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1.
患儿,男,4岁,病程2.5年,以"两年内间断无热抽搐后伴单侧肢体活动障碍5次,抽搐加重伴左侧肢体活动障碍4 d"为主诉入院.患儿19个月时头部外伤后出现抽搐,表现为意识丧失,头后仰,双眼向侧方凝视(具体方向不详),牙关紧闭,无颜面发绀及口吐沫,无二便失禁,四肢情况不详,持续约1 min后自行缓解,缓解后家属发现患儿舌头不灵活,眼向一侧凝视,左侧肢体瘫痪.抽搐后患儿出现间断高热,行头部CT、MRI检查未见异常;静点丙戊酸3 d后改口服丙戊酸1~2周后停药.瘫痪肢体1周后开始出现微小活动,1个月后恢复正常活动.  相似文献   

2.
患儿,男,4岁,病程2.5年,以“两年内间断无热抽搐后伴单侧肢体活动障碍5次,抽搐加重伴左侧肢体活动障碍4d”为主诉入院。患儿19个月时头部外伤后出现抽搐,表现为意识丧失,头后仰,双眼向侧方凝视(具体方向不详),牙关紧闭,无颜面发绀及口吐沫,无二便失禁,四肢情况不详,持续约1min后自行缓解,缓解后家属发现患儿舌头不灵活,眼向一侧凝视,左侧肢体瘫痪。  相似文献   

3.
患儿,男,9岁,因发作性意识丧失伴左肢体抽搐五年来诊。患者系第二胎足月顺产,二岁前发育正常,二岁后渐发现双上肢关节伸面有黄色瘤发生,继之渐延及下肢及臀部,呈结节状,三岁半时有左侧肢体短暂抽搐一次,四岁后有发作性意识丧失伴左侧肢抽搐,初始每3—4个月发作一次,近半年来发作频繁,平均每天发作3—5次。家族史阴性,其一姐及两妹均健康。  相似文献   

4.
<正>例1,男,4个月,因反复抽搐3周入院。患儿3周前无明显诱因出现频繁发作无热抽搐,每日发作2~10次不等,持续数分钟,最长达40 min,表现为双眼紧闭,牙关紧闭,双手握拳,四肢僵硬。患儿为双  相似文献   

5.
患儿女 ,10岁。因发作性呼吸困难 6个月入院。半年前患儿出现呼吸困难 ,呈发作性 ,突然发作、突然终止 ,每次持续 3~ 15min ,发作时伴心悸和视物模糊 ,无意识障碍 ,无肢体阵挛性抽搐、强直 ,无咬舌及尿失禁 ,无自动症及精神失常 ,无短暂性发愣及点头等。未经治疗可自然缓解 ,缓解后无意识朦胧、昏睡、头痛、肌肉痛等。发作多出现在白天 ,尤其在雪地上和夏季阳光下行走时 ,夜间极少发作 ,每月发作3~ 5次 ;间歇期正常。曾在当地诊断为“支气管哮喘” ,给予口服氨茶碱、阿斯咪唑、异丙嗪治疗 2 0d ,症状无缓解。患儿为第 1胎第 1产 ,足月…  相似文献   

6.
患儿,男,3个月,主因间断抽搐半个月,精神差、呼吸深慢1d以“颅内感染?”收住PICU.患儿自入院前半个月开始出现无热抽搐,表现为双眼凝视,双上肢屈曲,双下肢强直,持续3~5s自行缓解,均为清醒时出现,最短间隔30 min发作1次,最长间隔2d,至住院时共发作30余次,入院当天发作6次,缓解后精神好,吃奶如常.  相似文献   

