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1.
S. F. Fonseca M. C. Teles V. G. C. Ribeiro F. C. Magalh?es V. A. Mendon?a M. F. D. Peixoto L. H. R. Leite C. C. Coimbra A. C. R. Lacerda 《Brazilian journal of medical and biological research》2015,48(12):1122-1129
Individuals with systemic arterial hypertension have a higher risk of heat-related
complications. Thus, the aim of this study was to examine the thermoregulatory
responses of hypertensive subjects during recovery from moderate-intensity exercise
performed in the heat. A total of eight essential hypertensive (H) and eight
normotensive (N) male subjects (age=46.5±1.3 and 45.6±1.4 years, body mass
index=25.8±0.8 and 25.6±0.6 kg/m2, mean arterial pressure=98.0±2.8 and
86.0±2.3 mmHg, respectively) rested for 30 min, performed 1 h of treadmill exercise
at 50% of maximal oxygen consumption, and rested for 1 h after exercise in an
environmental chamber at 38°C and 60% relative humidity. Skin and core temperatures
were measured to calculate heat exchange parameters. Mean arterial pressure was
higher in the hypertensive than in the normotensive subjects throughout the
experiment (P<0.05, unpaired t-test). The hypertensive subjects
stored less heat (H=-24.23±3.99 W·m−2
vs N=-13.63±2.24 W·m−2, P=0.03, unpaired
t-test), experienced greater variations in body temperature
(H=-0.62±0.05°C vsN=-0.35±0.12°C, P=0.03, unpaired
t-test), and had more evaporated sweat (H=-106.1±4.59
W·m−2
vs N=-91.15±3.24 W·m−2, P=0.01, unpaired
t-test) than the normotensive subjects during the period of
recovery from exercise. In conclusion, essential hypertensive subjects showed greater
sweat evaporation and increased heat dissipation and body cooling relative to
normotensive subjects during recovery from moderate-intensity exercise performed in
hot conditions. 相似文献
2.
AimThe study sought to determine whether there is any relationship between plasma homocysteine and blood pressure levels in Nigerians with essential hypertension.MethodIt was a cross-sectional analytical study done on 120 randomly selected hypertensive patients and 120 normal healthy controls seen at the large Conference hall of the Ahmadu Bello University (ABU) Medical Centre, Zaria as well as the ABU Teaching Hospital, Zaria, Northern-Nigeria. Pearson''s Correlation and Binary Logistic Regression analysis determined the relationship between homocysteine and hypertension.ResultsHyperhomocysteinaemia found in the hypertensive patients (22.8 ± 6.6 µmol/L) differed significantly (p<0.001) from controls (10.9 ± 2.8 µmol/L) with significant (p<0.001), blood pressure difference between both groups. Homocysteine significantly positively correlated with systolic (r = 0.51, p<0.001) and diastolic (r = 0.47, p<0.001) blood pressures in hypertensive subjects. The relation of plasma hcy to hypertension was statistically significant for SBP; OR: 1.08 (95% CI, 1.05–1.11) and DBP; OR: 1.08 (95% CI, 1.03–1.13) in the unadjusted model. When adjusted for confounding variables, hcy was significantly related to SBP; OR: 1.1 (95% CI, 1.04–1.18) but not DBP (p=0.25; OR: 1.06 (95 % CI, 0.96–1.18). The mean plasma folate level was high (115.2 ± 48.0 ng/mL) in the hypertensive subjects. The hyperhomocysteinaemic subjects showed a 2.8 times Odds of developing hypertension.ConclusionThis study showed higher mean plasma homocysteine levels in hypertensives than controls not accounted for by sub-optimal folate levels. Hyperhomocysteinaemia showed a positive relationship to systolic hypertension after adjusting for confounders. 相似文献
3.
