胶样粟丘疹

患者男,52岁。因面部黄色丘疹3个月,无自觉症状,于2004年11月20日来我科就诊。患者于3个月前,面部出现粟粒大淡黄色丘疹,无自觉症状。嗣后皮损逐渐增多,且蔓延至颈部、肩部、腰部、背部、上肢及臀疗。     

胶样粟丘疹1例

患者女，47岁。因双颧外侧褐黑色丘疹5个月，于2006年1月就诊。患者5个月前双颧部出现少许褐黑色丘疹，时有微痒，后皮损逐渐增多，在外院给予氧化锌糊剂治疗，疗效不住。患者务农，长期日晒。既往体健。家族成员无类似疾病。体格检查：系统检查无异常。皮肤科检查：双颧外上方可见对称分布的黑褐色半透明扁平丘疹，圆形或类圆形，粟粒大，成簇排列，互不融合（图1A），全身其他部位未见类似皮损。皮损组织病理检查：表皮变薄，真皮层有嗜伊红均质性物质．嗜伊红物质内有裂隙（图1B）。诊断：胶样粟丘疹。[第一段]     

胶样粟丘疹1例

患者女,47岁,农民。双颧部可见对称分布的淡黄色半透明扁平丘疹4年。皮损组织病理示:真皮乳头内可见无结构的嗜伊红均质性物质,内有裂隙,甲紫蓝染色、PAS染色均(+)。诊断:胶样粟丘疹。     

胶样粟丘疹1例

临床资料患者,男,25岁,牧民。因双眼周丘疹3年余就诊。患者3年前不明原因双眼周出现粟米大小、淡黄色半透明丘疹,无自觉症状,未治疗,后皮损逐渐增多。自诉皮损冬重夏轻,日晒后加重。既往体健,否认家族史。查体:一般情况好,系统检查无异常。     

胶样粟丘疹1例

患者男,57岁.左鼻翼出现斑块3年,于2008年3月19日就诊.患者3年前无明显诱因左鼻翼出现一米粒大淡黄色半透明丘疹,伴轻微瘙痒.其后皮损渐增多,融合成斑块,用针挑破后可挤出透明胶样物质,未诊治.既往体健,否认局部曾有外伤史.常年从事户外劳动.家族中无类似疾病患者.     

胶样粟丘疹1例

报告1例胶样粟丘疹。患者女,60岁,务农。双眼周粟粒大小、淡黄色半透明扁平丘疹,逐渐增多,无自觉症状2年。组织病理显示真皮上部可见均质化并有裂隙的团块,类似淀粉样物质。弹力纤维染色显示弹力纤维断裂。诊断为胶样粟丘疹。     

胶样粟丘疹2例

例1．女,58岁。颜而部淡黄色半透明丘疹5年,于2005年7月就诊。5年前无明显诱因患者双侧颊部出现粟粒大淡黄色丘疹,并逐渐增多、增大,无自觉症状。皮损无季节变化．一直不消退。既往体健．无长期日晒史,家族成员中无类似疾病患者。体格检查：系统检查无异常。皮肤科检查：双侧颧部可见粟粒至绿豆大、密集的淡黄色半透明丘疹,质地韧,左侧较重,部分皮损融合（图1A、B）。面部皮肤较粗糙,纹理粗,肤色无明显异常。实验室检查：血、尿常规及肝、肾功能均正常。皮损组织病理检查：表皮角化过度,棘层变薄,真皮上部可见多处嗜伊红、胶样有裂隙的团块状物质沉积,周围有裂隙,胶样物质周围有少许淋巴细胞浸润（图2）。根据临床表现及组织病理改变．诊断为胶样粟丘疹。[第一段]     

胶样粟丘疹1例

患者男,55岁。因面部淡黄色丘疹5年,无自觉症状,于2004年10月27日在我科门诊就诊。患者5年前开始右面颊部出现粟粒大淡黄色丘疹,逐渐增多,增大,无自觉症状。日晒后加重。近两年左眼周围亦出现类似皮疹,无季节变化,并持续不退。患者既往体健,家族成员中无类似发病者。     

结节性胶样粟丘疹2例

例1女,39岁,右额角可见蚕豆大的淡黄色结节,周边散在分布绿豆大丘疹4年;例2女,41岁,左颊部可见一1.5cm×2.5cm大淡红色斑块,表面覆少许鳞屑。该2例均日晒后皮损加重,但无疼痛和瘙痒。皮损组织病理:例1示真皮上层胶原组织增生,可见嗜伊红色无结构均质性胶样物质,其间有裂隙;例2示表皮大致正常,真皮内可见大量粉红色均质性物质胶样团块,轻度嗜伊红改变,其间可见裂隙。2例结晶紫染色均(-)。     

手背部胶样粟丘疹1例

患者男,45岁.因双手背淡黄色扁平丘疹3年,于2008年7月24日就诊.患者3年前无明显诱因左手背出现淡黄色丘疹,丘疹渐增多,并累及右手背,无痒痛等.     

Juvenile colloid milium: a case report

Juvenile colloid milium is extremely rare, has its onset before puberty, may be inherited, may be caused by ultraviolet light, and is thought to result from the degeneration of keratinocytes. We report a 7-year-old girl with juvenile colloid milium. To the best of our knowledge this is the first reported case in Turkey.     

