血糖、尿糖检验诊断糖尿病的价值对比

目的:对比分析在糖尿病患者的诊断中进行血糖或尿糖检验的临床价值.方法:抽取2018年1月～2020年1月本院94例2型糖尿病患者,分别接受血糖、尿糖检验,比较2中检验方法的准确性.结果:血糖检验的糖尿病阳性率为98.94％,尿糖检验为91.49％,且P<0.05.结论:在糖尿病患者的诊断中进行血糖检验的价值高于尿糖检验...     

血糖与尿糖检验在糖尿病诊断中的应用

目的 探讨糖尿病诊断中血糖与尿糖检验的应用.方法 回顾性选取2018年1月—2020年1月林甸县鹤鸣湖镇卫生院医学检验科糖尿病患者240例,采用全自动生化仪,运用葡萄糖氧化酶法检验血糖;采用尿液分析仪检验尿糖,分析240例患者的血糖与尿糖检验结果.结果 240例患者中,血糖检验空腹血糖≤6.0 mmol/L10例,>6...     

糖尿病患者接受尿糖和血糖检验对病情控制的影响

目的:研究对糖尿病患者开展尿糖检验、血糖检验的价值.方法:此研究借助回顾性方式展开,研究时段为2018年1月-2019年10月,研究对象为我院接收的160例糖尿病患者,对其分别开展尿糖和血糖检验,分析检验结果.结果:糖尿病患者血糖、尿糖检验结果之间为正相关关系,而机体尿糖浓度越高,血糖水平越高.结论:对糖尿病患者开展筛...     

糖尿病患者的血糖及尿糖检验临床分析

目的 探究糖尿病患者血糖及尿糖检验的临床价值.方法 选取2018年1月—2019年12月林甸县鹤鸣湖镇卫生院收治的60例糖尿病患者作为研究对象,电脑随机数字表法分组,每组30例.对照组给予尿糖检验,观察组采用血糖检验.比较两种诊断方式准确率及血浆葡萄糖水平.结果 观察组与对照组对糖尿病诊断准确率分别为93.3％、70....     

尿糖和血糖检验在糖尿病诊断中应用分析

目的研究分析糖尿病患者接受尿糖和血糖检验的作用。方法 2014—2015年该院共选取了160例接受血糖和尿糖检验的患者,患者的血糖和尿糖检验结果相一致为阴性,不一致为阳性。结果全部患者共有8例阳性病例,比例是5%,阴性结果有152例,比例是95%;共有3例糖尿病病史阳性病例,比例是1.8%;妊娠糖尿病阳性病例2例,比例是1.2%;饮食性糖尿病病例3例,比例是1.8%;其他因素导致的糖尿病阳性病例4例,比例是2.5%。结论血糖和尿糖可以作为糖尿病患者临床诊断以及病情控制的参考信息,对血糖和尿糖检测结果进行综合的分析研究,让患者的病情监控更加合理,对于疾病的控制有非常重要的意义。     

糖化血红蛋白在糖尿病及空腹血糖受损诊断中的价值

目的 探讨HbA1c在糖尿病及IFG诊断中的意义。方法选取526名未诊断糖尿病及IFG者同时检测HbA1C和FPG。按ADA诊断标准（FI）G≥7．0mmol／L）、IFG标准（5．6mmol／L≤FPG46．9mmol／L）和2010年ADA新标准（HbA1c≥6．5％及5．7％≤HbA1c≤6．4％）将研究对象分组。以FPG为“金标准”,统计HbA1C诊断糖尿糖及IFG的敏感性（s）、特异性（Sp）、阳性似然比（＋ut）、阴性似然比（-LR）。结果HbA1c≥6．5％诊断糖尿病的s为96％,Sp为95％,＋LR为19．2,-LR为0．042;5．7N≤HbA1c≤6．4％诊断IFG的S为26％,sp为94％,＋LR为4．3,-LR为0．79。结论HbA1C诊断糖尿病有较高的诊断敏感性和特异性,在诊断IFG时特异性较高,而敏感性较低。     