M.G. Rocha V.A. Gomes J.E. Tanus-Santos J.C. Rosa-e-Silva F.J. Candido-dos-Reis A.A. Nogueira O.B. Poli-Neto 《Brazilian journal of medical and biological research》2015,48(4):363-369
The objective of this prospective study was to determine the plasma levels of nitric
oxide (NO) in women with chronic pelvic pain secondary to endometriosis (n=24) and
abdominal myofascial pain syndrome (n=16). NO levels were measured in plasma
collected before and 1 month after treatment. Pretreatment NO levels (μM) were lower
in healthy volunteers (47.0±12.7) than in women with myofascial pain (64.2±5.0,
P=0.01) or endometriosis (99.5±12.9, P<0.0001). After treatment, plasma NO levels
were reduced only in the endometriosis group (99.5±12.9 vs 61.6±5.9,
P=0.002). A correlation between reduction of pain intensity and reduction of NO level
was observed in the endometriosis group [correlation = 0.67 (95%CI = 0.35 to 0.85),
P<0.0001]. Reduction of NO levels was associated with an increase of pain
threshold in this group [correlation = -0.53 (-0.78 to -0.14), P<0.0001]. NO
levels appeared elevated in women with chronic pelvic pain diagnosed as secondary to
endometriosis, and were directly associated with reduction in pain intensity and
increase in pain threshold after treatment. Further studies are needed to investigate
the role of NO in the pathophysiology of pain in women with endometriosis and its
eventual association with central sensitization. 相似文献
4.
Adeseye A Akintunde 《African health sciences》2022,22(2):257
BackgroundLeft atrial enlargement (LAE) predispose to arrhythmias, atrial thrombogenesis and cardioembolic stroke. Whether LAE constitute a major risk among African hypertensive subjects is not well described. This study was aimed to describe the epidemiologic pattern of LAE among hypertensive subjects and determine their correlates.MethodsClinical and demographic details of 414 hypertensive subjects used were taken. Echocardiography was done. LAE was defined as Left atrial dimension (LAD)>3.7 cm. Statistical analysis was done using SPSS 17.0.Result414 subjects including 258 (62.3%) males were recruited. The mean age was 56.8±16.8 years. LAE was present in 57.73% of hypertensive subjects. Those with LAE were likely to be older (58.23±14.5 vs. 54.8 ±19.7 years, p<0.05), had a higher waist circumference (88.1 ±26.8 ±75.8 ±28.4 cm, p<0.05), left ventricular mass index (79.2 ± 12.4 vs. 48.7 ±15.5g/m2.7, p<0.05) and a higher frequency of left ventricular hypertrophy (LVH) (65.3% vs. 40.0 %, p<0.05) respectively than those without LAE. LAD was significantly higher among those with LVH than those without LVH (41.4 ±8.4 vs. 35.6 ±5.9 mm respectively, p<0.05).ConclusionLAE is common among Nigerian hypertensive subjects. Age, waist circumference, left ventricular wall dimension and mass index are the important correlates of LAE in hypertensive Nigerians. 相似文献
5.
Nasser M. Al-Daghri Omar S. Al-Attas Majed Alokail Hossam M. Draz Ahmed Bamakhramah Shaun Sabico 《Disease markers》2009,26(3):135-140
We studied the association between RBP4 and various markers related to insulin resistance and diabetic complications as well as inflammatory markers in Saudi population suffering from type 2 diabetes and coronary heart disease. Patients with type 2 diabetes were divided into 3 groups according to the type of treatment and involvement of coronary artery disease. Serum RBP4, TNF-α, insulin, CRP, resistin, leptin and adiponectin were analysed in all samples. RBP4 levels increased significantly in the group of diabetic subjects treated with oral hypoglycemic agents and diabetic patients with coronary heart disease (30.2 ± 11.8; 33.4 ± 13.6 respectively), while there was no significant change in the other group for diabetic subjects on low-carbohydrate diet (25.1 ± 10.9) compared to control group (22.6 ± 9.5). RPB4 levels were positively correlated with TNF-α in the group of diabetic subjects on oral hypoglycemic agents and diabetic patients with coronary heart disease (r = 0.52, P < 0.05; r = 0.58, P < 0.05 respectively). No correlations were found between RBP4 levels and insulin resistance in all studied groups. Our findings suggest that serum RBP4 levels is associated with pro-inflammatory cytokine (TNF-α) and is not associated with insulin resistance among patients with type 2 diabetes and coronary heart disease. 相似文献
6.
