美托洛尔联合步长稳心颗粒治疗心律失常的临床疗效

目的评价美托洛尔联合步长稳心颗粒治疗心律失常的疗效。方法将215例心律失常的患者随机分为3组：治疗组（A组）71例,给予口服美托洛尔12.5mg/次,2次/d,稳心颗粒9g/次,3次/d;对照组分为B组和C组,B组72例,口服美托洛尔12.5mg/次,2次/d;C组72例,口服稳心颗粒9g/次,3次/d。疗程均为4周,治疗前后均做心电图及动态心电图检查,以判断疗效并作对比分析。结果治疗4周后,美托洛尔联合步长稳心颗粒治疗组的有效率为91.5%,明显优于单用美托洛尔及步长稳心颗粒对照组,差异有统计学意义（P〈0.05）。结论美托洛尔联合步长稳心颗粒治疗心律失常疗效满意,不良反应少,具有明确的临床意义。     

美托洛尔联合稳心颗粒治疗不适当窦性心动过速的临床研究

目的观察美托洛尔联合稳心颗粒治疗不适当窦性心动过速的临床疗效。方法选择不适当窦性心动过速患者12例,随机分为治疗组7例和对照组5例。两组均口服美托洛尔,从12.5mg/次,2次/d开始,根据病情调整剂量。治疗组同时给予稳心颗粒口服,每次1袋(9g),3次/d。2组均以4周为l疗程。比较2组治疗前后临床症状、心动过速变化及美托洛尔总剂量情况。结果治疗组临床症状改善总有效率为100%,对照组临床症状改善总有效率为80%(P0.05)。治疗组平均心率低于对照组(P0.05)。治疗组美托洛尔总剂量低于对照组。结论稳心颗粒与美托洛尔联合治疗不适当窦性心动过速有效并且安全性高。     

步长稳心颗粒治疗Gavers病窦性心动过速的疗效观察

目的观察步长稳心颗粒治疗Gavers病窦性心动过速的疗效和不良反应。方法将60例Gavers病窦性心动过速患者随机分为两组,治疗组30例,对照组30例,均予以常规的抗甲亢基础治疗（抗甲状腺药物治疗）,对照组30例在此基础上服用普奈洛尔片,10mg/次,3次/d。治疗组30例在对照组基础上服用步长稳心颗粒,1包（9g）/次,3次/d。疗程均为2周。1周及2周后分别检查心电图,并观察临床疗效及不良反应。结果对照组总有效率为93.3%,治疗组总有效率为70%。两组不良反应无明显差异。结论步长稳心颗粒冲剂与普奈洛尔联用治疗Gavers病窦性心动过速显效更快,有效率更高,无明显不良反应。     

步长稳心颗粒治疗心律失常疗效观察

目的 观察心律失常患者应用步长稳心颗粒后心律失常控制情况.方法 将160例心律失常患者随机分为治疗组80例,对照组80例,治疗组应用稳心颗粒口服,1袋∕次,3次/d,治疗4周;对照组口服心律平150mg,3次/d,治疗4周.结果 两组临床症状改善比较,治疗组总有效率为92.5%,高于对照组的81.0%(P＜0.05);动态心电图疗效比较,治疗组总有效率为90.0%,对照组为72.5%,差异有统计学意义(P＜0.05).结论 步长稳心颗粒对各种心律失常均有较好的疗效,且无明显的不良反应,可作为治疗心律失常的首选中成药物.     

稳心颗粒联合美托洛尔治疗冠心病室性心律失常的疗效观察

目的 观察稳心颗粒联合美托洛尔治疗冠心病室性心律失常的疗效及不良反应.方法 将我院收治的110例冠心病室性心律失常患者随机分成两组,治疗组（55例）给予稳心颗粒和美托洛尔口服治疗,对照组（55例）单独口服美托洛尔治疗.4周为1个疗程,1个疗程结束后比较两组的疗效并观察治疗前后动态心电图的变化.结果 治疗组和对照组的总有效率分别为90.9%、69.1%,治疗组和对照组的动态心电图总有效率分别为89.1%、67.3%,两组比较有显著性差异.结论 稳心颗粒联合美托洛尔治疗冠心病室性心律失常疗效显著,且不良反应较少,值得临床推广.     

