正骨手法结合经皮锁定钢板固定治疗老年肱骨近端骨折的病例对照研究

目的 :探讨正骨手法闭合复位结合经皮微创固定治疗老年肱骨近端骨折的临床研究。方法 :2012年2月至2013年12月,收治老年肱骨近端骨折共39例,男17例,女22例;年龄67~88岁,平均(71.8±5.2)岁。分为经皮微创锁定钢板固定治疗组(MIPPO组)和切开复位锁定钢板内固定治疗组(ORIF组)。MIPPO组21例,男11例,女10例;平均年龄(70.0±5.3)岁;术中先用正骨手法闭合复位肱骨近端,位置满意后经皮锁定钢板固定治疗。ORIF组18例,男10例,女8例;平均年龄(72.0±4.2)岁;采取经三角肌胸大肌间隙入路,切开复位骨折后锁定钢板内固定治疗。记录两组患者的手术时间、术中出血量、骨折愈合时间及术后并发症。末次随访时应用Constant-Murley评分系统对患肩进行评定。结果:39例均获随访,时间11~27个月,平均18.1个月。MIPPO组平均出血量(176.0±57.4)ml,少于ORIF组的(356.0±66.9)ml;MIPPO组手术时间平均(47.4±14.9)min,短于ORIF组的(92.7±15.8)min;MIPPO组骨折愈合时间平均(17.6±5.8)周,短于ORIF组的(21.7±4.9)周。肩关节功能Constant-Murley评分,MIPPO组89.7±14.5,优于ORIF组的81.8±13.2。结论:正骨手法整复微创锁定钢板固定治疗肱骨近端骨折,具有创伤小、血供破坏少、固定可靠等优点,是治疗老年性肱骨近端骨折的有效方法。     

经皮微创新型锁定钢板治疗老年肱骨近端骨折的病例对照研究

目的:评价经皮微创新型锁定钢板内固定治疗老年性肱骨近端3、4部分骨折的临床意义。方法:2008年6月至2010年12月,采用锁定钢板内固定治疗老年肱骨近端3、4部分骨折98例,男43例,女55例;年龄65～84岁,平均(71.3±6.2)岁。47例采取经三角肌外侧入路,经皮微创新型肱骨近端锁定钢板内固定治疗(MIPPO组);51例采取三角肌胸大肌间隙入路,切开复位锁定钢板内固定治疗(ORIF组)。记录患者的手术时间、术中出血量、伤口并发症、住院时间。术后应用Constant评分系统对肩关节进行功能评定。结果:96例患者均获随访,时间13～42个月,平均18.1个月,2例患者随访期内死亡。MIPPO组较ORIF组平均出血量减少125ml(P<0.05)。手术时间两组比较差异无统计学意义。平均住院时间MIPPO组较ORIF组缩短5.1d(P<0.05)。两组患者骨折愈合时间比较差异无统计学意义。末次随访肩关节功能Constant评分两组比较差异无统计学意义,但并发症发生率MIPPO组低于ORIF组(P<0.05)。结论:经皮微创肱骨近端新型锁定钢板内固定具有术中出血少、术后患者恢复快和血运破坏少、并发症发生率低等优点,是治疗老年肱骨近端3、4部分骨折有效的方法。     

