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1.
《Emerging infectious diseases》2021,27(4):1077
Pneumonia caused by severe acute respiratory syndrome coronavirus 2 emerged in China at the end of 2019. Because of the severe immunomodulation and lymphocyte depletion caused by this virus and the subsequent administration of drugs directed at the immune system, we anticipated that patients might experience fungal superinfection. We collected data from 186 patients who had coronavirus disease–associated pulmonary aspergillosis (CAPA) worldwide during March–August 2020. Overall, 182 patients were admitted to the intensive care unit (ICU), including 180 with acute respiratory distress syndrome and 175 who received mechanical ventilation. CAPA was diagnosed a median of 10 days after coronavirus disease diagnosis. Aspergillus fumigatus was identified in 80.3% of patient cultures, 4 of which were azole-resistant. Most (52.7%) patients received voriconazole. In total, 52.2% of patients died; of the deaths, 33.0% were attributed to CAPA. We found that the cumulative incidence of CAPA in the ICU ranged from 1.0% to 39.1%. 相似文献
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《Emerging infectious diseases》2021,27(11):2892
We performed an observational study to investigate intensive care unit incidence, risk factors, and outcomes of coronavirus disease–associated pulmonary aspergillosis (CAPA). We found 10%–15% CAPA incidence among 823 patients in 2 cohorts. Several factors were independently associated with CAPA in 1 cohort and mortality rates were 43%–52%. 相似文献
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《Emerging infectious diseases》2021,27(1):85
We investigated the dynamics of seroconversion in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. During March 29–May 22, 2020, we collected serum samples and associated clinical data from 177 persons in London, UK, who had SARS-CoV-2 infection. We measured IgG against SARS-CoV-2 and compared antibody levels with patient outcomes, demographic information, and laboratory characteristics. We found that 2.0%–8.5% of persons did not seroconvert 3–6 weeks after infection. Persons who seroconverted were older, were more likely to have concurrent conditions, and had higher levels of inflammatory markers. Non-White persons had higher antibody concentrations than those who identified as White; these concentrations did not decline during follow-up. Serologic assay results correlated with disease outcome, race, and other risk factors for severe SARS-CoV-2 infection. Serologic assays can be used in surveillance to clarify the duration and protective nature of humoral responses to SARS-CoV-2 infection. 相似文献
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Hend Ben Lakhal Jos Bras Cachinho Pierre Kalfon Thierry Naas Zehaira Benseddik 《Emerging infectious diseases》2022,28(4):844
Patients infected with severe acute respiratory syndrome coronavirus 2 might have bacterial and fungal superinfections develop. We describe a clinical case of coronavirus disease with pulmonary aspergillosis associated with Bordetella hinzii pneumonia in an immunocompetent patient in France. B. hinzii infections are rare in humans and develop secondary to immunosuppression or debilitating diseases. 相似文献
5.
Weimin Liu Ronnie M. Russell Frederic Bibollet-Ruche Ashwin N. Skelly Scott Sherrill-Mix Drew A. Freeman Regina Stoltz Emily Lindemuth Fang-Hua Lee Sarah Sterrett Katharine J. Bar Nathaniel Erdmann Sigrid Gouma Scott E. Hensley Thomas Ketas Albert Cupo Victor M. Cruz Portillo John P. Moore Paul D. Bieniasz Theodora Hatziioannou Greer Massey Mary-Beth Minyard Michael S. Saag Randall S. Davis George M. Shaw William J. Britt Sixto M. Leal Jr. Paul Goepfert Beatrice H. Hahn 《Emerging infectious diseases》2021,27(9):2454
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Nicholas B. Lehnertz Xiong Wang Jacob Garfin Joanne Taylor Jennifer Zipprich Brittany VonBank Karen Martin Dana Eikmeier Carlota Medus Brooke Wiedinmyer Carmen Bernu Matthew Plumb Kelly Pung Margaret A. Honein Rosalind Carter Duncan MacCannell Kirk E. Smith Kathryn Como-Sabetti Kris Ehresmann Richard Danila Ruth Lynfield 《Emerging infectious diseases》2021,27(8):2052
Coronavirus disease has disproportionately affected persons in congregate settings and high-density workplaces. To determine more about the transmission patterns of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in these settings, we performed whole-genome sequencing and phylogenetic analysis on 319 (14.4%) samples from 2,222 SARS-CoV-2–positive persons associated with 8 outbreaks in Minnesota, USA, during March–June 2020. Sequencing indicated that virus spread in 3 long-term care facilities and 2 correctional facilities was associated with a single genetic sequence and that in a fourth long-term care facility, outbreak cases were associated with 2 distinct sequences. In contrast, cases associated with outbreaks in 2 meat-processing plants were associated with multiple SARS-CoV-2 sequences. These results suggest that a single introduction of SARS-CoV-2 into a facility can result in a widespread outbreak. Early identification and cohorting (segregating) of virus-positive persons in these settings, along with continued vigilance with infection prevention and control measures, is imperative. 相似文献
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Pyoeng Gyun Choe Kye-Hyung Kim Chang Kyung Kang Hyeon Jeong Suh EunKyo Kang Sun Young Lee Nam Joong Kim Jongyoun Yi Wan Beom Park Myoung-don Oh 《Emerging infectious diseases》2021,27(3):928
Waning humoral immunity in coronavirus disease patients has raised concern over usefulness of serologic testing. We investigated antibody responses of 58 persons 8 months after asymptomatic or mildly symptomatic infection with severe acute respiratory syndrome coronavirus 2. For 3 of 4 immunoassays used, seropositivity rates were high (69.0%–91.4%). 相似文献
10.
