巨大毛囊皮脂腺囊性错构瘤

报告1例巨大毛囊皮脂腺囊性错构瘤。患者男,15岁。右臀部丘疹,结节15年。体格检查示右臀部多个大小不一的丘疹及结节、部分融合成硬斑块。组织病理检查示毛囊扩张畸形,其上端为毛囊漏斗部扩张,形成囊性结构,下端为增生的皮脂腺,周围胶原增生硬化,且在真皮浅层及中部可见散在成熟的脂肪组织。诊断：巨大毛囊皮脂腺囊性错构瘤。     

毛囊皮脂腺囊性错构瘤

临床资料 患者女，37岁。因鼻部结节、斑块20余年来我院就诊。患者20年前，无明显诱因鼻梁右侧出现粟粒大红色小丘疹，其后数目逐渐增多，渐向上下发展，形成大小不一的结节，部分结节融合成斑块，偶觉瘙痒。既往体健，否认肝炎，结核等传染病史，否认家族中有同类疾病患者。体格检查：系统查体未见异常。皮肤科检查：鼻部以右侧鼻梁为主可见数个大小不一的红色丘疹、结节，部分融合成斑块，结节质韧，无明显压痛（图1）。皮肤组织病理示：真皮内见一不完整的囊腔，与表皮不相连，周围许多皮脂腺小叶，通过导管与囊腔相连，毛囊结构周围可见增生致密的胶原纤维（图2、3）。结合临床及组织病理学改变诊断为毛囊皮脂腺囊性错构瘤，给予电离子治疗。     

幼儿先天性毛囊皮脂腺囊性错构瘤

报告1例先天性毛囊皮脂腺囊性错构瘤。患儿女,2岁。出生时发现右侧面部一丘疹,逐渐增大2年。皮肤科检查:右侧面部一边界清楚,直径0.8 cm半球形淡红色丘疹,表面少许褐色痂皮。皮损组织病理检查:真皮上部较多扩大、畸形的毛囊皮脂腺囊性结构;皮脂腺小叶大量增生,呈放射状排列,与周围间质有明显裂隙;间质内有异位脂肪细胞和黏液样物质沉积。诊断:先天性毛囊皮脂腺囊性错构瘤。     

表现为浅表脂肪瘤样痣的毛囊皮脂腺囊性错构瘤1例

患者女,36岁。颈部丘疹30余年。颈部可见密集呈片状分布的皮色圆顶丘疹,约绿豆大小,质韧。皮损组织病理示:角化过度,表皮大致正常,真皮内可见多数大的分化成熟的皮脂腺体,开口于毛囊漏斗部,腺体周围间质有裂隙,真皮内胶原增生致密。诊断:毛囊皮脂腺囊性错构瘤。     

毛囊皮脂腺囊性错构瘤研究进展

临床上，毛囊皮脂腺囊性错构瘤比较少见，缺乏典型特征，是一种不对称，好发于面部的肤色丘疹或结节。病理学上是以毛囊皮脂腺组织和间叶细胞成分增生为主的皮肤附属器错构瘤，主要与皮脂腺毛囊瘤、皮样囊肿相鉴别。免疫组化结果与瘤体内上皮或非上皮成分有关，无特异性。概述毛囊皮脂腺囊性错构瘤的临床表现、诊断标准、免疫组化及治疗方面的研究进展。     

毛囊漏斗部肿瘤

报告1例毛囊漏斗部肿瘤。患儿女,11岁。因左颞部斑块、结节11年就诊。患儿出生后左颢部即有一粉红色斑块．3个月前在斑块表面出现一小结节。皮损组织病理检查示真皮乳头层见呈水平盘状生长的肿瘤,与表皮多部位相连。肿瘤细胞染色偏淡,周围细胞呈栅栏样排列。诊断：毛囊漏斗部肿瘤。     

斑块状毛母细胞瘤

报告1 例斑块状毛母细胞瘤.患者女,70 岁.左腕部淡红色斑块近30 年.皮肤科检查:左腕部屈侧一3 cm × 2 cm 淡暗红色斑块,微高出皮面,覆少量鳞屑,质稍硬.组织病理检查:真皮内可见大量结节状、网状瘤细胞团块及囊状结构,由基底细胞样上皮细胞组成,周边多排列呈栅栏状,细胞无明显异形性.阿新蓝染色示肿瘤团块及囊腔中有较多黏蛋白沉积.     

