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1.
T. G. Sazontova A. D. Durnev N. V. Guseva S. N. Kolmykova S. B. Seredenin 《Bulletin of experimental biology and medicine》1995,120(6):1196-1199
Superoxide dismutase and catalase activities and levels of thiobarbituric acid-reactive lipid peroxidation (LPO) products
were estimated in the liver of C57B1/6 and BALB/c mice. The results indicate that although antioxidant enzymes are more active
in BALB/c mice, compensation of oxidation processes in this strain is possible only if LPO-inducing agents are absent or present
at low levels, and that these agents, including exogenous ones, may be expected to activate lipid oxidation in this strain
to a greater extent than in C57Bl/6 mice.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N
o
12, pp. 580–583, December, 1995 相似文献
2.
Mast cells of the mesentery and subcutaneous tissue in BALB/c and C57Bl/6 mice were studied after single and repeated cold
exposure (−20°C, 3 min). Immediate adaptive reactions of mast cells in BALB/c and C57Bl/6 mice did not differ after single
cold exposure and were manifested in increased degranulation. Repeated cold exposure of BALB/c mice was followed by an adaptive
reaction, which included an increase in the count of mast cells in subcutaneous tissue and normalization of the degranulation
index. In C57Bl/6 mice the count of mast cells in subcutaneous tissue decreased, while the degranulation index remained high.
These changes reflect the disadaptive response of mast cells to repeated cold exposure.
Translated fromByulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 138, No. 8, pp. 207–209, August, 2004 相似文献
3.
Seredenin SB Lapitskaya AS Nadorov SA Kudrin VS Badyshtov BA 《Bulletin of experimental biology and medicine》2000,129(5):487-490
Monoamine metabolism in the hypothalamus and striatum of BALB/c and C57Bl/6 mice (intact and stressed in the open field test)
was studied using single-and multidimensional statistical methods. It is suggested that the revealed difference in neurotransmitter
metabolism is associated with genetically controlled behavior of these animals under conditions of emotional stress. The results
of discriminant analysis suggest that the regulation of monoamine metabolism during emotional stress is genetically determined.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 129, No. 5, pp. 574–577, May, 2000 相似文献
4.
《Microbial pathogenesis》1998,24(5):269-275
Burkholderia pseudomalleiis the aetiological agent of melioidosis, a life-threatening bacterial disease occurring in many species of animals, including man. Infection in humans commonly manifests as one of three clinical presentations: acute, subacute or chronic disease. Investigations were undertaken to assess the suitability of BALB/c and C57Bl/6 mice as animal models for the different forms of human melioidosis. The course of infection in BALB/c mice was similar to that which occurs in acute human infection. By contrast, infection of C57Bl/6 mice appeared to mimic chronic human melioidosis. While BALB/c mice suffered a rapidly-progressive bacteraemia which resulted in host death by 96 h, C57Bl/6 mice were able to prevent this, and typically remained asymptomatic for up to 6 weeks. LD50values of 4 cells and 2.5×104cells for BALB/c and C57Bl/6 mice, respectively, reflect these observations. The heightened level of resistance toB. pseudomalleiobserved in C57Bl/6 mice was suggested to have a genetic basis, when the susceptibilities of first filial and reciprocal backcross generations were examined. Growth kinetics ofB. pseudomalleiwithin BALB/c and C57Bl/6 peritoneal exudate cell (PEC) cultures were examined to investigate PEC microbicidal efficiency as a determinant of host susceptibility. C57Bl/6 PEC cultures exhibited greater microbicidal efficiency towardsB. pseudomalleiwhen compared to BALB/c cells, indicating that susceptibility may be determined by non-specific, cellular mechanisms. Collectively, these results suggest that the BALB/c and C57Bl/6 strains of mice may provide excellent models for acute and chronic human melioidosis, respectively. 相似文献
5.