A.S. Rodríguez-Pérez J.F. López-Rodríguez M.Z. Calvo-Turrubiartes V.M. Saavedra-Alanís L. Llamazares-Azuara M. Rodríguez-Martínez 《Brazilian journal of medical and biological research》2013,46(10):868-880
This study determined whether clinical salt-sensitive hypertension (cSSHT)
results from the interaction between partial arterial baroreceptor impairment
and a high-sodium (HNa) diet. In three series (S-I, S-II, S-III), mean arterial
pressure (MAP) of conscious male Wistar ChR003 rats was measured once before
(pdMAP) and twice after either sham (SHM) or bilateral aortic denervation (AD),
following 7 days on a low-sodium (LNa) diet (LNaMAP) and then 21 days on a HNa
diet (HNaMAP). The roles of plasma nitric oxide bioavailability (pNOB), renal
medullary superoxide anion production (RMSAP), and mRNA expression of NAD(P)H
oxidase and superoxide dismutase were also assessed. In SHM (n=11) and AD (n=15)
groups of S-I, LNaMAP-pdMAP was 10.5±2.1 vs 23±2.1 mmHg
(P<0.001), and the salt-sensitivity index (SSi; HNaMAP−LNaMAP) was 6.0±1.9
vs 12.7±1.9 mmHg (P=0.03), respectively. In the SHM group,
all rats were normotensive, and 36% were salt sensitive (SSi≥10 mmHg), whereas
in the AD group ∼50% showed cSSHT. A 45% reduction in pNOB (P≤0.004) was
observed in both groups in dietary transit. RMSAP increased in the AD group on
both diets but more so on the HNa diet (S-II, P<0.03) than on the LNa diet
(S-III, P<0.04). MAP modeling in rats without a renal hypertensive genotype
indicated that the AD*HNa diet interaction (P=0.008) increases the likelihood of
developing cSSHT. Translationally, these findings help to explain why subjects
with clinical salt-sensitive normotension may transition to cSSHT. 相似文献
7.
8.
P.L. da Luz S. Coimbra D. Favarato C. Albuquerque R.I. Mochiduky C.E. Rochitte E. Hojaij C.R.L. Gonsalves F.R. Laurindo 《Brazilian journal of medical and biological research》2014,47(8):697-705
Observational studies suggest there are clinical benefits to moderate red wine (RW)
consumption. However, the effects on coronary vasculature and overall lifestyle are
unclear. We investigated whether a lifestyle of regular long-term RW consumption is
associated with changes in coronary plaque burden, calcium score, carotid
intima/media thickness, endothelial function, and metabolic variables, compared with
alcohol abstinence. Healthy volunteers were evaluated by coronary computed tomography
angiography (CTA) as well as carotid and brachial artery ultrasound. Nutritional
status, psychological status, and metabolic variables were assessed. The study
included 101 drinkers [aged 58.9±7.3 years (means±SD)], from wine brotherhoods, and
104 abstainers, from Anglican, Evangelical and Catholic churches both in the city of
São Paulo, Brazil. No significant differences in demographics were noted. Lesion
prevalence per patient assessed by coronary CTA and classified as absent (0), 1-25,
26-49, and ≥50% stenosis was similar between groups. When analyzed by individual
arteries, i.e., left anterior descending, circumflex, and right coronary, prevalence
was also not different. On the other hand, calcium scores were higher among drinkers
than abstainers (144.4±362.2 vs 122.0±370.3; P<0.01). However,
drinkers reported less history of diabetes and exercised more. RW drinkers consumed
2127.9±387.7 kcal/day while abstainers consumed 1836.0±305.0 (P<0.0001). HDL
cholesterol was significantly higher among drinkers compared to abstainers (46.9±10.9
vs 39.5±9.0 mg/dL; P<0.001), while fasting plasma glucose was
lower (97.6±18.2 vs 118.4±29.6 mg/dL; P<0.02). Liver enzymes were
normal in both groups. In conclusion, long-term wine drinkers displayed a similar
plaque burden but greater calcium score than abstainers, despite a more atherogenic
diet, and the mechanisms for the increased calcium scores in the former remain
speculative. 相似文献
9.
