席纹状胶原瘤1例

患者男,20岁,左侧鼻翼发疹7年,渐增大。皮肤科情况:左侧鼻翼有一枚直径约0.9 cm×0.9 cm大小皮色结节,表面光滑,质地坚韧。皮损组织病理示:肿瘤占据真皮全层,边界尚清,无包膜。瘤体主要由席纹状或旋涡状排列的胶原纤维束组成,结构致密,散布星状或梭形纤维母细胞。诊断:席纹状胶原瘤。     

头皮席纹状胶原瘤1例

患者女,48岁,左侧头皮肤色结节4年。皮损组织病理示：真表皮乳头样增生,真皮内见由增粗、肥大,排列成席纹状的胶原纤维束组成的结节,其间可见少量成纤维细胞散在分布。诊断：孤立性席纹状胶原瘤。     

皮肤肿瘤

20110641席纹状胶原瘤/耿松梅(西安交大二附院皮肤科),王倩倩,李政霄∥临床皮肤科杂志.-2010,39(1).-1~2患者男,34岁。十余年前无明显诱因左膝关节外下方出现一黄豆大肤色皮下结节,无明显增大,也无自觉症状。皮肤科情况:左膝关节外下方见     

面部发疹性胶原瘤伴太田痣一例

报告面部皮肤发疹性胶原瘤1例。患者女,30岁。面部出现多发性扁平丘疹、结节4年。皮损为正常皮色或红色,直径2－10mm,无自觉症状,无家族史。组织病理检查示：胶原显著增厚,胶原束宽大,弹力纤维减少、碎裂。诊断为发疹性皮肤胶原瘤。     

左侧额部孤立性胶原瘤1例并文献复习

患儿男性,6岁,左侧额部扁平丘疹6年。皮肤科情况：左侧额部可见1处约2.0 cm×1.5 cm扁平丘疹,皮损隆起于皮面,质韧,可移动,局部皮肤无红肿、渗出,皮温正常,无明显触痛、压痛。组织病理示表皮大致正常,真皮胶原纤维增生,胶原束粗大,部分呈团块状、均质状改变,个别毛囊周围轻微灶性淋巴细胞浸润。弹力纤维染色见真皮弹性纤维明显减少或缺失,局部呈碎片状。结合临床诊断为孤立性胶原瘤。     

栅栏状有包膜神经瘤6例临床及病理分析

目的分析栅栏状有包膜神经瘤临床和组织病理特点。方法对我科诊断的6例栅栏状有包膜神经瘤临床和组织病理资料进行系统性回顾分析。结果栅栏状有包膜神经瘤临床表现为孤立性肤色丘疹。组织病理学表现为真皮内界限清楚的以施旺细胞束增生为主的良性肿瘤,肿瘤组织间伴有明显裂隙,瘤细胞无异形性。免疫组化检查肿瘤细胞S-100蛋白阳性,神经束膜细胞EMA阳性。讨论栅栏状有包膜神经瘤临床表现无特异性,临床症状的多样性造成临床诊断困难,组织病理学和免疫组化检查为本病确诊提供主要依据。     

硬化性神经束膜瘤3例临床及组织病理分析

目的探讨硬化性神经束膜瘤的临床、组织病理和免疫组化特征。方法对2015—2018年第四军医大学西京皮肤医院确诊的3例硬化性神经束膜瘤的临床、组织病理及免疫组化结果进行回顾性分析。结果 3例患者均为女性,就诊年龄为8～25岁。肿瘤均位于手指,表现为小丘疹。组织病理显示硬化的胶原束间上皮样或梭形神经束膜细胞增生,细胞排列成束状或旋涡状。肿瘤细胞表达EMA,Claudin-1和GLUT1,不表达S-100和CD34。结论硬化性神经束膜瘤相对罕见,皮损好发于年轻人手指,EMA,Claudin-1,GLUT1免疫组化有助于确诊。     

获得性肢端纤维角皮瘤七例临床分析

回顾性分析2016-2019年间我科确诊为获得性肢端纤维角皮瘤的7例患者，平均发病年龄（30.25±15.17）岁，平均病程（4.15±5.12）年，男女比例4∶3。皮损表现为发生于肢端的无症状的单发丘疹状、柱状或角化斑块状增生物、直径多＜1 cm，呈正常皮色或黄褐色。组织病理学特征性表现为胶原束与表皮垂直。皮肤镜特征因皮损部位、生长模式、胶原及毛细血管形成的不同而表现不同。     

