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Identification of human granzyme B promoter regulatory elements interacting with activated T-cell-specific proteins: implication of Ikaros and CBF binding sites in promoter activation. 总被引:2,自引:0,他引:2
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A Wargnier S Legros-Maida R Bosselut J F Bourge C Lafaurie C J Ghysdael M Sasportes P Paul 《Proceedings of the National Academy of Sciences of the United States of America》1995,92(15):6930-6934
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Regulation of the NK-1 receptor gene expression in human macrophage cells via an NF-kappa B site on its promoter
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Simeonidis S Castagliuolo I Pan A Liu J Wang CC Mykoniatis A Pasha A Valenick L Sougioultzis S Zhao D Pothoulakis C 《Proceedings of the National Academy of Sciences of the United States of America》2003,100(5):2957-2962
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血红素加氧酶(HO)是血红素降解的起始酶和限速酶,其主要功能是代谢血红素成为一氧化碳、胆绿素及铁离子。HO—1是HO的一种同工酶,为诱导型HO。HO-1及血红素代谢产物具有抗炎、抗氧化、抗凋亡、扩张血管等生理作用。HO-1作为一种重要的应激蛋白,在急性肾脏损伤、肾小球肾炎、肾间质纤维化等肾脏疾病的病理生理发展过程中发挥着重要的保护作用,有效地调控其表达有可能成为预防和治疗相关疾病的新策略。 相似文献
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