补骨合剂促进口腔骨内种植体骨性结合的临床研究

目的：从中医药角度,寻找促进口腔种植体骨性结合的方法。方法：CDIC二段式种植体植入下颌骨后牙缺失区,口服补骨合剂。于术后1、2、3月检查种植体－－骨界面结合情况。结果：临床X线摄片与CT扫描显示补骨合剂组,界面达到骨性结合时间、质量明显优于对照组（P＜0.05）。结论：补骨合剂可以促进口腔种植体的骨性结合。     

补骨合剂促进口腔种植体骨性结合的组织学研究

目的：从中医药角度,寻找促进口腔种植体骨性结合的方法。方法：ＣＤＩＣ种植入狗的下颌骨,以补骨合剂或生理盐水灌胃,于术后１、２、４、８、１２周检查种植体－骨界面骨性结合情况。结果：组织学检查显示补骨合剂组界面达到骨性结合时间、质量明显优于生量盐水组。结论：补骨合剂可以促进口腔种植体骨性结合。     

口腔种植体植入放疗骨组织骨整合作用的研究

放疗可降低骨组织再生能力,口腔种植体植入放疗后骨组织中,其成功率低于植入正常骨组织。影响其成功率的主要因素有放疗的剂量、时间、放疗与种植术的间隔时间、高压氧的应用与否及种植体自身的情况等。本文就口腔种植体植入放疗骨组织的临床应用和实验研究作一综述。     

补骨合剂促进口腔种植体骨性结构的组织形态学研究

目的：观察补骨合剂对口腔骨内种植体内性结合的组织形态学指标的影响,探讨补骨合剂促进骨性结合的作用机理。方法：成年杂种犬20只,拔除左侧下颌第二、三、四前磨牙,3个月后植后CDIC种植体3枚,随机分为实验组与对照组。实验组每日予补骨合剂1ml/kg灌胃,分别于术后1、2、4、8、12周取出标本行组织形态计量学分析,观察种植体－骨界面骨性结合情况。结果：实验组每1周成骨细胞指数和骨矿化沉积速率显著高于对照组（P＜0．01）;第2、12周实验组骨融合指数比对照组显著提高（P＜0．05）;第2周实验组骨缺损面积显著减少（P＜0．05）。结论：补骨合剂可以促进口腔骨内种植体骨性结合,①可增加早期成骨细胞的数量与活性,促进骨基质的合成;②提高早期骨矿化沉积速率,促进钙磷酸盐的沉积。     

补骨合剂促进口腔种植体骨性结合的组织形态学研究

目的 :通过观察补骨合剂对口腔骨内种植体骨性结合的组织形态学指标的影响 ,探讨补骨合剂促进骨性结合的作用机理。方法 :成年杂种犬20只 ,拔除左侧下颌第二、三、四前磨牙 ,3个月后植入CDIC种植体3枚,随机分为实验组与对照组。实验组每日予补骨合剂1ml/kg灌胃 ,分别于术后1、2、4、8、12周取出标本行组织形态计量学分析 ,观察种植体 -骨界面骨性结合情况。结果:实验组第1周成骨细胞指数和骨矿化沉积速率显著高于对照组(P<0.01) ;第2、12周实验组骨融合指数比对照组显著提高(P<0.05) ;第2周实验组骨缺损面积显著减少(P<0.05)。结论 :补骨合剂可以促进口腔骨内种植体骨性结合,①可增加早期成骨细胞的数量与活性 ,促进骨基质的合成 ;②提高早期骨矿化沉积速率 ,促进钙磷酸盐的沉积     

促进口腔种植体骨整合因素研究进展

口腔种植体骨性结合是牙种植成功的标志,运用骨引导再生膜、骨基质明胶、骨形成蛋白、羟基磷灰石涂层、激素、高压氧、电磁场等用以诱导和促进种植体－骨界面骨的形成和生长,加速和改善骨结合,取得成效。     

影响口腔种植体骨整合形成因素的分析研究

口腔种植体起始于19世纪使用金属种植体，随着金属钛的应用使口腔种植体得到完善和长足的发展。在牙种植体-骨组织界面结合方式的认识过程中，历史上存在两种不同的观点，即骨整合和纤维骨性结合两种方式。由于骨整合形式得到临床实践的支持，目前公认牙种植体-骨组织界面是较优的结合方式，即在光镜水平下，     

骨整合牙种植体修复的生物力学研究概况

骨整合牙种植体修复能否取得长期成功，不仅取决于种植材料的生物相容性，病例的选择及手术技术，而且决于种植体修复系统（包括种植体和修复体）与骨组织的生物力学适应性。本文对此作一综述。     