7.
婴儿脑面血管瘤病1例   总被引:1,自引:0,他引:1  
患儿女 ,9个月 ,因间断抽搐 7个月 ,发热伴抽搐加重半小时于 1999年6月 2 4日入院。患儿于 7个月前无明显诱因出现左侧肢体间断性抽搐 ,伴意识丧失 ;无双眼凝视、尖叫、口吐白沫、发绀及尿便失禁 ;每次持续约 5~15min ,每月发作 2~ 3次 ,可自行缓解。母孕期正常 ,患儿足月顺产 ,无产伤、窒息史 ;出生时有右侧面部皮肤毛细血管瘤。出生后母乳喂养 ,5个月才会笑、认人 ,6个月会抬头 ,至入院时患儿仍不能翻身、坐立等。患儿父母健康 ,非近亲结婚 ,否认家族中有类似疾病史及遗传病史。体检 :体温 37.8℃、呼吸 42 /min、脉搏 16 0 /mi…  相似文献   

8.
间断抽搐伴进行性智力运动倒退4年   总被引:1,自引:1,他引:0  
<正>病例介绍患儿女,11岁,因间断抽搐、进行性智力运动倒退4年就诊。患儿于4年前(7岁4月龄)无明显诱因出现抽搐,表现为双眼上翻,四肢及躯体僵硬,呼之不应,约10余秒后出现四肢阵挛,持续1~2 min缓解,伴面色及口唇发绀。初始每半年发作1次,后逐渐增多,醒、睡均有发作,最频繁时1 d内7~8次。2年余前出现第2种发作形式,表现为全身快速抖动一下,醒睡均有,每天  相似文献   

9.
病例摘要:男,12岁半。因反复抽搐3个月入院。3个月前无明显诱因在课后突然趺倒,四肢屈曲抽搐,吐白沫,双眼凝视,呼之不应,咬伤舌。2~3分钟后止抽。不发热,抽搐时无大小便失禁,抽后乏力乃入睡。此后,类似发作3次,当地医院见EEG示广泛中度异常,诊为癫痫。予苯妥英钠、安定治疗,仍频繁发作,有时1日数次,但多不伴意识丧失,仅为单侧肢体抽搐,病后学习成绩下降。患儿为足月顺产,否认外伤史、甲状腺手术及抽搐史。家  相似文献   

10.
同胞姐弟共患结节性硬化症4例   总被引:1,自引:0,他引:1  
例1先证者,女,12岁,因反复抽搐十余年入院,1.5岁时患儿不明原因出现抽搐,表现为频繁眨眼、口角右斜、右上下肢强直,进而发展为四肢强直或屈曲、呼之不应,持续约数十秒后缓解,抽后全身乏力,伴发热37.8℃左右,无嗜睡、呕吐、肢体瘫痪等。类似抽搐发作数百次以上,无时间规律性,当受凉、进食甜酒、饮料后抽搐更频繁,曾服用苯妥英钠等药物无效。生长发育基本正常,现读小学四年级,成绩中等。  相似文献   

11.

The development of adolescent health and medicine as a medical discipline lags behind in Europe compared with other regions of the world. This study aims to evaluate the structure and content of adolescent medicine and health training curricula for medical students, paediatricians, and other primary care physicians in the European region. A questionnaire survey was sent by e-mail to experts in the field from 36 European countries, addressing the content of adolescent health issues. Data was obtained from all 36 countries. At the undergraduate level, seven countries reported some mandatory stand-alone teaching (sessions dealing specifically with adolescents), while seven countries reported optional stand-alone teaching. In only 7 out of 36 countries were issues critical to adolescents covered as stand-alone sessions. At the postgraduate level, 15 countries delivered stand-alone mandatory training sessions to primary, secondary, or tertiary care paediatricians, covering most of the five critical areas listed in the questionnaire. In another 13 countries, such sessions were not mandatory and were inexistent in eight of them. The coverage among school physicians was similar but was much lower among general practitioners.

Conclusion: Paediatric associations and academic institutions should advocate for a better coverage of adolescent health and medicine in the training curricula of health care providers.

What is known:

In most European countries, adolescent medicine is still poorly represented as a discipline.

Experts have recently published recommendations regarding what form the structure and content of a training curriculum in this field should take.

