沙利度胺联合醋酸曲安奈德治疗口腔扁平苔藓

目的探讨沙利度胺口服联合醋酸曲安奈德局部注射治疗口腔扁平苔藓(OLP)临床效果。方法对2009年7月—2011年7月郑州市口腔医院牙周黏膜科64例口腔扁平苔藓患者随机分为观察组和对照组,观察组予以沙利度胺片剂口服和醋酸曲安奈德注射液和2%利多卡因局部黏膜下注射,对照组采用醋酸曲安奈德注射液及2%利多卡因局部黏膜下注射,通过临床症状判定疗效。结果观察组的总有效率为96.8%,高于对照组90.6%,观察组满意率96.8%,高于对照组87.5%。结论采用口服用药和局部注射相结合的方法对于治疗OLP有更好的临床疗效。     

局部注射复方倍他米松和醋酸曲安奈德治疗斑秃的疗效观察

目的比较局部注射复方倍他米松注射液和醋酸曲安奈德注射液治疗斑秃的临床疗效及不良反应。方法182例斑秃患者随机分为治疗组和对照组各91例,治疗组采用复方倍他米松注射液1ml加2%利多卡因2ml,0.2ml/cm2局部注射,每4周1次,连续3次,对照组采用醋酸曲安奈德注射液1ml加2%利多卡因2ml,0.2ml/cm2局部注射,每周1次,连续3周,治疗组和对照组均同时口服维生素B6片(20mg,3次/d),谷维素片(20mg,3次/d),分别观察治疗后第4、8、12周的临床疗效及不良反应。结果治疗第4周时治疗组和对照组有效率分别为17.58%和30.77%,P<0.05;第8周时治疗组和对照组有效率分别为46.15%和53.85%,P>0.05;第12周时治疗组和对照组有效率分别为83.52%和70.33%,P<0.05。结论局部注射糖皮质激素治疗斑秃疗效确切,早期醋酸曲安奈德组疗效高于复方倍他米松组,但后期复方倍他米松组疗效高于醋酸曲安奈德组。     

帕夫林联合曲安奈德治疗口腔扁平苔藓

目的　观察帕夫林联合曲安奈德局部注射治疗口腔扁平苔藓 (OLP)的临床疗效。 方法　 将口腔扁平苔藓患者 6 0例随机分为两组 ,治疗组 30例口服帕夫林 ,局部注射曲安奈德注射液 ,对照组 30例服用左旋咪唑片 ,进行临床疗效观察。 结果　 治疗组有效 2 7例 ,总有效率为 90 % ;对照组有效 2 1例 ,总有效率为70 % ,P <0 .0 5 ,有差异。 结论　 帕夫林联合曲安奈德局部注射治疗口腔扁平苔藓有良好的疗效     

醋酸曲安奈德局部注射对变应性鼻炎患者血清白介素4和γ干扰素的影响

目的：评价醋酸曲安奈德局部注射对变应性鼻炎患者血清白介素4（interleukin-4,IL-4）和Y干扰素（interferon-γ,INF-γ）表达水平的影响.方法：60例变应性鼻炎患者随机分成观察组和对照组各30例,对照组予盐酸西替利嗪片10 mg,po,qd,观察组患者双侧中、下鼻甲黏膜下局部注射醋酸曲安奈德治疗.治疗4周后,检测两组患者血清IL-4、IFN-γ水平,比较两组疗效和药品不良反应.结果：观察组总有效率为93.33％,高于对照组的73.33％,但差异无统计学意义（P＞0.05）.治疗4周后,观察组IL-4浓度低于对照组（P＜0.01）,IFN-γ浓度高于对照组（P＜0.01）.两组均未发现不能耐受的不良反应或严重不良反应.结论：醋酸曲安奈德局部注射治疗变应性鼻炎疗效较佳,能够降低患者血清IL-4水平,并提高血清IFN-γ水平.     

手术切除联合两种不同方式曲安奈德局部注射治疗瘢痕疙瘩疗效观察

目的探讨手术切除联合两种不同方式曲安奈德局部注射治疗瘢痕疙瘩的疗效。方法对瘢痕疙瘩行核心切除,切除后治疗组即时用醋酸曲安奈德混悬液（5ml：∶0 mg）按1：1的比例加2%利多卡因混匀行创缘和基底部注射,对照组于拆线后1周开始行局部曲安奈德注射治疗。然后两组患者每周局部注射1次,连续注射6周,观察疗效。结果对43例患者进行为期2年的观察。治疗组19例痊愈,1例显效,总有效率为90.91%,对照组17例痊愈,2例显效,总有效率为90.48%。两组比较差异无统计学意义（P〉0.05）。结论手术核心切除联合两种不同方式曲安奈德局部注射治疗瘢痕疙瘩疗效确切。     

醋酸泼尼松治疗糜烂型口腔扁平苔藓的疗效分析

目的 观察醋酸泼尼松治疗糜烂型口腔扁平苔藓(OLP)的临床疗效.方法 选择48 例经病理检查确诊为双侧颊黏膜糜烂型OLP 患者.经患者同意,以患者一侧病损为治疗组,另一侧为对照组.治疗组局部注射醋酸泼尼松10mg 加利多卡因1mL,每天1 次,4 次为1 个疗程.对照组不予任何治疗.结果 治疗组显效及好转45 例,对照组显效及好转24 例(P ＜ 0.01).结论 醋酸泼尼松治疗糜烂型OLP 效果良好.     

