中药复方溶石剂对人体胆结石的直接溶解作用及其安全性评价

目的:研究中药复方溶石剂对人体胆结石的直接溶解作用及其安全性。方法:采用体外和动物体内溶石方法观察中药复方溶石剂的溶石效果,并通过观察给药前后动物的血液生化指标、各脏器的病理改变情况、进行急性毒性实验和黏膜刺激性实验评价中药复方溶石剂的安全性。结果:中药复方溶石剂在体外和体内对胆固醇型和混合型胆结石均有较好的溶解作用,体外实验胆石全溶的时间为4~5 d,体内实验胆石全溶的时间为7 d之内,无毒副作用。结论:中药复方溶石剂对胆结石有溶解效果好、安全性高的特点,有必要进一步开展中药复方溶石剂溶石机制和有效成分的实验研究。     

溶排石汤治疗胆道结石临床观察

目的观察溶排石汤治疗胆道结石的临床疗效。方法将76例胆道结石患者随机分为两组(每组38例),以溶排石汤治疗的为治疗组,以胆石利通片治疗的为对照组,以影像学结果为疗效判定依据,比较两组治疗前后临床症状及结石变化。结果治疗组总有效率为78.95%;对照组总有效率为52.63%,两组疗效比较有显著差异(P<0.05)。结论溶排石汤治疗胆道结石疗效可靠,安全可行。     

溶石口服液的制备及临床应用

目的：研究溶石口服液的制备工艺,并观察其临床疗效。方法：采用水提醇沉法进行制备,以肾石通颗粒为对照,进行临床疗效观察。结果：溶石口服液治疗泌尿系统结石的总有效率为87．8％,对照组总有效率为58．3％,治疗组明显优于对照组（P〈0．01）。结论：溶石口服液制法简单,l临床疗效较好。     

自拟溶石利胆汤治疗胆道结石86例

2005年1月-2008年12月,笔者采用自拟溶石利胆汤治疗胆道结石症86例,取得满意疗效,现报告如下。临床资料 1.一般资料 86例均选自我院门诊病例,经过B超声像检查确诊,均符合胆道结石诊断。其中男63例,女23例;年龄17-67岁,平均42岁;其中肝胆管内结石28例,结石直径最大0.65cm,最小0.4cm;胆囊结石37例,结石最大1.1cm,     

复方蛇床子搽剂的制备与临床疗效观察

复方蛇床子搽剂为我院自制制剂,由蛇床子、苦参、百部、地肤子等组成,具有清热燥湿、杀虫止痒功能。婴幼儿湿疹是临床常见的皮肤病,笔者采用该制剂治疗50例,取得满意疗效,现报道如下。     

白花合剂的研制及临床疗效观察

目的：观察白花合剂治疗慢性前列腺炎的疗效。方法：发病期间患者服用白花合剂50m1，bid，连服28天。结果：用白花合剂治疗慢性前列腺炎病人45例，痊愈32例(71．5％)，好转9例(20．0％)，无效4例(8．9％)，总有效率91．5％。结论：白花合剂治疗慢性前列腺炎有较好疗效。     

溶石饮治疗泌尿系结石58例疗效观察

目的 :探讨溶石饮治疗泌尿系结石的疗效。方法 :将 88例泌尿系结石患者随机分为 2组 ,治疗组 (5 8例 )予溶石饮治疗 ,对照组 (3 0例 )予排石冲剂治疗 ,评价两组疗效。结果 :治疗组总有效率为 80 % ,治愈率为 48% ;对照组分别为5 0 %和 2 0 % ,治疗组疗效明显优于对照组 (P <0 .0 5 )。结论 :溶石饮具有溶石排石的独特作用     