What is new:

This paper gives information on the extent and content of training in adolescent medicine and health as currently offered within under- and postgraduate European training curricula, in terms of stand-alone mandatory (versus optional) sessions.

In many European countries, both medical students and residents are poorly exposed to the basic knowledge and skills pertaining to adolescent health care.

  相似文献   

12.
Objective—To describe the long term effectiveness of a community based program targeting prevention of burns in young children.

Design—Quasiexperimental.

Setting—The Norwegian city of Harstad (main intervention), six surrounding municipalities (intervention diffusion), and Trondheim (reference).

Participants—Children under age 5 years in the three study populations.

Methods—Outpatient and inpatient hospital data were coded according to the Nordic system, and collected as part of a national injury surveillance system. Burn data collection started in May 1985. The first 19.5 months of the study provided baseline data, while the last 10 years involved community based intervention, using a mix of passive and active interventions.

Results—The mean burn injury rate decreased by 51.5% after the implementation of the intervention in Harstad (p<0.05) and by 40.1% in the six municipalities (not significant). Rates in the reference city, Trondheim, increased 18.1% (not significant). In Harstad and the six surrounding municipalities there was a considerable reduction in hospital admissions, operations, and bed days. Interventions with passive strategies were more effective, stove and tap water burns being eliminated in the last four years, while active strategies were less effective.

Conclusions—A program targeting burns in children can be effective and sustainable. Local injury data provided the stimulus for community action.

  相似文献   

13.
Background

In recent years, there has been a movement toward more judicious use of computed tomography (CT) imaging in an attempt to limit exposure of pediatric patients to ionizing radiation. The Image Gently Alliance and like-minded movements began advocating for safe and high-quality pediatric imaging worldwide in the late 2000s.

Objective

In the context of these efforts, we evaluate CT utilization rates in the pediatric emergency department at a major academic medical center.

Materials and methods

We tracked utilization in several categories of CT, magnetic resonance imaging (MRI) and ultrasonography (US) between July 2008 and June 2017 and compared them with utilization rates from 2000 to 2006.

Results

A total of 4,955 pediatric patients underwent a total of 5,973 CT scans, 2,775 US studies and 293 MRI scans while in the pediatric emergency department during the 2008–2017 study period. We observed decreases in CT scans across all categories, ranging from a 19% decrease in abdominal CT to a 66% decrease in chest CT. Relatively greater decreases in CT scans were observed in patients younger than 3 years of age as compared to older children and adolescents. Abdominal and pelvic US increased. Brain MRI also increased over the final two years of the study.

Conclusion

CT utilization decreased throughout the 2008–2017 study period.

  相似文献   

14.
Renesme  Laurent  Allen  A.  Audeoud  F.  Bouvard  C.  Brandicourt  A.  Casper  C.  Cayemaex  L.  Denoual  H.  Duboz  M. A.  Evrard  A.  Fichtner  C.  Fischer-Fumeaux  C. J.  Girard  L.  Gonnaud  F.  Haumont  D.  Hüppi  P.  Knezovic  N.  Laprugne-Garcia  E.  Legouais  S.  Mons  F.  Pelofy  V.  Picaud  J. C.  Pierrat  V.  Pladys  P.  Reynaud  A.  Souet  G.  Thiriez  G.  Tourneux  P.  Touzet  M.  Truffert  P.  Zaoui  C.  Zana-Taieb  E.  Zores  C.  Sizun  J.  Kuhn  P. 《European journal of pediatrics》2019,178(10):1545-1558

We sought to establish guidelines for hygiene care in newborns based on a systematic review of the literature and grading of evidence using the Groupe de Réflexion et d’Evaluation de l’Environement des Nouveau-nés (GREEN) methodology. We examined 45 articles and 4 reports from safety agencies. These studies recommend a tub bath (rather than a sponge bath) for full-term infants and a swaddle bath for preterm newborns. They also recommend against daily cleansing of preterm infants. The literature emphasized that hygiene care must consider the clinical state of the newborn, including the level of awareness and behavioral responses. Hospitalized newborns treated with topical agents may also experience high exposure to potentially harmful excipients of interest. Caregivers should therefore be aware of the excipients present in the different products they use. In high-resource countries, the available data do not support the use of protective topical agents for preterm infants.

