全胃切除术后消化道重建方式的临床研究

目的探讨全胃切除术后更符合生理的消化道重建方式。方法对1985年1月-2002年12月间经病理证实行全胃切除术胃癌病例682例进行回顾性分析。682例中，功能性间置空肠代胃术(FJI)163例；袢式吻合47例，改良袢式吻合Ⅰ型和Ⅱ型340例，‘P’型Roux—en—y空肠代胃术87例、‘P’型空肠间置代胃术45例。比较其术后并发症、体重变化。结果功能性间置空肠代胃术在Roux—en—y综合征发生率、预后营养指数、进食量、体重减轻各个方面分别优于或等于袢式吻合、改良袢式吻合I型和Ⅱ型、‘P’型Roux—en—y空肠代胃术和‘P’型空肠间置代胃术。结论功能性间置空肠代胃术保持了重建消化道神经一肌肉功能的连续性，恢复食物经过十二指肠通道，对于减少全胃术后并发症、提高生存质量有重要的临床意义，是全胃切除术后一种合理的消化道重建方式。     

全胃切除术后两种消化道重建术式的比较

目的探讨全胃切除术后两种消化道重建术式手术操作时间、病人术后生活质量的影响。方法对2003年1月-2007年6月我院施行全胃切除术的218例病人的临床资料进行回顾性分析。全胃切除后消化道重建分别采用P型空肠袢食管空肠Roux—en—Y吻合术（PR法）（A组,96例）和改良空肠间置代胃吻合术（FJI法）（B组,44例）。记录术中消化道重建时间、术后12个月营养状况和胃肠道症状（GSRS）评分等。结果消化道重建术所需时间两组比较,差异无统计学意义（P〉0．05）。术后12个月B组与A组比较,进食量明显增加（P〈0．05）,而GSRS评分降低（P〈0．05）。术后12个月B组体重恢复较A组更佳,差异有统计学意义（P〈0．05）。结论改良空肠间置代胃吻合术有利于维持病人术后生活质量,在每天进食量及体重恢复方面改良空肠间置代胃吻合术优于P型空肠袢食管空肠Rottx—en—Y吻合术。     

近端胃次全切除间置空肠移植架桥术

近端胃次全切除术,常规术式多为残胃与食管吻合。本文报告间置空肠代胃术移植于残胃食管间,即成为残胃食管间间置空肠移植架桥术。自1996年至1998年收治5例,施以上述术式,术后得以良好的康复,现就其术式操作及优点予以探讨。1 手技与方法贲门侧胃次全切除后予以残胃食管间行间置空肠（interposition）移植重建架桥术（图1）。操作可使用吻合器。 A、B分别为空肠与胃、食管吻合处 C系空肠间侧侧吻合处 D、 E为丝线结扎处,AD长约 15cm,AE长约 30cm C点距离屈氏韧带为 15cm图1 残胃食管间行间置空肠移植重建架桥术2 术式优点1）输出…     

胃癌全胃切除空肠间置代胃术临床评价

[目的]评价胃癌全胃切除术后连续性空肠间置代胃消化道重建术的临床应用.[方法]全胃切除后距屈氏韧带50cm处结肠后提起空肠,顶端与食管行端侧吻合(A),在A下方行空肠侧侧吻合(B),在B下方再行空肠侧侧吻合(C),在吻合口B、C降支空肠与十二指肠断端行端侧吻合(D),在D的下方降支空肠和B的下方升支空肠以7号丝线结扎.[结果]本术式有四个吻合口,借助管型吻合器吻合,不费时,手术时间平均3小时,不输血.全组36例患者均得到随访,患者均有食欲感,每日进餐4～6次,体重多恢复至术前水平或有增加,血红蛋白、血清蛋白均在正常范围,患者能从事家务及部分体力劳动,对术后生活质量感到满意.[结论]空肠间置代胃术使食物通过十二指肠符合生理;有效防止了反流性食管炎及倾倒综合征;无需切断空肠,手术省时、简捷安全,是胃癌全胃切除术后一种较为合理的消化道重建术式.     