八正合剂体外抗菌及对动物的解热抗炎作用

目的 探讨八正合剂治疗泌尿系统感染性疾病的作用机制。方法 采用ig给药观察八正合剂对大鼠尿量和角叉菜胶致大鼠发热的影响。及巴豆油致小鼠耳部肿胀和0.6%醋酸致小鼠腹腔毛细血管通透性增高的影响。并用二倍稀释法观察该药对泌尿系8种常见致病菌的体外抑菌作用。结果 八正合剂可明显增加大鼠尿量，减轻角叉菜胶所致大鼠体温升高，巴豆油所致小鼠耳部炎性肿胀和醋酸所致小鼠腹腔毛细血管通透性增高，对大肠杆菌等常见致病菌也有一定抑制作用。结论 八正合剂对泌尿系感染的病因治疗机制主要在于清除尿路致病菌，同时该药还可缓解感染后多种炎性反应症状。     

氨茶碱膜剂中促进剂的作用及膜剂控释规律研究

 目的 建立氨茶碱膜剂中氨茶碱体外经皮渗透试验方法,考察促进剂对氨茶碱经皮渗透的影响并探讨膜剂控释规律。方法 以双室渗透扩散装置进行体外渗透试验,筛选促进剂。结果 膜剂中氨茶碱以零级动力学透过皮肤。在几种典型的促进剂中,对氨茶碱的促进作用依次为：月桂氮艹（上）卓（下）酮油酸、丙二醇;膜剂中氨茶碱的渗透速率与聚合物线速膜厚度的倒数成良好线性关系。结论 氨茶碱膜剂属膜控型给药系统,选择5%的月桂氮酮时,促进作用最好。     

菟丝子总黄酮对大鼠排卵障碍的治疗作用及其机制研究

目的 探讨菟丝子黄酮对排卵障碍大鼠的治疗作用.方法 将50只SD大鼠平均随机分为对照组、模型组、低剂量菟丝子黄酮组、高剂量菟丝子黄酮组以及阳性对照组,每组10只.采用羟基脲灌胃法制作排卵障碍动物模型,模型制作成功后,高剂量菟丝子黄酮组给予2 g/L菟丝子黄酮进行干预,低剂量菟丝子黄酮组给予1 g/L菟丝子黄酮进行干预,阳性对照组给予4.5 mg/kg克罗米芬,模型组及对照组均给予相同剂量生理盐水进行干预.均连续干预4周.观察并比较各组大鼠一般状况、动情周期、卵巢及子宫指数,并对卵巢组织学进行观察.结果 菟丝子黄酮可显著改善排卵障碍大鼠的一般状况,恢复大鼠动情周期,改善子宫及卵巢指数,且以高剂量菟丝子黄酮更为显著(P＜0.05);菟丝子黄酮对排卵障碍大鼠卵泡的生长发育具有促进作用,能够提高次级卵泡的数量.结论 菟丝子黄酮对排卵障碍具有显著的改善作用.     

Pharmacological and therapeutic effects of Berberis vulgaris and its active constituent, berberine

Barberry (Berberis vulgaris L. family Berberidaceae) is well known in Iran and various parts of this plant including its root, bark, leaf and fruit have been used as folk medicine. The two decades of research has demonstrated different pharmacological and therapeutic effects of B. vulgaris and its isoquinoline alkaloids (particularly berberine). Studies carried out on the chemical composition of the plant show that the most important constituents of this plant are isoquinoline alkaloids such as berberine, berbamine and palmatine. Berberine represents one of the most studied among the naturally occurring protoberberine alkaloids. In addition to B. vulgaris (barberry), berberine is present in many other plants and is used for the treatment of different diseases. This article reviews the traditional uses and pharmacological effects of total extract and the most active ingredient of B. vulgaris (berberine).     

Deoxypodophyllotoxin: A promising therapeutic agent from herbal medicine

Background

Recently, biologically active compounds isolated from plants used in herbal medicine have been the center of interest. Deoxypodophyllotoxin (DPT), structurally closely related to the lignan podophyllotoxin, is a potent antitumor and anti-inflammatory agent. However, DPT has not been used clinically yet. Also, DPT from natural sources seems to be unavailable. Hence, it is important to establish alternative resources for the production of such lignan; especially that it is used as a precursor for the semi-synthesis of the cytostatic drugs etoposide phosphate and teniposide.