亲水种植体促进骨整合机制研究进展

 快速稳定的骨整合一直是口腔种植学研究的重要目标。近年来，通过种植体表面改性的方法提高种植体表面的亲水性以促进骨整合，已成为研究的热点。种植体植入后，可引发一系列级联事件，影响骨整合的发生发展。文章就亲水种植体促进骨整合机制的相关研究进展做一综述。     

影响纯钛种植体骨整合界面形成的临床因素分析

目的 通过临床实践探讨影响钝钛种植体骨整合界面形成的因素,寻求防治措施,提高种植义齿的成功率。方法 对230例门诊种植病人采用Branemark纯钛种植体行延期种植术,3～6个月后行Ⅱ期手术。结合X线及术中所见,评价钝钛种植体骨整合界面形成状况。结果 在植入的520颗纯钛种植体中,获得骨整合界面的有503颗,失败17颗,成功率96.7%。结论 影响纯钛种植体骨整合界面形成的因素有术前严格选择适应证及充分的术前准备,防止骨灼烧,预防感染,防止术中种植体被污染。     

放疗对骨组织及种植体周围骨结合影响的研究进展

种植义齿逐渐成为牙列缺损和牙列缺失成年患者的最佳修复方法。对于头颈部恶性肿瘤患者,通常采取手术切除联合放化疗。然而,放疗对机体颌骨组织产生一定的损害,进而间接影响种植体周围的骨结合。本文将主要就放疗对骨组织的影响及放疗对种植体周围骨结合的作用作一综述。     

Effects of Untreated Periodontitis on Osseointegration of Dental Implants in a Beagle Dog Model

Background: There have been previous studies on the relationship between periodontitis and peri‐implantitis, but limited information is available on how periodontitis affects osseointegration and wound healing of newly placed dental implants adjacent to natural teeth. The objective of the present experiment is to evaluate healing around dental implants adjacent to teeth with untreated experimental periodontitis. Methods: The study included six male beagle dogs. Scaling and plaque control procedures were performed on three dogs (control group). In the other three dogs (experimental group), retraction cords and ligature wires were placed subgingivally around all premolars and the first molars. Induced experimental periodontitis was confirmed after 3 months. Each control or experimental group was divided into two subgroups depending on the timing of implant placement (immediate/delayed). Twelve dental implants (two implants for each dog) were placed immediately, and the other 12 dental implants (two implants for each dog) were placed 2 months after extraction. The animals were sacrificed 2 months after implant placement. Histologic and histometric analyses were performed. Results: Four implants (three from the immediate placement group and one from the delayed placement group) failed in the experimental group. There were significant differences in the percentage of bone‐to‐implant contact and marginal bone volume density between the control and experimental groups. Both parameters were significantly lower in the experimental group than in the control group (P <0.05). There was a tendency toward more marginal bone loss in the experimental group than the control group. Conclusions: Immediate placement of implants is associated with a higher failure rate compared with delayed placement. Untreated experimental periodontitis was correlated with compromised osseointegration in the implants with delayed placement.     

Rates of Osseointegration of Dental Implants With Regard to Anatomical Location

PURPOSE: Implantation of commercially pure titanium dental implants can be obtained predictably and consistently. The initial research focused on the edentulous population, with most of the fixtures being placed into the anterior mandibular area. There has been increased use of dental implants for partially edentulous patients. MATERIALS AND METHODS: This study reports the results of 169 consecutively treated patients with 673 fixtures. Patients were observed for 7 months to 8 years following occlusal loading. RESULTS: Implant osseointegration was 89.1% in the anterior maxillae; 71.4% in the posterior maxillae; 96.7% in the anterior mandible; and 98.7% in the posterior mandible. CONCLUSION: Osseointegration may be most dependent on anatomical location in the jaws.     

种植术后放疗对兔胫骨种植体骨结合影响的实验研究

目的:探讨种植术后放疗对种植体周围骨密度、种植体骨结合的影响。方法:在16只日本大白兔双侧后肢胫骨同一位置各植入纯钛种植体1枚,2周后随机选取8只作为放疗组,一次性给予60Co15Gy剂量的放疗,余下8只作为对照组不接受放射治疗。通过大体观察、双能X线分析、组织形态学、骨计量学分析及骨-种植体磨片观察等手段,研究术后4、8、16、24周时种植体骨结合情况,应用F检验对实验结果进行统计学分析。结果:术后4周时放疗组种植体周围骨密度比未放疗组降低(P<0.05),种植体骨结合率也较未放疗组降低;术后8周时放疗组种植体周围出现明显的骨结合现象,相当于未放疗组术后4周时的水平;术后16周以后放疗组与未放疗组种植体周围骨密度及种植体骨结合率的差异无显著性。结论:放疗可在一段时间内延缓种植体周围骨的生长,降低骨种植体结合率。