稳心颗粒联合美托洛尔对冠心病合并心律失常的疗效观察

目的研究稳心颗粒联合美托洛尔对冠心病合并心律失常的疗效。方法选取2014年12月~2016年6月我院收治的冠心病合并心律失常患者98例作为研究对象,将其随机分为对照组与观察组,各49例。对照组给予患者单独采用美托洛尔治疗;观察组在对照组基础上,添加稳心颗粒进行治疗。对比两组患者治疗后的疗效及不良反应发生率。结果观察组患者的疗效总有效率(93.88%)以及不良反应发生概率(4.08%)均优于对照组,差异有统计学意义(P0.05)。结论冠心病合并心律失常患者使用稳心颗粒联合美托洛尔进行治疗的疗效可观,不良反应发生概率低,安全性高。     

稳心颗粒联合美托洛尔缓释片对远期老年阵发性房颤病人负荷的影响

目的分析稳心颗粒联合美托洛尔缓释片对远期老年阵发性房颤病人的治疗效果。方法采用随机数字表法将46例老年既往行双腔起搏器目前合并阵发性房颤病人分为两组。对照组22例给予口服美托洛尔缓释片治疗,观察组24例给予口服美托洛尔联合冲服稳心颗粒治疗,连续治疗6个月后对比临床疗效。结果两组对比,观察组的起搏器自动模式转换(AMS)次数较对照组减少,分别为(122±35)次与(168±48)次(P0.05),AMS持续时间缩短,(50±17)h与(74±32)h(P0.05),房颤总负荷减轻(14±6)%和(22±5)%(P0.05)。结论稳心颗粒联合美托洛尔缓释剂对于远期老年阵发性房颤病人疗效确切。     

稳心颗粒控制持续性房颤患者心室律的疗效观察

目的观察稳心颗粒控制持续性房颤患者心室律的疗效。方法将我院2010~2014年诊断为持续房颤的252例随机分为治疗组和对照组,治疗组120例,对照组132例。对照组予以常规治疗,治疗组在常规基础用稳心颗粒口服,每次1袋,每日3次,治疗12周后比较两者患者的临床疗效,运动实验结果,不良反应。结果治疗组患者的临床治疗总有效率为89.17%,对照组总有效率69.70%,两组疗效对比具有差异性(P0.05)。结论稳心颗粒控制持续性房颤患者心室律疗效确切,安全性好,值得临床推广应用。     

步长稳心颗粒联合心律平治疗房性期前收缩临床观察

目的 观察步长稳心颗粒与心律平联合治疗房性期前收缩的疗效与不良反应.方法 将62例房性期前收缩患者随机分为两组,治疗组32例采用步长稳心颗粒联合心律平治疗;对照组30例单纯应用心律平治疗.观察临床疗效及心室率的变化.结果 治疗组总有效率为93.8%,对照组总有效率为80.0%,两组治疗效果比较,差异有统计学意义(P＜0.01).结论 步长稳心颗粒联合心律平治疗房性期前收缩疗效明显、安全性好.     

稳心颗粒联合美托洛尔治疗老年冠心病心律失常的疗效观察

目的探讨稳心颗粒联合美托洛尔治疗老年冠心病心律失常的疗效。方法选取本院冠心病合并心律失常患者90例为研究对象,随机分为两组,各45例。观察组予以稳心颗粒联合美托洛尔治疗,对照组予以美托洛尔治疗,比较两组的疗效。结果观察组总有效率93.3%,对照组总有效率73.3%,组间比较差异有统计学意义(P0.05),观察组治疗后心律失常发作次数和持续时间均明显好于对照组,观察组用药期间心动过缓、胃肠道反应发生率为4.4%、6.7%,对照组心动过缓、胃肠道反应发生率8.9%、4.4%,组间比较差异无统计学意义(P0.05)。结论稳心颗粒联合美托洛尔改善老年冠心病心律失常症状,疗效显著,值得应用。     

Cement and Concrete Nanoscience and Nanotechnology

Concrete science is a multidisciplinary area of research where nanotechnology potentially offers the opportunity to enhance the understanding of concrete behavior, to engineer its properties and to lower production and ecological cost of construction materials. Recent work at the National Research Council Canada in the area of concrete materials research has shown the potential of improving concrete properties by modifying the structure of cement hydrates, addition of nanoparticles and nanotubes and controlling the delivery of admixtures. This article will focus on a review of these innovative achievements.     