C.O. Francisco A.M. Catai S.C.G. Moura-Tonello S.L.B. Lopes B.G. Benze A.M. Del Vale A.M.O. Leal 《Brazilian journal of medical and biological research》2014,47(5):426-431
The objective of this study was to evaluate cardiorespiratory fitness and pulmonary
function and the relationship with metabolic variables and C-reactive protein (CRP)
plasma levels in individuals with diabetes mellitus (DM). Nineteen men with diabetes
and 19 age- and gender-matched control subjects were studied. All individuals were
given incremental cardiopulmonary exercise and pulmonary function tests. In the
exercise test, maximal workload (158.3±22.3 vs 135.1±25.2, P=0.005),
peak heart rate (HRpeak: 149±12 vs 139±10, P=0.009), peak
oxygen uptake (VO2peak: 24.2±3.2 vs 18.9±2.8,
P<0.001), and anaerobic threshold (VO2VT: 14.1±3.4 vs
12.2±2.2, P=0.04) were significantly lower in individuals with diabetes than in
control subjects. Pulmonary function test parameters, blood pressure, lipid profile
(triglycerides, HDL, LDL, and total cholesterol), and CRP plasma levels were not
different in control subjects and individuals with DM. No correlations were observed
between hemoglobin A1C (HbA1c), CRP and pulmonary function test and cardiopulmonary
exercise test performance. In conclusion, the results demonstrate that nonsmoking
individuals with DM have decreased cardiorespiratory fitness that is not correlated
with resting pulmonary function parameters, HbA1c, and CRP plasma levels. 相似文献
10.
You Jung Ha Eun-Jin Kang Sang-Won Lee Soo-Kon Lee Yong-Beom Park Jung-Soo Song Sang Tae Choi 《Journal of Korean medical science》2014,29(9):1199-1204
Our study aimed to investigate whether serum leucine-rich alpha-2-glycoprotein (LRG) levels are elevated in patients with rheumatoid arthritis (RA). In addition, we assessed their correlation with disease activity parameters and pro-inflammatory cytokine, tumor necrosis factor-α (TNF-α). Our study included 69 patients with RA and 48 age- and sex-matched healthy controls. Serum concentrations of TNF-α and LRG were determined by enzyme-linked immunosorbent assay. Serum LRG concentrations were significantly elevated in patients with RA compared with those in healthy controls (30.8±14.4 vs. 22.2±6.1 ng/mL; P<0.001). In patients with RA, serum LRG levels were found to be correlated with disease activity score 28 (DAS28), erythrocyte sedimentation rate, and C-reactive protein levels (γ=0.671; γ=0.612; and γ=0.601, P<0.001, respectively), but not with serum TNF-α levels. Serum LRG levels in patients with an active disease status (DAS28≥2.6) were significantly higher than those in remission (DAS28<2.6) (36.45±14.36 vs. 24.63±8.81 ng/mL; P<0.001). Our findings suggest that serum LRG could contribute to the inflammatory process independent of TNF-α and it may be a novel biomarker for assessing inflammatory activity in patients with RA.
Graphical Abstract
相似文献11.