胃癌全胃切除术后三种消化道重建方法对比研究

目的:探讨胃癌全胃切除术后理想的消化道重建方式。方法:对98例胃癌患者按全胃切除术后消化道重建方式的不同,分为Lahey+Braun式食管空肠端侧吻合术（Ⅰ组,n=34)、P型空肠袢食管空肠Roux-en-Y吻合术（Ⅱ组,n=28）及改良功能性空肠间置代胃术（Ⅲ组,n=36)。比较3种术式患者术后并发症发生率及营养指标。结果:Ⅱ组和Ⅲ组术后患者的营养状况均明显优于Ⅰ组,P<0．05;Ⅱ组和Ⅲ组术后并发症也明显少于Ⅰ组,P<0．05。Ⅱ组与Ⅲ组患者的营养指标变化和术后并发症相比,除体重外均无明显差异,P>0．05。结论:全胃切除后P型空肠袢Roux-en-Y吻合术和改良功能性空肠间置代胃重建方式较Lahey+Braun式食管空肠端侧吻合术为胃癌行全胃切除消化道重建较理想的术式,更有利于患者的营养恢复及减少术后并发症发生率。     

近端胃大部切除后两种消化道重建术式的比较

目的:探讨近端胃癌行近端胃大部切除后理想的消化道重建方式。方法:1995年~2006年对145例近端胃癌行根治性近端胃大部分切除后随机采用两种常用的消化道重建术式:食管与胃直接吻合73例(吻合组);食管与胃之间空肠间置72例(间置组)。对两种重建术的手术时间、术中出血量、术后并发症及术后1年生活质量、反流性食管炎及营养指标进行了比较。结果:与吻合组比较,间置组手术时间显著延长(P<0.01),但术中出血量、术后并发症发生率两组间无显著差异,术后1年间置组生活质量优于吻合组,反流性食管炎显著减少(P<0.01),而营养状态两组间无显著差异(P>0.05)。结论:食管残胃间空肠间置是近端胃大部分切除后较为合适的消化道重建术式。     

贲门癌切除术后预防反流性食管炎术式探讨

[目的]探讨贲门癌胃大部根治切除术后理想的预防反流性食管炎消化道重建术式。[方法]对83例贲门癌患者行根治性近端胃大部切除术后,分别行食管残胃吻合术(A组),食管残胃吻合并幽门成形术(B组),食管残胃吻合并残胃空肠吻合引流术(C组)三种消化道重建方式,术后观察临床症状和行上消化道钡餐、胃镜检查。[结果]A组反流性食管炎22例(64.7%),B组8例(34.8%),C组1例(3.8%)。通过术后随访对临床症状、上消化道钡餐、胃镜检查进行对比,贲门癌行近端胃大部根治切除、残胃食管吻合并残胃空肠吻合引流术在预防反流性食管炎上优于幽门成形术,差异有显著性(P<0.01),且并发症少,体重恢复好。[结论]贲门癌行近端胃大部根治切除、残胃食管吻合并残胃空肠吻合引流术具有预防反流性食管炎和十二指肠液反流的作用,同时能促进残胃排空,是一种安全简便、较理想的消化道重建术式。     

胃癌全胃切除术三种消化道重建方式的对比分析

目的探讨比较胃癌全胃切除术3种消化道重建方式的优缺点。方法 2000年1月至2009年12月对68例患者施行全胃切除术,消化道重建方式分别为Lahey+Braun式食管空肠端侧吻合术(Ⅰ组,n=46)、P型空肠袢食管空肠Roux-en-Y吻合术(Ⅱ组,n=12)及改良功能性空肠间置代胃术(Ⅲ组,n=10),探讨3种消化道重建方式的优缺点。结果Ⅱ组和Ⅲ组术后患者的营养状况均明显优于Ⅰ组,均P<0.05;Ⅱ组和Ⅲ组术后并发症也明显少于Ⅰ组,均P<0.05。Ⅱ组与Ⅲ组患者的营养指标变化和术后并发症相比,除体重外均无明显差异,P>0.05。结论全胃切除后P型空肠袢Roux-en-Y吻合术和改良功能性空肠间置代胃重建方式较Lahey+Braun式食管空肠端侧吻合术更有利于患者的营养恢复及减少术后并发症发生率。     

间置空肠P袢在全胃切除术中的应用

目的探讨全胃切除术中间置空肠P袢消化道重建的效果。方法对30例符合全胃切除术条件的患者施行全胃切除、间置空肠P袢消化道重建。观察术后症状、术前术后体重、进食量、血浆营养参数（血浆总蛋白、血红蛋白）、全血细胞计数、预后营养指数（PNI）以及钡餐造影。结果本组无手术死亡，无腹腔感染及吻合口瘘。术后进食量、体重恢复快，血浆营养参数和PNI较高，钡餐检查P型空肠袢充盈良好，未见明显反流。结论全胃切除间置空肠P袢符合解剖生理规律，并发症少，代胃效果理想。     