Gopalakrishna G Choo P Leo YS Tay BK Lim YT Khan AS Tan CC 《Emerging infectious diseases》2004,10(3):395-400
An outbreak of severe acute respiratory syndrome (SARS) was detected in Singapore at the beginning of March 2003. The outbreak, initiated by a traveler to Hong Kong in late February 2003, led to sequential spread of SARS to three major acute care hospitals in Singapore. The critical factor in containing this outbreak was early detection and complete assessment of movements and follow-up of patients, healthcare workers, and visitors who were contacts. Visitor records were important in helping identify exposed persons who could carry the infection into the community. In the three hospital outbreaks, three different containment strategies were used to contain spread of infection: closing an entire hospital, removing all potentially infected persons to a dedicated SARS hospital, and managing exposed persons in place. On the basis of this experience, if a nosocomial outbreak is detected late, a hospital may need to be closed in order to contain spread of the disease. Outbreaks detected early can be managed by either removing all exposed persons to a designated location or isolating and managing them in place. 相似文献
11.
Natalia Fintelman-Rodrigues Aline P.D. da Silva Monique Cristina dos Santos Felipe B. Saraiva Marcelo A. Ferreira Joo Gesto Danielle A.S. Rodrigues Andr M. Vale Isaclaudia G. de Azevedo Vinícius C. Soares Hui Jiang Hongdong Tan Diogo A. Tschoeke Carolina Q. Sacramento Fernando A. Bozza Carlos M. Morel Patrícia T. Bozza Thiago Moreno L. Souza 《Emerging infectious diseases》2021,27(5):1446
The dynamics underlying severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reinfection remain poorly understood. We identified a small cluster of patients in Brazil who experienced 2 episodes of coronavirus disease (COVID-19) in March and late May 2020. In the first episode, patients manifested an enhanced innate response compared with healthy persons, but neutralizing humoral immunity was not fully achieved. The second episode was associated with different SARS-CoV-2 strains, higher viral loads, and clinical symptoms. Our finding that persons with mild COVID-19 may have controlled SARS-CoV-2 replication without developing detectable humoral immunity suggests that reinfection is more frequent than supposed, but this hypothesis is not well documented. 相似文献
12.
M. Tumbarello G. Ventura G. Caldarola G. Morace R. Cauda L. Ortona 《European journal of epidemiology》1993,9(6):638-644
Invasive pulmonary aspergillosis usually occurs in patients with severe granulocytopenia or defects of cell-mediated immunity secondary to cytotoxic chemotherapy or high-dose corticosteroids, but it is an unusual opportunistic infection in patients with AIDS. Eleven cases of Aspergillus pulmonary disease were diagnosed in HIV-infected patients from January 1985 to December 1992, in the Department of Infectious Diseases of the Catholic University. Four patients had invasive pulmonary aspergillosis, six probable pulmonary invasive aspergillosis and one allergic broncopulmonary aspergillosis. Fiberoptic broncoscopy with bronco-alveolar lavage was confirmed to be an useful tool for the diagnosis of pulmonary aspergillosis in AIDS patients. The response of aspergillosis to therapy, either amphotericin B or itraconazole, has usually been poor. It is possible to speculate that the longer survival of AIDS patients and the latter development of other functional immunological abnormalities related to HIV infection may allow the appearance of opportunistic infection, such as pulmonary aspergillosis, different from those more often observed.Corresponding author. 相似文献
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Andrew Fox-Lewis Felicity Williamson Jay Harrower Xiaoyun Ren Gerard J.B. Sonder Andrea McNeill Joep de Ligt Jemma L. Geoghegan 《Emerging infectious diseases》2022,28(3):501
In New Zealand, international arrivals are quarantined and undergo severe acute respiratory syndrome coronavirus 2 screening; those who test positive are transferred to a managed isolation facility (MIF). Solo traveler A and person E from a 5-person travel group (BCDEF) tested positive. After transfer to the MIF, person A and group BCDEF occupied rooms >2 meters apart across a corridor. Persons B, C, and D subsequently tested positive; viral sequences matched A and were distinct from E. The MIF was the only shared location of persons A and B, C, and D, and they had no direct contact. Security camera footage revealed 4 brief episodes of simultaneous door opening during person A’s infectious period. This public health investigation demonstrates transmission from A to B, C, and D while in the MIF, with airborne transmission the most plausible explanation. These findings are of global importance for coronavirus disease public health interventions and infection control practices. 相似文献
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Kenichiro Takahashi Masahiro Ishikane Mugen Ujiie Noriko Iwamoto Nobumasa Okumura Testsuro Sato Maki Nagashima Ataru Moriya Michiyo Suzuki Masayuki Hojo Takayuki Kanno Shinji Saito Sho Miyamoto Akira Ainai Minoru Tobiume Takeshi Arashiro Tsuguto Fujimoto Tomoya Saito Masaya Yamato Tadaki Suzuki Norio Ohmagari 《Emerging infectious diseases》2022,28(5):998
To determine virus shedding duration, we examined clinical samples collected from the upper respiratory tracts of persons infected with severe acute respiratory syndrome coronavirus 2 Omicron variant in Japan during November 29–December 18, 2021. Vaccinees with mild or asymptomatic infection shed infectious virus 6–9 days after onset or diagnosis, even after symptom resolution. 相似文献
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Lex E.X. Leong Julien Soubrier Mark Turra Emma Denehy Luke Walters Karin Kassahn Geoff Higgins Tom Dodd Robert Hall Katina DOnise Nicola Spurrier Ivan Bastian Chuan K. Lim 《Emerging infectious diseases》2021,27(8):2219
Hotel quarantine for international travelers has been used to prevent coronavirus disease spread into Australia. A quarantine hotel–associated community outbreak was detected in South Australia. Real-time genomic sequencing enabled rapid confirmation tracking the outbreak to a recently returned traveler and linked 2 cases of infection in travelers at the same facility. 相似文献
16.