The purpose of this study was to investigate the effect of supplementary vitamin D
therapy in addition to amitriptyline on the frequency of migraine attacks in
pediatric migraine patients. Fifty-three children 8-16 years of age and diagnosed
with migraine following the International Headache Society 2005 definition, which
includes childhood criteria, were enrolled. Patients were classified into four groups
on the basis of their 25-hydroxyvitamin D [25(OH)D] levels. Group 1 had normal
25(OH)D levels and received amitriptyline therapy alone; group 2 had normal 25(OH)D
levels and received vitamin D supplementation (400 IU/day) plus amitriptyline; group
3 had mildly deficient 25(OH)D levels and received amitriptyline plus vitamin D (800
IU/day); and group 4 had severely deficient 25(OH)D levels and was given
amitriptyline plus vitamin D (5000 IU/day). All groups were monitored for 6 months,
and the number of migraine attacks before and during treatment was determined.
Calcium, phosphorus alkaline phosphatase, parathormone, and 25(OH)D levels were also
determined before and during treatment. Results were compared between the groups.
Data obtained from the groups were analyzed using one-way analysis of variance. The
number of pretreatment attacks in groups 1 to 4 was 7±0.12, 6.8±0.2, 7.3±0.4, and
7.2±0.3 for 6 months, respectively (all P>0.05). The number of attacks during
treatment was 3±0.25, 1.76±0.37 (P<0.05), 2.14±0.29 (P<0.05), and 1.15±0.15
(P<0.05), respectively. No statistically significant differences in calcium,
phosphorus, alkaline phosphatase, or parathormone levels were observed (P>0.05).
Vitamin D given in addition to anti-migraine treatment reduced the number of migraine
attacks. 相似文献
12.
13.
R.C. Santana A.A. Machado A.L.C. Martinelli A.A. Jord?o L.N.Z. Ramalho H. Vannucchi 《Brazilian journal of medical and biological research》2016,49(1)
Subjects with chronic liver disease are susceptible to hypovitaminosis A due to
several factors. Therefore, identifying patients with vitamin deficiency and a
requirement for vitamin supplementation is important. Most studies assessing vitamin
A in the context of hepatic disorders are conducted using cirrhotic patients. A
cross-sectional study was conducted in 43 non-cirrhotic patients with chronic
hepatitis C to evaluate markers of vitamin A status represented by serum retinol,
liver retinol, and serum retinol-binding protein levels. We also performed the
relative dose-response test, which provides an indirect estimate of hepatic vitamin A
reserves. These vitamin A indicators were assessed according to the stage of liver
fibrosis using the METAVIR score and the body mass index. The sample study was
predominantly composed of male subjects (63%) with mild liver fibrosis (F1). The
relative dose-response test was <20% in all subjects, indicating vitamin A
sufficiency. Overweight or obese patients had higher serum retinol levels than those
with a normal body mass index (2.6 and 1.9 µmol/L, respectively; P<0.01). Subjects
with moderate liver fibrosis (F2) showed lower levels of serum retinol (1.9
vs 2.5 µmol/L, P=0.01) and retinol-binding
protein levels compared with those with mild fibrosis (F1) (46.3 vs
67.7 µg/mL, P<0.01). These results suggested an effect of being overweight on
serum retinol levels. Furthermore, more advanced stages of liver fibrosis were
related to a decrease in serum vitamin A levels. 相似文献
14.