胃切除后食管癌手术方法选择

 目的　探讨胃大部切除或全胃切除后再患食管癌手术治疗术式。方法　回顾分析 1990年 1月至 2 0 0 1年 12月收治胃切除术后再患食管癌 2 9例资料。食管癌切除后的消化道重建方式 :残胃代食管术 2 0例、空肠代食管术 3例、结肠代食管术 6例。结果　 2 9例除 1例颈部食管结肠吻合口瘘、1例胸部食管残胃吻合口瘘、1例吻合口狭窄、3例肺部感染、其余均Ⅰ期愈合。结论　胃大部切除术后食管中下段癌采用残胃代食管术 ,食管中上段癌行结肠代食管术更为合理     

胃癌术式对患者术后营养的影响

全胃切除对机体的生理干扰较大,破坏了消化道的连续性和完整性,影响食物的消化和吸收,术后患者均有一些并发症出现。如：返流性食管炎、早期或晚期倾倒综合征、顽固性贫血、消化吸收不良以及腹泻、餐后上腹部轻度闷痛、食欲低下等症状,统称为胃切除术后综合征。全胃切除后消化道重建术式已达70多种,以期克服上述并发症。其中保持经十二指肠通路间置空肠（附加/无空肠袋）被认为可以提高患者的生活质量,降低上述并发症。近端或远端胃次全切除术后在残胃和十二指肠间间置一段空肠（附加空肠袋/无袋）可以改善患者的营养状况,提高患者的生活质量。预后营养指数（PNI）、Visik评分、Spitzer指数和欧洲癌症研究治疗机构问卷（EORTCQLQ-C30）都可以被用于评估胃切除术后患者的生活治疗及营养状况。     

Effects of Different Operative Procedures on the Digestive and Nutritional Status of Patients Treated with a Gastrectomy for Gastric Cancer

Gastric cancer is one of the most common malignancies in China. So far surgical excision of diseased gastric and nodal compo- nents remains the primary therapy. As the detection rate of early can- cer has increased, owing to improved radiography, endoscop…     

Nutritional effects of postgastrectomy reconstruction: a clinical evaluation

To evaluate the nutritional benefits of a jejunal pouch vs. esophagojejunostomy following total gastrectomy, we reviewed 24 consecutive cases of total gastrectomy: 14 males and 10 females, 39 to 85 years of age (mean 66.6 y.) undergoing 9 jejunal pouches (JP) and 15 Roux-en-Y esophagojejunostomy (EJ). Indications for surgery included 15 adenocarcinomas, 3 lymphomas, 1 leiomyoma, and 5 hemorrhagic gastritis. The operative mortality was 12.5%. One JP patient was lost to follow-up. The mean survival for EJ was 13.3 months and for JP 36 months. Total gastrectomy resulted in persistent weight loss and hypoalbuminemia, and the creation of a jejunal pouch did not seem to improve significantly the nutritional status following total gastrectomy.     

胃癌患者全胃切除术后两种消化道重建方式的比较

目的 探讨功能性空肠间置代胃重建术(FJI)和P型Roux-en-Y全胃切除空肠代胃术(PR)两种不同消化道重建方式对胃癌患者全胃切除术后生活质量、营养状态及术后辅助化疗耐受性的影响.方法 实施全胃切除的107例胃癌患者中,49例行FJI重建术,58例行PR重建术.其中79例患者(FJI组40例,PR组39例),术后3周按XELOX方案行辅助化疗,监测两组患者的术后消化道并发症发生率及化疔耐受性.结果 107例患者均未发生严重手术并发症,无围手术期及化疗相关死亡.FJI组反流性食管炎、倾倒综合征、滞留综合征及消瘦的发生率分别为18.4%、6.1%、4.1%和8.2%,PR组分别为19.0%、19.0%、15.5%和22.4%,两组倾倒综合征、滞留综合征及消瘦的发生率差异有统计学意义(均P＜0.05).FJI组接受辅助化疗的患者中,28例完成了6个周期的辅助化疗,中断化疗12例;PR组接受辅助化疗的患者中,19例完成了6个周期的辅助化疗,中断化疗20例.两组Ⅲ～Ⅳ度毒副反应发生率及化疗完成率差异有统计学意义(均P＜0.05).结论 FJI和PR消化道重建术安全可行,FJI组术后远期并发症的发生率低于PR组,术后辅助化疗的耐受性优于PR组.