Sarah Reagan-Steiner Julu Bhatnagar Roosecelis B. Martines Nicholas S. Milligan Carly Gisondo Frank B. Williams Elizabeth Lee Lindsey Estetter Hannah Bullock Cynthia S. Goldsmith Pamela Fair Julie Hand Gillian Richardson Kate R. Woodworth Titilope Oduyebo Romeo R. Galang Rebecca Phillips Elizaveta Belyaeva Xiao-Ming Yin Dana Meaney-Delman Timothy M. Uyeki Drucilla J. Roberts Sherif R. Zaki 《Emerging infectious diseases》2022,28(3):510
17.
Souheil Zayet Vincent Gendrin Catherine Gay Philippe Selles Timothe Klopfenstein 《Emerging infectious diseases》2022,28(5):1048
We conducted a retrospective study of pregnant persons hospitalized for severe acute respiratory syndrome coronavirus 2 infection in France. Delta variant infection had a relative risk of 14.33 for intensive care unit admission and 9.56 for high supplemental oxygen support. The Delta variant might cause more severe illness during pregnancy. 相似文献
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Rocío M. Coelho Natalia Periolo Carolina Perez Duhalde Daniel O. Alonso Carla M. Bellomo Marisa Corazza Ayeln A. Iglesias Valeria P. Martinez 《Emerging infectious diseases》2022,28(4):876
We describe a patient in Argentina with severe acute respiratory syndrome coronavirus 2 infection and hantavirus pulmonary syndrome (HPS). Although both coronavirus disease and HPS can be fatal when not diagnosed and treated promptly, HPS is much more lethal. This case report may contribute to improved detection of co-infections in HPS-endemic regions. 相似文献
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新型冠状病毒(SARS-CoV-2)在全球大流行,给世界各国的医疗环境都带来了严重冲击。目前,其导致的新型冠状病毒肺炎(COVID-19)缺乏特效的治疗方法,早发现、早报告、早隔离、早诊断便成为了遏制疫情传播的有效手段。由于临床表现和体征等方面对COVID-19诊断的灵敏性较差,因此医生需要通过实验室病毒核酸检测等手段以鉴别感染者和非感染者。本文综述了SARS-CoV-2基因组特征以及相关检测原理与细节。在COVID-19的不同阶段,不同检测的效果差异很大。RT-PCR核酸检测在感染早中期阶段较灵敏,血清学检测则可能识别感染后期阶段,可作为核酸检测阴性但疑似感染者的辅助检测手段。为避免出现“假阴性”,造成误诊或漏诊,在病毒检测时应采用多指标联合,以弥补单一方法的不足。 相似文献
20.
Alexandra K. Heaney Jennifer R. Head Kelly Broen Karen Click John Taylor John R. Balmes Jon Zelner Justin V. Remais 《Emerging infectious diseases》2021,27(5):1266
We review the interaction between coronavirus disease (COVID-19) and coccidioidomycosis, a respiratory infection caused by inhalation of Coccidioides fungal spores in dust. We examine risk for co-infection among construction and agricultural workers, incarcerated persons, Black and Latino populations, and persons living in high dust areas. We further identify common risk factors for co-infection, including older age, diabetes, immunosuppression, racial or ethnic minority status, and smoking. Because these diseases cause similar symptoms, the COVID-19 pandemic might exacerbate delays in coccidioidomycosis diagnosis, potentially interfering with prompt administration of antifungal therapies. Finally, we examine the clinical implications of co-infection, including severe COVID-19 and reactivation of latent coccidioidomycosis. Physicians should consider coccidioidomycosis as a possible diagnosis when treating patients with respiratory symptoms. Preventive measures such as wearing face masks might mitigate exposure to dust and severe acute respiratory syndrome coronavirus 2, thereby protecting against both infections. 相似文献