下唇血管平滑肌瘤1例

患者男,26岁。下唇结节半年,无自觉不适。皮损组织病理示:瘤组织由大量纵横交错的平滑肌束组成,瘤细胞呈长梭形,胞浆丰富,胞核两端钝圆,肌束间见大小不等的血管管腔,部分呈裂隙状,无核分裂和细胞异型性。诊断:血管平滑肌瘤。手术切除后无复发。     

组织样麻风瘤1例

患者男,30岁。躯干、下肢散在结节,眉毛稀疏十个月。皮肤科情况:躯干、四肢散在大小不等的结节,双侧眉毛稀疏,双侧眶上神经和耳大神经明显粗大,踝以下感觉减退。皮损组织病理示:表皮萎缩,可见无浸润带,真皮可见团块状组织样细胞浸润,细胞交织排列成席纹状,神经肿大,周围单一核细胞为主的中度浸润,未见典型的泡沫细胞。抗酸染色可见组织细胞内外大量阳性棒状杆菌。诊断:组织样麻风瘤。     

Storiform collagenoma of the nail.

The term circumscribed storiform collagenoma was coined by Maize et al in 1989 to describe four dermal fibromas with pathologic features resembling the sclerotic fibromas associated with Cowden's disease. We report a subungual nodule with the pathologic features of circumscribed storiform collagenoma in a patient without Cowden's disease.     

Pacinian collagenoma: A distinct form of sclerotic fibroma

Sclerotic fibroma (storiform collagenoma) is a rare benign skin tumor. A solitary tumor, as well as multifocal lesions, are found either sporadically, or associated with Cowden syndrome. The tumor usually presents as clinically asymptomatic, slowly growing papule or nodule on the skin of the head, neck, and upper extremities. Microscopically the lesion is sharply demarcated, composed of hyalinized bands of collagen with low cellularity and a distinctive irregularly whorled or storiform pattern. We describe a case of a unique variant of this tumor in the scalp of a 33-year-old male. The tumor was microscopically composed of concentrically arranged collagen bundles with prevailing type III collagen, which resembled an enlarged Vater-Pacini corpuscle, with low density of CD34-positive and glucose transporter 1-negative spindle shaped cells. The specific microscopic appearance is suggestive of the term “Pacinian collagenoma” for this unique benign tumor.     

Giant cell collagenoma: case report and review of the literature

BACKGROUND: Giant cell collagenoma (GCC) is a recently described cutaneous fibrous neoplasm that usually affects young to middle-aged adults. Despite its similar histological appearance with circumscribed storiform collagenoma, no association of GCC with Cowden's syndrome has been described so far. To the best of our knowledge only five cases of this rare fibrous tumor have been reported so far. METHODS: We report a case of a 79-year-old male patient presenting with a slow growing flesh-colored dome-shaped lesion in his left forearm, with a clinical diagnosis of fibroma. No stigma of Cowden's syndrome was depicted. RESULTS: The histological analysis showed a symmetrical and well-circumscribed flat-dome-shaped lesion covered by an atrophic overlying epidermis. The neoplasm was composed of hyalinized collagen bundles disposed in a whorled storiform pattern. Admixed with the collagen matrix, there were two distinct cell populations, one composed by spindle-shaped mononuclear cells, and the other composed by bizarre multinucleated giant cells. Immunohistochemical analysis showed positivity for vimentin and actin HHF35 in the mononucleated. The multinucleated cells only immunoexpressed vimentin. CONCLUSION: GCC is an unusual cutaneous fibrous tumor that should be differentiated from circumscribed storiform collagenoma, pleomorphic fibroma, regressive forms of dermatofibroma, and solitary myofibroma based on its histological features.     