Abstract：

Objective To evaluate the influence of two different types of digestive tract reconstruction on the life quality,nutritional status and tolerance to adjuvant chemotherapy after total gastrectomy in patients with gastric carcinoma. Methods The clinical data of a total of 107 patients treated in our department from January 2005 to december 2008 were analyzed retrospectively.Among them,49 patients underwent digestive tract reconstruction with functional jejunal interposition(FJI group) and 58 patients underwent Roux en-Y jejunal P-type anastomosis(PR group) after total gastrectomy.79 of 107 (73.8%) patients received postoperative adjuvant chemotherapy with XELOX regimen.The digestive complications and tolerance to chemotherapy were assessed respectively.Resuits Neither severe complications nor surgery-related or chemotherapy-related death were observed among the 107 patients.There were statistical differences in the incidence rate of emaciation,dumping syndrome and retention syndrome between the FJI and PR groups(P＜0.05),but no significant statistical difference in incidence rate of reflux esophagitis(P＞0.05).28 of 40(70.0%) patients in the FJI group completed all six cycles of chemotherapy,while 12(30.0%) patients interrupted the treatment due to chemotherapy-related toxicity.39 patients in the PR group received chemotherapy,19(48.7%) of them completed 6 cycles of chemotherapy but 20(51.3%) patients interrupted.There was a significant difference in the incidence rate of grade Ⅲ/Ⅳ chemotherapeutic toxicity and completion rate of chemotherapy(P ＜0.05). Conclusions Both functional jejunal interposition and Roux-Y operation are reasonable and safe procedures of digestive tract reconstruction.The incidence rates of emaciation,dumping syndrome and retention syndrome are lower in the patients with FJI,showing a better tolerance to adjuvant chemothterapy than Roux en-Y jejunal p type anastomosis.     

全胃切除术后FJI消化道重建的临床研究

Objective To investigate the optimum reconstruction after total gastrectomy for malignant disease, especially the necessity of gastric substitute and duodenal passage. Methods Among the 459 total gastrectomy cases, 6 kinds of reconstructions had been used, including Braun, modified Braun I (mBraun I), modified Braun II (mBraun II), Roux-en-Y, “P” jejunal interposition (PJI) and functional jejunal interposition (FJI). Postoperative complains, body weight, food intake, serum nutritional paraments, complete blood count, half-emptying time of the gastric substitute, PNI, Visick index were evaluated one year after surgery. Results As compared with Braun group, the mBraun I, II and Roux-en-Y groups which had some kinds of gastric substitute showed less reflux esophagitis and higher serum total protein (P<0.01). As compared with mBraun I, II, Roux-en-Y, PJI and FJI groups which had duodenal passage showed better body weight, higher nutritional paraments and PNI (P<0.05). Conclusion It is essential to construct a gastric substitute and maintain the food chyme flowing through the duodenum after total gastrectomy, and the FJI is a better choice in this study.     

Proximal gastrectomy and jejunal pouch interposition: evaluation of postoperative symptoms and gastrointestinal hormone secretion

Reflux esophagitis, dumping syndrome and malnutrition are included in the postgastrectomy complications. To prevent or minimize such sequelae, proximal gastrectomy with an interposed jejunal pouch has been advocated as an organ-preserving surgical strategy to improve quality of life for the patients. Proximal gastrectomy was performed in 44 patients with tumors in the upper third of the stomach; 21 had reconstruction using jejunal pouch interposition between the esophagus and the remnant stomach (JP group), while 23 had reconstruction by esophagogastrostomy (EG group). Re-construction method was selected by each patient on the basis of the informed consent. Thirty-five patients had early gastric cancer. Postoperative courses of patients were reviewed in terms of symptoms, weight maintenance, nutritional status, blood chemistry values, endoscopic findings, and radiographic appearances after a barium meal. Concentrations of gastrointestinal hormones were measured in response to a test meal. The JP procedure permitted increased dietary volume. The JP group showed fewer severe postoperative symptoms than the EG group. After operation, all patients examined in both groups showed hypergastrinemia and all patients examined in the JP group showed hypersecretinemia. In proximal gastrectomy, the JP procedure improved patient's post-operative quality of life.     