血糖与尿糖的关系及其临床意义

本文对190例口服葡萄糖耐量试验(OGTT)各时相的血糖与尿糖半定量值进行了比较;并对85例尿糖与血糖变化关系进行了动态观察。提出:用尿糖来筛查糖尿病和判断糖尿病的控制情况并不完全可靠,如掌握正确的留尿方法,注意摸索出每个病人的肾糖阀,尿糖测定是有参考价值的。     

不同时间测定血糖标本的初步观察

在测定血糖时出现的误差会给临床诊断和治疗带来一定的困难 ,作者对 15份血清标本在不同时间内测定血糖结果并进行比较。1　材料与方法静脉采血后行 37℃水浴 2 0 min后立即离心 ,吸取血清测定血糖。共测标本 15份 ,每份标本测 5次。测定时实验室温度为2 3℃～ 2 6℃。采用上海科华—东菱诊断用品有限公司生产的血糖试剂盒 ,用氧化酶法测定 ,正常参考值为 (3.89～ 6 .11)mmol/ L (批内 :均值为 3.91mmol/ L ,标准差为 0 .0 96 ,变异系数2 .5 % )。使用日立 70 6 0型全自动生化分析仪。按试剂盒说明书及该公司所提供的日立 70 6 0全自动生化…     

血糖全自动生化仪和尿糖检验在糖尿病患者中的临床价值比较

目的 分析在糖尿病患者临床诊断期间血糖全自动生化仪、尿糖检验两种方式的应用效果。方法 选取福建省福鼎市医院前岐分院2020年10月—2022年3月收治的疑似糖尿病患者110例为研究对象,对患者分别进行血糖全自动生化仪检验、尿糖检验,以口服葡萄糖耐量试验（oral glucose tolerance test, OGTT）作为诊断的金标准,以此对比两种方式下的检验结果,评价诊断效能。结果 OGTT诊断结果显示110例患者中,阳性87例,阴性23例;经尿糖检验结果显示,阳性74例,阴性36例;血糖全自动生化仪检验结果显示阳性86例,阴性24例。血糖全自动生化仪诊断糖尿病敏感性、特异度、诊断符合率、阳性预测值及阴性预测值均高于尿糖检验,差异有统计学意义（P<0.05）。结论 在糖尿病患者临床诊断过程中,血糖全自动生化仪和尿糖检验均有一定使用价值,但尿糖检验更适合糖尿病的初步筛查,而血糖全自动生化仪则适合对患者实施进一步诊断,提升临床诊治的诊断符合率,且操作更加便捷。     

空腹血糖、血脂及糖耐量检验在糖尿病生化检验中的应用价值

目的 探究糖尿病生化检验中空腹血糖、血脂和糖耐量检验的作用。方法 选取2022年1—12月麻城市人民医院收治的41例糖尿病患者作为观察组,选取41例同期来本院健康体检人群作为对照组,分别针对两组人群进行生化指标检测,分析两组空腹血糖、餐后血糖、总胆固醇、三酰甘油、低密度脂蛋白胆固醇及高密度脂蛋白胆固醇。结果 观察组空腹血糖（8.42±3.62）mmol/L及餐后血糖（11.23±3.12）mmol/L均高于对照组,差异有统计学意义（t=4.652、12.441,P<0.05）;观察组总胆固醇（5.18±1.23）mmol/L、三酰甘油（2.43±0.87）mmol/L、低密度脂蛋白胆固醇（3.41±1.33）mmol/L均高于对照组,高密度脂蛋白胆固醇（1.03±0.47）mmol/L低于对照组,差异有统计学意义（t=9.544、9.254、8.261、6.890,P<0.05）。结论 通过空腹血糖、血脂和糖耐量检验,能够为糖尿病患者的临床诊断提供重要参考依据,方便患者尽早接受治疗。     

Association between sitagliptin adherence and self-monitoring of blood glucose

Background:

We evaluated the association between self-monitoring of blood glucose (SMBG) use and sitagliptin or sitagliptin/metformin (SSMT) adherence. SSMT was chosen as these medications have little risk of hypoglycemia and are believed to not require SMBG data for titration.

Methods

This was an observational study using data extracted from a large United States insurance claims database (i3 InVision™ Data Mart, Ingenix, Inc.). Data were extracted on noninsulin-using patients initiating SSMT for each 12-month period pre- and post-SSMT initiation. Logistic regression was used to assess the relationship between SMBG use and the likelihood of being medication adherent (defined as a medication possession ratio of ≥75%) while controlling for covariates.