Conclusions: We recommend individualization of hygiene care for newborns. There is increasing concern regarding the safety of excipients in topical agents that are used in neonatology. A multidisciplinary approach should be used to identify an approach that requires lower levels of excipients and alternative excipients.

What is known:

Hygiene care is one of the most basic and widespread types of care received by healthy and sick newborns worldwide.

• There is no current guideline on hygiene for preterm or hospitalized term newborn.

What is new:

The French Group of Reflection and Evaluation of the environment of Newborns (GREEN) provided here guidelines based on the current body of evidence.

• Caregivers should be aware of the many issues related to hygiene care of newborns including newborns’ behavioral responses to hygiene care, exposition to excipients of interest, and the potential risk of protective topical agents in a preterm infant. provided here guidelines based on the current body of evidence.

• Caregivers should be aware of the many issues related to hygiene care of newborns including newborns’ possible behavioral responses to hygiene care, exposition to excipients of interest and the potential risk of protective topical agents in a preterm infant.

  相似文献   

15.

The prevalence of allergic diseases in children is markedly increasing to epidemic proportions. The aim of this study is to describe the presence and examine associated parental and child characteristics of allergic sensitization and physician-diagnosed allergy in Dutch children at age 10 years. This study among 5471 children was performed in a population-based prospective cohort from fetal life onwards. Allergic sensitization was measured by skin prick tests. Physician-diagnosed allergy and parental and child characteristics were collected by questionnaires. In children aged 10 years, inhalant and food allergic sensitization was present in 32.2% and 7.1%, and physician-diagnosed inhalant and food allergy in 12.4% and 2.3%. Maternal and paternal history of allergy, eczema or asthma was associated with increased risks of physician-diagnosed inhalant allergy (aOR (95% CI) 1.44 (1.23–1.70) and 1.59 (1.30–1.94), respectively), but not with food allergy. Asthma and eczema ever at age 10 years were associated with increased risks of physician-diagnosed inhalant allergy (4.60 (3.55–5.96) and 2.42 (1.94–3.03), respectively). Eczema ever at age 10 years was associated with an increased risk of physician-diagnosed food allergy (5.78, 3.04–9.52), with the highest risk of cashew (7.36, 3.20–16.94) and peanut (5.58, 3.08–10.10) food allergy.

Conclusions: We found strong effects of parental history of allergy, eczema or asthma on the presence of physician-diagnosed inhalant allergy in children at age 10 years. Eczema ever at age 10 years was a strong risk factor for the development of physician-diagnosed inhalant and food allergy.

What is Known:

• The prevalence of allergic diseases in children has markedly increased.

• Early-life influences are critically important in the development of allergic diseases.

What is New:

• Maternal and paternal history of allergy, eczema or asthma is associated with increased risks of physician-diagnosed inhalant allergy but not with food allergy.

• Eczema ever at age 10 years is associated with an increased risk of physician-diagnosed food allergy, with the highest risk for cashew and peanut food allergy.

  相似文献   

16.

Inherited antithrombin (AT) deficiency is a rare autosomal dominant disorder, caused by mutations in the AT gene (SERPINC1). Considering that the genotype phenotype relationship in AT deficiency patients remains unclear, especially in pediatric patients, the aim of our study was to evaluate genotype phenotype correlation in a Serbian pediatric population. A retrospective cohort study included 19 children younger than 18 years, from 15 Serbian families, with newly diagnosed AT deficiency. In 21% of the recruited families, mutations affecting exon 4, 5, and 6 of the SERPINC1 gene that causes type I AT deficiency were detected. In the remaining families, the mutation in exon 2 causing type II HBS (AT Budapest 3) was found. Thrombosis events were observed in 1 (33%) of those with type I, 11 (85%) of those with AT Budapest 3 in the homozygous respectively, and 1(33%) in the heterozygous form. Recurrent thrombosis was observed only in AT Budapest 3 in the homozygous form, in 27% during initial treatment of the first thrombotic event. Abdominal venous thrombosis and arterial ischemic stroke, observed in almost half of the children from the group with AT Budapest 3 in the homozygous form, were unprovoked in all cases.