近端胃癌保功能手术后消化道重建及术后功能评价#br#

早期胃癌相对于进展期胃癌,淋巴结转移发生率低、预后较好,因此功能保留胃切除手术被广泛探索,并运用于早期癌患者的治疗中。对于食管胃结合部早期腺癌,根治性近端胃切除术与全胃切除相比,5年总生存率未见明显差异,同时具有术后胃部分功能保留、患者营养状态好的优点。近端胃癌根治术后消化道重建的方法有很多,如食管 管状胃吻合、空肠间置吻合、双通道吻合、Kamikawa吻合等,以及我国学者开展的giraffe吻合、胃间置吻合,这些重建方式降低了近端胃根治术后反流性食管炎等的发生。但目前尚缺乏重建标准方案。该文回顾了关于近端胃切除术后重建方式的文献,梳理消化道重建方式的演变和研究进展,期望为系统评估近端胃癌切除术后保留胃功能手术的改进及选择提供参考。     

全胃切除功能性间置空肠代胃术72例临床分析

目的：探讨功能性间置空肠代胃消化道重建在全胃切除术后的应用价值.方法：回顾性分析2006年1月-2011年12月施行全胃切除功能性间置空肠代胃术72例患者的临床资料.结果：全组无手术死亡和吻合口瘘发生.随访12个月至24个月,部分病例出现轻度反流性食管炎,代胃容量300ml以上,排空时间30-100min.术后生活质量有所提高.结论：功能性间置空肠代胃术是一种安全可靠、效果满意的消化道重建手术方式.     

Functional jejunal interposition versus Roux-en-Y anastomosis after total gastrectomy for gastric cancer: A prospective randomized clinical trial

BackgroundNutritional status and quality of life deteriorate significantly after total gastrectomy for patients with gastric cancer. The numerous types of reconstruction proposed by medical researchers around the world have limited effect. This prospective, randomized clinical trial compared functional jejunal interposition with Roux-en-Y anastomosis to identify the optimal reconstruction procedure.MethodsThis was a multi-center, prospective, randomized control trial. The enrolled patients were randomly assigned into the functional jejunal interposition group and the Roux-en-Y group. All patients were followed up at regular intervals after surgery. The endpoints were postoperative nutritional status, quality of life, and long-term postoperative complications.ResultsA total of 113 patients were enrolled from August 2012 to September 2017. Until March 2018, the median follow-up period was 18 months. At 12 months after surgery, food intake per meal (P = 0.021), Prognosis Nutritional Index (P = 0.015), weight loss (P = 0.019), and Gastrointestinal Symptom Rating Scale score (P = 0.015) of the functional jejunal interposition group were significantly worse than those of the Roux-en-Y group. There was no significant difference in operative time, intraoperative blood loss, perioperative complications, time of first flatus and defecation after surgery, postoperative plasma nutritional parameters, Visick score, Eastern Cooperative Group physical condition score, and survival rate.ConclusionFor patients with long-term survival after total gastrectomy for gastric cancer, the Roux-en-Y anastomosis is a better choice compared with functional jejunal interposition.     

Blood concentrations of futraful, uracil and 5-fluorouracil (5-FU) after UFT administration in the various reconstructions after gastrectomy. Saitama UFT Research Group]

The study was undertaken in the total of 58 gastric cancer patients among which 17 of Billroth (BI), 14 of Billroth II (B II) anastomosis after subtotal gastrectomy, and 7 of jejunal interposition, 9 of double tract and 11 of Roux en Y anastomosis after total gastrectomy were included. Blood samples were taken before 200 mg of per oral UFT administration and after 1, 2, 3, 5 and 7hrs. consecutively. The blood Futraful (FT) level in the total gastrectomy groups reached peak concentration within 1hr and kept in relatively high level during the observation period of 7hrs. The time to maximum FT concentration delayed in almost of B I and a few of B II patients. The concentration curves of uracil (URA) and 5-FU were similar in shape, revealing steep increase and decrease except B I anastomosis which showed gentle course. The plotted maximum concentrations of URA and 5-FU in the every type of reconstruction showed a significant correlation in the regression line. In the analysis of AUC, URA/FT was under 10%, suggesting the longer retention of the unmetabolite type of FT and early disappearance of URA. The ratio of 5-FU/FT was indifferent in each reconstruction. 5-FU/URA was higher in subtotal rather than total gastrectomy groups. From the data obtained, blood concentration of 5-FU after UFT administration was considered to depend on the emptying status in the gastrectomies. And moreover, it depended on blood URA level, since FT from which 5-FU was derived, was kept still sufficiently remained during observation period.