TriGen髓内钉与锁定钢板固定肱骨近端骨折比较

[目的]比较TriGen肱骨髓内钉锁定钢板固定肱骨近端骨折的临床效果。[方法]回顾性分析2014年5月—2018年5月本院采用开放复位内固定治疗的NeerⅢ、Ⅳ型肱骨近端骨折120例患者的临床资料。依据术前医患沟通结果,62例患者采用TriGen髓内钉固定(髓内钉组),58例患者采用锁定钢板固定(钢板组)。比较两组患者围手术期、随访与影像学资料。[结果]两组均顺利完成手术,术中均无严重并发症。髓内钉组手术时间[(70.52±6.78) min vs (91.50±8.01) min,P0.05]、切口长度[(6.32±1.51) cm vs (12.52±1.73) cm,P0.05]、术中失血量[(141.98±10.08) ml vs (224.91±12.67) ml,P0.05]、住院时间[(9.33±1.82) d vs (12.47±2.38) d,P0.05]和切口拆线时间[(12.43±1.78) d vs (15.38±2.35) d,P0.05]均显著优于钢板组。所有患者均获随访12个月以上,两组恢复主动伤肩活动和完全负重活动时间的差异均无统计学意义(P0.05)。相应时间点,两组间VAS、Constant-Murley评分和前屈ROM的差异均无统计学意义(P0.05)。影像方面,两组患者术后影像显示骨折复位质量的差异无统计学意义(P0.05)。相应时间点,两组间肱骨颈干角的差异均无统计学意义(P0.05)。至末次随访时,两组患者骨折均愈合,两组影像骨折愈合时间的差异无统计学意义(P0.05)。[结论] TriGen髓内钉与锁定钢板均可有效治疗肱骨近端骨折,但TriGen髓内钉的医源性损伤明显小于锁定钢板。     

MIPPO技术结合PHILOS治疗老年骨质疏松性肱骨近端骨折

[目的]探讨采用MIPPO技术结合肱骨近端内固定锁定系统(PHILOS)治疗老年骨质疏松性肱骨近端骨折的疗效。[方法]回顾分析本院2009年4月²012年5月具有完整随访资料的68例老年骨质疏松性肱骨近端骨折患者,其中采用MIPPO技术结合PHILOS治疗老年骨质疏松性肱骨近端骨折患者37例(MIPPO组),传统切开复位内固定(ORIF)PHILOS治疗老年骨质疏松性肱骨近端骨折患者31例(ORIF组)。记录切口长度、手术时间、出血量、住院天数,观察骨折愈合时间、功能恢复情况及并发症,并进行统计学分析。[结果]68例患者术后随访122012年5月具有完整随访资料的68例老年骨质疏松性肱骨近端骨折患者,其中采用MIPPO技术结合PHILOS治疗老年骨质疏松性肱骨近端骨折患者37例(MIPPO组),传统切开复位内固定(ORIF)PHILOS治疗老年骨质疏松性肱骨近端骨折患者31例(ORIF组)。记录切口长度、手术时间、出血量、住院天数,观察骨折愈合时间、功能恢复情况及并发症,并进行统计学分析。[结果]68例患者术后随访12³6个月(平均19.7个月),MIPPO组切口长度、手术时间、出血量、住院天数、骨折愈合时间等比较明显优于ORIF组,差异具有统计学意义(P<0.05);而功能恢复优良率及并发症发生率等比较MIPPO组优于ORIF组,但差异未见统计学意义(P>0.05)。[结论]MIPPO技术结合PHILOS治疗老年骨质疏松性肱骨近端骨折符合生物学固定原则,较传统切开复位内固定方法具有轻微优势,如:创伤小、切口小、住院时间短、出血量少、手术时间短、骨折愈合早等优点,是治疗老年骨质疏松性肱骨近端骨折的有效方法。     

前侧入路MIPPO技术与髓内钉内固定治疗肱骨干骨折的疗效比较

目的比较前侧入路微创经皮钢板内固定技术(MIPPO)与髓内钉内固定治疗肱骨干骨折的临床效果。方法回顾性分析自2009-05—2013-08分别采用MIPPO技术、顺行髓内钉内固定与逆行髓内钉内固定治疗的肱骨干骨折54例,MIPPO组21例,顺行髓内钉组18例,逆行髓内钉组15例。比较3组手术时间、术中出血量、骨折愈合情况、功能恢复情况、术后并发症。结果 3组术中出血量(F=72.040,P0.001)、骨折愈合时间(F=9.351,P0.001)比较差异无统计学意义,但MIPPO组手术时间较顺行髓内钉组和逆行髓内钉组短,差异有统计学意义(F=84.783,P=0.058)。54例均获得平均18.9(11~39)个月随访。MIPPO组疗效优良率明显高于顺行髓内钉组和逆行髓内钉组,并发症发生率明显低于顺行髓内钉组和逆行髓内钉组,差异有统计学意义(P0.05)。结论采用前侧入路MIPPO技术治疗肱骨干骨折避免了传统切开复位钢板内固定的缺点,也避免了髓内钉内固定术后的并发症,而且操作简单,学习曲线较短。     