Results

This analysis included 7,306 patients (57.6% male; mean age 54.2 years). Mean pre-SSMT hemoglobin A1c (HbA1c) was 8.0%. In the post-SSMT initiation period, 58% of patients were adherent with SSMT. Older age, male gender, prior use of oral diabetes medication, and lower HbA1c were associated with improved SSMT adherence. SMBG use was associated with improved adherence [odds ratio (OR) ranged from 1.198 to 1.338; p < .05] compared with patients with no SMBG use pre- or post-SSMT initiation. For patients who began SMBG after starting SSMT, greater SMBG use was associated with better adherence (OR 1.449 for higher vs 1.246 for lower strip use; p < .05).

Conclusions

This study demonstrated that SMBG is associated with improved SSMT adherence. This relationship is strengthened with greater SMBG use.     

Effect of the nurse-led program on blood glucose control and microalbuminuria development in type 2 diabetic populations

Current study was to evaluate whether the nurse-led program can improve glycated hemoglobin (HbA1c) control and reduce the incidence of microalbuminuria in type 2 diabetic mellitus (DM2) populations. A total of 150 DM2 subjects were randomly assigned to the usual-care group and nurse-led program group. Study endpoints included the HbA1c value, the percentage of subjects with HbA1c < 7.0%, the incidence of microalbuminuria, and the rate of adhering to antidiabetic drug at 6 months’ follow-up. At baseline, there was no difference in fasting plasma glucose, HbA1c, proportion of subjects with HbA1c < 7.0%, the use of antidiabetic drug, and urinary albumin-creatinine ratio between these two groups. After 6 months’ follow-up, the mean fasting plasma glucose and HbA1c were lower in the nurse-led program group, as was the proportion of subjects with HbA1c < 7.0%. The median urinary albumin-creatinine ratio and rate of incident microalbuminuria were also lower in the nurse-led program. The nurse-led program was associated with higher odds of achieving HbA1c < 7.0% and a lower incidence of microalbuminuria. After adjusted for covariates, the nurse-led program was still associated with 32% higher odds of achieving HbA1c < 7.0% and 11% lower incidence of microalbuminuria. These benefits were consistent by sex and age, while greater in those with obesity or hypertension (P interaction < .05). The nurse-led program is beneficial for blood glucose control and prevention of microalbuminuria.     

Gastrointestinal motor function in diabetes mellitus: Relationship to blood glucose concentrations

Abstract The application of novel investigative techniques has established that there is a high prevalence of disordered gastrointestinal motor function in patients with diabetes mellitus and has provided insights into its pathogenesis and clinical significance. Acute changes in the blood glucose concentration, even within the normal postprandial range, affect both gastrointestinal motor function and the perception of sensations arising from the gastrointestinal tract. Gastric emptying is slower during hyperglycaemia and accelerated during hypoglycaemia; the perception of gastric distension is greater during hyperglycaemia than euglycaemia. The pathways mediating the effects of the blood glucose concentration on gut motility and sensation are poorly defined. The rate of gastric emptying is an important determinant of postprandial blood glucose concentrations and there is increasing evidence that gastric emptying can be modulated therapeutically in order to optimize glycaemic control in patients with diabetes.     

卒中后首次随机血糖水平与卒中严重程度和预后的相关性研究

目的 探讨卒中患者急性期血糖水平与卒中严重程度和预后的关系.方法:根据随机血糖水平足否>7.8 mmol/L,将连续173例急性卒中患者分为随机血糖升高组(72例)和止常组(101例).平均发病至入院时间为(6.5±5.1)h,接诊20 min内对其进行美国国立卫生院卒中量表(National Institutes of Health Stroke Scale,NIHSS)评定和格拉斯哥昏迷量表(Glasgow Coma Stroke,GCS)评分,40 min完成血浆血糖测定和头颅CT扫描,对脑梗死患者进行OCSP分型,并且在3个月后对存活患者进行改良Rankin量表(modified Rankin Stroke,mRS)评定.结果:两组在年龄、性别、血管危险因素以及卒中性质和治疗原则方面无统计学差异,首次就诊时的NHISS、GCS和3个月时的mRS评分差异显著(P<0.01).随机血糖升高组有糖尿病史的比例显著高于正常血糖组(P<0.01).在两组有糖尿病史的患者之间,随机血糖水平与卒中严重程度尤关;在无糖尿病史的患者之间,随机血糖升高与卒中严重程度和预后存在显著相关性(P<0.01).结论:无糖尿病史的卒中患者急性期血糖升高是病情严重程度和预后的独立危险因素.卒中患者急性期随机血糖升高可提示有糖尿病史.     