Trunova GV Makarova OV Diatroptov ME Bogdanova IM Mikchailova LP Abdulaeva SO 《Bulletin of experimental biology and medicine》2011,151(1):99-102
Inbred animals serve as an adequate model to study the role of genetic factors in adaptive, disadaptive, and pathological
processes. Morphofunctional study of the immune system was performed on intact BALB/c and C57Bl/6 mice. The structural and
functional parameters of the immune system in BALB/c and C57Bl/6 mice differ under physiological conditions. In BALB/c mice,
volume density of T zone in the spleen and production of IL-2, IL-3, IL-4, IL-10, and TNF-α were much higher than in C57Bl/6
mice. However, IL-12 production in BALB/c mice was lower than in C57Bl/6 mice. C57Bl/6 mice were characterized by higher cytostatic
activity of splenic NK cells. The observed interstrain differences are genetically determined and contribute to the type of
adaptive processes and different sensitivity of these mice to pathogenic agents. 相似文献
6.
The difference in severity of Pseudomonas aeruginosa-induced chronic lung infection may be determined by differences in host inflammatory responses. In the present study we investigate this possibility using BALB/c and C57Bl/6 mice, resistant and susceptible, respectively, to chronic lung infection with P. aeruginosa. Following intratracheal inoculation of P. aeruginosa-impregnated agar beads, C57Bl/6 mice mounted a stronger inflammatory response with significantly higher total cell numbers in the bronchoalveolar lavage fluid compared with BALB/c mice. While polymorphonuclear leucocytes were the predominant cell in C57Bl/6 mice, macrophages constituted the majority in BALB/c mice at day 7 post-infection. Alveolar macrophages from C57Bl/6 mice showed significantly higher spontaneous production of nitric oxide (NO) at day 7 post-infection compared with BALB/c mice. Following in vitro stimulation with heat-killed Pseudomonas antigen, these cells produced significantly higher NO compared with cells from BALB/c mice at day 21 post-infection. Production of tumour necrosis factor-alpha (TNF-α) by alveolar macrophages was significantly higher at day 7 in BALB/c mice compared with C57Bl/6 mice, which showed significantly higher levels at day 28 post-infection. Taken together, these results suggest that defects in the host inflammatory process contribute to the variable outcome of chronic lung infection with P. aeruginosa. An exaggerated inflammatory response dominated by polymorphonuclear cells correlates with susceptibility to infection, whilst a modest inflammatory response dominated by macrophages correlates with resistance. Moreover, the quantity and timing of production of NO and TNF-α by alveolar macrophages may modulate the course and outcome of infection. 相似文献
7.
Trunova GV 《Bulletin of experimental biology and medicine》2004,138(2):182-184
Mast cells of the mesentery and subcutaneous tissue in BALB/c and C57Bl/6 mice were studied after single and repeated cold exposure (-20 degrees C, 3 min). Immediate adaptive reactions of mast cells in BALB/c and C57Bl/6 mice did not differ after single cold exposure and were manifested in increased degranulation. Repeated cold exposure of BALB/c mice was followed by an adaptive reaction, which included an increase in the count of mast cells in subcutaneous tissue and normalization of the degranulation index. In C57Bl/6 mice the count of mast cells in subcutaneous tissue decreased, while the degranulation index remained high. These changes reflect the disadaptive response of mast cells to repeated cold exposure. 相似文献
8.
Seredenin SB Gudasheva TA Boiko SS Kovalev GI Voronin MV Yarkova MA 《Bulletin of experimental biology and medicine》2002,133(4):360-362
Experiments on two mouse strains with opposite reactions to emotional stress showed selectivity of the anxiolytic effect of endogenous dipeptide cycloprolylglycine. In the open field test cycloprolylglycine (0.01-0.10 mg/kg intraperitoneally) dose-dependently (1.8-2.1-fold) increased motor activity of BALB/c mice with manifest fear reaction and had no effect on C57Bl/6 mice with active behavior. The content of endogenous cycloprolylglycine in mouse brain correlated with the type of emotional stress reaction: its content in the brain of C57Bl/6 mice 1.5 times surpassed that in BALB/c mice. It is concluded that cycloprolylglycine is involved in the endogenous regulation of fear reaction. 相似文献
9.