毛囊皮脂腺囊性错构瘤

<正>患者女,43岁。主诉:右枕后结节20年余,渐增大。现病史:患者20多年前右枕后无明显诱因出现一小米粒大、肤色丘疹,无自觉症状,多年来未予诊治,皮疹渐增大呈蘑菇状,表面较平滑,偶有黏稠伴异味分泌物排出。既往史:既往体健,家族成员中无类似疾病患者。体格检查:一般情况好,各系统检查无异常。实验室及辅助检查:血、尿常规和肝、肾功能均正常。皮肤科检查:右枕后见一枚蚕豆大、带细蒂结节,质地中等,表面较平滑,无红肿、破溃、血痂,可见小凹陷和毛发贯穿(图1),挤压无分泌物排出,周围无红肿、浸润。皮损组织病理学检查:真皮内较多的毛囊皮脂腺囊性结构,皮脂腺小叶大量增生呈放射状排列,毛囊漏斗部扩大、畸形,毛囊周     

小汗腺血管瘤样错构瘤1例

患儿男,3岁2个月。左大腿出现皮疹伴疼痛1年。皮肤科情况:左股伸侧多个丘疹、结节,融合成境界清楚斑块,可见散在毛发分布,按压疼痛明显,无明显多汗。皮损组织病理示:表皮角化过度伴灶性角化不全,棘层呈轻度乳头瘤样增生,真皮浅中层血管成簇、密集增生,深层大量小汗腺腺体和腺管增生。诊断:小汗腺血管瘤样错构瘤。     

皮脂腺毛囊瘤

报告1例皮脂腺毛囊瘤.患者男,36岁.因右颧部结节2年就诊.皮损组织病理检查示真皮内可见一大而不规则的腔,腔壁由鳞状上皮构成,腔内有不同粗细的毛发及角质碎屑,周围有许多呈放射状排列的皮脂腺毛囊与腔相连.诊断:皮脂腺毛囊瘤.治疗:手术切除.     

Giant folliculosebaceous cystic hamartoma of the upper extremity

BACKGROUND: Folliculosebaceous cystic hamartoma (FSCH) is a rare cutaneous hamartoma consisting of dilated folliculosebaceous units invested in mesenchymal elements. These lesions have a striking predilection for the central face and scalp of adults. The vast majority of lesions present as 0.5-1.5-cm papules or exophytic nodules. A single case of giant FSCH has been reported on the upper back. METHODS: A 32-year-old woman presented with a (15 cm in greatest dimension) plaque-like, multinodular lesion on her left upper arm for several years. The lesion was clinically suspected to be a nevus sebaceus. RESULTS: The skin excision showed numerous dermal and subcutaneous dilated follicular structures with peripherally radiating sebaceous lobules, hair follicles, and surrounding mesenchymal elements consistent with FSCH. CONCLUSION: To our knowledge, this is the second case of giant FSCH. Our case is unique for its larger size, more plaque-like growth, and location on an extremity when compared to the seminal case of giant FSCH.     

A Case of Giant Folliculosebaceous Cystic Hamartoma

Clinically, folliculosebaceous cystic hamartoma (FSCH) lacks distinct features, but it has been reported as an asymptomatic, 1- to 3-cm, dome-shaped nodule on the face. Histopathologically, FSCH is characterized by adnexal and folliculosebaceous cystic proliferation with various mesenchymal changes. This case presented an unusually large, small-fist-sized mass in the right mandibular area that was accompanied by intermittent itching. Histopathologic findings demonstrated appropriate features of FSCH. We present an interesting case of giant FSCH in a 48-year-old female.     