Fauzia Musa Nathan Shaviya Fidelis Mambo Collins Abonyo Erick Barasa Philemon Wafula George Sowayi Mustafa Barasa Tom Were 《African health sciences》2021,21(4):1584
BackgroundCytokines play an important role in signaling the immune system to build an adequate immune response against HIV. HIV distorts the balance between pro and anti-inflammatory cytokines causing viral replication. Highly active antiretroviral treatment (HAART) acts by trying to restore pro and anti-inflammatory cytokine balance. It is not clear how HAART non-adherence influences circulating cytokine levels. This study therefore determined cytokine levels in HAART non-adherent individuals.MethodsThis cross-sectional study recruited 163 participants (51 controls, 23 HIV-1+ HAART naive, 28 HAART-adherent 6 months, 19 HAART-adherent 12 months and 42 HAART non-adherent). Cytokines were analyzed by ELISA while CD4 T cells determined in 3.0 µl of whole blood using BD FACSCaliburTM and viral load in 0.2ml plasma sample using Abbott Molecular m2000sp sample preparation and m2000rt real-time amplification and detection systems (Abbott Molecular Inc., Illinois, USA) according to the manufacturer''s methods.ResultsIL-4, IL-6, IL-10, TNF-α and TGF-β were significantly elevated in HIV-1 HAART non-adherent compared with HIV-1 HAART adherent and healthy controls P<0.01. IFN- γ was significantly decreased in HIV-1 HAART non-adherent compared with HIV-1 HAART adherent and healthy controls P<0.01. TNF-α and TGF-β were significantly reduced in HIV-1 HAART adherent patients at 12 months compared to those at 6 months P<0.01. IL-4 and IL-10 correlated positively with viral load. IL-4, IL-6, IL-10, TNF-α and TGF- β associated inversely with CD4 T cell counts and body mass index (BMI).ConclusionThis study established that HAART adherence is immunologically beneficial to the pro and anti-inflammatory cytokine balance milieu while non-adherence appears to cause alterations in pro and anti-inflammatory cytokines warping the balance in this dichotomy. 相似文献
15.
S. Zhang J.G. Xie B.T. Su J.L. Li N. Hu J. Chen G.W. Luo T.P. Cui 《Brazilian journal of medical and biological research》2015,48(11):1032-1038
Milk fat globule epidermal growth factor 8 (MFG-E8) is an opsonin involved in the
phagocytosis of apoptotic cells. In patients with chronic obstructive pulmonary
disease (COPD), apoptotic cell clearance is defective. However, whether aberrant
MFG-E8 expression is involved in this defect is unknown. In this study, we examined
the expression of MFG-E8 in COPD patients. MFG-E8, interleukin (IL)-1β and
transforming growth factor (TGF)-β levels were measured in the plasma of 96 COPD
patients (93 males, 3 females; age range: 62.12±10.39) and 87 age-matched healthy
controls (85 males, 2 females; age range: 64.81±10.11 years) using an enzyme-linked
immunosorbent assay. Compared with controls, COPD patients had a significantly lower
plasma MFG-E8 levels (P<0.01) and significantly higher plasma TGF-β levels
(P=0.002), whereas there was no difference in plasma IL-1β levels between the two
groups. Moreover, plasma MFG-E8 levels decreased progressively between Global
Initiative for Chronic Obstructive Lung Disease (GOLD) I and GOLD IV stage COPD.
Multiple regression analysis showed that the forced expiratory volume in 1 s
(FEV1 % predicted) and smoking habit were powerful predictors of MFG-E8
in COPD (P<0.01 and P=0.026, respectively). MFG-E8 was positively associated with
the FEV1 % predicted and negatively associated with smoking habit. The
area under the receiver operating characteristic curve was 0.874 (95% confidence
interval: 0.798-0.95; P<0.01). Our findings demonstrated the utility of MFG-E8 as
a marker of disease severity in COPD and that cigarette smoke impaired MFG-E8
expression in these patients. 相似文献
16.
Jia-Jun Ye Tian-Biao Zhou Yun-Fang Zhang Qi Wang Yan-Yan Su Jia-Min Tang Hong-Yan Li 《African health sciences》2016,16(2):462-467
ObjectiveThis study was performed to detect the expression of vitamin D receptor (VDR) and cytochrome P450, family 24, subfamily A, polypeptide 1 (CYP24A1) in 24 end stage renal disease (ESRD) patients and 24 healthy controls.MethodIn this study, 24 ESRD patients and 24 healthy controls were included.ResultsIn our study, the levels of VDR in patients with ESRD were reduced when compared with those from healthy controls (5.20±0.32 vs 8.59±1.03; P<0.01). However, the levels of CYP24A1 in ESRD patients were increased than those from healthy controls (50.18±21 vs 7.78±1.31; P<0.01). Correlation analysis showed that VDR levels were negatively correlated with CYP24A1 (r=−0.723; P<0.01).ConclusionVDR levels were reduced and CYP24A1 levels were increased in patients with ESRD, and VDR levels were negatively correlated with CYP24A1. 相似文献
17.