穴位注射联合中药外洗治疗手部湿疹的疗效观察

目的 探讨穴位注射醋酸曲安奈德注射液加利多卡因联合中药外洗治疗手部湿疹的疗效.方法 将108例手部湿疹患者随机分为对照组和治疗组各54例.对照组采用穴位注射醋酸曲安奈德注射液1 ml加2％利多卡因1 ml的混合液,分别对双手合谷穴注射,每3周1次,6周1个疗程;治疗组在对照组的基础上加用中药浸泡患部20～30 min,2次/d,6周1个疗程.2个疗程后对两组疗效进行比较.结果 治疗组治疗后EASI评分下降比对照组明显（P＜0.05）.治疗组和对照组有效率分别为96.3％和79.63％,两组比较差异有统计学意义（P＜0.05）.结论 穴位注射醋酸曲安奈德注射液加2％利多卡因联合中药洗剂治疗手部湿疹是安全有效的,值得推广应用.     

醋酸曲安奈德鼻喷剂长期应用对鼻粘膜影响动物实验

目的观察醋酸曲安奈德鼻喷剂长期应用对鼻粘膜和鼻纤毛有元损害作用.方法杂种狗,高剂量组4只;低剂量组4只;对照组4只,鼻腔给药0.64%醋酸曲安奈德鼻喷剂组每日一次,每次2个鼻孔各喷药1次(880ug);0.14%醋酸曲安奈德鼻喷剂每日一次,每次2个鼻孔各喷药1次(220ug,);0.9%生理盐水组每日一次,每次2个鼻孔各喷100ul.用药前后观察鼻腔粘膜,血常规,用药后,光镜和电镜观察鼻粘膜.结果用药后,鼻粘膜三组间无差异,血常规无差异,光镜电镜未见鼻粘膜病损.结论醋酸曲安奈德鼻喷剂长期应用对鼻粘膜无毒害作用.     

局部封闭联合冷冻治疗瘢痕疙瘩疗效分析

目的 观察局部封闭联合冷冻治疗增生性瘢痕疙瘩的临床疗效.方法 2006年12月至2011年6月共治疗瘢痕疙瘩120例,将其分为实验组和对照组.实验组采取醋酸曲安奈德局部注射联合液氮冷冻治疗,并以单纯局部冷冻治疗、单纯醋酸曲安奈德局部注射治疗作为时照组,每组40例,所有患者随访6个月至5年.结果 实验组治疗瘢痕疙瘩有效率达90.00％,复发率为2.50％;对照组有效率分别为75.00％、80.00％,复发率分别为10.00％、15.00％.结论 采用局部封闭联合冷冻治疗瘢痕疙瘩是行之有效的手段,可显著降低复发率.     

醋酸曲安奈德注射治疗霰粒肿的临床观察

目的评价醋酸曲安奈德注射治疗霰粒肿的临床疗效。方法将86例霰粒肿患者均分为试验组和对照组,试验组以醋酸曲安奈德瘤体局部注射,对照组以强的松龙局部注射,观察两组患者临床疗效及安全性。结果试验组患者治愈率明显高于对照组,差异有极显著性（P〈0．01）,并且试验组注射次数和治愈时间明显低于对照组,而霰粒肿体积减小比例明显高于对照组,差异有统计学意义（P〈0．05）。两组患者均未发生明显的不良反应。结论醋酸曲安奈德注射治疗霰粒肿安全、有效,值得临床推广。     

醋酸强的松龙局部注射治疗糜烂型口腔扁平苔藓疗效观察

目的观察醋酸强的松龙局部注射治疗糜烂型口腔扁平苔藓（OLP）效果。方法将70例糜烂型OLP患者随机分为两组各35例,治疗组采用醋酸强的松龙与利多卡因混合液于病损区基底部多点注射;对照组采用口服泼尼松片疗法;两组进行疗效观察。结果治疗组痊愈率22.9%,总有效率91.4%;对照组痊愈率14.3%,总有效率71.4%;两组疗效有统计学差异（P〈0.05）。结论本疗法是治疗糜烂型OLP的一种安全有效的方法 。     

Formulation and efficacy of triamcinolone acetonide mouthwash for treating oral lichen planus.