Folliculosebaceous Cystic Hamartoma Associated with Rosacea

A case of folliculosebaceous cystic hamartoma associated with rosacea is presented. Clinically, a solid, 5-mm-sized nodule was observed on the nose which showed telangiectasia and a waxy appearance. Histologically, a large horn cyst was located in the dermis, and was continuous with the surface epidermis. It was associated with mature sebaceous glands and immature hair follicles. Folliculosebaceous cystic hamartoma and similar cases have recently been reported, but this is the first report accompanied by rosacea.     

Folliculosebaceous cystic hamartoma with hair shaft fragments

We describe herein a 57-year-old Japanese male with a folliculosebaceous cystic hamartoma (FCH) presenting several hair shaft fragments in the cyst. Clinically, a skin-colored, dome-shaped, hard nodule, 5 x 4 mm in diameter was observed on the antitragus of his left ear. Histological examination revealed a large cystic structure surrounded by multiple mature sebaceous lobules and rudimentary hair follicules in the middle of the dermis. The cystic structure contained laminated orthokeratotic keratin and several hair shaft fragments. The fibrous stroma invaded the sebaceous lobules and obvious clefts were seen around the folliculosebaceous units located in the dermis. These features are characteristic histological findings of FCH. To our knowledge, this case is unusual with the presence of hair shaft fragments within the cystic structure. In addition, we discuss the histopathological findings of FCH and also review other cases of FCH in the literature.     

Giant folliculosebaceous cystic hamartoma

We report a case of a giant cystic cutaneous adnexal hamartoma which showed fibrofollicular units embedded in the stroma with aberrant fat tissue. There were many sebaaeous lobules in the fibrofollicular units, and its histologic features were consistent with conventional folliculosebaceous cystic hamartoma. Given the unique clinical history and appearance, this lesion is considered to be a congenital variant.     

Giant cutaneous melanoacanthoma

A 45‐year‐old male cook was seen for the evaluation and removal of a “mole on my eye” of steady growth during the previous 6 months. The patient stated that he had had a “brown spot” above his left eye for 17 years prior to its recent enlargement; it was now partly blocking the vision in his left eye. He denied a history or family history of cutaneous tumors, including skin cancer. On examination, a 2.5‐cm × 0.5‐cm × 0.8‐cm, horn‐like, darkly pigmented, cutaneous nodule was evident extending from the left upper eyelid downwards to below the lower eyelid ( Figs 1 and 2 ). He also had scattered, skin‐colored, 2–3‐mm cystic papules on his anterior mid‐chest. A shave excision specimen was obtained from the eyelid nodule.

Figure 1 Open in figure viewer PowerPoint Horn‐like, cutaneous nodule extending from the left upper eyelid downwards to below the lower eyelid     

皮内痣伴结缔组织增生性结节一例

患者男,28岁,因左侧胸部单发褐色肿物4年、多发小丘疹1年就诊。皮肤科检查：胸部左侧一1.2 cm × 1.1 cm × 1.0 cm褐色类圆形肿物,质韧,其右侧数个直径3 ~ 5 mm褐色丘疹,左侧腋下淋巴结未触及肿大。手术完整切除肿物后行组织病理检查：肿物和小丘疹内均可见真皮浅层痣细胞聚集成巢,考虑皮内痣;最大肿物...     

Two cases of folliculosebaceous cystic hamartoma

Folliculosebaceous cystic hamartoma (FSCH) is a rare cutaneous hamartoma composed of dilated folliculosebaceous units associated with mesenchymal elements. Two cases of FSCH with typical histopathological features are reported. Patient 1 was a 60-year-old man presented with a normal skin-coloured asymptomatic nodule on his scalp. Patient 2 was a 70-year-old man with an asymptomatic nodule on his right auricle that had persisted for the previous 15 years. In all, 34 cases of FSCH have been reported in the English literature. Clinically, the lesions are asymptomatic, usually rubbery to firm in consistency, and usually occur on or above the neck (> 90%). Most lesions do not exceed 25 mm in diameter (> 90%). Histopathologically, FSCH shares several similar features to sebaceous trichofolliculoma, but it is usually possible to differentiate these two tumours.