model, the optimal time was the the 4th week after treatment.     

PET/CT在评价及观察大鼠肺癌放疗效果中的应用

Objective The aim of this study was to understand the role of PET/CT in monitoring the therapeutic effect of radiotherapy (RT) on lung cancer with Wistar rats. Methods Thirty Wistar in-bred strain rats (6-8 weeks, weighed 180-280 g, female, ordinary) were made into Lewis pulmonary tumor model rats. 18F-fluorodeoxyglucose (FDG) PET/CT was performed when tumor reached 1.5-2.0 cm in greatest diameter (4-6 weeks) as a baseline. In order to get the optimal time point of PET/CT for moni-toring RT effect in rat cancer model, PET/CT was performed at the 3rd day, 1st, 2nd, 3rd, and 4th week after giving single dose of 5 Gy to each rat. Standardized uptake values (SUV) from FDG PET were measured and rats were sacrificed at different time point for validation. Besides, the expressions of glucose transport1 (Glut1) in tumor tissue were studied using immunohistochemistry. The level of tumor cell apoptosis, degra-dation, and necrosis were observed. SPSS 11.0 software was used for data analyses. Results A negative correlation of SUV uptake and time after RT and negative correlation of Glut1 expression and time after RT were observed in rat tumors, respectively. Positive correlation of SUV uptake and Glut1 expression in rat tumors was observed (Spearman rank correlation test, rs = 0.97, P < 0.01). Before RT, the SUV in rat tumor was 1.28 ± 0.31 and was decrease to 1. 00 ± 0.23 at the 3rd day and 0.18 ± 0. 10 at the 4th week after RT (F=15. 126, P<0.05). Before RT, the Glut1 in rat tumor was 0.2558 ±0.03 and was decrease to 0. 2320 ± 0. 01 at the 3rd day and 0. 1320±0.04 at the 4th week after RT. The amounts of tumor cell apopto-sis, degradation, and necrosis increased with time after RT. Conclusion Though FDG PET could monitor the therapeutic effect at the 3rd day after giving single dose of RT to rat lung tumor model, the optimal time was the the 4th week after treatment.     

PET/CT在评价及观察大鼠肺癌放疗效果中的应用

Objective The aim of this study was to understand the role of PET/CT in monitoring the therapeutic effect of radiotherapy (RT) on lung cancer with Wistar rats. Methods Thirty Wistar in-bred strain rats (6-8 weeks, weighed 180-280 g, female, ordinary) were made into Lewis pulmonary tumor model rats. 18F-fluorodeoxyglucose (FDG) PET/CT was performed when tumor reached 1.5-2.0 cm in greatest diameter (4-6 weeks) as a baseline. In order to get the optimal time point of PET/CT for moni-toring RT effect in rat cancer model, PET/CT was performed at the 3rd day, 1st, 2nd, 3rd, and 4th week after giving single dose of 5 Gy to each rat. Standardized uptake values (SUV) from FDG PET were measured and rats were sacrificed at different time point for validation. Besides, the expressions of glucose transport1 (Glut1) in tumor tissue were studied using immunohistochemistry. The level of tumor cell apoptosis, degra-dation, and necrosis were observed. SPSS 11.0 software was used for data analyses. Results A negative correlation of SUV uptake and time after RT and negative correlation of Glut1 expression and time after RT were observed in rat tumors, respectively. Positive correlation of SUV uptake and Glut1 expression in rat tumors was observed (Spearman rank correlation test, rs = 0.97, P < 0.01). Before RT, the SUV in rat tumor was 1.28 ± 0.31 and was decrease to 1. 00 ± 0.23 at the 3rd day and 0.18 ± 0. 10 at the 4th week after RT (F=15. 126, P<0.05). Before RT, the Glut1 in rat tumor was 0.2558 ±0.03 and was decrease to 0. 2320 ± 0. 01 at the 3rd day and 0. 1320±0.04 at the 4th week after RT. The amounts of tumor cell apopto-sis, degradation, and necrosis increased with time after RT. Conclusion Though FDG PET could monitor the therapeutic effect at the 3rd day after giving single dose of RT to rat lung tumor model, the optimal time was the the 4th week after treatment.     