MIPPO与ORIF治疗Neer Ⅱ型老年肱骨近端骨折病例对照研究

目的 :比较经皮微创接骨板内固定术(MIPPO)与切开复位内固定术(ORIF)两种术式治疗NeerⅡ型老年性肱骨近端骨折的临床疗效。方法:回顾性分析2014年3月至2016年3月分别采用MIPPO与ORIF手术治疗的NeerⅡ型老年性肱骨近端骨折46例患者,其中MIPPO组20例,男9例,女11例,年龄65~80(70.4±4.4)岁;ORIF组26例,男11例,女15例,年龄65~79(70.9±4.0)岁。比较两组术中透视次数,住院时间,骨折愈合时间,术后康复锻炼启动时间,术后3、6、12个月肩关节功能Constant-Murley评分,末次随访关节功能分级及腋神经损伤等并发症情况。结果:46例患者均获随访,时间12~24(16.8±3.7)个月。Mippo组骨折愈合时间(13.0±0.8)周较ORIF组(13.8±1.4)周短,康复锻炼启动时间(3.0±0.9)d较ORIF组(6.8±1.3)d短,术中透视次数(19.2±3.7)次较ORIF组(12.1±3.4)次多。术后3、6个月Constant-Murley肩关节功能评分81.3±3.9和86.6±5.4均高于ORIF组69.5±6.6和80.5±6.7。但两组住院时间、术后12个月Constant Murley肩关节功能评分及末次关节功能分级差异均无统计学意义;MIPPO组有1例腋神经损伤,ORIF组有2例延迟愈合,两组各有1例复位丢失,均无感染、内固定断裂等。结论:MIPPO与ORIF均能治疗NeerⅡ型老年性肱骨近端骨折,前者具有术后恢复更快、康复锻炼更早、早期肩关节功能恢复好等优点,但存在腋神经损伤、X线暴露多等缺点。     

微创钢板接骨术和传统切开复位内固定术治疗肱骨近端骨折的比较研究

目的比较微创经皮钢板接骨术(MIPPO)和传统切开复位内固定(ORIF)手术治疗肱骨近端骨折的临床效果。方法回顾性分析2010年1月至2013年1月廉江市人民医院和湛江中心人民医院收治的68例肱骨近端骨折患者的临床资料,其中32例采用MIPPO技术(MIPPO组),36例行ORIF治疗(ORIF组),两组钢板均选用肱骨近端锁定接骨板。比较两组手术时间、术中出血量,观察术后并发症发生率情况,采用肩关节Neer评分标准进行术后功能评价。结果 68例患者均获得随访,随访时间12~14个月,平均随访时间12.5个月。MIPPO组手术时间及术中出血量均少于ORIF组,两组比较,差异有统计学意义(P0.05)。ORIF组1例术后感染行二次手术治疗,2例术后半年出现肱骨头坏死;两组均未出现皮肤坏死、神经功能损伤及内固定松动、断裂并发症。术后1年随访时MIPPO组和ORIF组Neer评分优良率分别为94%(30/32)和75%(27/36),两组比较,差异有统计学意义(P0.05)。结论对于肱骨近端骨折而言,MIPPO较之ORIF操作简便,手术创伤小,术后并发症少,肩关节功能恢复良好。     

肱骨近端锁定钢板与髓内钉治疗肱骨外科颈骨折的临床对比研究

目的分析肱骨近端锁定钢板与髓内钉治疗NeerII型肱骨外科颈骨折的疗效。方法回顾性研究自2009-09—2012—06收治的48例NeerⅡ型肱骨外科颈骨折,其中25例行肱骨近端锁定钢板（PHIL05组）固定,23例行肱骨髓内钉（PHN组）固定。结果PHILOS组手术时间为（110_＋26）min高于PHN组（78±12）min,PHILOS组术中出血量为（96±15）ml高于PHN组（52±10）ml,PHILOS组骨折愈合为（15±4）周,高于PHN组（10±2）周,差异均具有统计学意义（P〈0．05）。2组术后在颈干角比较．差异无统计学意义（P〉0．05）。2组术后肩关节Constant评分比较差异无统计学意义,但PHN组的外展前屈功能稍差。结论肱骨近端锁定钢板与髓内钉在治疗NeerII型肱骨外科颈骨折临床疗效相当,但肱骨近端髓内钉手术创伤更小,有利于骨折愈合。     