Aims and objectives

The update paper provides an overview of DPT as an effective anticancer natural compound and a leader for cytotoxic drugs synthesis and development in order to highlight the gaps in our knowledge and explore future research needs.

Approach and methods

The present review covers the literature available from 1877 to 2012. The information was collected via electronic search using Chinese papers and the major scientific databases including PubMed, Sciencedirect, Web of Science and Google Scholar using the keywords. All abstracts and full-text articles reporting database on the history and current status of DPT were gathered and analyzed.

Results

Plants containing DPT have played an important role in traditional medicine. In light of the in vitro pharmacological investigations, DPT is a high valuable medicinal agent that has anti-tumor, anti-proliferative, anti-inflammatory and anti-allergic properties. Further, DPT is an important precursor for the cytotoxic aryltetralin lignan, podophyllotoxin, which is used to obtain semisynthetic derivatives like etoposide and teniposide used in cancer therapy. However, most studies have focused on the in vitro data. Therefore, DPT has not been used clinically yet.

Conclusions

DPT has emerged as a potent chemical agent from herbal medicine. Therefore, in vivo studies are needed to carry out clinical trials in humans and enable the development of new anti-cancer agents. In addition, DPT from commercial sources seems to be unavailable due to its rarity from natural sources and cumbersome extraction procedures. Hence, it is important to establish alternative, cost-effective and renewable resources, such plant cell cultures and (semi-) synthesis strategies for the production of DPT.     

针刺与药物治疗经前期综合征疗效对比

目的:对比观察针刺方法与药物治疗经前期综合征的临床疗效,寻找治疗该病的最佳方法.方法:将61例病人按就诊先后顺序分为针刺组30例,药物对照组31例.针刺组主穴取百会、关元、膻中、内关、太冲、三阴交,配穴取背俞穴;药物组口服安宫黄体酮.治疗3个月后比较2组的疗效.结果:针刺组与药物组的疗效比较,差异有显著性意义(P<0.05).结论:针刺疗法治疗本病的临床疗效优于药物.     

针灸治疗原发性痛经疗效观察

目的:评价针灸治疗原发性痛经的临床疗效.方法:按随机单盲法将80 例患者分为2 组,针灸组40 例采用针刺配合隔姜灸治疗,西药组40 例采用口服布洛芬缓释胶囊治疗.连续治疗3 个月经周期后观察疗效.结果:针灸组总有效率为85.0%, 西药组为70.0%, 两组比较差异有统计学意义(P＜0.05).结论:针刺配合隔姜灸治...     

Observation on therapeutic effects of acupuncture treatment for insomnia

目的：观察针刺治疗失眠症的疗效。方法：将96例失眠症患者按就诊顺序分成2组,治疗组51例,采用针刺治疗;对照组45例,口服艾司唑仑片治疗。治疗2星期后,进行疗效比较。结果：治疗组总有效率为94．1％,对照组总有效率77．7％,两组总有效率差异有统计学意义（P〈0．01）。结论：针刺治疗失眠症疗效优于口服艾司唑仑片。     

针刺治疗勃起功能障碍的疗效观察(英文)

目的:观察辨证针刺治疗勃起功能障碍的临床疗效。方法:勃起功能障碍患者82例,辨证分为肾阳虚衰与湿热下注两个证型,根据证型采用不同穴位进行针刺治疗。结果:总有效率87.6%。肾阳虚衰型痊愈率为45.0%,湿热下注型痊愈率为59.1%。结论:针刺治疗勃起功能障碍临床疗效与患者年龄及病程有关,年龄越大,病程越长,疗效越差。湿热下注型痊愈率高于肾阳虚衰型。