Evaluation of the analytical performance of the coulometry-based Optium Omega blood glucose meter

Background

The goal of diabetes treatment is maintaining near normoglycemia based on self-monitoring of blood glucose (SMBG). In this study, an evaluation of the analytical performance of the coulometry-based Optium Omega™ glucose meter designed for SMBG has been carried out.

Methods

The assessment of precision and between-lot variability was based on glucose measurements in ethylene-diaminetetraacetic acid venous blood samples. Glucose concentrations measured in 289 fresh capillary blood samples using the Omega glucose meter and the Biosen C_line analyzer were compared.

Results

Within-run imprecision coefficient of variation for the lower and higher glucose concentrations amounted to 5.09 and 2.1%, respectively. The relative lot-dependent differences found for the lower and higher glucose concentrations were equal to 6.8 and 2.6%, respectively. The glucose meter error calculated for various concentration ranges amounted from 2.22 to 4.48%. The glucose meter error met the accuracy criteria recommended by the International Organization for Standardization and the American Diabetes Association. The Passing-Bablok agreement test and error grid analysis with 96% of results in zone A indicated good concordance of results, including glucose concentrations below 100 mg/dl.

Conclusions

The evaluated Optium Omega glucose meter fits the analytical requirements for its use in blood glucose monitoring in diabetes patients.     

Relationship between blood glucose level and mortality in Type 2 diabetes mellitus: a systematic review

Aim To review the relationship between blood glucose level and mortality in patients with Type 2 diabetes mellitus (DM) as reported in the literature. Methods Literature search using Medline Search: January 1966 – April 1998. Keywords: Diabetes, Non Insulin Dependent, Mortality. Inclusion criteria for papers were: Type 2 DM; follow-up for at least 3 years; glucose or glycated haemoglobin (HbA_1c) was used as parameter; published in the form of an article. Additionally all references in the selected articles that dealt with the relationship between blood glucose level and mortality in Type 2 DM were included in the search. Results Twenty-seven eligible articles were found. Twenty-three of them showed a positive association: measures of elevated blood glucose concentrations were associated with higher mortality; in 15 out of 23 studies the positive association was statistically significant, in two only for postprandial blood glucose. One study found a nonsignificant negative relationship in a very old population. Conclusion In the literature there is a positive, but rather weak, association between the measures of blood glucose control and the risk of dying of patients with Type 2 DM. In the six larger studies (more than 100 deceased patients) that used a continuous categorization of glycaemia, the Risk ratio per unit varies from 1.03 to 1.12. Diabet. Med. 16, 2–13 (1999)     

Effects of simulated altitude on blood glucose meter performance: implications for in-flight blood glucose monitoring

BACKGROUND: Most manufacturers of blood glucose monitoring equipment do not give advice regarding the use of their meters and strips onboard aircraft, and some airlines have blood glucose testing equipment in the aircraft cabin medical bag. Previous studies using older blood glucose meters (BGMs) have shown conflicting results on the performance of both glucose oxidase (GOX)- and glucose dehydrogenase (GDH)-based meters at high altitude. The aim of our study was to evaluate the performance of four new-generation BGMs at sea level and at a simulated altitude equivalent to that used in the cabin of commercial aircrafts. Methodology/Principal Findings: Blood glucose measurements obtained by two GDH and two GOX BGMs at sea level and simulated altitude of 8000 feet in a hypobaric chamber were compared with measurements obtained using a YSI 2300 blood glucose analyzer as a reference method. Spiked venous blood samples of three different glucose levels were used. The accuracy of each meter was determined by calculating percentage error of each meter compared with the YSI reference and was also assessed against standard International Organization for Standardization (ISO) criteria. Clinical accuracy was evaluated using the consensus error grid method. The percentage (standard deviation) error for GDH meters at sea level and altitude was 13.36% (8.83%; for meter 1) and 12.97% (8.03%; for meter 2) with p = .784, and for GOX meters was 5.88% (7.35%; for meter 3) and 7.38% (6.20%; for meter 4) with p = .187. There was variation in the number of time individual meters met the standard ISO criteria ranging from 72-100%. Results from all four meters at both sea level and simulated altitude fell within zones A and B of the consensus error grid, using YSI as the reference. CONCLUSIONS: Overall, at simulated altitude, no differences were observed between the performance of GDH and GOX meters. Overestimation of blood glucose concentration was seen among individual meters evaluated, but none of the results obtained would have resulted in dangerous failure to detect and treat blood glucose errors or in giving treatment that was actually contradictory to that required.     

