The 2007 WHO Classification of Tumours of the Central Nervous System

The fourth edition of the World Health Organization (WHO) classification of tumours of the central nervous system, published in 2007, lists several new entities, including angiocentric glioma, papillary glioneuronal tumour, rosette-forming glioneuronal tumour of the fourth ventricle, papillary tumour of the pineal region, pituicytoma and spindle cell oncocytoma of the adenohypophysis. Histological variants were added if there was evidence of a different age distribution, location, genetic profile or clinical behaviour; these included pilomyxoid astrocytoma, anaplastic medulloblastoma and medulloblastoma with extensive nodularity. The WHO grading scheme and the sections on genetic profiles were updated and the rhabdoid tumour predisposition syndrome was added to the list of familial tumour syndromes typically involving the nervous system. As in the previous, 2000 edition of the WHO 'Blue Book', the classification is accompanied by a concise commentary on clinico-pathological characteristics of each tumour type. The 2007 WHO classification is based on the consensus of an international Working Group of 25 pathologists and geneticists, as well as contributions from more than 70 international experts overall, and is presented as the standard for the definition of brain tumours to the clinical oncology and cancer research communities world-wide.     

Comparison between the 2007 and the 2016 WHO Classification of Tumours of the Central Nervous System

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对WHO中枢神经系统肿瘤新分类的理解

新方案中的主要进展有:①对某些肿瘤的组织起源作了进一步确认;②更新了肿瘤定级标准,对各种肿瘤的生物学特性能更正确地认识;③重新编排了各类肿瘤的归属,提出了多种新发现的肿瘤类型;④删除了某些命名不当及认识上有错误的肿瘤类型。作者建议将新分类中肿瘤的排列次序作适当更改可成为中枢神经系统肿瘤的编码依据。