Circumscribed storiform collagenoma (sclerosing fibroma)

In the past several years we have examined eight dermal nodules that have morphologic features identical to the nodules described in patients with Cowden's disease. The patients in this series had no other clinical manifestations of Cowden's disease. In an attempt to better define this distinctive entity, we subjected tissue sections to a battery of histochemical and immunohistochemical stains and examined tissue from one of the nodules ultrastructurally. Although we found similarities between these nodules and other common dermal fibrotic lesions, we believe that they are distinctive architecturally (they are sharply circumscribed and have a strikingly uniform storiform pattern) and immunohistochemically (with uniformly scattered factor 13a-positive cells). Because of the unique histologic features, we propose that the term "circumscribed storiform collagenoma" be applied to these nodules.     

Eruptive collagenoma

A case of eruptive collagenoma in a male is being reported. He presented with asymptomatic nodules and plaques over the trunk, upper extremity and face of 15 years duration. Family history was negative. Histopathology with H & E stain followed by Verhoeff van Gieson's staining revealed increased collagen in dermis confirming the diagnosis of eruptive collagenoma. Patient also had Beckers naevus.     

A Case of Eruptive Collagenoma on the Left Calf

Eruptive collagenoma is an acquired connective tissue nevus without family history. It is typically described as numerous small papules or nodules on the trunk and arms with histopathological features of decreased or degenerated elastic fibers. We report a case of a 16-year-old male who presented with multiple asymptomatic 2 to 5 mm sized yellowish grouped papules on the left calf. Histopathologically, the lesion showed thickened homogenized collagen fibers highlighted by Masson trichrome stain and decreased and fragmented elastic fibers stained by Verhoeff-van Gieson stain. The skin lesion was diagnosed as eruptive collagenoma and no treatment was provided.     

Familial cutaneous collagenoma: genetic studies on a family.

Familial cutaneous collagenoma is an inherited condition characterized by the presence of multiple dermal nodules symmetrically distributed on the trunk and upper arms. In this study, six patients, the proband, his four siblings and a niece, representing a kindred of fifty-two subjects, were examined for aymptomatic cutaneous nodules mainly on the back and chest. The individual lesions varying from a few millimetres to several centimetres in size, were indurated, and showed minimal epidermal changes. Histologically, the nodules were characterized by an excessive accumulation of dense, coarse collagen fibres in the dermis. The elastic fibres appeared diminished in number, and in some areas they were abnormally thin and fragmented. The lesions, therefore, were connective tissue naevi of the collagen type. On the basis of the family history and histological observations the patients were diagnosed as having familial cutaneous collagenoma. Examination of the family pedigree indicated that the dermal nodules in familial cutaneous collagenoma were inherited in an autosomal dominant pattern. It was also observed that the lesions had an onset at the age of 15 to 19 years, and their number increased significantly during pregnancy. It is conceivable that familial cutaneous collagenoma is an inherited condition whose expression may be under a hormonal control.     

Eruptive collagenoma. Apropos of a case with ultrastructural study

A 29-year-old male patient was examined for numerous asymptomatic dermal nodules symmetrically distributed over the back and the shoulders. The nodules were firm, round to oval and varied in size from a few millimeters to 2 centimeters. They had appeared in normal skin without any known previous inflammation or injury, and they has been present without modification for nine years. At histological examination a dermal accumulation of abundant and large collagen bundles was observed. Elastic fibers seemed to be less numerous than normally. Alcian blue showed no increase in acid mucopolysaccharides. An ultrastructural study displayed normal, mature collagen fibers arranged in large bundles. Cutaneous collagenoma, initially described by Colomb as "eruptive collagenoma" is a rare disorder of unknown etiology occurring in young adults as symptomless dermal nodules without previous history of illness or injury and mostly localized to the back. No change is usually observed in these nodules for several years. Histologically, the nodules are characterized by a proliferation of collagen in the dermis; elastic fibers are generally reduced in number. Our ultrastructural study showed that proliferation of normal collagen fibers is the main morphological finding.     

发疹性皮肤胶原瘤1例

报告发疹性皮肤胶原瘤1例,患者男,38岁。背部,肩部出现多发性扁平丘疹,结节及斑块8年,皮损为正常肤色,直径数毫米至数厘米,部分融合成斑块,无自觉症状,无家族史,组织病理检查示,胶原纤维变厚,增殖,弹性纤维减少,诊断为发疹性皮肤胶原瘤。