G. Borghetti R.K. Yamazaki I. Coelho D.C.T. Pequito D.L. Schiessel M. Kryczyk R. Mamus K. Naliwaiko L.C. Fernandes 《Brazilian journal of medical and biological research》2013,46(8):696-699
We investigated the effect of fish oil (FO) supplementation on tumor growth,
cyclooxygenase 2 (COX-2), peroxisome proliferator-activated receptor gamma (PPARγ),
and RelA gene and protein expression in Walker 256 tumor-bearing rats. Male Wistar
rats (70 days old) were fed with regular chow (group W) or chow supplemented with 1
g/kg body weight FO daily (group WFO) until they reached 100 days of age. Both groups
were then inoculated with a suspension of Walker 256 ascitic tumor cells
(3×107 cells/mL). After 14 days the rats were killed, total RNA was
isolated from the tumor tissue, and relative mRNA expression was measured using the
2-ΔΔCT method. FO significantly decreased tumor growth (W=13.18±1.58
vs WFO=5.40±0.88 g, P<0.05). FO supplementation also resulted
in a significant decrease in COX-2 (W=100.1±1.62 vs WFO=59.39±5.53,
P<0.001) and PPARγ (W=100.4±1.04 vs WFO=88.22±1.46, P<0.05)
protein expression. Relative mRNA expression was W=1.06±0.022 vs
WFO=0.31±0.04 (P<0.001) for COX-2, W=1.08±0.02 vs WFO=0.52±0.08
(P<0.001) for PPARγ, and W=1.04±0.02 vs WFO=0.82±0.04 (P<0.05)
for RelA. FO reduced tumor growth by attenuating inflammatory gene expression
associated with carcinogenesis. 相似文献
18.
A.A. Fernandes T. de O. Faria R.F. Ribeiro Júnior G.P. Costa B. Marchezini E.A. Silveira J.K. Angeli I. Stefanon D.V. Vassallo J.H. Lizardo 《Brazilian journal of medical and biological research》2015,48(9):813-821
Resistance training evokes myocardial adaptation; however, the effects of a single
resistance exercise session on cardiac performance are poorly understood or
investigated. This study aimed to investigate the effects of a single resistance
exercise session on the myocardial contractility of spontaneously hypertensive rats
(SHRs). Male 3-month-old SHRs were divided into two groups: control (Ct) and exercise
(Ex). Control animals were submitted to sham exercise. Blood pressure was measured in
conscious rats before the exercise session to confirm the presence of arterial
hypertension. Ten minutes after the exercise session, the animals were anesthetized
and killed, and the hearts were removed. Cardiac contractility was evaluated in the
whole heart by the Langendorff technique and by isometric contractions of isolated
left ventricular papillary muscles. SERCA2a, phospholamban (PLB), and phosphorylated
PLB expression were investigated by Western blot. Exercise increased force
development of isolated papillary muscles (Ex=1.0±0.1 g/mg vs
Ct=0.63±0.2 g/mg, P<0.05). Post-rest contraction was greater in the exercised
animals (Ex=4.1±0.4% vs Ct=1.7±0.2%, P<0.05). Papillary muscles
of exercised animals developed greater force under increasing isoproterenol
concentrations (P<0.05). In the isolated heart, exercise increased left
ventricular isovolumetric systolic pressure (LVISP; Δ +39 mmHg; P<0.05) from
baseline conditions. Hearts from the exercised rats presented a greater response to
increasing diastolic pressure. Positive inotropic intervention to calcium and
isoproterenol resulted in greater LVISP in exercised animals (P<0.05). The results
demonstrated that a single resistance exercise session improved myocardial
contractility in SHRs. 相似文献
19.