E. V. Nesterova A. D. Durnev S. B. Seredenin 《Bulletin of experimental biology and medicine》1999,128(6):1254-1258
Acrylamide significantly increased the number of cells with chromosome aberrations in BALB/c and C57B1/6, but not in CBA mice.
No difference was found between the BALB/c and C57B1/6 strains in the clastogenic effect of acrylamide. Within the studied
concentration range acrylonitrile exerted no genotoxic effects. Verapamil significantly potentiated the clastogenic effect
of acrylamide in BALB/c mice, while in C57B1/6 mice potentiation was observed only after the repeated intragastric administration
of verapamil in a dose of 2.5 mg/kg. Acrylonitrile in combination with verapamil also produced a slight clastogenic effect
after single and repeated administrations. Thein vivo comutagenic activity of verapamil depended on the dose, administration route and schedule, and genotype of experimental animals.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 128, No. 12, pp. 684–689, December, 1999 相似文献
10.
E. Yu. Gusev N. N. Kevorkov V. L. Ponosov 《Bulletin of experimental biology and medicine》1994,118(5):1196-1198
CBA, CC57BR, C57B1/6, BALB/c, and outbred white mice were intraperitoneally or subcutaneously (C57B1/6 strain) immunized with
sheep red cells in a dose optimal for the development of delayed-type hypersensitivity but subthreshold for antibody production.
Seven days later the mice were reimmunized with sheep red cells in various doses subcutaneously (CBA, C57B1/6, BALB/c, outbred
mice) or intraperitoneally (CBA, CC57BR, outbred mice), and 5 days after reimmunization the intensity of antibody production
and delayed-type hypersensitivity was assessed. Intact mice were controls. The immunization was found to selectively enhance
delayed-type hypersensitivity in C57B1/6, CC57BR, and BALB/c mice and to intensify antibody production in CBA mice; both phenomena
were observed in outbred mice.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N
o
11, pp. 499–501, November, 1994
Presented by K. P. Kashkin, Member of the Russian Academy of Medical Sciences 相似文献
11.
E. P. Kiseleva V. P. Puzyreva R. P. Ogurtsov I. G. Kovaleva 《Bulletin of experimental biology and medicine》2000,130(2):783-785
Effects of experimental hyperlipidemia on apoptosis and proliferation of thymocytes in response to mitogens were studied in
CBA and C57Bl/6 mice. The concentrations of cholesterol in the serum and thymocyte membranes increased in both mouse strains.
Spontaneous and dexamethasone-induced apoptosisin vitro and the proliferative response to phytohemagglutinin and concanavalin A were enhanced in thymocytes from C57Bl/6 mice and
suppressed in cells from CBA mice. These data suggest opposite reactions of thymocyte to increased serum cholesterol concentration
in these two strains, associated with stimulation and suppression of cell activity.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 130, No. 8, pp. 200–202, August, 2000 相似文献
12.
The severity of systemic infection with the yeastCandida albicanshas been shown to be under complex genetic control. C57/L mice carry an allele that is associated with an increase in tissue destruction when compared with C57Bl/6 mice; however, the gene affects only the severity of tissue lesions, and does not influence the magnitude of the fungal burden in either kidney or brain. Studies in [C57/L×C57Bl/6]F1 hybrid mice, and [C57/L×C57Bl/6]F1×C57/L backcross mice, demonstrated that the gene behaves as a simple Mendelian co-dominant. 相似文献
13.
U Malorny M Goebeler J Gutwald J Roth C Sorg 《International archives of allergy and applied immunology》1990,92(4):356-360
Two strains of mice, BALB/c and C57Bl/6, which are known to differ in their inflammatory responsiveness to allergens, were analyzed regarding their expression of macrophage migration inhibitory factor (MIF). Allergic contact dermatitis to 2,4-dinitro-1-fluorobenzene and irritant contact dermatitis to croton oil were studied immunohistologically at designated time intervals after elicitation. BALB/c mice presented a significantly more intense ear swelling response than C57Bl/6 mice and showed a strong endothelial MIF expression in the early phase of inflammation in both allergic and irritant contact dermatitis. Endothelial MIF expression was much weaker in C57Bl/6 mice. Furthermore, the infiltration rate of inflammatory cells (MIF+ and BM8+ macrophages, Lyt2+ and L3T4+ T cells) was significantly higher in BALB/c than in C57Bl/6 mice. We conclude that genetically determined differences of susceptibility to allergens and irritants in BALB/c and C57Bl/6 mice are reflected by the intensity of MIF expression in the microvascular endothelium and immigrating inflammatory cells. MIF seems to appear as first molecular equivalent of developing inflammation and probably determines the degree of cellular infiltration. 相似文献
14.