2型糖尿病患者血浆Apelin-12水平与血糖的关系

目的探讨2型糖尿病患者血浆脂肪细胞因子Apelin-12水平变化及其与血糖的关系。方法选取2012年1月至2015年6月在民航总医院内分泌科住院的41例2型糖尿病患者作为研究对象,并招募44例健康对照者作为对照组。根据有无合并冠心病、脑血管病及高血压病将2型糖尿病患者再分为2型糖尿病合并心脑血管疾病组(21例)和单纯糖尿病组(20例)。酶联免疫吸附法测定Apelin-12的水平,测定其糖化血红蛋白、总胆固醇、甘油三酯、低密度脂蛋白以及空腹和餐后2 h血糖、C肽的水平,并对以上指标进行相关性分析。结果与对照组相比,2型糖尿病患者血浆Apelin-12水平显著降低(t=2.70,P=0.01); 2型糖尿病合并心脑血管疾病组血浆Apelin-12的水平与单纯糖尿病组差异无统计学意义(t=-0.44,P=0.67)。多元逐步回归分析显示,在2型糖尿病患者中,空腹血糖与Apelin-12相关(B=-0.12,β=-0.42,t=-2.03,P=0.04)。结论 2型糖尿病患者血浆Apelin-12水平显著降低且与空腹血糖呈负相关。     

血糖波动与老年人糖尿病血管并发症的研究进展

对于早期2型糖尿病患者,强化降糖治疗可以降低糖尿病微血管和大血管慢性并发症的发生风险。但老年糖尿病患者多伴有重要脏器功能减退、多种疾病共存、用药复杂、血糖波动幅度大及易发低血糖等特点,而过大的血糖波动和严重的低血糖被认为与糖尿病血管并发症密切相关。因此新的治疗理念认为,对于病程较长的老年2型糖尿病患者,在控制血糖的基础上,应减少血糖波动和严重低血糖的发生,从而减少糖尿病慢性并发症的发生发展。     

The blood glucose lowering effects of exercise and glibenclamide in patients with Type 2 diabetes mellitus

Physical exercise is associated with a fall in serum insulin levels, whereas sulphonylurea administration increases insulin release. To date, the opposing effects of exercise and sulphonylurea administration have not been systematically studied in Type 2 diabetic patients, who are not infrequently treated with sulphonylureas. In this study nine patients with Type 2 diabetes mellitus were subjected to four treatments in random order on separate days: (A) endurance exercise after the administration of 3.5 mg glibenclamide; (B) as A but given only 1.75 mg glibenclamide; (C) as A but with placebo; (D) rest and administration of 1.75 mg glibenclamide. Exercise and placebo resulted in only a small decrease in glycaemia. Rest and administration of 1.75 mg glibenclamide led to a moderate but steady fall in blood glucose concentrations. If glibenclamide administration and exercise were combined, blood glucose concentrations declined more markedly. Serum insulin concentrations showed a physiological decrease during exercise and placebo administration. If patients rested after administration of glibenclamide serum insulin levels rose and remained elevated. When exercise and glibenclamide were combined the rise in serum insulin levels was blunted and insulin levels fell once exercise was begun. Thus, exercise attenuates the glibenclamide induced increase in serum insulin in moderately hyperglycaemic Type 2 diabetic patients. Nevertheless, exercise has a substantial hypoglycaemic effect in glibenclamide treated Type 2 diabetic patients. © 1998 John Wiley & Sons, Ltd.