PET/CT在评价及观察大鼠肺癌放疗效果中的应用

Objective The aim of this study was to understand the role of PET/CT in monitoring the therapeutic effect of radiotherapy (RT) on lung cancer with Wistar rats. Methods Thirty Wistar in-bred strain rats (6-8 weeks, weighed 180-280 g, female, ordinary) were made into Lewis pulmonary tumor model rats. 18F-fluorodeoxyglucose (FDG) PET/CT was performed when tumor reached 1.5-2.0 cm in greatest diameter (4-6 weeks) as a baseline. In order to get the optimal time point of PET/CT for moni-toring RT effect in rat cancer model, PET/CT was performed at the 3rd day, 1st, 2nd, 3rd, and 4th week after giving single dose of 5 Gy to each rat. Standardized uptake values (SUV) from FDG PET were measured and rats were sacrificed at different time point for validation. Besides, the expressions of glucose transport1 (Glut1) in tumor tissue were studied using immunohistochemistry. The level of tumor cell apoptosis, degra-dation, and necrosis were observed. SPSS 11.0 software was used for data analyses. Results A negative correlation of SUV uptake and time after RT and negative correlation of Glut1 expression and time after RT were observed in rat tumors, respectively. Positive correlation of SUV uptake and Glut1 expression in rat tumors was observed (Spearman rank correlation test, rs = 0.97, P < 0.01). Before RT, the SUV in rat tumor was 1.28 ± 0.31 and was decrease to 1. 00 ± 0.23 at the 3rd day and 0.18 ± 0. 10 at the 4th week after RT (F=15. 126, P<0.05). Before RT, the Glut1 in rat tumor was 0.2558 ±0.03 and was decrease to 0. 2320 ± 0. 01 at the 3rd day and 0. 1320±0.04 at the 4th week after RT. The amounts of tumor cell apopto-sis, degradation, and necrosis increased with time after RT. Conclusion Though FDG PET could monitor the therapeutic effect at the 3rd day after giving single dose of RT to rat lung tumor model, the optimal time was the the 4th week after treatment.     

多层CT灌注成像诊断周围型肺癌及与微血管密度对照研究

目的:探讨多层螺旋CT(MSCT)灌注成像技术诊断肺癌的临床价值及其与肿瘤微血管密度(MVD)的相关性。方法:利用16层MSCT灌注成像技术前瞻性研究38例经手术病理证实的肺肿瘤(周围型肺癌25例,肺良性肿块13 例),并与25例肺癌的免疫组化法MVD进行相关性研究。采用Perfusion 2体部肿瘤灌注软件包分析以下灌注参数:血液流速(BF)、血流量(BV)、平均通过时间(MTT)和表面通透性(PS)。结果:肺癌各项CT灌注参数值均高于肺良性肿块, 其中MTT和PS值在两组之间差异有显著性意义(P<0．05),BV值差异有极显著性意义(P<0．01);肺癌的MVD明显高于肺良性肿块(P<0．05),肺腺癌MVD高于肺鳞癌(P<0．05);肺癌仅BV值与其MVD呈正相关性(r=0．852,P< 0．01)。结论:MSCT灌注成像有助于周围型肺癌的诊断及与良性肿瘤的鉴别诊断,其病理基础与肿瘤微血管密度有关。     

多层螺旋CT灌注成像在直肠癌术后应用价值的初步研究

目的利用多层螺旋CT灌注成像评价直肠癌术后局部复发及瘢痕组织的血流动力学差异。资料与方法对直肠癌术后复发12例、瘢痕组织8例行CT灌注成像,20例均经病理或随访证实。所有病例均对选定的层面进行快速CT动态扫描,并运用随机非去卷积灌注软件计算局部复发灶、瘢痕组织及肌肉组织的血流量(BF)、血容量(BV)并计算平均通过时间(MTT)。结果12例直肠癌术后复发的BF、BV值明显高于瘢痕组织和正常肌肉组织(P<0.05)。术后复发、瘢痕组织及正常的肌肉组织的MTT值差异无统计学意义(P>0.05)。瘢痕组织与正常肌肉组织的BF、BV值差异均无统计学意义(P>0.05)。结论多层螺旋CT灌注成像能够反映直肠癌术后复发和瘢痕组织的血流动力学差异,对判断直肠癌术后复发具有重要的价值。     

多层螺旋CT灌注成像在食管癌诊断中的应用价值

目的:探讨多层螺旋CT(MSCT)灌注成像技术诊断食管癌的价值。方法:利用4层MSCT灌注成像技术前瞻性研究分析87例食管癌及40例非食管病变患者食管的各项灌注参数,包括血液流速(BF)、血流量(BV)、平均通过时间(MTT)及表面通透性(PS)。结果:食管癌各项灌注参数值均高于正常食管的灌注参数值,其中MTT及BV在两者之间差异有显著性意义(P<0.05),PS值有极显著性意义(P<0.01)。结论:MSCT灌注成像技术在食管癌诊断中有积极的临床应用价值。     