PURPOSE: The stability of a triamcinolone acetonide mouthwash and its efficacy in treating oral lichen planus are described. METHODS: The solubility of triamcinolone acetonide in ethanol, propylene glycol, and glycerin was determined by shaking and equilibrating an excess of triamcinolone acetonide with the solvents for 72 hours. All three solvents were used in formulating a mouthwash. A stock solution of triamcinolone acetonide standard was prepared in ethanol and diluted to yield concentrations of 2, 4, 8, 12, and 16 microg/mL. Analytical sample solutions were prepared by pipetting 0.1 mL of triamcinolone acetonide mouthwash into 10-mL volumetric flasks and diluting to volume with the mobile phase. Accelerated stability studies were conducted by storing the samples in 60-mL amber glass bottles at 45, 60, 70, and 80 degrees C and 75% relative humidity until the triamcinolone concentration decreased markedly. Efficacy was tested by 20 subjects with a clinical diagnosis of and histologically confirmed symptomatic oral lichen planus who were randomized to use the mouthwash (n = 11) or the commercially available triamcinolone acetonide paste (n = 9). RESULTS: The mouthwash had a satisfactory shelf life and was well accepted by patients. Ten of 11 patients treated with the mouthwash for four weeks reported a positive response, and a complete response in signs and symptoms occurred in 4 and 5 of 11 patients, respectively. No significant difference in clinical improvement was observed between groups. CONCLUSION: A triamcinolone acetonide mouthwash had a satisfactory shelf life and was well accepted by patients. It did not have a significantly different therapeutic efficacy from the commercial paste dosage form in the treatment of oral lichen planus.     

平阳霉素与地塞米松局部注射治疗口腔扁平苔藓远期疗效对照研究

目的 探讨平阳霉素局部注射治疗口腔扁平苔藓的临床效果.方法 选择2013年5月至2016年1月收治的 57 例口腔扁平苔藓(OLP)患者,根据临床病历和处方随机分为2组,观察组26例采用盐酸平阳霉素局部多点位注射治疗;对照组31例地塞米松磷酸钠局部多点注射治疗.分别观察治疗前、治疗后1、3、6个月VAS评分、REU评分、总有效率及复发率,部分病例作治疗前后病理观察.所有数据采用SPSS 13.0软件进行统计分析.结果 治疗后1个月,2组治疗对OLP均有疗效.3个月后,各项统计学指标与治疗前差异有统计学意义(P<0.05),观察组在VAS、REU评分、复发率及总有效率方面均优于对照组(P<0.05).结论 平阳霉素局部注射化疗方案对OLP有显著的临床治愈效果,能够消除或显著缓解患者疼痛症状,缩短糜烂皮损面的愈合时间,且复发率低,毒副反应轻微,可以达到彻底消除 OLP 糜烂病损和降低癌变危险度的目标,值得临床借鉴应用.     

Total glucosides of paeony (TGP) inhibits the production of inflammatory cytokines in oral lichen planus by suppressing the NF-κB signaling pathway

Total glucosides of paeony (TGP) is a bioactive compound extracted from paeony roots and has been widely used to ameliorate inflammation in several autoimmune and inflammatory diseases. However, the anti-inflammatory effect of TGP on oral lichen planus (OLP), a chronic inflammatory oral condition characterized by T-cell infiltration and abnormal epithelial keratinization cycle remains unclear. In this study, we found that TLR4 was highly expressed and activation of the NF-κB signaling pathway was obviously observed in the OLP tissues. Moreover, there was significant higher mRNA expression of inflammatory cytokines interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in OLP keratinocytes than normal oral epithelial keratinocytes. With the help of the cell culture model by stimulating the keratinocyte HaCaT cells with lipopolysaccharides (LPS), we mimicked the local inflammatory environment of OLP. And we further confirmed that TGP could inhibit LPS-induced production of IL-6 and TNF-α in HaCaT cells via a dose-dependent manner. TGP treatment decreased the phosphorylation of IκBα and NF-κB p65 proteins, thus leading to less nuclear translocation of NF-κB p65 in HaCaT cells. Therefore, our data suggested that TGP may be a new potential candidate for the therapy of OLP.     