慢性饮酒、吸烟与骨质疏松的相关性研究

目的 探讨长期大量慢性饮酒、吸烟等不良生活方式与骨质疏松的关系.方法 以乏力、腰背痛、双下肢酸困为主诉,且有长期大量慢性饮酒史、吸烟史,无其他慢性疾病史的年轻男性患者45例为观察对象,测定其血钙(Ca)、血磷(P)和血肌酐(Cr)、尿素氮(BUN)、血糖(Glu)、天门冬酸氨基转移酶(AST)、丙氨酸基转移酶(ALT)、血清碱性磷酸酶(ALP)、甲状腺功能、全段甲状旁腺激素(iPTH)、1,25-二羟维生素D3[1,25-(OH) 2D3]、双能X线骨密度仪测定腰椎L1-4及左侧股骨近段(包括颈、股骨颈上部、大粗隆)骨密度(BMD),分析饮酒、吸烟对骨量的影响.以感冒发热就诊、年龄相当、无饮酒、吸烟史及慢性疾病史的45例男性为对照组.结果 观察组1,25(OH)2D3水平均降低,血钙水平偏低,血磷正常,碱性磷酸酶呈不同程度地升高,骨密度T值提示观察组27例骨质疏松,12例骨量减少,6例正常骨量;而对照组仅有6例为骨量减少,1例骨质疏松,38例为正常骨量,两组比较差异有统计学意义(P＜0.05).结论 长期慢性大量饮酒吸烟影响骨量,甚至易导致骨质疏松.     

Medical and Psychology Students' Knowledge and Attitudes Regarding Aging and Sexuality

The current study surveys medical and doctoral psychology students (N = 100) from an urban northeastern university regarding knowledge and attitudes toward elderly sexuality and aging using the Facts on Aging Quiz, the Aging Sexuality Knowledge and Attitudes Scale, and measures of interest in gerontology, academic/clinical exposure to aging and sexuality, and contact with elders. The current study found that psychology students demonstrated greater aging knowledge than medical students; however, both groups showed gaps in knowledge about sexuality. Married students had greater academic/clinical exposure and greater knowledge about aging but less permissive attitudes toward elderly sexuality. Generally, knowledge about aging was the strongest correlate of knowledge about sexuality. Level of knowledge about sexuality was not associated with attitudes. Attitudes toward sexuality and aging may be more strongly tied to demographic variables reflective of religious beliefs or adherence to sociocultural norms.     

Leptin and cellular and innate immunity in abstinent alcoholics and controls

BACKGROUND: Basic studies indicate that in vitro and in vivo doses of leptin modulate cellular immune responses. Given evidence that concentrations of leptin are altered in alcoholics who also show immune abnormalities, this study examined the relationships between circulating levels of leptin and markers of cellular and innate immunity. METHODS: Circulating levels of leptin, natural killer cell (NK) activity, interleukin-2 (IL-2)-stimulated NK activity, and concanavalin A-stimulated production of IL-2, IL-6, IL-10, and IL-12 were compared between abstinent DSM-IV alcohol-dependent men (n = 27) and age- and gender-matched controls (n = 34). RESULTS: As compared with controls, alcoholics showed lower NK activity (p < 0.01) and a trend for lower levels of leptin (p = 0.055). In the total sample, leptin predicted NK activity (beta = 0.33; p < 0.05) after controlling for the confounding influence of body mass index, alcohol intake, and smoking. Leptin was not correlated with any of the cytokine measures. To examine whether the effects of leptin were mediated by its direct action on NK, additional studies examined in vitro effects of leptin on NK activity in healthy volunteers (n = 10); leptin doses (0.1, 1, and 10 nM) yielded levels of NK activity comparable to those with media alone. CONCLUSIONS: These data show that circulating levels of leptin are associated with NK activity in humans and suggest that abnormal in vivo concentrations of leptin may contribute to the declines of NK activity in alcoholics who are at risk for infectious diseases.     

自身免疫与动脉粥样硬化的发生发展

在动脉粥样硬化的发生发展过程中,自身免疫具有重要作用,本文就近年有关动脉粥样硬化的免疫机制的研究进展作一简要综述.     

中青年超重和肥胖与高血压及高同型半胱氨酸血症的相关性研究

目的探讨中青年超重和肥胖与高血压及高同型半胱氨酸血症的相关性。方法选取2012年1月—2013年10月在我院进行常规健康体检者750例,测量受试者血压、身高、体质量及血清同型半胱氨酸(Hcy)水平。结果男性超重、肥胖检出率分别为36.87%(198/537)和13.97%(75/537),均高于女性的16.43%(35/213)和7.50%(16/213)(P0.05)。超重者和肥胖者高血压和高同型半胱氨酸血症检出率分别为21.03%(49/233)和11.16%(26/233)、46.12%(42/91)和41.76%(38/91),均高于正常者的9.16%(37/404)和2.23%(9/404),肥胖者高于超重者(P0.01)。收缩压(SBP)、舒张压(DBP)及血清Hcy与BMI呈正相关(r值分别为0.639、0.515、0.497,P0.01)。结论中青年尤其是男性超半数存在超重或肥胖,高血压及高同型半胱氨酸血症与BMI呈正相关,超重和肥胖者高血压及高同型半胱氨酸血症的发生率高,应积极防治。