髓内钉与髓外内固定治疗不稳定型股骨转子下骨折的疗效比较

目的 比较髓内钉与髓外内固定治疗不稳定型股骨转子下骨折的疗效. 方法 回顾性分析2005年1月至2011年8月期间收治且获得随访的65例不稳定型(Russell-Taylor分型B型)股骨转子下骨折患者资料,男40例,女25例;年龄为32～ 87岁,平均53.4岁.根据内固定方式不同分为两组:髓内钉组34例,髓外内固定组31例(其中锁定加压钢板内固定治疗21例,动力髋螺钉内固定治疗10例).记录并比较两组患者的手术时间、术中出血量、骨折复位质量、住院时间、骨折愈合时间及术后12个月髋关节Harris评分. 结果 65例患者术后获12 ～ 18个月(平均15.6个月)随访.髓内钉组患者的手术时间[(67.9±19.0) min]较髓外内固定组[(79.8±22.4) min]短,术中出血量[(112.6±63.4) mL]较髓外内固定组[(178.5±97.5)mL]少,骨折愈合时间[(21.0±6.5)周]较髓外内固定组[(28.0±8.7)周]短,术后12个月髋关节Harris评分[(83.4±8.1)分]较髓外内固定组[(79.2±7.4)分]高,差异均有统计学意义(P＜0.05).但两组患者的骨折复位质量、住院时间比较差异均无统计学意义(P＞0.05).2例患者出现骨不连,均为采用锁定加压钢板固定者,改为髓内钉固定后骨折获愈合;2例患者出现畸形愈合,其中髓外内固定组1例,髓内钉组1例. 结论 髓内钉较髓外内固定治疗不稳定型股骨转子下骨折更有优势.     

闭合复位髓内钉与切开复位锁定接骨板固定治疗肱骨中上段骨折的疗效比较

目的比较闭合复位髓内钉与切开复位锁定接骨板固定治疗肱骨中上段骨折的疗效。方法回顾性分析2017年10月至2021年2月荆门市第一人民医院骨科和解放军中部战区总医院骨科收治的62例肱骨中上段骨折患者资料。男35例, 女27例;年龄27～86岁;左侧24例, 右侧38例。骨折均为新鲜骨折;按AO分型:A型16例, B型32例, C型14例。根据治疗方法不同分为2组:髓内钉组29例(采用闭合复位髓内钉内固定)和接骨板组33例(采用切开复位锁定接骨板内固定)。记录并比较两组患者的手术切口长度、手术时间、术中出血量、住院时间、骨折愈合情况及并发症发生情况。术后1周、1个月采用疼痛视觉模拟评分(VAS)评价疼痛程度, 术后1、12个月采用Constant-Murley评分评价肩关节功能恢复情况。结果髓内钉组与接骨板组患者术前一般资料比较差异均无统计学意义(P<0.05), 具有可比性。髓内钉组患者术后随访12～29个月, 接骨板组患者术后随访15～50个月。髓内钉组手术切口长度[(4.1±0.7) cm]、手术时间[(58.3±7.7) min]、术中出血量[(52.7±6.5) mL]及住...     

