环状肉芽肿病因及发病机制

环状肉芽肿是一种以环状丘疹或结节性损害为特征的慢性皮肤病,目前病因和发病机制尚不明确。一般认为是机体对病毒感染、外伤、日晒或糖尿病、甲状腺炎相关免疫性疾病、疫苗接种、恶性肿瘤等异常免疫状态下的肉芽肿反应。对上述几个方面的涉及病因、发病机制的研究报告进行了综述。     

环状肉芽肿病因及发病机制

环状肉芽肿是一种以环状丘疹或结节性损害为特征的慢性皮肤病，目前病因和发病机制尚不明确。一般认为是机体对病毒感染、外伤、日晒或糖尿病、甲状腺炎相关免疫性疾病、疫苗接种、恶性肿瘤等异常免疫状态下的肉芽肿反应。对上述几个方面的涉及病因、发病机制的研究报告进行了综述。     

环状肉芽肿的病因及相关发病机制的研究进展

环状肉芽肿是发生于真皮或皮下组织的慢性皮肤病,以环状丘疹或结节性损害为主要特征,其病因可能与遗传、虫咬、外伤、病毒感染(包括HIV,EB和带状疱疹病毒)、自身免疫、肿瘤、药物等多种因素有关,但具体的发病机制仍不清楚。文中对该病的病因、发病机制的最新研究进展进行综述。     

环状肉芽肿的研究进展

环状肉芽肿发生于真皮或皮下组织，以环状丘疹或结节性损害为特征。其发病可能与遗传、自身免疫、骨桥蛋白、基质金属蛋白酶、糖尿病等多种因素有关，发病机制未明。目前尚无确切有效的治疗方法，冷冻、外用糖皮质激素、维生素E、苯丁酸氮芥、光化学疗法等有一定疗效。文中对其最新研究状况作一综述。     

环状肉芽肿的研究进展

环状肉芽肿发生于真皮或皮下组织,以环状丘疹或结节性损害为特征。其发病可能与遗传、自身免疫、骨桥蛋白、基质金属蛋白酶、糖尿病等多种因素有关,发病机制未明。目前尚无确切有效的治疗方法,冷冻、外用糖皮质激素、维生素E、苯丁酸氮芥、光化学疗法等有一定疗效。文中对其最新研究状况作一综述。     

环状肉芽肿的研究进展

环状肉芽肿是以肢端环状丘疹和结节性损害为特征的慢性炎症性皮肤病。病因不明,可能与免疫、遗传、系统性疾病、感染、药物等因素有关。无最佳治疗方法,局部外用糖皮质激素或钙调神经磷酸酶抑制剂、冷冻、PUVA、光动力疗法、富马酸酯、异维A酸、生物制剂等治疗有效。本文对环状肉芽肿的病因、临床表现和组织学特征、治疗的最新研究进展进行综述。     

环状肉芽肿发病机理的探讨

环状肉芽肿是一种表现特殊的疾病,皮损可突然出现而无任何前驱症状,也可迅速消退。除极个别情况外,皮肤及其炎症性病理变化都具独特之处。本病原因不明,据报道可发生在服药、虫咬、日晒、外伤、病毒感染及PUVA治疗之后。血管炎学说自Coleott-Fox描述此病至今的30年间,人们几乎一直认为本病是由血管病变所致,血管闭塞引起组织局部缺血导致渐进性坏死。此学说的证据如下:1.病变区的血管内     

环状肉芽肿治疗新进展

环状肉芽肿(granuloma annulare, GA)是一种良性的自限性肉芽肿性疾病。TNF-α抑制剂和阿普斯特既可治疗GA,也可诱发GA。该病可与糖尿病、高脂血症等共存,与恶性肿瘤和甲状腺疾病等的关系存在争议。近年来,JAK抑制剂及度普利尤单抗等药物取得了良好疗效。本文从GA的诱因、共病、发病机制及治疗进展等方面进行综述,为该病的研究提供参考。     

环状肉芽肿

环状肉芽肿病因及发病机制尚不明确。临床表现多种多样，需与许多疾病相鉴别。治疗可采用冷冻，手术切除，系统应用异维Ａ酸ＰＵＶＡ及其它方法。     

Concomitant occurrence of patch granuloma annulare and classical granuloma annulare

Granuloma annulare (GA) is characterized clinically as annularly-distributed, erythematous papules on the extremities in children and adolescents. GA is recognized histologically as palisading granulomas with central degenerated collagen and mucin deposits. Here, we present a case of concomitant occurrence of patch GA (PGA), the most rare type of GA, and classical GA in a patient. A 60-year-old man was referred to our hospital for asymptomatic eruptions on the upper arms, forearms, right flank and right lateral chest. Clinical examination revealed annular erythematous plaques composed of numerous small papules on bilateral upper arms and forearms. Moreover, an indurative, exudative erythematous to violaceous plaque was present on the right lateral chest and right flank. Histopathology of the former was compatible with palisade-type GA, and the latter interstitial-type GA. This is the first report of PGA concomitant with "classical" annular papular lesions.     

Generalized granuloma annulare

A 35-years-old female patient had generalized pruritic papular lesions, distributed like dermatitis herpetiformis for last 4 years. Histopathologic changes were typical of granuloma annulare with negative results of direct immunofluorescence. The patient did not have association of diabetes mellitus or any other systemic disease. She failed to respond to dapsone therapy and 13-cis-retinoic acid.     

先天性白甲病1例报告

先天性白甲病１例报告朱淳①范志莘②白甲系指甲板呈点状、线状或全部变白，有多种疾病可引起部分或全部白甲。先天性白甲甚为少见，现报道１例。患儿男性，２岁６个月，回族。１９９５年８月其父母亲随同来院就诊，主诉患儿出生后全部指甲呈白色，４个月时白色更加明显，...     

Penile granuloma annulare

A case of granuloma annulare (GA) localised to the shaft of the penis is reported with a brief review of the current literature. We concluded that penile GA, although rare, should be considered in the differential diagnosis of granulomatous lesions of the penis and that histopathological examination of the lesion is essential for the diagnosis.     

穿通性环状肉芽肿

患儿女．13岁。主诉：双肘关节伸侧多发性角化性丘疹3年。现病史：患儿3年前无明显诱因双肘关节伸侧出现多个肤色或淡红色丘疹,逐渐增大、增多,表面粗糙,无自觉症状。曾在当地医院就诊,诊断为“寻常疣”,予以冷冻治疗,效果不佳。为明确诊断遂来我科门诊就诊。起病前局部无明确外伤史。既往史：既往体健,否认有糖尿病等系统疾病史。     

Generalized granuloma annulare

Granuloma annulare is an inflammatory condition that is primarily idiopathic, but it has been associated with certain diseases, most notably diabetes mellitus. Lesions usually resolve, but resolution is less likely to occur with diffuse disease. This case report presents a patient with diffuse granuloma annulare. Recent advances in pathogenesis and treatment options are discussed.