J.L. Jiang W. Ren J. Song Q.L. Sun X.Y. Xiao X.Z. Diao Y.H. Huang L. Lan P. Wang Z. Hu 《Brazilian journal of medical and biological research》2013,46(7):629-633
Anemia is a frequent complication in hemodialysis patients. Compared to
conventional hemodialysis (CHD), short daily hemodialysis (sDHD) has been
reported to be effective in many countries except China. The aim of the present
study was to determine whether sDHD could improve anemia and quality of life
(QOL) for Chinese outpatients with end-stage renal disease. Twenty-seven
patients (16 males/11 females) were converted from CHD to sDHD. All laboratory
values were measured before conversion (baseline), at 3 months after conversion
(sDHD1), and at 6 months after conversion (sDHD2). The patient''s QOL was
evaluated at baseline and 6 months after conversion using the Medical Outcomes
Study 36-Item Short Form Health Survey (SF-36). Hemoglobin concentration
increased significantly from 107.4±7.9 g/L at baseline to 114.4±6.8 g/L
(P<0.05) at sDHD1, and 118.3±8.4 g/L (P<0.001) at sDHD2 (Student paired
t-test). However, the dose requirement for erythropoietin
decreased from 6847.8±1057.3 U/week at baseline to 5869.6±1094.6 U/week
(P<0.05) at sDHD2. Weekly stdKt/V increased significantly from 2.05±0.13 at
baseline to 2.73±0.20 (P<0.001) at sDHD1, and 2.84±0.26 (P<0.001) at
sDHD2. C-reactive protein decreased from baseline to sDHD1 and sDHD2, but
without statistically significant differences. Physical and mental health survey
scores increased in the 6 months following conversion to sDHD. sDHD may increase
hemoglobin levels, decrease exogenous erythropoietin dose requirements, and
improve QOL in Chinese hemodialysis patients compared to CHD. A possible
mechanism for improvement of clinical outcomes may be optimized management of
uremia associated with the higher efficiency of sDHD. 相似文献
20.
Pirkko J. Pussinen Tiina Laatikainen Georg Alfthan Sirkka Asikainen Pekka Jousilahti 《Clinical and Vaccine Immunology : CVI》2003,10(5):897-902
This study aimed to clarify how concentrations of vitamin C in plasma relate to the serology of periodontitis. The random sample used comprised 431 men, 194 from Finland and 237 from Russia. The plasma vitamin C concentration was determined by o-phtaldialdehyde-fluorometry, and serum immunoglobulin G antibodies to Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis were determined by a multiserotype enzyme-linked immunosorbent assay (ELISA). The mean plasma vitamin C concentration was higher (P < 0.001) in Finnish subjects (mean ± standard deviation, 4.5 ± 2.8 mg/liter) than in Russian subjects (1.4 ± 1.8 mg/liter). Mean antibody levels to both A. actinomycetemcomitans (4.7 ± 3.6 versus 5.2 ± 3.1 ELISA units [P = 0.05]) and P. gingivalis (5.7 ± 2.5 versus 7.6 ± 2.9 ELISA units [P < 0.001]) were lower in Finnish men than in Russian men. In the combined Finnish and Russian population, the antibody levels to P. gingivalis were negatively correlated with vitamin C concentrations (r = −0.22; P < 0.001); this association remained statistically significant (P = 0.010) in a linear regression model after adjustment for confounding factors. The proportion of P. gingivalis-seropositive subjects decreased with increasing vitamin C concentrations (P for trend, <0.01), but no trend was seen among A. actinomycetemcomitans-seropositive subjects. In conclusion, P. gingivalis infection is associated with low concentrations of vitamin C in plasma, which may increase colonization of P. gingivalis or disturb the healing of the infected periodontium. 相似文献