维生素D受体在糖尿病肾病足细胞损伤及蛋白尿缓解中的作用

目的探讨维生素D受体(VDR)在糖尿病肾病(DKD)足细胞中的表达水平及在足细胞损伤及蛋白尿缓解中的作用。方法(1)本研究纳入了65例诊断患有2型糖尿病(伴或不伴蛋白尿)的患者,并纳入了25例年龄和性别相匹配的健康体检者为对照组。根据白蛋白/肌酐(ACR)的尿排泄比例对2型糖尿病患者进行分组,分别为无蛋白尿(ACR<30 mg/g,n=24)、微量白蛋白尿(ACR 30~300 mg/g,n=18)和临床蛋白尿(ACR>300 mg/g,n=23)。另选择25例经肾活检确诊的DKD患者作为DKD组。正常肾脏组织标本均取自泌尿外科同一时期肾脏肿瘤切除患者10例。将各组检测指标进行对比,同时采用实时定量PCR、ELISA法和免疫组化法检测VDR在各组患者的血液、尿液样本和肾脏组织中的表达情况,以及使用Pearson相关分析分析VDR与尿蛋白的相关性。(2)在2型糖尿病肾病小鼠模型中对上述结果进行验证,将遗传背景均为C57BLKs/J的雄性db/db小鼠及同窝出生的db/m小鼠,随机分为正常对照组(A组)、DKD对照组(B组)、DKD二甲基亚砜处理组(C组)、DKD帕立骨化醇(VDR激动剂)处理组(D组),C、D组连续腹腔注射处理8周,对照组不做任何处理。小鼠10周龄时开始连续干预8周,在小鼠22周龄(开始干预后12周)检测各组小鼠体重、血、尿生化指标对比;Western印迹法检测β⁃catenin、VDR的变化;免疫荧光观察足细胞标志蛋白podocin及足细胞损伤蛋白α⁃SMA的表达变化。结果(1)与正常健康对照组相比,无蛋白尿组、微量白蛋白尿组和临床蛋白尿组的糖尿病患者血浆中VDR的mRNA和蛋白水平均较低(均P<0.05);与无蛋白尿组的糖尿病患者相比,微量白蛋白尿组和临床蛋白尿组的糖尿病患者血浆中VDR的mRNA和蛋白水平均较低(均P<0.05)。(2)与正常健康对照组相比,无蛋白尿糖尿病组和DKD组患者血浆中VDR的mRNA和蛋白水平均较低(均P<0.05);与无蛋白尿糖尿病组患者相比,DKD组患者血浆中VDR的mRNA和蛋白水平亦较低(均P<0.05)。(3)免疫组化结果显示,DKD组肾组织中VDR的表达明显少于正常对照组。(4)DKD患者血浆中VDR mRNA相对水平与ACR呈负相关(r=-0.342,P<0.05)。(5)各组尿液上清液中VDR的水平与血浆中的水平呈相反趋势。(6)Western印迹结果显示,B组、C组肾小球足细胞β⁃catenin蛋白表达高于D组(均P<0.05),VDR蛋白的表达低于D组(均P<0.05);免疫荧光结果显示,B组、C组肾小球足细胞podocin的表达低于D组(均P<0.05),α⁃SMA的表达高于D组(均P<0.05)。结论VDR高表达缓解DKD足细胞损伤及蛋白尿。     

Anterior Interosseous Nerve Palsy After Shoulder Arthroscopy Treated With Surgical Decompression: A Case Series and Systematic Review of the Literature

Background: Anterior interosseous nerve (AIN) palsy is a very uncommon cause of upper extremity pain and weakness that comprises less than 1% of all upper extremity nerve palsies. Rarely reported but also mentioned in the literature is AIN palsy after shoulder arthroscopy. Methods: A systematic review of the literature to date using PubMed was conducted to identify patients who suffered AIN palsy after shoulder arthroscopy procedures. Articles included met the following criteria: (1) published in English; (2) primary presentation of the data; (3) patients had undergone shoulder arthroscopy before developing symptoms of AIN palsy; and (4) diagnosis was confirmed with clinical symptoms of AIN palsy. Measured outcomes included patient demographics, specific shoulder procedure, anesthesia procedure, intra-operative patient positioning, intra-operative compressive dressing, intra-operative traction, surgical versus conservative treatment, abnormal findings during decompression procedure, proposed mechanism of injury, and follow-up. Results: The search yielded 6 articles, of which 4 (13 cases) met inclusion criteria. An additional 2 cases were included in this report totaling 15 cases. The average patient age was 49 years (range: 31-64) with 73% males. At average follow-up of 24 months, 67% of patients experienced complete resolution of symptoms—more than half of which underwent surgical decompression. Patients who failed to progress experienced weakness of the flexor digitorum profundus and flexor pollicis longus muscles. Conclusions: Proposed injury mechanisms for AIN palsy after shoulder arthroscopy range from mechanical trauma, compressive hematoma, and direct anesthetic neurotoxicity. Management should be directed by clinical symptoms, imaging, and patient factors with majority of patients expected to have excellent clinical outcomes.     