曲安奈德联合磷酸氯喹治疗口腔扁平苔藓30例

目的：观察曲安奈德联合磷酸氯喹治疗口腔扁平苔藓的临床疗效。方法收集2012年1月到2013年1月收治的60例口腔扁平苔藓患者的临床资料,将患者随机分为观察组和对照组,各30例。对照组单纯采用磷酸氯喹治疗,观察组采用曲安奈德联合磷酸氯喹治疗,分析两组患者的治疗效果。结果观察组的总有效率为93.34%,明显高于对照组的73.33%（ P ﹤0.05）。观察组不良反应发生率为6.67%,明显低于对照组的13.33%（ P ﹤0.05）。观察组患者治疗后疼痛评分、血清 IgM,IgG 水平明显优于对照组（ P ﹤0.05）。结论曲安奈德联合磷酸氯喹治疗口腔扁平苔藓,有利于降低口腔疾病复发率,安全性与有效性显著,值得临床推广。     

口炎清颗粒联合曲安奈德治疗口腔扁平苔藓的临床研究

目的探讨口炎清颗粒联合曲安奈德治疗口腔扁平苔藓的临床疗效。方法回顾性分析2014年1月—2015年10月在中国医科大学附属口腔医院接受治疗的口腔扁平苔藓患者临床资料78份,随机分为对照组(39例)和治疗组(39例)。所有患者均进行基础治疗以减轻对口腔黏膜的刺激。对照组病灶黏膜基底部注射醋酸曲安奈德注射液,10 mg溶于2%利多卡因2.5 mL中,1次/周。治疗组在对照组基础上口服口炎清颗粒,2袋/次,2次/d。两组患者均连续治疗4周。比较两组的临床疗效,同时比较两组体征评分、疼痛评分和生活质量评分变化,观察两组治疗前后血清IL-2、IL-4和TNF-α水平变化。结果治疗后,对照组和治疗组的总有效率为84.62%、97.44%,两组比较差异有统计学意义(P0.05)。治疗后,两组体征评分、疼痛评分和生活质量评分均较同组治疗前降低(P0.05),且治疗组比对照组降低的更显著(P0.05)。治疗后两组血清IL-2、IL-4和TNF-α水平均较同组治疗前降低(P0.05),且治疗组降低的更显著(P0.05)。结论口炎清颗粒联合曲安奈德治疗口腔扁平苔藓疗效显著,可明显降低患者血清炎性因子水平,有效改善患者临床症状,具有一定的临床推广应用价值。     

Immune response in patients with oral lichen planus and HCV infection

In recent years an association between oral lichen planus (OLP) and HCV infection has been reported, but the frequency of this association seems to differ in the various geographic areas. It is clear, instead, that some abnormalities occur in the immune-regulation mechanisms of patients with OLP and it is thought to be due to the chronic antigenic stimulus of HCV that causes functional disorders of the immune system in infected patients. Possible immunologic difference between 17 patients with OLP and HCV+ and 17 patients with OLP and HCV- were investigated using standard immunofluorescence and flow cytometry techniques. The distribution of T and B cells was normal in all patients examined, while NK CD56+ cells were increased, above all in HCV- patients. About 65% of T CD4+ lymphocytes coexpressed the CD45RO isoform (p=0.002), while approximately 32% expressed CD45RA, without significant differences in comparison to HCV+ subjects (p>0.05). Moreover, almost all the CD4+CD45RO+ subpopulation coexpressed CD29 in all patients examined. No significant differences between the two groups of patients were detected as to the increase of cytotoxic T CD8+CD57+ lymphocytes. The B cells CD19+CD5+ responsible for the production of "natural" antibodies were detectable in both the examined groups, even if not in all HCV+ subjects (30% +/- 10.1 in HCV- and 27% +/- 19.4 in HCV+ patients; p=0.47). These findings suggest the existence of differences in lymphocyte subpopulations between OLP-HCV+ subjects and OLP-HCV- patients.     

口腔扁平苔藓的治疗研究

目的对口腔扁平苔藓的临床特点及治疗方法进行探讨和分析。方法回顾性分析了经我院确诊并给予治疗的68例患有口腔扁平苔藓的患者。68例患者随机分为两组,对照组及治疗组各34例,对照组采用西医常规治疗,治疗组在西医治疗的基础上均采用中药方剂进行治疗,比较两组的疗效。结果痊愈率及有效率治疗组均优于对照组,两组疗效有显著性差异（P＜0.05）。结论中药方剂配合西医常规治疗可显著提高口腔扁平苔藓的治愈率,方法安全可靠,无副作用,值得临床推广。     

维甲酸联合曲安奈德局部注射治疗口腔扁平苔藓疗效观察

目的探讨维甲酸联合曲安奈德局部注射对糜烂型口腔扁平苔藓的临床疗效。方法选择40名临床诊断为急性糜烂型口腔扁平苔藓的患者,随机分为治疗组和对照组,治疗组：曲安奈德局部注射后,给予维甲酸软膏涂敷,1次／d,连续5d,维生素E胶丸100mg,1次／d,1：3服2周,维生素B：片10mg,3次／d,口服2周。2周后观察临床疗效。对照组：不用曲安奈德局部注射,其他治疗同治疗组,2周复诊观察疗效。结果治疗组患者在治疗后2周有效率明显高于对照组（P〈0．01）。结论说明联合治疗对糜烂型口腔扁平苔藓患者有明显疗效。