Conclusion: Type II HBS (AT Budapest 3) in the homozygous form is a strong risk factor for arterial and venous thrombosis in pediatric patients.

What is Known:

Inherited AT deficiency is a rare autosomal dominant disorder, caused by mutations in the SERPINC1gene.

The genotype phenotype correlation in AT deficiency patients remains unclear, especially in pediatric patients.

What is New:

The genetic results for our paediatric population predominantly showed the presence of a single specific mutation in exon 2, that causes type II HBS deficiency (AT Budapest 3).

In this group thrombosis mostly occurred as unprovoked, in almost half of them as abdominal thrombosis or stroke with high incidence of recurrent thrombosis, in 27% during initial treatment.

  相似文献   

17.
Background

No normal measurements or specific size criteria have been described for cervical lymph nodes in children.

Objective

To determine the normal measurements of cervical lymph nodes in children on CT.

Materials and methods

We included 142 children (ages 1–17 years) who underwent cervical CT examination after high-energy trauma. We evaluated axial and coronal 2-mm reconstructions for lymph nodes at six cervical levels. For the largest lymph node at each level, we measured diameters in both the long and short axial axes and the long coronal axis.

Results

A total of 733 lymph nodes were measured in 142 children (62% boys, 38% girls). The greatest measured diameters were 14 mm for the short axis in the axial plane, 24 mm for the long axis in the axial plane and 28 mm for the long axis in the coronal plane. The Pearson correlation coefficient for age and lymph node size at Levels IV–VI was in the range of 0.19–0.47.

Conclusion

Lymph nodes with an axial short-axis diameter exceeding 15 mm for Level II and 10 mm for all other cervical levels are uncommon in otherwise healthy children.

  相似文献   

18.
19.

Early recognition of critically ill patients is of paramount importance to reduce pediatric mortality and morbidity. We created a risk stratification system combining vital parameters and predefined risk factors aimed at reducing the risk of unrecognized clinical deterioration compared with conventional Pediatric Early Warning Systems (PEWS). This single-center retrospective case cohort study included infants (gestational age ≥ 37 weeks) to adolescents (aged <18 years) with unplanned pediatric intensive care unit (PICU) admission between April 01, 2014, and February 28, 2018. The sensitivity in the 24 h prior to endpoint of the Pediatric Risk Evaluation and Stratification System (PRESS) was compared with that of the conventional PEWS and calculated as the proportion of study patients who received a high-risk score. Seventy-four PICU admissions were included. PRESS and PEWS sensitivities at 2 h prior to endpoint were 0.70 (95%CI 0.59 to 0.80) and 0.30 (95%CI 0.20 to 0.42) respectively (p < 0.001). Excluding patients with seizures, PRESS sensitivity increased to 0.75 (95%CI 0.64 to 0.85). Forty-nine patients (66%) scored positive on at least one high-risk factor, and “worried sign” was scored in 31 patients (42%).

Conclusion: Risk stratification seems advantageous for a faster detection of clinical deterioration, providing opportunity for earlier intervention.

What is Known:

• Prompt detection of clinical deterioration is of essential importance to reduce morbidity and mortality.

• Conventional Pediatric Early Warning Systems (PEWS) have limited sensitivity and a short window of detection of 1 to 2 h.

What is New:

• Risk stratification based on context factors allows earlier identification of patients at risk, well before deviation of vital signs.

• Risk stratification combined with continuous monitoring of deteriorating trends in vital signs could lead to the development of next-generation warning systems achieving true patient safety.

  相似文献   

20.
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