不同尿钙水平的Gitelman综合征患者临床特点比较

目的观察不同尿钙水平Gitelman综合征(GS)患者的临床特点,探讨尿钙在GS疾病临床分型中的价值。方法收集2016—2018年来自中国国家罕见病注册系统(NRSC)、在北京协和医院行SLC12A3基因检测诊断为GS患者的临床资料,分析其尿钙特点,比较不同尿钙水平患者的临床和实验室检查指标。氢氯噻嗪试验按照标准操作流程进行,测定患者基线和用药后3 h内氯离子排泄分数改变量的最大值(ΔFECl)。结果共有83例GS患者被纳入研究,其中低尿钙患者53例(63.86%)。低尿钙组尿钙/肌酐比明显低于非低尿钙组[(0.085±0.058)mmol/mmol比(0.471±0.284)mmol/mmol,t=7.349,P<0.001]。两组患者在年龄、性别、估算肾小球滤过率、血压、血尿电解质水平、代谢性碱中毒方面差异均无统计学意义。低尿钙组患者乏力(χ2=4.595,P=0.032)及多尿(χ2=5.778,P=0.016)发生比例低于非低尿钙组,两组患者在其他临床症状方面差异无统计学意义。低尿钙和非低尿钙组各有16例患者行氢氯噻嗪试验,中位ΔFECl结果分别为0.539%(0.430%,1.283%)和0.829%(0.119%,1.298%),均提示对氢氯噻嗪无反应,组间差异无统计学意义(U=130.000,P=0.956)。结论GS患者中低尿钙比例为63.86%,尿钙水平与疾病临床表型、NCC功能损伤严重程度之间均无明确相关性。     

Fibrinogen-thrombin collagen patch reinforcement of highrisk colonic anastomoses in rats

AIM To evaluate the effectiveness of human fibrinogenthrombin collagen patch(TachoSil~?) in the reinforcement of high-risk colon anastomoses.METHODS A quasi-experimental study was conducted in Wistar rats(n = 56) that all underwent high-risk anastomoses(anastomosis with only two sutures) after colectomies. The rats were divided into two randomized groups: Control group(24 rats) and treatment group(24 rats). In the treatment group, high-risk anastomosis was reinforced with TachoSil~? (a piece of Tacho Sil? was applied over this high-risk anastomosis, covering the gap). Leak incidence, overall survival, intra-abdominal adhesions, and histologic healing of anastomoses were analyzed. Survivors were divided into two subgroups and euthanized at 15 and 30 d after intervention in order to analyze the adhesions and histologic changes. RESULTS Overall survival was 71.4% and 57.14% in the TachoSil~? group and control group, respectively(P = 0.29); four rats died from other causes and six rats in the treatment group and 10 in the control group experienced colonic leakage(P 0.05). The intra-abdominal adhesion score was similar in both groups, with no differences between subgroups. We found non-significant differences in the healing process according to the histologic score used in both groups(P = 0.066).CONCLUSION In our study, the use of TachoSil~? was associated with a non-statistically significant reduction in the rate of leakage in high-risk anastomoses. TachoSil~? has been shown to be a safe product because it does not affect the histologic healing process or increase intra-abdominal adhesions.     

Role of Conventional and Diffusion-Weighted Magnetic Resonance Imaging of Spinal Treatment Protocol for Hydatid Disease

Objective:

To demonstrate the role of magnetic resonance imaging (MRI) in determining the treatment protocol for hydatid disease of the spine.

Design:

Case report; literature review.