Gol'dberg ED Masnaya NV Churin AA 《Bulletin of experimental biology and medicine》2005,140(2):219-221
Quantitative composition and functional activity of immunocompetent cells differ in mice of different strains. The counts
of T cells in the bone marrow and spleen, proliferative activity of T cells in the spleen, levels of IL-2 and IL-10 production
by splenic T cells, number of antigen-specific T cells and their functional activity are low in C57Bl/6, BALB/c, and CC57W
mice and high in CBA/CaLac, DBA/2, and C3H animals. Low phagocytic activity of peritoneal macrophages was detected in BALB/c
and CC57W mice and high activity in C3H animals. The content of antibody-producing cells in the spleens of C57Bl/6, BALB/c,
and CC57W mice is higher than in CBA/CaLac, DBA/2, C3H, A/SN, and AKR/JY mice. Functional activity of B cells is lower in
BALB/c and CC57W compared to CBA/CaLac and DBA/2 mice.
__________
Translated from Byulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 140, No. 8, pp. 189–191, August, 2005 相似文献
15.
William B. Siesser Xiaodong Zhang Jacob P.R. Jacobsen Tatyana D. Sotnikova Raul R. Gainetdinov Marc G. Caron 《Neuroscience letters》2010
Tryptophan hydroxylase 2 (TPH2) catalyzes the rate-limiting step in the synthesis of brain serotonin (5-HT). In a previous report, a single nucleotide polymorphism in mTph2 (C1473G) reduced 5-HT synthesis by 55%. Mouse strains expressing the 1473C allele, such as C57Bl/6, have higher 5-HT synthesis rates than strains expressing the 1473G allele, such as BALB/c. Many studies have attributed strain differences to Tph2 genotype without ruling out the potential role of alterations in other genes. To test the role of the C1473G polymorphism in strain differences, we generated C57Bl/6 and BALB/c mice congenic for the Tph2 locus. We found that the 1473G allele reduced 5-HT synthesis in C57Bl/6 mice but had no effect on 5-HT tissue content except for a slight reduction (15%) in the frontal cortex. In BALB/c mice, the 1473C allele increased 5-HT synthesis but again did not affect 5-HT tissue content. At the same time, 5-hydroxyindoleacetic acid (5-HIAA) was significantly elevated in BALB/c congenic mice. In C57Bl/6 mice, there was no effect of genotype on 5-HIAA levels. BALB/c mice had lower expression of monoamine oxidase A and B than C57Bl/6 mice, but there was no effect of Tph2 genotype. On the tail suspension test, escitalopram treatment reduced immobility regardless of genotype. These data demonstrate that the C1473G polymorphism determines differences in 5-HT synthesis rates among strains but only minimally affects 5-HT tissue levels. 相似文献
16.
C57B1/6 mice with low intensity of metabolic processes are more resistant to hypoxic hypoxia than BALB/c mice.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 128, No. 11, pp. 511–513, November, 1999 相似文献
17.
M. Rad M. Ahmadi R. Farid Hosseini A. A. Ashkar J. Tavakkol Afshari 《Comparative clinical pathology》2006,14(4):197-201
Synthetic oligodeoxynucleotides containing CpG motifs have several immune effects such as cytokine production in normal mice. In this study, we demonstrated the protective effect of CpG ODN against Listeria monocytogenes in BALB/c and C57BL/6. With a single dose of 40 μg/mouse of CpG ODN 48 h before bacterial challenge, protection was achieved in both strains of mice based on survival rates compared with controls. Serum IL-12 from each mouse was measured by using enzyme-linked immunosorbent assay (ELISA), at day 0 (48 h after CpG treatment) and at days 5, 11, and 15 after bacterial challenge. It was shown that serum IL-12 was only elevated at day 0 in BALB/c mice. However, for C57BL/6 mice, IL-12 was elevated at days 0, 5, and 11. These data support the hypothesis that CpG DNA motifs activate protective innate immune defenses. 相似文献
18.