单次对比增强双源CT双能肺灌注成像扫描及重组参数的优化

目的探讨不同扫描技术对双源CT(DSCT)双能肺灌注成像的影响,优化扫描和重组参数。资料与方法在相同对比剂浓度、负荷和注射流率前提下,60例患者随机分为5组,组1～3:利用人工智能触发扫描trigger技术,将感兴趣区设在肺动脉主干,当CT值达到100 HU时,再分别延迟3 s、6 s、9 s后扫描自动开始,其余扫描参数均为探测器准直14 mm×1.2 mm,球管旋转时间为0.5 s,螺距为0.5,重组层厚1.5 mm,间隔1.0 mm,足头方向。组4:头足方向,其他扫描参数同组2;组5:重组层厚1.5 mm,间隔1.5 mm,其他扫描参数同组2。测量升主动脉、肺动脉主干以及上腔静脉的CT值,并观察肺动脉分支显示级别和上腔静脉线束硬化伪影出现情况,评价DSCT双能肺灌注及肺动脉CT血管造影(CTA)的图像质量。结果与其他组相比,组2肺动脉强化值较高,上腔静脉强化值较低且线束硬化伪影较少,肺动脉5级分支显示清晰,同时具备优良的双能肺灌注和肺动脉图像质量,差别有统计学意义(P<0.05)。结论在相同对比剂浓度、负荷和注射流率前提下,组2的扫描方案可获得满意的肺双能灌注成像及肺动脉CTA的图像质量,结合临床实用情况...     

灶周CT灌注参数对孤立性肺部球形病变的诊断价值

目的探讨肺部孤立性球形病变灶周CT灌注(CT perfusion,CTP)参数定量分析的诊断价值。资料与方法选取位于肺动脉或右心室所在层面的孤立性肺部球形病变22例,其中恶性组14例(腺癌8例,肺泡癌3例,大细胞癌1例,腺鳞癌及血管外皮瘤各1例),良性组8例(炎性假瘤2例,活动性结核1例,结核球2例,硬化性血管瘤3例)。采用64层CT行灌注检查。将所得原始数据传至Syngo工作站行后处理得到CTP图,测量病变灶周及对侧肺与病变相对应区域的近、远肺门侧的血流量(BF)、血容量(BV)、表面通透性(PS)、平均通过时间(MTT)等灌注参数值。所有病例取得术后病灶近、远肺门侧边缘外1.0 cm范围内的肺组织以及远离病变区域的肺组织各一块,行免疫组织化学染色,比较微血管密度(MVD)有无差异。结果 (1)良、恶性组灶周近/远肺门侧灌注参数BF、BV、PS、MTT相对值(病变灶周灌注参数/对侧肺灌注参数)分别为rBF 1.37±0.59/0.99±0.38、0.88±0.53/0.92±0.41,rBV1.78±1.29/1.08±0.35、1.18±0.88/0.96±0.40,rPS 1.25±1.07/0.78±...     

周围型肺癌CT灌注参数与PET的SUV值及患者预后的相关性研究

目的:研究周围型肺癌肺肿瘤CT灌注参数与PET的标准摄取值(SUV)及患者预后的相关性.方法:42例有同期PET的周围型肺癌行肺肿瘤灌注CT扫描,病例均经病理证实并追踪1年以上.扫描数据用CT灌注2--体部肿瘤软件包进行分析.结果:42例周围型肺癌中,病灶强化差值14～63 HU,平均(32.80±12.35) HU;PET的最大SUV值2.76～18.50,平均8.63±3.47;肿瘤灌注的血容量值(BV)为6.0～17.8 ml/100g,平均(8.47±2.60) ml/100g;毛细血管通透性(PS值)为5.95～95.00 ml/(100g·min),平均(49.13±17.33) ml/(100g·min).PET和肺灌注的BV值对肺癌的诊断最为敏感,敏感度达100%,PS和CT强化值敏感性稍差,敏感度分别为95%和91%.42例中,CT强化值与PS值、SUV值和预后无相关性,r值分别为0.053、0.212和0.07,P值均＞0.05;BV值与强化值有很好的正相关性,r值为0.341,P＜0.05,SUV值和PS值与预后有明显的正相关性,r值分别为0.319和0.378,P值分别为0.039和0.014,均＜0.05,且PS值与SUV值也有正相关性,r值为0.318,P＜0.05.结论:BV有较高的诊断敏感性,但与预后没有明确的相关性;PS诊断敏感性稍差,但其数值与PET的SUV值和患者的预后正相关,PS值与SUV值共同反映肿瘤的恶性特征.     