Findings:

Diffusion-weighted MRI can help differentiate complicated infected hydatidosis from abscesses, epidermoid cysts from arachnoid cysts, and benign from malignant vertebral compression fractures. It is also helpful in differentiating between abscesses and necrotic tumors.

Conclusion:

Diffusion-weighted MRI can help differentiate between infections requiring immediate surgery and those that can be treated medically with antihelmintic treatment.     

Fluorescence in the Sclera,Nails, and Teeth Secondary to Favipiravir Use for COVID-19 Infections

Favipiravir, an antiviral agent originally used for influenza infections, has become popular due to its beneficial signals in coronavirus disease. It is currently used in some countries within COVID-19 treatment protocols. This is an initial report of favipiravir-related fluorescence observed in three healthcare providers working in the same ward in our hospital. All three individuals had been diagnosed with COVID-19 two months earlier and were treated with favipiravir. None of the three individuals received hydroxychloroquine or tetracyclines. Wood’s light examination led to an incidental discovery of favipiravir-induced fluorescence involving the sclera, nails, and teeth. In all patients, white linear, square, and band-like specks of fluorescence were noticed on the sclera of both eyes, some teeth, and the proximal part of all fingernails and toenails. Exposure of the eyes to the Wood’s light was for a brief duration of 3 to 5 seconds during examination and photodocumentation. Favipiravir might cause bright white fluorescence of nails, sclera, and teeth, detectable by Wood’s light even two months after its cessation.     

Safety and tolerability of single intravenous doses of sugammadex administered simultaneously with rocuronium or vecuronium in healthy volunteers

BACKGROUND: Sugammadex rapidly reverses rocuronium- and vecuronium-induced neuromuscular block. To investigate the effect of combination of sugammadex and rocuronium or vecuronium on QT interval, it would be preferable to avoid the interference of anaesthesia. Therefore, this pilot study was performed to investigate the safety, tolerability, and plasma pharmacokinetics of single i.v. doses of sugammadex administered simultaneously with rocuronium or vecuronium to anaesthetized and non-anaesthetized healthy volunteers. METHODS: In this phase I study, 12 subjects were anaesthetized with propofol/remifentanil and received sugammadex 16, 20, or 32 mg kg(-1) combined with rocuronium 1.2 mg kg(-1) or vecuronium 0.1 mg kg(-1); four subjects were not anaesthetized and received sugammadex 32 mg kg(-1) with rocuronium 1.2 mg kg(-1) or vecuronium 0.1 mg kg(-1) (n=2 per treatment). Neuromuscular function was assessed by TOF-Watch SX monitoring in anaesthetized subjects and by clinical tests in non-anaesthetized volunteers. Sugammadex, rocuronium, and vecuronium plasma concentrations were measured at several time points. RESULTS: No serious adverse events (AEs) were reported. Fourteen subjects reported 23 AEs after study drug administration. Episodes of mild headache, tiredness, cold feeling (application site), dry mouth, oral discomfort, nausea, increased aspartate aminotransferase and gamma-glutamyltransferase levels, and moderate injection site irritation were considered as possibly related to the study drug. The ECG and vital signs showed no clinically relevant changes. Rocuronium/vecuronium plasma concentrations declined faster than those of sugammadex. CONCLUSIONS: Single-dose administration of sugammadex 16, 20, or 32 mg kg(-1) in combination with rocuronium 1.2 mg kg(-1) or vecuronium 0.1 mg kg(-1) was well tolerated with no clinical evidence of residual neuromuscular block, confirming that these combinations can safely be administered simultaneously to non-anaesthetized subjects. Rocuronium and vecuronium plasma concentrations decreased faster than those of sugammadex, reducing the theoretical risk of neuromuscular block developing over time.     