Papuloverrucous colloid milium: an occupational variant

We report a case of adult colloid milium in a 47-year-old mechanic with a long history of professional contact with lubricating oils and of sun exposure. In addition to the typical translucent papules seen on the forehead, there were warty papules on the backs of both hands with unusual histological and ultrastructural features: marked hyperplasia of the epidermis with orthokeratotic hyperkeratosis and papillary deposits of colloid material that were contiguous with the basal layer of the epidermis. The hand lesions caused by occupational exposure to mineral oils and solar radiation represent an occupational variant of adult colloid milium.     

Infrared‐induced adult colloid milium treated with fractionated CO2 laser

Adult colloid milium is a rare cutaneous deposition disorder that frequently involves areas of chronic sun exposure. The most common clinical presentation exhibits multiple, firm, and amber‐colored papules that cluster to form large plaques. Histologically, there are masses of amorphous, eosinophilic material expanding the papillary dermis, and at times extending into the mid‐dermis, with adjacent solar elastosis. When this disorder affects the face, disfiguring is of great concern and treatment is often sought. Attempts to safely remove colloid milium are generally unsuccessful. Dermabrasion has been reported to be effective. The present authors present a case with extensive facial colloid milium successfully ablated by the fractionated CO₂ laser.     

Nodular colloid milium mimicking keloid

Colloid milium is a rare cutaneous deposit disease that usually presents clinically by the development of yellowish translucent or flesh‐colored papules or plaques on sun‐exposed skin. Histologically, it is characterized by the presence of colloid in the dermal papillae. In this case report, we present a 52‐year‐old man who presented with a nodule on his upper lip that mistakenly was diagnosed and treated as keloid.     

Pigmented coalescing papules on the dorsa of the hands: pigmented colloid milium associated with exogenous ochronosis

Colloid milium is a rare cutaneous deposition disorder that frequently occurs in areas of chronic sun exposure such as the face, neck and backs of the hands and is characterized by multiple small, discrete, usually amber-colored, dome-shaped papules that cluster to form large plaques. A 50-year-old white woman with esophageal squamous cell carcinoma was referred to us with asymptomatic, slowly spreading lesions localized to the dorsa of her hands which had been present for 4 years. The condition was diagnosed histopathologically as pigmented colloid milium associated with exogenous ochronosis (EO). Colloid milium associated with EO is very rarely reported in the published work. We think that a possible interaction between sunlight and exposure to chemical fertilizers may have played a role in the pathogenesis of both of the disorders in our case.     

Non‐Hodgkin's lymphoma and auricular hypoplasia: associated with juvenile colloid milium or ligneous conjunctivitis?

The exact nature of amyloid‐like hyaline material deposits in the skin is not well understood in some disorders. Three of those – ligneous conjunctivitis, ligneous periodontitis and colloid milium – have been rarely reported in a same patient. We report a case of mucosal and skin deposits of an amyloid‐like homogeneous material associated with non‐Hodgkin's lymphoma and congenital auricular hypoplasia. We discussed and reviewed the literature on these unique associations to determine whether these are the same pathological process. We also noted whether this case represents a new syndrome or a coincidental association.     

Dermoscopic observation of Bowen''s disease

BACKGROUND: In the literature no specific dermoscopic criteria have been described for the diagnosis of Bowen's disease (BD). OBJECTIVE/AIM: To assess the morphological findings of BD seen under dermoscopic observation. METHODS: Clinical and dermoscopic images of 14 patients affected by BD with various amount of pigmentation were obtained by means of Heine Dermaphot. Dermoscopic images were analysed by experienced observers applying the modified pattern analysis. RESULTS: The most frequently occurring dermoscopic features were found to be: multicomponent pattern (100%); atypical vascular structures (86.6%); absence of pigmented network (64.3%) or presence of pseudo-network (35.7%); irregular diffuse pigmentation or blotches of pigment (64.2%); irregularly distributed dots and globules (64.2%); focal/multifocal hypopigmentation (78.5%), scaly surface (64.2%) and haemorrages (26.6%). CONCLUSIONS: Dermoscopically, BD is mainly characterized by a multicomponent global pattern associated with a prominent vascular pattern (mainly dotted vessels) and a scaly surface. Although no specific dermoscopic criteria can be given for BD, epiluminescence can be a valuable aid in the diagnosis of such a mimicker lesion.     

A case of adult colloid milium with chronic sun exposure

A 57‐year‐old woman presented with a sudden onset of skin‐colored papules, mainly on the forehead ( Fig. 1 ), around the eyes, and on the dorsum of the hands ( Fig. 2 ). The papules had grown in number and size over 1 month. The papules were discrete, shiny, and dome‐shaped, varying in size between 1 and 5 mm. The patient was a farmer and had commonly been exposed to UV radiation in her work in the fields for a period of more than 45 years. She was fair‐skinned and admitted that she was reluctant to use sun protection during her outdoor work. No lesions were observed on the covered areas of the body. The diagnosis was uncertain and clinical differential diagnoses were those of primary cutaneous amyloidosis, senile sebaceous hyperplasia, adult colloid milium (ACM), and papular mucinosis.

Figure Figure 1  Open in figure viewer PowerPoint Skin‐colored papules on the forehead