256层螺旋CT结直肠癌灌注成像扫描时间对灌注参数的影响

目的 评估256层螺旋CT结直肠癌灌注扫描时间变化对灌注参数的影响,以获取基于首过效应阶段灌注扫描序列的最佳灌注扫描时间.方法 搜集术前经纤维结肠镜检查并由术后病理证实结直肠腺癌病例29例,进行256层螺旋CT全肿瘤灌注检查.每位患者总灌注扫描时间为60.8s,通过后处理软件由两位放射科医师分别在60.8 s、57 s、53.2 s、49.4 s、45.6 s、41.8 s、38 s测量肿瘤最大层面灌注参数(BF,BV,TTP,PEI)值,观察其变化.将扫描时间60.8s所测灌注参数分别与扫描时间(57 s、53.2 s、49.4 s、45.6 s、41.8 s、38 s)灌注参数进行配对样本t检验.对不同医师两次分析结果运用Bland-Altman分析进行一致性分析.P＜0.05为差异具有统计学意义.结果 灌注参数(BF,BV,TTP,PEI)值受到总扫描时间影响.扫描时间为60.8s时,灌注参数BF、BV、TTP、PEI值分别为(34.12±17.83)ml·min-1·100g-1、(14.76±4.99) ml/100g、(18.92±10.22)s、(36.35±14.64)HU.总扫描时间减至41.8s,其BF值为(40.35±28.52)ml·min-1· 100g-1,与60.8s所测BF值之间差异有统计学意义(P=0.049);总扫描时间减至45.6 s,其TTP值、PEI值分别为(15.23±7.79)s、(33.68±13.72) HU,与60.8s所测值之间差异有统计学意义(P =0.024;P=0.022).随着扫描时间缩短,BV值逐渐减小,与60.8s所测BV值之间差异均存在统计学意义(P＜0.05).结论 基于首过效应法256层螺旋CT结直肠癌灌注成像总扫描时间对灌注参数(BF,BV,TTP,PEI)值有明显影响.总扫描时间46 s左右能够保证BF、TTP及PEI测定的准确性,而BV值的准确测定可能需延长扫描时间.     

输入动脉选择对CT Perfusion 3.0软件包肺灌注成像的影响

目的:探讨输入动脉的选择对CT Perfusion 3.0软件包肺灌注成像的影响。方法:健康新西兰白兔2只,非离子型对比剂优维显5ml,对比剂的注射流率分别为0.1、0.3、0.5和0.8ml/s。所得数据传输到工作站,经Perfusion 3.0软件包以三种不同的灌注成像方案处理。结果:以主动脉为输入动脉的体部肿瘤方案组所计算的血容量(BV)、血流量(BF)分别与以肺动脉为输入动脉组和肝脏肿瘤方案组所得数值间差异存在显著性意义(t=4.376、t=2.779);以肺动脉为输入动脉组和肝脏肿瘤方案组所得数值组间差异无显著性意义(t=1.5)。结论:应用CT Perfusion 3.0软件包,选择不同的输入动脉会对肺灌注成像结果产生影响,其实际应用有待进一步研究。     

周围型肺癌双源CT灌注成像与肿瘤血管生成的相关性研究

目的 探讨周围型肺癌双源CT灌注成像与肿瘤微血管密度(MVD)、血管内皮生长因子(VEGF)的关系.方法 搜集经胸部X线平片或CT平扫发现肺部肿块并行双源CT容积灌注成像,后经病理证实的周围型肺癌30例.男18例,女12例,年龄40 ～ 77岁,平均58.01岁.将CT图像传至Siemens工作站进行图像处理.计算靶层面感兴趣区(ROI)的时间-密度曲线(TDC).通过最大斜率法获得血流量(BF)、血容量(BV)、对比剂的平均通过时间(MTT)、峰值时间(TFP)和表面通透性(PS)等灌注参数及灌注图像.30例病理标本行常规HE染色病理学检查,采用免疫组织化学检测MVD计数和VEGF的表达情况.分析周围型肺癌双源CT灌注参数与MVD、VEGF表达的关系,比较周围型肺癌有无淋巴转移及与MVD、VEGF表达的关系. 结果 (1)周围型肺癌的MVD、VEGF与CT灌注参数值BF、BV呈正相关;与MTT之间无相关性,与TTP之间呈负相关,MVD与PS无相关性,VEGF与PS呈正相关.与MVD及VEGF具有相关性的CT灌注参数中以BF的相关性最高.(2)有淋巴结转移组肺癌MVD值高于无淋巴结转移组肺癌(P＜0.05);有淋巴结转移组肺癌VEGF高于无淋巴结转移组肺癌(P＜0.05).结论 双源CT灌注成像可评价周围型肺癌的肿瘤微血管生成,有助于在活体评价肿瘤血管生成.MVD、VEGF可作为评价周围型肺癌是否发生淋巴结转移的指标.