Makarova OV Diatroptov ME Serebriakov SN Malaĭtsev VV Bogdanova IM 《Arkhiv patologii》2012,74(3):43-48
Chronic endotoxicosis was modeled by subcutaneous injection of the sepharose in complex with LPS. In these conditions we have studied morphofunctional changes of the immune system of BALB/c and C57Bl/6 mice, which are characterized by the different types of the immune response (Th2 type is predominant in BALB/c, Th1--in C57Bl/6). In the 1st-7th day t in the serum of BALB/c mice the endotoxin level increased in 21.3 times, in C57Bl/6--in 20.6 times. The endotoxin antibodies significantly decreased in 1th-7th days, on the 14th day it increased in the serum of both mice's strains. Morphofunctional changes of the immune system after chronic endotoxicosis were different in BALB/c and C57BI/6 mice. On the 1th day after injection of LPS and sepharose, in the thymus of C57Bl/6 mice the cortex layer was exhausted because of cell death, in the thymus of BALB/c mice II-III stages of accidental involution were developed. On the 7-14th day after injection of LPS and sepharose in the spleen of C57Bl/6 mice T- and B-zones were hyperplastic, however in spleen of BALB/c mice only T-zone were enlarged. After LPS and sepharose injection changes of cytokine production synthesized by KonA activated splenic cells were found out. In both strains the level of proinflammatory cytokines--TNFalpha and IL-1beta decreased, as well the Th1-cytokine IL-2. The production o fTh2-cytokine - IL-4, significantly decreased only in C57BI/6 mice. We suggest that damaging effect of LPS injection is determined by predominant Th2 or Th2 types of the immune response. 相似文献
19.
Immunosuppression in experimental infections with Trypanosoma congolense is mediated by the synergistic action of macrophages and a novel lymphocyte(s), which involves the activity of IFN-gamma as well as IL-10. BALB/c mice are highly susceptible while C57Bl/6 mice are relatively resistant to T. congolense infections. Plasma and/or supernatants of spleen cell cultures of infected susceptible BALB/c mice have more IL-10 but less IL-12 than those of infected relatively resistant C57Bl/6 mice. Cells of a BALB/c macrophage cell line, when pulsed with T. congolense, produce more IL-10 and IL-6, but have less TNF-alpha mRNA, than equally treated cells of a C57Bl/6 cell line. Peritoneal and/or bone marrow-derived macrophages obtained from BALB/c mice, pulsed with T. congolense in culture, produce less nitric oxide, TNF-alpha and IL-12, but more IL-6 and IL-10 than equally treated macrophages isolated from C57Bl/6 mice. We suggest that genetic resistance to African trypanosomiasis is expressed at the level of the macrophage. 相似文献
20.
Makarova OV Trunova GV Diatroptov ME Serebryakov SN Kondashevskaya MV Malaitsev VV 《Bulletin of experimental biology and medicine》2005,139(2):220-222
The level of cytokines produced by ConA activated splenocytes was studied in male BALB/c and C57Bl/6 mice after single and repeated cold exposure (–20°C, 3 min). Single cold exposure significantly decreased IL-2, -3, -4, -5, -10, -12, IFN- production in BALB/c mice and decreased IL-2 content and increased TNF- level in C57Bl/6 mice. Repeated cold exposure normalized the content of IL-2, -4, -10, -12, and IFN- in BALB/c mice, which reflects the development of adaptive immune reactions. In C57Bl/6 mice IL-2, -3, -5, -10, -12, and IFN- production remained significantly decreased, which attested to dysadaptive processes.__________Translated from Byulleten Eksperimentalnoi Biologii i Meditsiny, Vol. 139, No. 2, pp. 188–190, February, 2005 相似文献