血浆凝血因子VIII水平与IgA肾病患者临床病理改变及预后的关系

目的探讨血浆凝血因子VIII(factor VIII,FVIII)水平与IgA肾病(IgAN)患者临床参数及预后的关系。方法收集2016年1月至2016年12月中南大学湘雅二医院确诊的IgAN患者的临床资料。按照时间依赖的受试者工作特征曲线(ROC)得出的血浆FVIII预测IgAN预后的临界值,将患者分为高FVIII组(FVIII>140.50%)和低FVIII组(FVIII≤140.50%),比较两组患者肾活检时基线临床参数的差异。以估算肾小球滤过率(eGFR)下降≥30%或进入终末期肾脏病(ESRD)为终点事件,采用Kaplan-Meier生存曲线及Cox回归方程法分析血浆FVIII水平对IgAN患者预后的影响。结果共93例IgAN患者纳入本研究,中位随访时间为35.15(33.77,36.76)个月,12例(12.90%)患者发生终点事件。高FVIII组患者年龄、血肌酐、尿素氮、血三酰甘油、血总胆固醇、血浆纤维蛋白原、D-二聚体、24 h尿蛋白量、蛋白C、蛋白S和eGFR下降速率高于低FVIII组(均P<0.05);eGFR、血白蛋白、中位随访时间低于低FVIII组(均P<0.05)。Kaplan-Meier生存分析结果显示,与低FVIII组比较,高FVIII组患者肾脏累积生存率降低(χ2=5.635,P=0.018)。在校正收缩压、eGFR、尿蛋白、肾小管萎缩/间质纤维化程度等因素后,多因素Cox回归分析结果显示,高血浆FVIII水平是IgAN患者肾脏预后不良的独立危险因素(HR=4.147,95%CI 1.055~16.308,P=0.042)。结论血浆FVIII水平与IgAN患者临床指标及预后相关,高血浆FVIII水平是IgAN患者肾脏预后不良的独立危险因素。     

罗伊适应模式对腹股沟疝无张力疝修补术后恢复情况的影响

目的探讨罗伊适应模式对患者腹股沟疝无张力疝修补术后恢复情况的影响。 方法将2016年1月至2019年5月在秦皇岛市第二医院择期进行无张力修补术治疗的120例腹股沟疝患者，按照随机数字法分为对照组和观察组，每组各60例。对照组采用常规护理治疗，观察组在对照组的基础上采用罗伊适应模式。比较2组患者的术后临床指标、心理状态、围手术期并发症发生情况及满意度。 结果术后观察组患者的首次排气时间、恢复正常饮食时间、离床活动时间和术后住院时间均低于对照组（P<0.05）；术后观察组患者的抑郁自评量表（SDS）和焦虑自评量表（SAS）评分显著低于对照组（P<0.05）；术后2组患者均无切口感染发生，2组患者尿潴留、急性疼痛、认知功能障碍、发热、血肿等发生率相比无统计学差异（P>0.05）；术后观察组患者护理满意度为96.67%，显著高于对照组的83.33%（P<0.05）。 结论在常规护理的基础上，罗伊适应模式用于患者腹股沟疝无张力修补围手术期，能有效改善术后患者的焦虑/抑郁情绪，不增加围手术期并发症，促进术后患者的恢复及提高治疗满意度。     

Factors Associated With Reoperation After Silicone Proximal Interphalangeal Joint Arthroplasty

Background: Silicone proximal interphalangeal (PIP) joint arthroplasty has a high revision rate. It has been suggested that persistent ulnar deviation and joint instability influence the durability of PIP silicone arthroplasties. The goal of this study was to evaluate what factors are associated with reoperation after silicone PIP arthroplasty. Methods: We retrospectively evaluated all adult patients who underwent PIP silicone arthroplasty between 2002 and 2016 at one institutional system for inflammatory-, posttraumatic-, and primary degenerative arthritis. After manual chart review, we included 91 patients who underwent 114 arthroplasties. Fingers operated included 14 index, 41 middle, 38 ring, and 21 small fingers. Results: The overall reoperation rate was 14% (n = 16). Non-Caucasian race (P = .040), smoking (P = .022) and PIP silicone arthroplasty for post-traumatic osteoarthritis (P = .021) were associated with reoperation. The 1-, 5- and 10-year implant survival rates were 87%, 85%, and 85%, respectively. Conclusion: Caution should be exercised when considering PIP silicone arthroplasty of the index finger or in patients with post-traumatic osteoarthritis. It may be worthwhile addressing smoking behavior before pursuing silicone PIP arthroplasty.